Improving adiponectin levels in individuals with diabetes and obesity: Insights from look AHEAD

Diabetes Care

Volumn 38, Issue 8, 2015, Pages 1544-1550

  Belalcazar, L Maria ^a   Lang, Wei ^b   Haffner, Steven M ^c   Schwenke, Dawn C ^d   Kriska, Andrea ^e   Balasubramanyam, Ashok ^f   Hoogeveen, Ron C ^f   Pi Sunyer, F Xavier ^g   Tracy, Russell P ^h   Ballantyne, Christie M ^f,i  

^a University of Texas Medical Branch School of Medicine   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^d ARIZONA STATE UNIVERSITY   (United States)

^e UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^f BAYLOR COLLEGE OF MEDICINE   (United States)

^g Och Spine at New York Presbyterian Hospitals   (United States)

^h UNIVERSITY OF VERMONT   (United States)

ⁱ Center for Cardiovascular Disease Prevention   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; ADIPOQ PROTEIN, HUMAN;

ADULT; ARTICLE; BODY WEIGHT; CARDIORESPIRATORY FITNESS; CONTROLLED STUDY; EXERCISE TEST; FEMALE; HUMAN; INTENSIVE LIFESTYLE INTERVENTION; LIFESTYLE MODIFICATION; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; WEIGHT REDUCTION; BLOOD; CLINICAL TRIAL; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; FITNESS; KINESIOTHERAPY; LIFESTYLE; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; OVERWEIGHT; PHYSIOLOGY; PROCEDURES; RISK REDUCTION;

ADIPONECTIN; ADULT; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; EXERCISE TEST; EXERCISE THERAPY; FEMALE; HUMANS; LIFE STYLE; MALE; MIDDLE AGED; OBESITY; OVERWEIGHT; PHYSICAL FITNESS; RISK REDUCTION BEHAVIOR; WEIGHT LOSS;

EID: 84962427814     PISSN: 01495992     EISSN: 19355548     Source Type: Journal    
DOI: 10.2337/dc14-2775     Document Type: Article

References (26)

1. Yamauchi T, Kamon J, Waki H, et al. The fatderived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 2001;7:941-946.
2. Cnop M, Havel PJ, Utzschneider KM, et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 2003;46:459-469.
3. Basu R, Pajvani UB, Rizza RA, Scherer PE. Selective downregulation of the high molecular weight form of adiponectin in hyperinsulinemia and in type 2 diabetes: differential regulation from nondiabetic subjects. Diabetes 2007;56:2174-2177.
4. Kim JY, van de Wall E, Laplante M, et al. Obesity- Associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest 2007;117:2621-2637.
5. Cook JR, Semple RK. Hypoadiponectinemiad cause or consequence of human "insulin resistance"? J Clin Endocrinol Metab 2010;95:1544-1554.
6. Kizer JR. A tangled threesome: Adiponectin, insulin sensitivity, and adiposity: can Mendelian randomization sort out causality? Diabetes 2013;62:1007-1009.
7. Aguilar-Salinas CA, Garćia EG, Robles L, et al. High adiponectin concentrations are associated with the metabolically healthy obese phenotype. J Clin Endocrinol Metab 2008;93:4075-4079.
8. Esposito K, Pontillo A, Di Palo C, et al. Effect of weight loss and lifestyle changes on vascular inflammatory markers in obese women: A randomized trial. JAMA 2003;289:1799-1804.
9. Christiansen T, Paulsen SK, Bruun JM, Pedersen SB, Richelsen B. Exercise training versus diet-induced weight-loss on metabolic risk factors and inflammatory markers in obese subjects: A 12-week randomized intervention study. Am J Physiol Endocrinol Metab 2010;298:E824-E831.
10. Bouchonville M, Armamento-Villareal R, Shah K, et al. Weight loss, exercise, or both and cardiometabolic risk factors in obese older adults: results of a randomized controlled trial. Int J Obes (Lond) 2014;38:423-431.
11. Hawley JA, Lessard SJ. Exercise traininginduced improvements in insulin action. Acta Physiol (Oxf) 2008;192:127-135.
12. Blair SN, Cheng Y, Holder JS. Is physical activity or physical fitness more important in defining health benefits? Med Sci Sports Exerc 2001; 33(6 Suppl.):S379-S399; discussion S419-S420.
13. Wadden TA, West DS, Delahanty L, et al.; Look AHEAD Research Group. The Look AHEAD study: A description of the lifestyle intervention and the evidence supporting it. Obesity (Silver Spring) 2006;14:737-752.
14. Wadden TA, West DS, Neiberg RH, et al.; Look AHEAD Research Group. One-year weight losses in the Look AHEAD study: factors associated with success. Obesity (Silver Spring) 2009; 17:713-722.
15. Belalcazar LM, Lang W, Haffner SM, et al.; Look AHEAD Research Group. Adiponectin and the mediation of HDL-cholesterol change with improved lifestyle: The Look AHEAD Study. J Lipid Res 2012;53:2726-2733.
16. Look AHEAD Research Group. Reduction in weight and cardiovascular disease risk factors in individuals with type 2 diabetes: one-year results of the Look AHEAD trial. Diabetes Care 2007;30:1374-1383.
17. Jakicic JM, Jaramillo SA, Balasubramanyam A, et al.; Look AHEAD Study Group. Effect of a lifestyle intervention on change in cardiorespiratory fitness in adults with type 2 diabetes: results from the Look AHEAD Study. Int J Obes (Lond) 2009;33:305-316.
18. Heshka S, Ruggiero A, Bray GA, et al.; Look AHEAD Research Group. Altered body composition in type 2 diabetes mellitus. Int J Obes (Lond) 2008;32:780-787.
19. Apovian CM, Bigornia S, Mott M, et al. Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler Thromb Vasc Biol 2008;28:1654-1659.
20. Vandanmagsar B, Youm YH, Ravussin A, et al. The NLRP3 inflammasome instigates obesityinduced inflammation and insulin resistance. Nat Med 2011;17:179-188.
21. Holdstock C, Engström BE, Ohrvall M, Lind L, Sundbom M, Karlsson FA. Ghrelin and adipose tissue regulatory peptides: effect of gastric bypass surgery in obese humans. J Clin Endocrinol Metab 2003;88:3177-3183.
22. Wu H, Ghosh S, Perrard XD, et al. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation 2007; 115:1029-1038.
23. Black MA, Cable NT, Thijssen DH, Green DJ. Impact of age, sex, and exercise on brachial artery flow-mediated dilatation. Am J Physiol Heart Circ Physiol 2009;297:H1109-H1116.
24. Koh EH, KimM, Ranjan KC, et al. eNOS plays a major role in adiponectin synthesis in adipocytes. Am J Physiol Endocrinol Metab 2010;298:E846- E853.
25. Jakicic JM, Egan CM, Fabricatore AN, et al.; Look AHEAD Research Group. Four-year change in cardiorespiratory fitness and influence on glycemic control in adults with type 2 diabetes in a randomized trial: The Look AHEAD Trial. Diabetes Care 2013;36:1297-1303.
26. Gregg EW, Chen H, Wagenknecht LE, et al.; Look AHEAD Research Group. Association of an intensive lifestyle intervention with remission of type 2 diabetes. JAMA 2012;308:2489-2496.