Bidirectional electromagnetic control of the hypothalamus regulates feeding and metabolism

Nature

Volumn 531, Issue 7596, 2016, Pages 647-650

  Stanley, Sarah A ^a   Kelly, Leah ^a   Latcha, Kaamashri N ^a   Schmidt, Sarah F ^a   Yu, Xiaofei ^a   Nectow, Alexander R ^a   Sauer, Jeremy ^b   Dyke, Jonathan P ^c   Dordick, Jonathan S ^b   Friedman, Jeffrey M ^a,d  

^a ROCKEFELLER UNIVERSITY   (United States)

^b RENSSELAER POLYTECHNIC INSTITUTE   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERRITIN; GLUCAGON; GLUCOKINASE; GLUCOSE; INSULIN; VANILLOID RECEPTOR 1; CRE RECOMBINASE; GLUCOSE BLOOD LEVEL; HYBRID PROTEIN; INTEGRASE; PANCREAS HORMONE; TRPV1 RECEPTOR; VANILLOID RECEPTOR;

BIOPHYSICS; BLOOD; CELLS AND CELL COMPONENTS; FEEDING; GLUCOSE; HOMEOSTASIS; METABOLISM; NERVOUS SYSTEM; PHYSIOLOGICAL RESPONSE; PROTEIN; RODENT;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; ELECTROMAGNETIC FIELD; FEEDING; FOOD INTAKE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HYPOGLYCEMIA; HYPOTHALAMUS; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; MAGNETIC FIELD; MAGNETOTHERAPY; METABOLISM; MOUSE; NERVE CELL; NERVE CELL INHIBITION; NONHUMAN; PRIORITY JOURNAL; RADIOFREQUENCY RADIATION; ZONA INCERTA; ANIMAL; BLOOD; CYTOLOGY; EATING; GENETICS; HOMEOSTASIS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; PHYSIOLOGY; TIME FACTOR;

CAMELIDAE; MUS;

ANIMALS; BLOOD GLUCOSE; EATING; FERRITINS; GLUCAGON; GLUCOKINASE; HOMEOSTASIS; HYPOGLYCEMIA; INSULIN; INTEGRASES; MAGNETIC FIELDS; MICE; NEURAL INHIBITION; NEURONS; PANCREATIC HORMONES; RADIO WAVES; RECOMBINANT FUSION PROTEINS; TIME FACTORS; TRPV CATION CHANNELS; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

EID: 84962422564     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature17183     Document Type: Article

References (29)

1. Stanley, S. A., Sauer, J., Kane, R. S., Dordick, J. S. & Friedman, J. M. Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles. Nature Med. 21, 92-98 (2015).
2. Stanley, S. et al. Profiling of glucose-sensing neurons reveals that GHRH neurons are activated by hypoglycemia. Cell Metab. 18, 596-607 (2013).
3. Davies, R., Nakajima, S. & White, N. Enhancement of feeding produced by stimulation of the ventromedial hypothalamus. J. Comp. Physiol. Psychol. 86, 414-419 (1974).
4. Goto, Y., Carpenter, R. G., Berelowitz, M. & Frohman, L. A. Effect of ventromedial hypothalamic lesions on the secretion of somatostatin, insulin, and glucagon by the perfused rat pancreas. Metabolism 29, 986-990 (1980).
5. Shimazu, T., Fukuda, A. & Ban, T. Reciprocal influences of the ventromedial and lateral hypothalamic nuclei on blood glucose level and liver glycogen content. Nature 210, 1178-1179 (1966).
6. Schwartz, M. W. et al. Cooperation between brain and islet in glucose homeostasis and diabetes. Nature 503, 59-66 (2013).
7. Kang, L., Routh, V. H., Kuzhikandathil, E. V., Gaspers, L. D. & Levin, B. E. Physiological and molecular characteristics of rat hypothalamic ventromedial nucleus glucosensing neurons. Diabetes 53, 549-559 (2004).
8. Aponte, Y., Atasoy, D. & Sternson, S. M. AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training. Nature Neurosci. 14, 351-355 (2011).
9. Anthony, T. E. et al. Control of stress-induced persistent anxiety by an extra-amygdala septohypothalamic circuit. Cell 156, 522-536 (2014).
10. Nordlie, R. C., Foster, J. D. & Lange, A. J. Regulation of glucose production by the liver. Annu. Rev. Nutr. 19, 379-406 (1999).
11. Bito, H., Deisseroth, K. & Tsien, R. W. CREB phosphorylation and dephosphorylation: a Ca2+-and stimulus duration-dependent switch for hippocampal gene expression. Cell 87, 1203-1214 (1996).
12. Ghosh, A., Ginty, D. D., Bading, H. & Greenberg, M. E. Calcium regulation of gene expression in neuronal cells. J. Neurobiol. 25, 294-303 (1994).
13. Lozano, A. M. & Eltahawy, H. How does DBS work? Suppl. Clin. Neurophysiol. 57, 733-736 (2004).
14. Kühn, F. J., Knop, G. & Luckhoff, A. The transmembrane segment S6 determines cation versus anion selectivity of TRPM2 and TRPM8. J. Biol. Chem. 282, 27598-27609 (2007).
15. Landau, B. R. & Lubs, H. A. Animal responses to 2-deoxy-d-glucose administration. Proc. Soc. Exp. Biol. Med. 99, 124-127 (1958).
16. Kim, T., Moore, D. & Fussenegger, M. Genetically programmed superparamagnetic behavior of mammalian cells. J. Biotechnol. 162, 237-245 (2012).
17. Rowland, N. E., Bellush, L. L. & Carlton, J. Metabolic and neurochemical correlates of glucoprivic feeding. Brain Res. Bull. 14, 617-624 (1985).
18. Evans, M. L. et al. Hypothalamic ATP-sensitive K+ channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses. Diabetes 53, 2542-2551 (2004).
19. Murphy, B. A., Fakira, K. A., Song, Z., Beuve, A. & Routh, V. H. AMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons. Am. J. Physiol. Cell Physiol. 297, C750-C758 (2009).
20. Horvath, T. L. et al. Brain uncoupling protein 2: uncoupled neuronal mitochondria predict thermal synapses in homeostatic centers. J. Neurosci. 19, 10417-10427 (1999).
21. Chen, R., Romero, G., Christiansen, M. G., Mohr, A. & Anikeeva, P. Wireless magnetothermal deep brain stimulation. Science 347, 1477-1480 (2015).
22. Stanley, S. A. et al. Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice. Science 336, 604-608 (2012).
23. Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S. & Roth, B. L. Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc. Natl Acad. Sci. USA 104, 5163-5168 (2007).
24. Alexander, G. M. et al. Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron 63, 27-39 (2009).
25. Nawaratne, V. et al. New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug). Mol. Pharmacol. 74, 1119-1131 (2008).
26. Falowski, S. M., Ooi, Y. C. & Bakay, R. A. Long-term evaluation of changes in operative technique and hardware-related complications with deep brain stimulation. Neuromodulation 18, 670-677 (2015).
27. Caterina, M. J. et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816-824 (1997).
28. Wu, S. Y. & Chiang, C. M. Expression and purification of epitope-tagged multisubunit protein complexes from mammalian cells. Curr. Protoc. Mol. Biol. Chapter 16, Unit 16.13 (2002).
29. Nakaya, N., Sultana, A., Lee, H. S. & Tomarev, S. I. Olfactomedin 1 interacts with the Nogo A receptor complex to regulate axon growth. J. Biol. Chem. 287, 37171-37184 (2012).