The effect of kynurenic acid on the synthesis of selected cytokines by murine splenocytes - In vitro and ex vivo studies

Central European Journal of Immunology

Volumn 41, Issue 1, 2016, Pages 39-46

  Małaczewska, Joanna ^a   Siwicki, Andrzej K ^a   Wójcik, Roman M ^a   Turski, Waldemar A ^b   Kaczorek, Edyta ^a  

^a UNIVERSITY OF WARMIA AND MAZURY IN OLSZTYN   (Poland)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

Cytokine response; Immunomodulating properties; Kynurenic acid; Murine splenocytes

Indexed keywords

DRINKING WATER; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; KYNURENIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL ACTIVITY; CELL ISOLATION; CELL PROLIFERATION; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; CYTOTOXICITY; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; EX VIVO STUDY; IMMUNOMODULATION; IMMUNOSTIMULATION; IN VITRO STUDY; MALE; MOUSE; MTT ASSAY; NONHUMAN; SPLEEN CELL; TREATMENT DURATION;

EID: 84962377259     PISSN: 14263912     EISSN: 16444124     Source Type: Journal    
DOI: 10.5114/ceji.2016.58815     Document Type: Article

References (29)

1. Moroni F, Fossati S, Chiarugi A, et al. (2007): Kynurenic acid actions in brain and periphery. Int Congr Ser 1304: 305-313.
2. Chen Y, Guillemin GJ (2009): Kynurenine pathway metabolites in humans: disease and healthy states. Int J Tryptophan Res 2: 1-19.
3. Kudo Y, Boyd CA, Sargent IL, et al. (2001): Tryptophan degradation by human placental indoleamine 2,3-dioxygenase regulates lymphocyte proliferation. J Physiol 535: 207-215.
4. Mándi Y, Vécsei L (2012): The kynurenine system and immunoregulation. J Neural Transm 119: 197-209.
5. Terness P, Bauer TM, Röse L, et al. (2002): Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites. J Exp Med 196: 447-457.
6. Wang J, Simonavicius N, Wu X, et al. (2006): Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35. J Biol Chem 281: 22021-22028.
7. Kaszaki J, Palásthy Z, Érczes D, et al. (2008): Kynurenic acid inhibits intestinal hypermotility and xanthine oxidase activity during experimental colon obstruction in dogs. Neurogastroenterol Motil 20: 53-62.
8. Lugo-Huitrón R, Blanco-Ayala T, Ugalde-Muñiz P, et al. (2011): On the antioxidant properties of kynurenic acid: free radical scavenging activity and inhibition of oxidative stress. Neurotoxicol Teratol 33: 538-547.
9. Maes M, Mihaylova I, Ruyter M, et al. (2007): The immune effects of TRYCATs (tryptophan catabolites along the IDO pathway): relevance for depression and other conditions characterized by tryptophan depletion induced by inflammation. Neuro Endocrinol Lett 28: 826-831.
10. Małaczewska J, Siwicki AK, Wójcik RM, et al. (2014): Effect of oral administration of kynurenic acid on the activity of the peripheral blood leukocytes in mice. Cent Eur J Immunol 39: 6-13.
11. Tiszlavicz Z, Németh B, Fülöp F, et al. (2011): Different inhibitory effects of kynurenic acid and a novel kynurenic acid analogue on tumour necrosis factor-a (TNF-a) production by mononuclear cells, HMGB1 production by monocytes and HNP1-3 secretion by neutrophils. Naunyn Schmiedebergs Arch Pharmacol 383: 447-455.
12. DiNatale B, Murray IA, Schroeder JC, et al. (2010): Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling. Toxicol Sci 115: 89-97.
13. Maaetoft-Udsen K, Shimoda LM, Frøkiær H, et al. (2012): Aryl hydrocarbon receptor ligand effects in RBL2H3 cells. J Immunotoxicol 9: 327-337.
14. Paluszkiewicz P, Zgrajka W, Saran T, et al. (2009): High concentration of kynurenic acid in bile and pancreatic juice. Amino Acids 37: 637-641.
15. Zgrajka W, Turska M, Rajtar G, et al. (2013): Kynurenic acid content in anti-rheumatic herbs. Ann Agric Environ Med 20: 800-802.
16. Turski MP, Turska M, Zgrajka W, et al. (2009): Presence of kynurenic acid in food and honeybee products. Amino Acids 36: 75-80.
17. Turski MP, Turska M, Paluszkiewicz P, et al. (2013): Kynurenic acid in the digestive system - new facts, new challenges. Int J Tryptophan Res 6: 47-55.
18. Wejksza K, Rzeski W, Turski WA (2009): Kynurenic acid protects against the homocysteine-induced impairment of endothelial cells. Pharmacol Rep 61: 751-756.
19. Mosmann T (1983): Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63.
20. Małaczewska J, Siwicki AK, Wójcik R, et al. (2014): The in vitro effect of kynurenic acid on the rainbow trout (Oncorhynchus mykiss) leukocyte and splenocyte activity. Pol J Vet Sci 17: 453-458.
21. Turski WA, Małaczewska J, Marciniak S, et al. (2014): On the toxicity of kynurenic acid in vivo and in vitro. Pharm Rep 66: 1127-1133.
22. Klien C, Patte-Mensah C, Taleb O, et al. (2013): The neuroprotector kynurenic acid increases neuronal cell survival through neprilysin induction. Neuropharmacology 70: 254-260.
23. Di Serio C, Cozzi A, Angeli I, et al. (2005): Kynurenic acid inhibits the release of the neurotrophic fibroblast growth factor (FGF)-1 and enhances proliferation of glia cells, in vitro. Cell Mol Neurobiol 25: 981-993.
24. Małaczewska J, Siwicki AK, Wójcik R, et al. (2013): Effect of dietary administration of kynurenic acid on the activity of splenocytes of the rainbow trout (Oncorhynchus mykiss). Centr Eur J Immunol 38: 475-479.
25. Kiank C, Zeden JP, Drude S, et al. (2010): Psychologial stress-induced, IDO1-dependent tryptophan catabolism: implications on immunosuppression in mice and humans. PLoS One 5: e11825.
26. Steiner L, Gold M, Mengel D, et al. (2014): The endogenous a7 nicotinic acetylcholine receptor antagonist kynurenic acid modulates amyloid-β-induced inflammation in BV-2 microglial cells. J Neurol Sci 344: 94-99.
27. Moroni F, Cozzi A, Sili M, et al. (2012): Kynurenic acid: a metabolite with multiple actions and multiple targets in brain and periphery. J Neural Transm 119: 133-139.
28. Varga G, Erces D, Fazekas B, et al. (2010): N-methyl-D-aspartate receptor antagonism decreases motility and inflammatory activation in the early phase of acute experimental colitis in the rat. Neurogastroenterol Motil 22: 217-225.
29. Stone TW, Stoy N, Darlington LG (2013): An expanding range of targets for kynurenine metabolites of tryptophan. Trends Pharmacol Sci 34: 136-143.