Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential

Nature Communications

Volumn 7, Issue , 2016, Pages

  Bolton, Helen ^a   Graham, Sarah J L ^a   Van Der Aa, Niels ^b   Kumar, Parveen ^b   Theunis, Koen ^b   Fernandez Gallardo, Elia ^b   Voet, Thierry ^b,c   Zernicka Goetz, Magdalena ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASSESSMENT METHOD; CELLS AND CELL COMPONENTS; CHROMOSOME; EMBRYONIC DEVELOPMENT; INHIBITOR; RODENT;

ANEUPLOIDY; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BLASTOCYST; BLASTOMA; CELL COUNT; CELL DEATH; CELL DIVISION; CELL MATURATION; CELL SURVIVAL; CHROMOSOME MOSAICISM; CHROMOSOME SEGREGATION; CHROMOSOME STRUCTURE; CONTROLLED STUDY; EMBRYO; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; LETHALITY; M PHASE CELL CYCLE CHECKPOINT; MALE; MOUSE; NONHUMAN; PREIMPLANTATION EMBRYO; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CBA MOUSE; CELL LINEAGE; CHROMOSOME; CYTOLOGY; DRUG EFFECTS; GENETICS; HUMAN; IN VITRO FERTILIZATION; MITOSIS; MOSAICISM; NIDATION; ZYGOTE;

2-(4-MORPHOLINOANILINO)-6-CYCLOHEXYLAMINOPURINE; MORPHOLINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PURINE DERIVATIVE;

ANEUPLOIDY; ANIMALS; BLASTOCYST; CELL COUNT; CELL LINEAGE; CHROMOSOME SEGREGATION; CHROMOSOMES, MAMMALIAN; EMBRYO IMPLANTATION; FEMALE; FERTILIZATION IN VITRO; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; MITOSIS; MODELS, GENETIC; MORPHOLINES; MOSAICISM; PROTEIN KINASE INHIBITORS; PURINES; ZYGOTE;

EID: 84962349399     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms11165     Document Type: Article

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