Sialic acid-modified antigens impose tolerance via inhibition of T-cell proliferation and de novo induction of regulatory T cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 12, 2016, Pages 3329-3334

  Perdicchio, Maurizio ^a,e   Ilarregui, Juan M ^a   Verstege, Marleen I ^a   Cornelissen, Lenneke A M ^a   Schetters, Sjoerd T T ^a   Engels, Steef ^a   Ambrosini, Martino ^a   Kalay, Hakan ^a   Veninga, Henrike ^a   Den Haan, Joke M M ^a   Van Berkel, Lisette A ^b   Samsom, Janneke N ^b   Crocker, Paul R ^c   Sparwasser, Tim ^d   Berod, Luciana ^d   Garcia Vallejo, Juan J ^a   Van Kooyk, Yvette ^a   Unger, Wendy W J ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

^d INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

^e Fred Hutchinson Cancer Research Center   (United States)

Author keywords

Dendritic cells; Glycans; Regulatory T cells; Sialic acids; Tolerance

Indexed keywords

ANTIGEN; GAMMA INTERFERON; MYELIN; SIALIC ACID; TRANSCRIPTION FACTOR FOXP3; N ACETYLNEURAMINIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN SPECIFICITY; ARTICLE; CARBOHYDRATE ANALYSIS; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL REGENERATION; CIRCULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; EFFECTOR CELL; EX VIVO STUDY; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; IMMUNOGENICITY; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; INTERNALIZATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIALYLATION; TH1 CELL; TH17 CELL; ADAPTATION; ANIMAL; C57BL MOUSE; CELL PROLIFERATION; CHEMISTRY; CYTOLOGY; IMMUNOLOGY;

ADAPTATION, PHYSIOLOGICAL; ANIMALS; ANTIGENS; CELL PROLIFERATION; MICE; MICE, INBRED C57BL; N-ACETYLNEURAMINIC ACID; T-LYMPHOCYTES, REGULATORY;

EID: 84962263345     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1507706113     Document Type: Article

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