Antibodies against pneumococcal capsular polysaccharide in Malawian HIV-positive mothers and their HIV-exposed uninfected children

Infectious Diseases

Volumn 48, Issue 4, 2016, Pages 317-321

  Baroncelli, Silvia ^a   Galluzzo, Clementina Maria ^a   Mancinelli, Sandro ^b   Andreotti, Mauro ^a   Jere, Haswell ^c   Amici, Roberta ^a   Marazzi, Maria Cristina ^d   Vella, Stefano ^a   Palombi, Leonardo ^b   Giuliano, Marina ^a  

^a ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c DREAM Program   (Malawi)

^d LUMSA UNIVERSITY   (Italy)

Author keywords

Antipneumococcal IgG; HIV exposed infants; Malawi; Passive transfer

Indexed keywords

CD4 ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; LAMIVUDINE; NEVIRAPINE; PNEUMOCOCCUS POLYSACCHARIDE; STAVUDINE; VIRUS RNA; ZIDOVUDINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BACTERIAL POLYSACCHARIDE;

ADULT; ANTIBODY BLOOD LEVEL; ANTIBODY SPECIFICITY; ANTIBODY TITER; ARTICLE; BREAST FEEDING; CD4 LYMPHOCYTE COUNT; CHILDHOOD MORTALITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPOSURE; FEMALE; GESTATIONAL AGE; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; INFECTION RISK; INFECTION SENSITIVITY; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; MALAWIAN; MORBIDITY; PASSIVE TRANSPORT; PREGNANT WOMAN; THIRD TRIMESTER PREGNANCY; VIRUS LOAD; VULNERABLE POPULATION; BACTERIAL CAPSULE; BLOOD; HIV INFECTIONS; IMMUNOLOGY; MALAWI; MALE; NEWBORN; PNEUMOCOCCAL INFECTION; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PRESCHOOL CHILD; PREVENTION AND CONTROL; TRANSMISSION; VERTICAL TRANSMISSION; VIROLOGY;

ADULT; ANTI-HIV AGENTS; BACTERIAL CAPSULES; CHILD, PRESCHOOL; FEMALE; HIV INFECTIONS; HUMANS; IMMUNOGLOBULIN G; INFANT; INFANT, NEWBORN; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALAWI; MALE; NEVIRAPINE; PNEUMOCOCCAL INFECTIONS; POLYSACCHARIDES, BACTERIAL; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; VIRAL LOAD;

EID: 84962242078     PISSN: 23744235     EISSN: None     Source Type: Journal    
DOI: 10.3109/23744235.2015.1115895     Document Type: Article

References (40)

1. 2014 Countries Progress reports [Internet]. Joint United Nations Programme on HIV/AIDS (UNAIDS); 2014; [cited 2015 May 22]. Available from: http://www.unaids.org/en/dataanalysis/knowyourre-sponse/countryprogressreports/2014countries.
2. Stringer EM, Chintu NT, Levy JW, et al. Declining HIV prevalence among young pregnant women in Lusaka, Zambia. Bull WHO. 2008;86:697-702.
3. Stringer EM, Ekouevi DK, Coetzee D, et al. Coverage of nevirapine-based services to prevent mother-to-child HIV transmission in 4 African countries. JAMA. 2010;304:293-302.
4. World Health Organization. Mother to child transmission of HIV: data and statistics. Available online at: http://www.who.int/hiv/topics/mtct/data/en/index1.html. Accessed 25 September 2015.
5. Afran L, Garcia Knight M, et al. HIV-exposed uninfected children: a growing population with a vulnerable immune system? Clin Exp Immunol. 2014;176:11-22.
6. Moraleda C, de Deus N, Serna-Bolea C, et al. Impact of HIV exposure on health outcomes in HIV-negative infants born to HIV-positive mothers in Sub-Saharan Africa. J Acquir Immune Defic Syndr. 2014;65:182-189.
7. Koyanagi A, Humphrey JH, Ntozini R, et al. Morbidity among human immunodeficiency virus-exposed but uninfected, human immunodeficiency virus-infected, and human immunodeficiency virus-unex-posed infants in Zimbabwe before availability of highly active antiretroviral therapy. Pediatr Infect Dis J. 2011;30:45-51.
8. Landes M, van Lettow M, Chan AK, et al. Mortality and health outcomes of HIV-exposed and unexposed children in a PMTCT cohort in Malawi. PLoS One. 2012;7:e47337.
9. Fawzy A, Arpadi S, Kankasa C, et al. Early weaning increases diarrhea morbidity and mortality among uninfected children born to HIV-infected mothers in Zambia. J Infect Dis. 2011;203:1222-1230.
10. McNally LM, Jeena PM, Gajee K, et al. Effect of age, polymicrobial disease, and maternal HIV status on treatment response and cause of severe pneumonia in South African children: a prospective descriptive study. Lancet. 2007;369:1440-1451.
11. Rollins NC, Ndirangu J, Bland RM, et al. Exclusive breastfeeding, diarrhoeal morbidity and all-cause mortality in infants of HIV-infected and HIV uninfected mothers: an intervention cohort study in KwaZulu Natal, South Africa. PLoS One. 2013;8:e81307.
12. Hygino J, Lima PG, Filho RG, et al. Altered immunological reactivity in HIV-1-exposed uninfected neonates. Clin Immunol. 2008;127:340-347.
13. Filteau S. The HIV-exposed, uninfected African child. Trop Med Int Health. 2009;14:276-287. Review.
14. Heidari S, Mofenson L, Cotton MF, et al. Antiretroviral drugs for preventing mother-to-child transmission of HIV: a review of potential effects on HIV-exposed but uninfected children. J Acquir Immune Defic Syndr. 2011;57:290-296.
15. Kourtis AP, Wiener J, Kayira D, et al. Health outcomes of HIV-exposed uninfected African infants. AIDS. 2013;27:749-759.
16. Noguera-Julian A, Morén C, Rovira N, et al. decreased mitochondrial function among healthy infants exposed to antiretrovirals during gestation, delivery and the neonatal period. Pediatr Infect Dis J. 2015 Sep 12. [Epub ahead of print]
17. Jones CE, Naidoo S, De Beer C, et al. Maternal HIV infection and antibody responses against vaccine-preventable diseases in unin-fected infants. JAMA. 2011;305:576-584.
18. Sanz-Ramos M, Manno D, Kapambwe M, et al. Reduced Poliovirus vaccine neutralizing-antibody titres in infants with maternal HIVexposure. Vaccine. 2013;31:2042-2049.
19. Gupta A, Mathad JS, Yang WT, et al. Maternal pneumococcal capsular IgG antibodies and transplacental transfer are low in South Asian HIV-infected mother-infant pairs. Vaccine. 2014;32:1466-1472.
20. Dangor Z, Kwatra G, Izu A, et al. HIV-1 is associated with Lower Group B Streptococcus Capsular and surface-protein IgG antibody levels and reduced transplacental antibody transfer in pregnant women. J Infect Dis. 2015;212:453-462.
21. Reikie BA, Naidoo S, Ruck CE, et al. Antibody responses to vaccination among South African HIV-exposed and unexposed uninfected infants during the first 2 years of life. Clin Vaccine Immunol. 2013;20:33-38.
22. Gaensbauer JT, Rakhola JT, Onyango-Makumbi C, et al. Impaired haemophilus influenza type-b transplacental antibody transmission and declining antibody avidity through the first year of life represent potential vulnerabilities for HIV-exposed but uninfected infants. Clin Vaccine Immunol. 2014;21:1661-1667.
23. De Milito A. B-lymphocyte dysfunctions in HIV infection. Curr HIV Res. 2004;2:11-21 11.
24. Palmeira P, Quinello C, Silveira-Lessa AL, et al. IgG placental transfer in healthy and pathological pregnancies. Clin Dev Immunol. 2012;2012:985646.
25. de Moraes-Pinto MI, Almeida AC, Kenj G, et al. Placental transfer and maternally acquired neonatal IgG immunity in human immunodeficiency virus infection. J Infect Dis. 1996;173:1077-1084.
26. Giuliano M, Andreotti M, Liotta G, et al. Maternal antiretroviral therapy for the prevention of mother-to-child transmission of HIV in Malawi: maternal and infant outcomes two years after delivery. PLoS One. 2013;8:e68950.
27. Palombi L, Marazzi MC, Voetberg A, et al. Treatment acceleration program and the experience of the DREAM program in prevention of mother-to-child transmission of HIV. AIDS. 2007;21:S65-71.
28. Zar HJ, Jeena P, Argent A, et al. Working Groups of the Paediatric Assembly of the South African Thoracic Society Diagnosis and management of community-acquired pneumonia in childhood-South African Thoracic Society guidelines. South Afr J Epidemiol Infect. 2009;24:25-36.
29. Robbins JB, Austrian R, Lee CJ, et al. Considerations for formulating the second-generation pneumococcal capsular polysaccharide vaccine with emphasis on the cross-reactive types within groups. J Infect Dis. 1983;148:1136-1159.
30. Schauer U, Stemberg F, Rieger CH, et al. Levels of antibodies specific to tetanus toxoid, Haemophilus influenzae type b, and pneumococ-cal capsular polysaccharide in healthy children and adults. Clin Diagn Lab Immunol. 2003;10:202-207.
31. Jones C, Pollock L, Barnett SM, et al. Specific antibodies against vaccine-preventable infections: a mother-infant cohort study. BMJ Open. 2013;3:e002473.
32. WHO Expert Committee on Biological Standardization. Recommendations to assure the quality, safety and efficacy of pneumococcal conjugate vaccines. Replacement of WHO Technical Report Series, 2013 No. 927 Annex. World Health Organization. Available from: http://www.who.int/biologicals/vaccines/TRS-977-Annex-3.pdf?ua141. Accessed 8 January 2015.
33. Liu L, Johnson HL, Cousens S, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379:2151-2161.
34. Glennie SJ, Sepako E, Mzinza D, et al. Impaired CD4 T cell memory response to Streptococcus pneumoniae precedes CD4 T cell depletion in HIV-infected Malawian adults. PLoS One. 2011:6:e25610.
35. Baroncelli S, Galluzzo CM, Liotta G, et al. Anti-Streptococcus Pneumoniae and Rotavirus IgG levels in HIV positive women do not correlate with maternal status and infant morbidity and mortality. J Med Microbiol. 2015;64:795-797.
36. Scott S, Moss WJ, Cousens S, et al. The influence of HIV-1 exposure and infection on levels of passively acquired antibodies to measles virus in Zambian infants. Clin Infect Dis. 2007;45:1417-1424.
37. Moro L, Bardají A, Nhampossa T, et al. Malaria and HIV infection in Mozambican pregnant women are associated with reduced transfer of antimalarial antibodies to their newborns. J Infect Dis. 2015;211:1004-1014.
38. Farquhar C, Nduati R, Haigwood N, et al. High maternal HIV-1 viral load during pregnancy is associated with reduced placental transfer of measles IgG antibody. J Acquir Immune Defic Syndr. 2005;40:494-497.
39. Kolibab K, Smithson SL, Shriner AK, et al. Immune response to pneumococcal polysaccharides 4 and 14 in elderly and young adults. I. Antibody concentrations, avidity and functional activity. Immun Ageing. 2005;2:10.
40. Okoko BJ, Wesumperuma LH, Ota MO, et al. The influence of placental malaria infection and maternal hypergammaglobuline-mia on transplacental transfer of antibodies and IgG subclasses in a rural West African population. J Infect Dis. 2001;184:627-632.