Mortality and Health Outcomes of HIV-Exposed and Unexposed Children in a PMTCT Cohort in Malawi

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Landes, Megan ^a,b   van Lettow, Monique ^a,c   Chan, Adrienne K ^a,b,c   Mayuni, Isabell ^a   Schouten, Erik J ^c,d   Bedell, Richard A ^a  

^a DIGNITAS INTERNATIONAL   (Malawi)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d NONE   (Malawi)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; NEVIRAPINE;

ADULT; ARTICLE; BODY HEIGHT; BODY MASS; BODY WEIGHT; BREAST FEEDING; CHILD; CHILDHOOD MORTALITY; COHORT ANALYSIS; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; FEMALE; HEALTH CARE UTILIZATION; HEALTH STATUS; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HIV TEST; HOSPITAL ADMISSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFANT; INFANT MORTALITY; INFECTION PREVENTION; LANSKY SCALE; LIVE BIRTH; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALAWI; MALNUTRITION; MATERNAL MORTALITY; MEDICAL RECORD REVIEW; MORTALITY; PRESCHOOL CHILD; RATING SCALE; RETROSPECTIVE STUDY; SEMI STRUCTURED INTERVIEW; SINGLE DRUG DOSE; SOCIOECONOMICS; STILLBIRTH; VERTICAL TRANSMISSION;

ADOLESCENT; ADULT; BREAST FEEDING; CHILD; CHILD MORTALITY; CHILD, PRESCHOOL; COHORT STUDIES; COST OF ILLNESS; FEMALE; HEALTH; HIV INFECTIONS; HUMANS; INFANT; INFECTIOUS DISEASE TRANSMISSION, VERTICAL; MALAWI; MOTHERS; RISK FACTORS; SURVIVAL ANALYSIS; TIME FACTORS;

EID: 84867659784     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047337     Document Type: Article

References (29)

1. UNAIDS (2010) Global Report. 2010 report on the global AIDS epidemic 4th. Geneva.
2. Newell M, Brahmbatt H, Ghys P, (2004) Child mortality and HIV infection in Africa: a review. AIDS (supp 2)pp. s27-234.
3. Zaba B, Whitworth J, Marston M, Nakiyingi J, Ruberantwari A, et al. (2005) HIV and mortality of mothers and children: evidence from cohort studies in Uganda, Tanzania and Malawi. Epidemiol 16: 275-280.
4. Naniche D, Bardji A, Lahuerta M, Berenguera A, Mandomando I, et al. (2009) Impact of maternal human immunodeficiency virus infection on birth outcomes and infant survival in rural Mozambique. Am J Trop Med Hyg 80: 870-876.
5. Marinda E, Humphrey JH, Iliff P, Mutasa K, Nathoo KJ, et al. (2007) Child mortality according to maternal and infant HIV status in Zimbabwe. Pediatr Infect Dis J 26: 519-526.
6. Kurewa EN, Gumbo FZ, Munjoma MW, Mapingure MP, Chirenje MZ, et al. (2010) Effect of maternal HIV status on infant mortality: evidence from a 9-month follow-up of mothers and their infants in Zimbabawe. Journal of Perinatology 30: 88-92.
7. van Lettow M, Bedell R, Landes M, Gawa L, Gatto S, et al. (2011) Uptake and outcomes of a prevention-of mother-to-child transmission (PMTCT) program in Zomba district, Malawi. BMC Public Health 11: 426.
8. Ndirangu J, Newell ML, Tanser F, Herbst AJ, Bland R, (2010) Decline in early life mortality in a high HIV prevalence rural area of South Africa: evidence of HIV prevention or treatment impact? AIDS 24: 593-602.
9. Ndirangu J, Newell ML, Thorne C, Bland R, (2012) Treating HIV infected mothers benefits children under 5 years of age: evidence from longitudinal surveillance in rural, high HIV prevalence South Africa. Antiviral Therapy 17: 81-90.
10. Malawi Ministry of Health. (2008) Guidelines for ART Provision Third Edition. Malawi Ministry of Health, Lilongwe.
11. Payongayong E, Benson T, Ahmed A, Kanyanda S, Chankanza C, et al. (2006) Simple Household Poverty Assessment Models for Malawi: Proxy Means Test from the 1997-98 Malawi Integrated Household Survey. Malawi: National Statistical Office of the Government of Malawi, Lilongwe.
12. World Health Organization. (2011) World Health Statistics. WHO website. Available: http://www.who.int/whosis/whostat/EN_WHS2011_Full.pdf. Accessed 2012 Sep 24.
13. Lansky SB, List MA, Lansky LL, Ritter-Sterr C, Miller DR, (1987) The measurement of performance in childhood cancer patients. Cancer 60: 1651-6.
14. Patel D, Bland R, Coovadia H, Rollins N, Coutsoudis A, et al. (2010) Breastfeeding, HIV status and weights in South African children: a comparison of HIV-exposed and unexposed children. AIDS 24 (3): 437-445.
15. Newell M-L, Coovadia H, Cortina-Borja M, Rollins N, Gaillard P, et al. (2004) Mortality of infected and uninfected infants born to HIV-infected mothers in Africa: a pooled analysis. The Lancet 364 (9441): 1236-1243.
16. Shapiro RL, Lockman S, Kim S, Smeaton L, Rahkola JT, et al. (2007) Infant morbidity, mortality, and breast milk immunologic profiles among breast- feeding HIV-infected and HIV-uninfected women in Botswana. Journal of Infectious Diseases 196: 562-569.
17. Brahmbhatt H, Kigozi G, Wabwire-Mangen F, Serwadda D, Lutalo T, et al. (2006) Mortality in HIV infected and uninfected children of HIV-infected and uninfected mothers in rural Uganda. J Acquir Immune Defic Syndr 1: 504-508.
18. Kuhn L, Kasonde P, Sinkala M, Kankasa C, Semrau K, et al. (2005) Does severity of HIV disease in HIV_infected mothers affect mortality and morbidity among their uninfected infants? Clin Infect Dis 41: 654-661.
19. Gupta A, Nayak U, Ram M, Bhosale R, Patil S, et al. (2007) Postpartum Tuberculosis Incidence and Mortality among HIV-Infected Women and Their Infants in Pune, India, 2002-2005. Clin Infect Dis 45 (2): 241-249.
20. Brahmbhatt H, Gray RH, (2003) Child mortality associated with reasons for non-initiation of breastfeeding and weaning: is breastfeeding best for HIV-positive mothers? AIDS 17: 879-885.
21. Abubakar A, Van Baar A, Van de Vijver FJR, Holding P, Newton CRJC, (2008) Paediatric HIV and neurodevelopment in sub-Saharan Africa: a systematic review. Tropical Medicine & International Health 13 (7): 880-887.
22. Hesseling AC, Cotton MF, Jennings T, Whitelaw A, Johnson LF, et al. (2009) High Incidence of Tuberculosis among HIV-Infected Infants: Evidence from a South African Population-Based Study Highlights the Need for Improved Tuberculosis Control Strategies. Clin Infect Dis 48 (1): 108-114.
23. Madhi SA, Kuwanda L, Cutland C, Klugman KP, (2006) Five-year cohort study of hospitalization for respiratory syncytial virus associated lower respiratory tract infection in African children. J Clin Virol 36 (3): 215-21 Epub 2006 May 5.
24. Kimani-Murage EW, Norris SA, Pettifor JM, Tollman SM, Klipstein-Grobusch K, et al. (2001) Nutritional status and HIV in rural South African children. BMC Pediatrics 11: 23.
25. Nalwoga A, Maher D, Todd J, Karabarinde A, Biraro S, et al. (2010) Nutritional status of children living in a community with high HIV prevalence in rural Uganda: a cross-sectional population-based survey. Tropical Medicine & International Health 15 (4): 414-22.
26. Malawi MOH (2008) HIV and Syphilis Sero-Survey and National HIV Prevalence and AIDS Estimates Report 2007. Lilongwe.
27. Schouten EJ, Jahn A, Midiani D, Makombe SD, Mnthambala A, et al. (2011) Prevention of mother-to-child transmission of HIV and the health-related Millenium Development Goals: time for a public health approach. Lancet 378: 282-84.
28. Liu KC, Mulindwa J, Giganti MJ, Putta NB, Chintu N, et al. (2011) Predictors of CD4 Eligibility for Antiretroviral Therapy Initiation Among HIV-Infected Pregnant Women in Lusaka, Zambia. JAIDS 6: 1-5.
29. Manda SO, (1999) Birth intervals, breastfeeding and determinants of childhood mortality in Malawi. Soc Sci Med 48 (3): 301-12.