PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 12, 2016, Pages 3347-3352

  Nicholls, Russell E ^a   Sontag, Jean Marie ^b   Zhang, Hong ^a   Staniszewski, Agnieszka ^a   Yan, Shijun ^a   Kim, Carla Y ^c   Yim, Michael ^c   Woodruff, Caitlin M ^c   Arning, Erland ^d   Wasek, Brandi ^d   Yin, Deqi ^c   Bottiglieri, Teodoro ^d   Sontag, Estelle ^b   Kandel, Eric R ^c   Arancio, Ottavio ^a  

^a Department of Medicine   (United States)

^b UNIVERSITY OF NEWCASTLE   (Australia)

^c Baylor Research Institute ^*  (United States)

^d BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alzheimer's disease; Cognitive impairment; Methylation; Protein phosphatase 2A; amyloid

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ESTERASE; LEUCINE CARBOXYL METHYLTRANSFERASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN PHOSPHATASE METHYLESTERASE 1; RNA; S ADENOSYLMETHIONINE; UNCLASSIFIED DRUG; PHOSPHOPROTEIN PHOSPHATASE 2;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; COGNITIVE DEFECT; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; FEAR CONDITIONING TEST; FEMALE; FOREBRAIN; HIPPOCAMPAL CA1 REGION; LATENT PERIOD; MALE; MORRIS WATER MAZE TEST; MOTOR PERFORMANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN METHYLATION; PYRAMIDAL NERVE CELL; ANIMAL; ANIMAL BEHAVIOR; METABOLISM; METHYLATION; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

AMYLOID BETA-PEPTIDES; ANIMALS; BEHAVIOR, ANIMAL; COGNITION DISORDERS; METHYLATION; MICE; MICE, TRANSGENIC; PROTEIN PHOSPHATASE 2;

EID: 84962222120     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1521018113     Document Type: Article

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