Approach to Modeling, Therapy Evaluation, Drug Selection, and Biomarker Assessments for a Multicenter Pre-Clinical Drug Screening Consortium for Acute Therapies in Severe Traumatic Brain Injury: Operation Brain Trauma Therapy

Journal of Neurotrauma

Volumn 33, Issue 6, 2016, Pages 513-522

  Kochanek, Patrick M ^a   Bramlett, Helen M ^b,c   Dixon, C Edward ^d   Shear, Deborah A ^e   Dietrich, W Dalton ^f   Schmid, Kara E ^e   Mondello, Stefania ^g   Wang, Kevin K W ^h   Hayes, Ronald L ^h   Povlishock, John T ⁱ   Tortella, Frank C ^e  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF MIAMI   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^f UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^g UNIVERSITY OF MESSINA   (Italy)

^h UNIVERSITY OF FLORIDA HEALTH   (United States)

ⁱ VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

biomarker; controlled cortical impact; fluid percussion; micropig; neuroprotection; penetrating ballistic like brain injury; rat; therapy

Indexed keywords

BIOLOGICAL MARKER;

ARTICLE; BATTLE INJURY; BLOOD SAMPLING; BRAIN PERFUSION; CLINICAL PROTOCOL; DRUG SCREENING; DRUG SELECTIVITY; HUMAN; NONHUMAN; OPERATION BRAIN TRAUMA THERAPY; SPINAL CORD INJURY; TRAUMATIC BRAIN INJURY; ANIMAL; BRAIN INJURIES, TRAUMATIC; DISEASE MODEL; PRECLINICAL STUDY;

ANIMALS; BIOMARKERS; BRAIN INJURIES, TRAUMATIC; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; HUMANS;

EID: 84962213717     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2015.4113     Document Type: Article

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