Effects of pegorgotein on neurologic outcome of patients with severe head injury: A multicenter, randomized controlled trial

JAMA

Volumn 276, Issue 7, 1996, Pages 538-543

  Young, Byron ^a,h   Runge, Jeffrey W ^b   Waxman, Kenneth S ^c   Harrington, Timothy ^d   Wilberger, Jack ^e   Muizelaar, J Paul ^f   Boddy, Alex ^g   Kupiec, James W ^g  

^a UNIVERSITY OF KENTUCKY   (United States)

^b CAROLINAS MEDICAL CENTER   (United States)

^c SANTA BARBARA COTTAGE HOSPITAL   (United States)

^d BARROW NEUROLOGICAL INSTITUTE   (United States)

^e ALLEGHENY GENERAL HOSPITAL   (United States)

^f WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g Sanofi Winthrop Inc ^*  (United States)

^h UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISMUTEC; OXYGEN RADICAL; PEGORGOTEIN; SCAVENGER; SUPEROXIDE DISMUTASE MACROGOL; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ADULT RESPIRATORY DISTRESS SYNDROME; AGED; ANAPHYLAXIS; ARTICLE; BRAIN HEMORRHAGE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISABILITY; DRUG EFFICACY; FEMALE; FOLLOW UP; HEAD INJURY; HUMAN; INJURY SCALE; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; NEUROLOGICAL COMPLICATION; PHASE 3 CLINICAL TRIAL; PNEUMONIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINUSITIS; TREATMENT OUTCOME;

EID: 0029761661     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.276.7.538     Document Type: Article

References (15)

1. Hall ED, Braughler JM. Free radicals in CNS injury. In: Waxman SG, ed. Molecular and Cellular Approaches to the Treatment of Neurological Disease. New York, NY: Raven Press; 1993:81-105.
2. Kontos HA, Wei EP. Superoxide production in experimental brain injury. J Neurosurg. 1986;64: 803-807.
3. Muizelaar JP, Marmarou A, Young HF, et al. Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycol-conjugated superoxide dismutase: a phase II trial. J Neurosurg. 1993;78:375-382.
4. Muizelaar JP. Cerebral ischemia-reperfusion injury after severe head injury and its possible treatment with polyethylene glycol-superoxide dismutase. Ann Emerg Med. 1993;22:1014-1021.
5. Teasdale G, Jennett B. Assessment of coma and impaired consciousness: a practical scale. Lancet. 1974;2:81-84.
6. Abramson NS, Safer P. Deferred consent: use in clinical resuscitation research. Ann Emerg Med. 1990;19:781-784.
7. Jennett B, Bond M. Assessment of outcome after severe brain damage. Lancet. 1975;1:480-484.
8. Rappaport M, Hall KM, Hopkins K, Belleza T, Cope DN. Disability rating scale for severe head trauma: coma to community. Arch Phys Med Rehabil. 1982;63:118-123.
9. Choi SC, Muizelaar JP, Barnes TY, Marmarou A, Brooks DM, Young HF. Prediction tree for severely head injured patients. J Neurosurg. 1991; 75:251-255.
10. Liu TH, Beckman JS, Freeman BA, Hogan EL, Hsu CY. Polyethylene glycol-conjugated superoxide dismutase and catalase reduce ischemic brain injury. Am J Physiol 1989;256:H589-H593.
11. He YY, Hsu CY, Ezrin AM, Miller MS. Polyethylene glycol-conjugated superoxide dismutase in focal cerebral ischemia-reperfusion. Am J Physiol. 1993;265:H252-H256.
12. Cross CE, Frei B, Louie S. The adult respiratory distress syndrome (ARDS) and oxidative stress: therapeutic implications. Adv Exp Med Biol. 1990; 264:435-448.
13. van Asbeck BS, van Der Wal WA. Role of oxygen radicals and antioxidants in adult respiratory distress syndrome: potentials in therapy. Resuscitation. 1989;18(suppl):S63-S83.
14. Brigham KL. Oxygen radicals - an important mediator of sepsis and septic shock. Klin Wochenschr. 1991;69:1004-1008.
15. Leff JA, Wilke CP, Hybertson BM, Shanley PF, Beehler CJ, Repine JE. Postinsult treatment of N-acetyl-L-cystein decreases IL-1-induced neutrophil influx and lung leak in rats. Am J Physiol. 1993;265:L501-L506.