Amantadine improves cognitive outcome and increases neuronal survival after fluid percussion traumatic brain injury in rats

Journal of Neurotrauma

Volumn 31, Issue 4, 2014, Pages 370-377

  Wang, Tao ^a,b   Huang, Xian Jian ^a,c   Van, Ken C ^a   Went, Gregory T ^d   Nguyen, Jack T ^d   Lyeth, Bruce G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c THE FIRST AFFILIATED HOSPITAL OF SHENZHEN UNIVERSITY   (China)

^d Adamas Pharmaceuticals Inc   (United States)

Author keywords

dopamine; hippocampus; Morris water maze; pharmacokinetics; traumatic brain injury

Indexed keywords

AMANTADINE; ANALYSIS OF VARIANCE; ANIMALS; BODY WEIGHT; BRAIN INJURIES; CA2 REGION, HIPPOCAMPAL; CA3 REGION, HIPPOCAMPAL; CELL COUNT; CELL SURVIVAL; COGNITION; DOPAMINE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; LEARNING; MALE; MAZE LEARNING; MEMORY; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; TREATMENT OUTCOME;

EID: 84891621858     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2013.2917     Document Type: Article

References (31)

1. Faul, M., Xu, L., Wald, M.M., and Coronado, V.G. (2010). Traumatic brain injury in the United States: emergency department visits, hospitalizations and deaths 2002-2006. Centers for Disease Control and Prevention, Control, N.C.f.I.P.a. (eds). U.S. Department of Health and Human Services: Atlanta, GA.
2. Bales, J.W., Wagner, A.K., Kline, A.E., and Dixon, C.E. (2009). Persistent cognitive dysfunction after traumatic brain injury: a dopamine hypothesis. Neurosci. Biobehav. Rev. 33, 981-1003
3. Bakay, R.A., Sweeney, K.M., and Wood, J.H. (1986). Pathophysiology of cerebrospinal fluid in head injury: Part 1. Pathological changes in cerebrospinal fluid solute composition after traumatic injury. Neurosurgery 18, 234-243
4. Hamill, R.W., Woolf, P.D., McDonald, J.V., Lee, L.A., and Kelly, M. (1987). Catecholamines predict outcome in traumatic brain injury. Ann. Neurol. 21, 438-443
5. van Woerkom, T.C., Teelken, A.W., and Minderhous, J.M. (1977). Difference in neurotransmitter metabolism in frontotemporal-lobe contusion and diffuse cerebral contusion. Lancet 1, 812-813
6. White, H., Cook, D., and Venkatesh, B. (2006). The use of hypertonic saline for treating intracranial hypertension after traumatic brain injury. Anesth. Analg. 102, 1836-1846
7. Sydenham, E., Roberts, I., and Alderson, P. (2009). Hypothermia for traumatic head injury. Cochrane Database Syst. Rev. CD001048
8. Plenger, P.M., Dixon, C.E., Castillo, R.M., Frankowski, R.F., Yablon, S.A., and Levin, H.S. (1996). Subacute methylphenidate treatment for moderate to moderately severe traumatic brain injury: a preliminary double-blind placebo-controlled study. Arch. Phys. Med. Rehabil. 77, 536-540
9. Zhang, L., Plotkin, R.C., Wang, G., Sandel, M.E., and Lee, S. (2004). Cholinergic augmentation with donepezil enhances recovery in shortterm memory and sustained attention after traumatic brain injury. Arch. Phys. Med. Rehabil. 85, 1050-1055
10. Fann, J.R., Uomoto, J.M., and Katon, W.J. (2000). Sertraline in the treatment of major depression following mild traumatic brain injury. J. Neuropsychiatry Clin. Neurosci. 12, 226-232
11. Nahas, Z., Arlinghaus, K.A., Kotrla, K.J., Clearman, R.R., and George, M.S. (1998). Rapid response of emotional incontinence to selective serotonin reuptake inhibitors. J. Neuropsychiatry Clin. Neurosci. 10, 453-455
12. Giacino, J.T., Whyte, J., Bagiella, E., Kalmar, K., Childs, N., Khademi, A., Eifert, B., Long, D., Katz, D.I., Cho, S., Yablon, S.A., Luther, M., Hammond, F.M., Nordenbo, A., Novak, P., Mercer, W., Maurer-Karattup, P., and Sherer, M. (2012). Placebo-controlled trial of amantadine for severe traumatic brain injury. N. Engl. J. Med. 366, 819-826
13. Hammond, F. (2010). Use of amantadine hydrochloride in the treatment irritability and aggression in chronic traumatic brain injury: a randomized, controlled trial. American Neuropsychiatric Association Annual Conference, March 18, 2010, Tampa, FL.
14. Gianutsos, G., Chute, S., and Dunn, J.P. (1985). Pharmacological changes in dopaminergic systems induced by long-term administration of amantadine. Eur. J. Pharmacol. 110, 357-361
15. Grelak, R.P., Clark, R., Stump, J.M., and Vernier, V.G. (1970). Amantadine-dopamine interaction: possible mode of action in Parkinsonism. Science 169, 203-204
16. Von Voigtlander, P.F., and Moore, K.E. (1971). Dopamine: release from the brain in vivo by amantadine. Science 174, 408-410
17. Parsons, C.G., Panchenko, V.A., Pinchenko, V.O., Tsyndrenko, A.Y., and Krishtal, O.A. (1996). Comparative patch-clamp studies with freshly dissociated rat hippocampal and striatal neurons on the NMDA receptor antagonistic effects of amantadine and memantine. Eur. J. Neurosci. 8, 446-454
18. Owen, J.C., and Whitton, P.S. (2005). Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular 5-HT in the frontal cortex of freely moving rats. Br. J. Pharmacol. 145, 587-592
19. Ossola, B., Schendzielorz, N., Chen, S.H., Bird, G.S., Tuominen, R.K., Mannisto, P.T., and Hong, J.S. (2011). Amantadine protects dopamine neurons by a dual action: reducing activation of microglia and inducing expression of GNDF in astroglia. Neuropharmacology 61, 574-582
20. Dixon, C.E., Kraus, M.F., Kline, A.E., Ma, X., Yan, H.Q., Griffith, R.G., Wolfson, B.M., and Marion, D.W. (1999). Amantadine improves water maze performance without affecting motor behavior following traumatic brain injury in rats. Restor. Neurol. Neurosci. 14, 285-294
21. Dixon, C.E., Lyeth, B.G., Povlishock, J.T., Findling, R.L., Hamm, R.J., Marmarou, A., Young, H.F., and Hayes, R.L. (1987). A fluid percussion model of experimental brain injury in the rat. J. Neurosurg. 67, 110-119
22. McIntosh, T.K., Vink, R., Noble, L., Yamakami, I., Fernyak, S., Soares, H., and Faden, A.I. (1989). Traumatic brain injury in the rat: characterization of a lateral fluid-percussion model. Neuroscience 28, 233-244
23. West, M.J., Slomianka, L., and Gundersen, H.J. (1991). Unbiased stereological estimation of the total number of neurons in thesubdivisions of the rat hippocampus using the optical fractionator. Anat. Rec. 231, 482-497
24. Morrison, D., Roy, S., Rayner, C., Amer, A., Howard, D., Smith, J.R., and Evans, T.G. (2007). A randomized, crossover study to evaluate the pharmacokinetics of amantadine and oseltamivir administered alone and in combination. PloS One 2, e1305
25. Hamm, R.J. (2001). Neurobehavioral assessment of outcome following traumatic brain injury in rats: an evaluation of selected measures. J. Neurotrauma 18, 1207-1216
26. Hammond, F. (2010). Use of amantadine hydrochloride in the treatment of irritability and aggression in chronic traumatic brain injury: a randomized, controlled trial. In: American Neuropsychiatric Association Annual Conference, March 18, 2010, Tampa, FL.
27. Kotapka, M.J., Graham, D.I., Adams, J.H., and Gennarelli, T.A. (1994). Hippocampal pathology in fatal human head injury without high intracranial pressure. J. Neurotrauma 11, 317-324
28. Kim, B.T., Rao, V.L., Sailor, K.A., Bowen, K.K., and Dempsey, R.J. (2001). Protective effects of glial cell line-derived neurotrophic factor on hippocampal neurons after traumatic brain injury in rats. J. Neurosurgery 95, 674-679
29. Smith, D.H., Chen, X.H., Pierce, J.E., Wolf, J.A., Trojanowski, J.Q., Graham, D.I., and Mcintosh, T.K. (1997). Progressive atrophy and neuron death for one year following brain trauma in the rat. J. Neurotrauma 14, 715-727
30. Thompson, H.J., Lifshitz, J., Marklund, N., Grady, M.S., Graham, D.I., Hovda, D.A., and McIntosh, T.K. (2005). Lateral fluid percussion brain injury: a 15-year review and evaluation. J. Neurotrauma 22, 42-75
31. Qin, Z.H., Chen, R.W., Wang, Y., Nakai, M., Chuang, D.M., and Chase, T.N. (1999). Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum. J. Neurosci. 19, 4023-4033.