-
1
-
-
84912106277
-
Long-term risk of cardiovascular events across a spectrum of adverse major plasma lipid combinations in the Framingham Heart Study
-
83.e1
-
Andersson C, Lyass A, Vasan RS, et al. Long-term risk of cardiovascular events across a spectrum of adverse major plasma lipid combinations in the Framingham Heart Study. Am Heart J 2014, 168:878. 83.e1.
-
(2014)
Am Heart J
, vol.168
, pp. 878
-
-
Andersson, C.1
Lyass, A.2
Vasan, R.S.3
-
2
-
-
4444382796
-
Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study
-
Yusuf S, Hawken S, Ounpuu S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study. Lancet 2004, 364:937-952.
-
(2004)
Lancet
, vol.364
, pp. 937-952
-
-
Yusuf, S.1
Hawken, S.2
Ounpuu, S.3
-
3
-
-
84871260146
-
Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a mendelian randomization analysis
-
Ference B, Yoo W, Alesh I, et al. Effect of long-term exposure to lower low-density lipoprotein cholesterol beginning early in life on the risk of coronary heart disease: a mendelian randomization analysis. J Am Coll Cardiol 2012, 60:2631-2639.
-
(2012)
J Am Coll Cardiol
, vol.60
, pp. 2631-2639
-
-
Ference, B.1
Yoo, W.2
Alesh, I.3
-
4
-
-
84928026823
-
Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: a 2 × 2 factorial Mendelian randomization study
-
Ference BA, Majeed F, Penumetcha R, Flack JM, Brook RD Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: a 2 × 2 factorial Mendelian randomization study. J Am Coll Cardiol 2015, 65:1552-1561.
-
(2015)
J Am Coll Cardiol
, vol.65
, pp. 1552-1561
-
-
Ference, B.A.1
Majeed, F.2
Penumetcha, R.3
Flack, J.M.4
Brook, R.D.5
-
5
-
-
33645103550
-
Sequence variations in PCSK9, low LDL, and protection against coronary heart disease
-
Cohen JC, Boerwinkle E, Mosley TH, Hobbs HH Sequence variations in PCSK9, low LDL, and protection against coronary heart disease. N Engl J Med 2006, 354:1264-1272.
-
(2006)
N Engl J Med
, vol.354
, pp. 1264-1272
-
-
Cohen, J.C.1
Boerwinkle, E.2
Mosley, T.H.3
Hobbs, H.H.4
-
6
-
-
56349147086
-
Longitudinal evaluation and assessment of cardiovascular disease in patients with homozygous familial hypercholesterolemia
-
Kolansky DM, Cuchel M, Clark BJ, et al. Longitudinal evaluation and assessment of cardiovascular disease in patients with homozygous familial hypercholesterolemia. Am J Cardiol 2008, 102:1438-1443.
-
(2008)
Am J Cardiol
, vol.102
, pp. 1438-1443
-
-
Kolansky, D.M.1
Cuchel, M.2
Clark, B.J.3
-
7
-
-
84864832599
-
The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials
-
Cholesterol Treatment Trialists' (CTT) Collaborators
-
The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet 2012, 380:581-590. Cholesterol Treatment Trialists' (CTT) Collaborators.
-
(2012)
Lancet
, vol.380
, pp. 581-590
-
-
-
8
-
-
0023910325
-
Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid
-
Carlson LA, Rosenhamer G Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid. Acta Med Scand 1988, 223:405-418.
-
(1988)
Acta Med Scand
, vol.223
, pp. 405-418
-
-
Carlson, L.A.1
Rosenhamer, G.2
-
9
-
-
0023001772
-
Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin
-
Canner PL, Berge KG, Wenger NK, et al. Fifteen year mortality in Coronary Drug Project patients: long-term benefit with niacin. J Am Coll Cardiol 1986, 8:1245-1255.
-
(1986)
J Am Coll Cardiol
, vol.8
, pp. 1245-1255
-
-
Canner, P.L.1
Berge, K.G.2
Wenger, N.K.3
-
10
-
-
0003309652
-
The relationship of reduction in incidence of coronary heart disease to cholesterol lowering
-
The Lipid Research Clinics Coronary Primary Prevention Trial Results: II
-
The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA 1984, 251:365-374. The Lipid Research Clinics Coronary Primary Prevention Trial Results: II.
-
(1984)
JAMA
, vol.251
, pp. 365-374
-
-
-
11
-
-
84933673677
-
Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174000 participants in 27 randomised trials
-
Cholesterol Treatment Trialists' (CTT) Collaboration
-
Efficacy and safety of LDL-lowering therapy among men and women: meta-analysis of individual data from 174000 participants in 27 randomised trials. Lancet 2015, 385:1397-1405. Cholesterol Treatment Trialists' (CTT) Collaboration.
-
(2015)
Lancet
, vol.385
, pp. 1397-1405
-
-
-
12
-
-
84905189482
-
Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials
-
Boekholdt SM, Hovingh GK, Mora S, et al. Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials. J Am Coll Cardiol 2014, 64:485-494.
-
(2014)
J Am Coll Cardiol
, vol.64
, pp. 485-494
-
-
Boekholdt, S.M.1
Hovingh, G.K.2
Mora, S.3
-
13
-
-
84890205396
-
Colesevelam for type 2 diabetes mellitus: an abridged Cochrane review
-
Ooi CP, Loke SC Colesevelam for type 2 diabetes mellitus: an abridged Cochrane review. Diabet Med 2014, 31:2-14.
-
(2014)
Diabet Med
, vol.31
, pp. 2-14
-
-
Ooi, C.P.1
Loke, S.C.2
-
15
-
-
84982995031
-
AACE/ACE comprehensive diabetes management algorithm
-
Garber AJ, Abrahamson MJ, Barzilay JI, et al. AACE/ACE comprehensive diabetes management algorithm. Endocr Pract 2015, 21:438-447.
-
(2015)
Endocr Pract
, vol.21
, pp. 438-447
-
-
Garber, A.J.1
Abrahamson, M.J.2
Barzilay, J.I.3
-
16
-
-
84949034519
-
Colesevelam as an add-on treatment for control of dyslipidemia and hyperglycemia in type 2 diabetes
-
published online Nov 12.
-
Sandhu S, Moosavi M, Golmohammadi K, Francis GA Colesevelam as an add-on treatment for control of dyslipidemia and hyperglycemia in type 2 diabetes. Can J Diabetes 2015, published online Nov 12. 10.1016/j.jcjd.2015.07.008.
-
(2015)
Can J Diabetes
-
-
Sandhu, S.1
Moosavi, M.2
Golmohammadi, K.3
Francis, G.A.4
-
17
-
-
84931411520
-
Ezetimibe added to statin therapy after acute coronary syndromes
-
Cannon CP, Blazing MA, Giugliano RP, et al. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med 2015, 372:2387-2397.
-
(2015)
N Engl J Med
, vol.372
, pp. 2387-2397
-
-
Cannon, C.P.1
Blazing, M.A.2
Giugliano, R.P.3
-
18
-
-
84871945617
-
Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study
-
Cuchel M, Meagher EA, du Toit Theron H, et al. Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open-label, phase 3 study. Lancet 2013, 381:40-46.
-
(2013)
Lancet
, vol.381
, pp. 40-46
-
-
Cuchel, M.1
Meagher, E.A.2
du Toit Theron, H.3
-
19
-
-
77949485460
-
Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial
-
Raal FJ, Santos RD, Blom DJ, et al. Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial. Lancet 2010, 375:998-1006.
-
(2010)
Lancet
, vol.375
, pp. 998-1006
-
-
Raal, F.J.1
Santos, R.D.2
Blom, D.J.3
-
20
-
-
84868518061
-
Apolipoprotein B synthesis inhibition with mipomersen in heterozygous familial hypercholesterolemia: results of a randomized, double-blind, placebo-controlled trial to assess efficacy and safety as add-on therapy in patients with coronary artery disease
-
Stein EA, Dufour R, Gagne C, et al. Apolipoprotein B synthesis inhibition with mipomersen in heterozygous familial hypercholesterolemia: results of a randomized, double-blind, placebo-controlled trial to assess efficacy and safety as add-on therapy in patients with coronary artery disease. Circulation 2012, 126:2283-2292.
-
(2012)
Circulation
, vol.126
, pp. 2283-2292
-
-
Stein, E.A.1
Dufour, R.2
Gagne, C.3
-
21
-
-
84924415690
-
Long-term efficacy and safety of mipomersen in patients with familial hypercholesterolaemia: 2-year interim results of an open-label extension
-
Santos RD, Duell PB, East C, et al. Long-term efficacy and safety of mipomersen in patients with familial hypercholesterolaemia: 2-year interim results of an open-label extension. Eur Heart J 2015, 36:566-575.
-
(2015)
Eur Heart J
, vol.36
, pp. 566-575
-
-
Santos, R.D.1
Duell, P.B.2
East, C.3
-
22
-
-
84983160332
-
ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia
-
Kastelein JJP, Ginsberg HN, Langslet G, et al. ODYSSEY FH I and FH II: 78 week results with alirocumab treatment in 735 patients with heterozygous familial hypercholesterolaemia. Eur Heart J 2015, 36:2996-5003.
-
(2015)
Eur Heart J
, vol.36
, pp. 2996-5003
-
-
Kastelein, J.J.P.1
Ginsberg, H.N.2
Langslet, G.3
-
23
-
-
84926191670
-
Efficacy and safety of alirocumab in reducing lipids and cardiovascular events
-
Robinson JG, Farnier M, Krempf M, et al. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med 2015, 372:1489-1499.
-
(2015)
N Engl J Med
, vol.372
, pp. 1489-1499
-
-
Robinson, J.G.1
Farnier, M.2
Krempf, M.3
-
24
-
-
84921483643
-
PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial
-
Raal FJ, Stein EA, Dufour R, et al. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Lancet 2015, 385:331-340.
-
(2015)
Lancet
, vol.385
, pp. 331-340
-
-
Raal, F.J.1
Stein, E.A.2
Dufour, R.3
-
25
-
-
84902142901
-
Anti-PCSK9 monotherapy for hypercholesterolemia: the MENDEL-2 randomized, controlled phase III clinical trial of evolocumab
-
Koren MJ, Lundqvist P, Bolognese M, et al. Anti-PCSK9 monotherapy for hypercholesterolemia: the MENDEL-2 randomized, controlled phase III clinical trial of evolocumab. J Am Coll Cardiol 2014, 63:2531-2540.
-
(2014)
J Am Coll Cardiol
, vol.63
, pp. 2531-2540
-
-
Koren, M.J.1
Lundqvist, P.2
Bolognese, M.3
-
26
-
-
84900303213
-
Effect of evolocumab or ezetimibe added to moderate- or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial
-
Robinson JG, Nedergaard BS, Rogers WJ, et al. Effect of evolocumab or ezetimibe added to moderate- or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial. JAMA 2014, 311:1870-1882.
-
(2014)
JAMA
, vol.311
, pp. 1870-1882
-
-
Robinson, J.G.1
Nedergaard, B.S.2
Rogers, W.J.3
-
27
-
-
84926206074
-
Efficacy and safety of evolocumab in reducing lipids and cardiovascular events
-
Sabatine MS, Giugliano RP, Wiviott SD, et al. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med 2015, 372:1500-1509.
-
(2015)
N Engl J Med
, vol.372
, pp. 1500-1509
-
-
Sabatine, M.S.1
Giugliano, R.P.2
Wiviott, S.D.3
-
28
-
-
84921459685
-
Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial
-
Raal FJ, Honarpour N, Blom DJ, et al. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebo-controlled trial. Lancet 2015, 385:341-350.
-
(2015)
Lancet
, vol.385
, pp. 341-350
-
-
Raal, F.J.1
Honarpour, N.2
Blom, D.J.3
-
29
-
-
52649120889
-
Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis
-
Rossebø AB, Pedersen TR, Boman K, et al. Intensive lipid lowering with simvastatin and ezetimibe in aortic stenosis. N Engl J Med 2008, 359:1343-1356.
-
(2008)
N Engl J Med
, vol.359
, pp. 1343-1356
-
-
Rossebø, A.B.1
Pedersen, T.R.2
Boman, K.3
-
30
-
-
41649107358
-
Simvastatin with or without ezetimibe in familial hypercholesterolemia
-
Kastelein JJP, Akdim F, Stroes ESG, et al. Simvastatin with or without ezetimibe in familial hypercholesterolemia. N Engl J Med 2008, 358:1431-1443.
-
(2008)
N Engl J Med
, vol.358
, pp. 1431-1443
-
-
Kastelein, J.J.P.1
Akdim, F.2
Stroes, E.S.G.3
-
31
-
-
79959746706
-
The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial
-
Baigent C, Landray MJ, Reith C, et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet 2011, 377:2181-2192.
-
(2011)
Lancet
, vol.377
, pp. 2181-2192
-
-
Baigent, C.1
Landray, M.J.2
Reith, C.3
-
32
-
-
84915819121
-
Inactivating mutations in NPC1L1 and protection from coronary heart disease
-
Stitziel NO, Won H-H, Morrison AC, et al. Inactivating mutations in NPC1L1 and protection from coronary heart disease. N Engl J Med 2014, 371:2072-2082.
-
(2014)
N Engl J Med
, vol.371
, pp. 2072-2082
-
-
Stitziel, N.O.1
Won, H.-H.2
Morrison, A.C.3
-
33
-
-
84963710967
-
-
European Society of Cardiology, (accessed Feb 20, 2016).
-
Ezetimibe reduces cardiovascular events in diabetics with recent acute coronary syndrome European Society of Cardiology, (accessed Feb 20, 2016). http://www.escardio.org/The-ESC/Press-Office/Press-releases/Last-5-years/ezetimibe-reduces-cardiovascular-events-in-diabetics-with-recent-acute-coronary-syndrome.
-
Ezetimibe reduces cardiovascular events in diabetics with recent acute coronary syndrome
-
-
-
34
-
-
84885447918
-
Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis
-
Urban D, Poss J, Bohm M, Laufs U Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis. J Am Coll Cardiol 2013, 62:1401-1408.
-
(2013)
J Am Coll Cardiol
, vol.62
, pp. 1401-1408
-
-
Urban, D.1
Poss, J.2
Bohm, M.3
Laufs, U.4
-
35
-
-
0037603589
-
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
-
Abifadel M, Varret M, Rabès J-P, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 2003, 34:154-156.
-
(2003)
Nat Genet
, vol.34
, pp. 154-156
-
-
Abifadel, M.1
Varret, M.2
Rabès, J.-P.3
-
36
-
-
2342451128
-
Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype
-
Maxwell KN, Breslow JL Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Proc Natl Acad Sci USA 2004, 101:7100-7105.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 7100-7105
-
-
Maxwell, K.N.1
Breslow, J.L.2
-
37
-
-
13844310887
-
Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment
-
Maxwell KN, Fisher EA, Breslow JL Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proc Natl Acad Sci USA 2005, 102:2069-2074.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 2069-2074
-
-
Maxwell, K.N.1
Fisher, E.A.2
Breslow, J.L.3
-
38
-
-
33646199829
-
Effect of mutations in the PCSK9 gene on the cell surface LDL receptors
-
Cameron J, Holla OL, Ranheim T, Kulseth MA, Berge KE, Leren TP Effect of mutations in the PCSK9 gene on the cell surface LDL receptors. Hum Mol Genet 2006, 15:1551-1558.
-
(2006)
Hum Mol Genet
, vol.15
, pp. 1551-1558
-
-
Cameron, J.1
Holla, O.L.2
Ranheim, T.3
Kulseth, M.A.4
Berge, K.E.5
Leren, T.P.6
-
39
-
-
13944265645
-
Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
-
Cohen J, Pertsemlidis A, Kotowski IK, Graham R, Garcia CK, Hobbs HH Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet 2005, 37:161-165.
-
(2005)
Nat Genet
, vol.37
, pp. 161-165
-
-
Cohen, J.1
Pertsemlidis, A.2
Kotowski, I.K.3
Graham, R.4
Garcia, C.K.5
Hobbs, H.H.6
-
41
-
-
84945925195
-
Proprotein convertase subtilisin/kexin type 9 inhibition: a new therapeutic mechanism for reducing cardiovascular disease risk
-
Bergeron N, Phan BAP, Ding Y, Fong A, Krauss RM Proprotein convertase subtilisin/kexin type 9 inhibition: a new therapeutic mechanism for reducing cardiovascular disease risk. Circulation 2015, 132:1648-1666.
-
(2015)
Circulation
, vol.132
, pp. 1648-1666
-
-
Bergeron, N.1
Phan, B.A.P.2
Ding, Y.3
Fong, A.4
Krauss, R.M.5
-
42
-
-
33750597734
-
Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice
-
Lagace TA, Curtis DE, Garuti R, et al. Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice. J Clin Invest 2006, 116:2995-3005.
-
(2006)
J Clin Invest
, vol.116
, pp. 2995-3005
-
-
Lagace, T.A.1
Curtis, D.E.2
Garuti, R.3
-
43
-
-
84938213783
-
Dyslipidaemia: promising results for TA-8995 in TULIP
-
Mearns BM Dyslipidaemia: promising results for TA-8995 in TULIP. Nat Rev Cardiol 2015, 12:443.
-
(2015)
Nat Rev Cardiol
, vol.12
, pp. 443
-
-
Mearns, B.M.1
-
44
-
-
84930088585
-
Anacetrapib as lipid-modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE): a randomised, double-blind, placebo-controlled, phase 3 study
-
Kastelein JJP, Besseling J, Shah S, et al. Anacetrapib as lipid-modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE): a randomised, double-blind, placebo-controlled, phase 3 study. Lancet 2015, 385:2153-2161.
-
(2015)
Lancet
, vol.385
, pp. 2153-2161
-
-
Kastelein, J.J.P.1
Besseling, J.2
Shah, S.3
-
45
-
-
85027211334
-
Abstract 16404: CETP inhibitor K-312 lowers PCSK9 expression and LDL cholesterol levels in vivo
-
Miyosawa K, Singh S, Watanabe Y, et al. Abstract 16404: CETP inhibitor K-312 lowers PCSK9 expression and LDL cholesterol levels in vivo. Circulation 2014, 130:A16404.
-
(2014)
Circulation
, vol.130
, pp. A16404
-
-
Miyosawa, K.1
Singh, S.2
Watanabe, Y.3
-
46
-
-
84937558497
-
New CETP inhibitor K-312 reduces PCSK9 expression: a potential effect on LDL cholesterol metabolism
-
Miyosawa K, Watanabe Y, Murakami K, et al. New CETP inhibitor K-312 reduces PCSK9 expression: a potential effect on LDL cholesterol metabolism. Am J Physiol Endocrinol Metab 2015, 309:E177-E190.
-
(2015)
Am J Physiol Endocrinol Metab
, vol.309
, pp. E177-E190
-
-
Miyosawa, K.1
Watanabe, Y.2
Murakami, K.3
-
47
-
-
84931466071
-
Use of ETC-1002 to treat hypercholesterolemia in patients with statin intolerance
-
Thompson PD, Rubino J, Janik MJ, et al. Use of ETC-1002 to treat hypercholesterolemia in patients with statin intolerance. J Clin Lipidol 2015, 9:295-304.
-
(2015)
J Clin Lipidol
, vol.9
, pp. 295-304
-
-
Thompson, P.D.1
Rubino, J.2
Janik, M.J.3
-
48
-
-
84884366154
-
Efficacy and safety of a novel dual modulator of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase in patients with hypercholesterolemia: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial
-
Ballantyne CM, Davidson MH, Macdougall DE, et al. Efficacy and safety of a novel dual modulator of adenosine triphosphate-citrate lyase and adenosine monophosphate-activated protein kinase in patients with hypercholesterolemia: results of a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial. J Am Coll Cardiol 2013, 62:1154-1162.
-
(2013)
J Am Coll Cardiol
, vol.62
, pp. 1154-1162
-
-
Ballantyne, C.M.1
Davidson, M.H.2
Macdougall, D.E.3
-
49
-
-
0043011486
-
Effectiveness and tolerability of a new lipid-altering agent, gemcabene, in patients with low levels of high-density lipoprotein cholesterol
-
Bays HE, McKenney JM, Dujovne CA, et al. Effectiveness and tolerability of a new lipid-altering agent, gemcabene, in patients with low levels of high-density lipoprotein cholesterol. Am J Cardiol 2003, 92:538-543.
-
(2003)
Am J Cardiol
, vol.92
, pp. 538-543
-
-
Bays, H.E.1
McKenney, J.M.2
Dujovne, C.A.3
-
50
-
-
80052539818
-
MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin
-
Bays HE, Schwartz S, Littlejohn T, et al. MBX-8025, a novel peroxisome proliferator receptor-delta agonist: lipid and other metabolic effects in dyslipidemic overweight patients treated with and without atorvastatin. J Clin Endocrinol Metab 2011, 96:2889-2897.
-
(2011)
J Clin Endocrinol Metab
, vol.96
, pp. 2889-2897
-
-
Bays, H.E.1
Schwartz, S.2
Littlejohn, T.3
-
52
-
-
84884517120
-
Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-β agonist
-
Taub R, Chiang E, Chabot-Blanchet M, et al. Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-β agonist. Atherosclerosis 2013, 230:373-380.
-
(2013)
Atherosclerosis
, vol.230
, pp. 373-380
-
-
Taub, R.1
Chiang, E.2
Chabot-Blanchet, M.3
-
53
-
-
84927578440
-
Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in statin-treated subjects with hypercholesterolemia
-
Ballantyne CM, Neutel J, Cropp A, et al. Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in statin-treated subjects with hypercholesterolemia. Am J Cardiol 2015, 115:1212-1221.
-
(2015)
Am J Cardiol
, vol.115
, pp. 1212-1221
-
-
Ballantyne, C.M.1
Neutel, J.2
Cropp, A.3
-
54
-
-
84963693550
-
-
(accessed Feb 20, 2016).
-
Fitzgerald K, Simon A, White S, et al. ALN-PCSsc, an RNAi investigational agent that inhibits PCSK9 synthesis with the potential for effective bi-annual dosing: interim results (accessed Feb 20, 2016). https://my.americanheart.org/idc/groups/ahamah-public/@wcm/@sop/@scon/documents/downloadable/ucm_479191.pdf.
-
ALN-PCSsc, an RNAi investigational agent that inhibits PCSK9 synthesis with the potential for effective bi-annual dosing: interim results
-
-
Fitzgerald, K.1
Simon, A.2
White, S.3
-
55
-
-
84904395849
-
LDL cholesterol reduction with BMS-962476, an adnectin inhibitor of PCSK9: results of a single ascending dose study
-
Stein EA, Kasichayanula S, Turner T, et al. LDL cholesterol reduction with BMS-962476, an adnectin inhibitor of PCSK9: results of a single ascending dose study. J Am Coll Cardiol 2014, 63:A1372.
-
(2014)
J Am Coll Cardiol
, vol.63
, pp. A1372
-
-
Stein, E.A.1
Kasichayanula, S.2
Turner, T.3
-
56
-
-
84915746642
-
Peptide-based anti-PCSK9 vaccines-an approach for long-term LDLc management
-
Galabova G, Brunner S, Winsauer G, et al. Peptide-based anti-PCSK9 vaccines-an approach for long-term LDLc management. PLoS One 2014, 9:e114469.
-
(2014)
PLoS One
, vol.9
-
-
Galabova, G.1
Brunner, S.2
Winsauer, G.3
-
57
-
-
84937132242
-
ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys
-
Gusarova V, Alexa CA, Wang Y, et al. ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys. J Lipid Res 2015, 56:1308-1317.
-
(2015)
J Lipid Res
, vol.56
, pp. 1308-1317
-
-
Gusarova, V.1
Alexa, C.A.2
Wang, Y.3
-
58
-
-
84941877077
-
Management of patients with familial hypercholesterolaemia
-
Reiner Z Management of patients with familial hypercholesterolaemia. Nat Rev Cardiol 2015, 12:565-575.
-
(2015)
Nat Rev Cardiol
, vol.12
, pp. 565-575
-
-
Reiner, Z.1
-
59
-
-
55749088063
-
Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study
-
Neil A, Cooper J, Betteridge J, et al. Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study. Eur Heart J 2008, 29:2625-2633.
-
(2008)
Eur Heart J
, vol.29
, pp. 2625-2633
-
-
Neil, A.1
Cooper, J.2
Betteridge, J.3
-
60
-
-
84897934189
-
Improvement in LDL-cholesterol levels of patients with familial hypercholesterolemia: can we do better? Analysis of results obtained during the past two decades in 1669 French subjects
-
Beliard S, Carreau V, Carrie A, et al. Improvement in LDL-cholesterol levels of patients with familial hypercholesterolemia: can we do better? Analysis of results obtained during the past two decades in 1669 French subjects. Atherosclerosis 2014, 234:136-141.
-
(2014)
Atherosclerosis
, vol.234
, pp. 136-141
-
-
Beliard, S.1
Carreau, V.2
Carrie, A.3
-
62
-
-
84869220345
-
Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the Reduction of LDL-C with PCSK9 Inhibition
-
Raal F, Scott R, Somaratne R, et al. Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the Reduction of LDL-C with PCSK9 Inhibition. Circulation 2012, 126:2408-2417.
-
(2012)
Circulation
, vol.126
, pp. 2408-2417
-
-
Raal, F.1
Scott, R.2
Somaratne, R.3
-
63
-
-
84906716305
-
Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society
-
Cuchel M, Bruckert E, Ginsberg HN, et al. Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society. Eur Heart J 2014, 35:2146-2157.
-
(2014)
Eur Heart J
, vol.35
, pp. 2146-2157
-
-
Cuchel, M.1
Bruckert, E.2
Ginsberg, H.N.3
-
64
-
-
0020472786
-
The LDL receptor defect in familial hypercholesterolemia. Implications for pathogenesis and therapy
-
Goldstein JL, Brown MS The LDL receptor defect in familial hypercholesterolemia. Implications for pathogenesis and therapy. Med Clin North Am 1982, 66:335-362.
-
(1982)
Med Clin North Am
, vol.66
, pp. 335-362
-
-
Goldstein, J.L.1
Brown, M.S.2
-
65
-
-
81355160365
-
Reduction in mortality in subjects with homozygous familial hypercholesterolemia associated with advances in lipid-lowering therapy
-
Raal FJ, Pilcher GJ, Panz VR, et al. Reduction in mortality in subjects with homozygous familial hypercholesterolemia associated with advances in lipid-lowering therapy. Circulation 2011, 124:2202-2207.
-
(2011)
Circulation
, vol.124
, pp. 2202-2207
-
-
Raal, F.J.1
Pilcher, G.J.2
Panz, V.R.3
-
66
-
-
84887164358
-
Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia
-
Stein EA, Honarpour N, Wasserman SM, Xu F, Scott R, Raal FJ Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia. Circulation 2013, 128:2113-2120.
-
(2013)
Circulation
, vol.128
, pp. 2113-2120
-
-
Stein, E.A.1
Honarpour, N.2
Wasserman, S.M.3
Xu, F.4
Scott, R.5
Raal, F.J.6
-
67
-
-
84899883299
-
An assessment by the Statin Intolerance Panel: 2014 update
-
Guyton JR, Bays HE, Grundy SM, Jacobson TA An assessment by the Statin Intolerance Panel: 2014 update. J Clin Lipidol 2014, 8:S72-S81.
-
(2014)
J Clin Lipidol
, vol.8
, pp. S72-S81
-
-
Guyton, J.R.1
Bays, H.E.2
Grundy, S.M.3
Jacobson, T.A.4
-
68
-
-
84902157271
-
Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: the GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab
-
Stroes E, Colquhoun D, Sullivan D, et al. Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: the GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab. J Am Coll Cardiol 2014, 63:2541-2548.
-
(2014)
J Am Coll Cardiol
, vol.63
, pp. 2541-2548
-
-
Stroes, E.1
Colquhoun, D.2
Sullivan, D.3
-
69
-
-
84922313473
-
-
(accessed Feb 20, 2016).
-
Moriarty PM, Thompson PD, Cannon CP, et al. ODYSSEY ALTERNATIVE: efficacy and safety of the proprotein convertase subtilisin/kexin type 9 monoclonal antibody, alirocumab, versus ezetimibe, in patients with statin intolerance as defined by a placebo run-in and statin rechallenge arm (accessed Feb 20, 2016). https://my.americanheart.org/idc/groups/ahamah-public/@wcm/@sop/@scon/documents/downloadable/ucm_469597.pdf.
-
ODYSSEY ALTERNATIVE: efficacy and safety of the proprotein convertase subtilisin/kexin type 9 monoclonal antibody, alirocumab, versus ezetimibe, in patients with statin intolerance as defined by a placebo run-in and statin rechallenge arm
-
-
Moriarty, P.M.1
Thompson, P.D.2
Cannon, C.P.3
-
70
-
-
84888876867
-
Lipoprotein(a), cardiovascular disease, and contemporary management
-
Jacobson TA Lipoprotein(a), cardiovascular disease, and contemporary management. Mayo Clin Proc 2013, 88:1294-1311.
-
(2013)
Mayo Clin Proc
, vol.88
, pp. 1294-1311
-
-
Jacobson, T.A.1
-
71
-
-
79953748675
-
Genetic determinants of LDL, lipoprotein(a), triglyceride-rich lipoproteins and HDL: concordance and discordance with cardiovascular disease risk
-
Nordestgaard BG, Tybjærg-Hansen A Genetic determinants of LDL, lipoprotein(a), triglyceride-rich lipoproteins and HDL: concordance and discordance with cardiovascular disease risk. Curr Opin Lipidol 2011, 22:113-122.
-
(2011)
Curr Opin Lipidol
, vol.22
, pp. 113-122
-
-
Nordestgaard, B.G.1
Tybjærg-Hansen, A.2
-
72
-
-
73549097512
-
Genetic variants associated with Lp(a) lipoprotein level and coronary disease
-
Clarke R, Peden JF, Hopewell JC, et al. Genetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med 2009, 361:2518-2528.
-
(2009)
N Engl J Med
, vol.361
, pp. 2518-2528
-
-
Clarke, R.1
Peden, J.F.2
Hopewell, J.C.3
-
73
-
-
67049167090
-
Genetically elevated lipoprotein(a) and increased risk of myocardial infarction
-
Kamstrup PR, Tybjaerg-Hansen A, Steffensen R, Nordestgaard BG Genetically elevated lipoprotein(a) and increased risk of myocardial infarction. JAMA 2009, 301:2331-2339.
-
(2009)
JAMA
, vol.301
, pp. 2331-2339
-
-
Kamstrup, P.R.1
Tybjaerg-Hansen, A.2
Steffensen, R.3
Nordestgaard, B.G.4
-
74
-
-
84870065743
-
Emerging therapeutic agents to lower lipoprotein (a) levels
-
Kolski B, Tsimikas S Emerging therapeutic agents to lower lipoprotein (a) levels. Curr Opin Lipidol 2012, 23:560-568.
-
(2012)
Curr Opin Lipidol
, vol.23
, pp. 560-568
-
-
Kolski, B.1
Tsimikas, S.2
-
75
-
-
84899846576
-
A 52-week placebo-controlled trial of evolocumab in hyperlipidemia
-
Blom DJ, Hala T, Bolognese M, et al. A 52-week placebo-controlled trial of evolocumab in hyperlipidemia. N Engl J Med 2014, 370:1809-1819.
-
(2014)
N Engl J Med
, vol.370
, pp. 1809-1819
-
-
Blom, D.J.1
Hala, T.2
Bolognese, M.3
-
76
-
-
84897471477
-
Reduction in lipoprotein(a) with PCSK9 monoclonal antibody evolocumab (AMG 145): a pooled analysis of more than 1300 patients in 4 phase II trials
-
Raal FJ, Giugliano RP, Sabatine MS, et al. Reduction in lipoprotein(a) with PCSK9 monoclonal antibody evolocumab (AMG 145): a pooled analysis of more than 1300 patients in 4 phase II trials. J Am Coll Cardiol 2014, 63:1278-1288.
-
(2014)
J Am Coll Cardiol
, vol.63
, pp. 1278-1288
-
-
Raal, F.J.1
Giugliano, R.P.2
Sabatine, M.S.3
-
77
-
-
84939786809
-
PCSK9 inhibitors and cardiovascular events
-
Auer J, Berent R, Primus C PCSK9 inhibitors and cardiovascular events. N Engl J Med 2015, 373:773-775.
-
(2015)
N Engl J Med
, vol.373
, pp. 773-775
-
-
Auer, J.1
Berent, R.2
Primus, C.3
-
79
-
-
84912127068
-
Safety profile of subjects treated to very low low-density lipoprotein cholesterol levels (<30 mg/dl) with rosuvastatin 20 mg daily (from JUPITER)
-
Everett BM, Mora S, Glynn RJ, MacFadyen J, Ridker PM Safety profile of subjects treated to very low low-density lipoprotein cholesterol levels (<30 mg/dl) with rosuvastatin 20 mg daily (from JUPITER). Am J Cardiol 2014, 114:1682-1689.
-
(2014)
Am J Cardiol
, vol.114
, pp. 1682-1689
-
-
Everett, B.M.1
Mora, S.2
Glynn, R.J.3
MacFadyen, J.4
Ridker, P.M.5
-
80
-
-
26844468578
-
Can low-density lipoprotein be too low? The safety and efficacy of achieving very low low-density lipoprotein with intensive statin therapy: a PROVE IT-TIMI 22 substudy
-
Wiviott SD, Cannon CP, Morrow DA, Ray KK, Pfeffer MA, Braunwald E Can low-density lipoprotein be too low? The safety and efficacy of achieving very low low-density lipoprotein with intensive statin therapy: a PROVE IT-TIMI 22 substudy. J Am Coll Cardiol 2005, 46:1411-1416.
-
(2005)
J Am Coll Cardiol
, vol.46
, pp. 1411-1416
-
-
Wiviott, S.D.1
Cannon, C.P.2
Morrow, D.A.3
Ray, K.K.4
Pfeffer, M.A.5
Braunwald, E.6
-
81
-
-
84892741671
-
Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial
-
Fitzgerald K, Frank-Kamenetsky M, Shulga-Morskaya S, et al. Effect of an RNA interference drug on the synthesis of proprotein convertase subtilisin/kexin type 9 (PCSK9) and the concentration of serum LDL cholesterol in healthy volunteers: a randomised, single-blind, placebo-controlled, phase 1 trial. Lancet 2014, 383:60-68.
-
(2014)
Lancet
, vol.383
, pp. 60-68
-
-
Fitzgerald, K.1
Frank-Kamenetsky, M.2
Shulga-Morskaya, S.3
-
82
-
-
84920830034
-
Contemporary aspects of the biology and therapeutic regulation of the microsomal triglyceride transfer protein
-
Hooper AJ, Burnett JR, Watts GF Contemporary aspects of the biology and therapeutic regulation of the microsomal triglyceride transfer protein. Circ Res 2015, 116:193-205.
-
(2015)
Circ Res
, vol.116
, pp. 193-205
-
-
Hooper, A.J.1
Burnett, J.R.2
Watts, G.F.3
-
83
-
-
84895548648
-
Lomitapide and mipomersen: two first-in-class drugs for reducing low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia
-
Rader DJ, Kastelein JJP Lomitapide and mipomersen: two first-in-class drugs for reducing low-density lipoprotein cholesterol in patients with homozygous familial hypercholesterolemia. Circulation 2014, 129:1022-1032.
-
(2014)
Circulation
, vol.129
, pp. 1022-1032
-
-
Rader, D.J.1
Kastelein, J.J.P.2
-
84
-
-
84963681124
-
Abstract 10818: Lomitapide Observational Worldwide Evaluation Registry (LOWER): one-year data
-
Blom D, Kastelein JJ, Larrey D, et al. Abstract 10818: Lomitapide Observational Worldwide Evaluation Registry (LOWER): one-year data. Circulation 2015, 132:A10818.
-
(2015)
Circulation
, vol.132
, pp. A10818
-
-
Blom, D.1
Kastelein, J.J.2
Larrey, D.3
-
85
-
-
84897584807
-
Severe hypertriglyceridemia with pancreatitis: thirteen years' treatment with lomitapide
-
Sacks FM, Stanesa M, Hegele RA Severe hypertriglyceridemia with pancreatitis: thirteen years' treatment with lomitapide. JAMA Intern Med 2014, 174:443-447.
-
(2014)
JAMA Intern Med
, vol.174
, pp. 443-447
-
-
Sacks, F.M.1
Stanesa, M.2
Hegele, R.A.3
-
86
-
-
20744442541
-
Familial hypobetalipoproteinemia: genetics and metabolism
-
Schonfeld G, Lin X, Yue P Familial hypobetalipoproteinemia: genetics and metabolism. Cell Mol Life Sci 2005, 62:1372-1378.
-
(2005)
Cell Mol Life Sci
, vol.62
, pp. 1372-1378
-
-
Schonfeld, G.1
Lin, X.2
Yue, P.3
-
87
-
-
77949485460
-
Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial
-
Raal FJ, Santos RD, Blom DJ, et al. Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial. Lancet 2010, 375:998-1006.
-
(2010)
Lancet
, vol.375
, pp. 998-1006
-
-
Raal, F.J.1
Santos, R.D.2
Blom, D.J.3
-
88
-
-
84948799852
-
Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9
-
van der Tuin SJL, Kuhnast S, Berbee JFP, et al. Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9. J Lipid Res 2015, 56:2085-2093.
-
(2015)
J Lipid Res
, vol.56
, pp. 2085-2093
-
-
van der Tuin, S.J.L.1
Kuhnast, S.2
Berbee, J.F.P.3
-
89
-
-
84897530418
-
Future of cholesteryl ester transfer protein inhibitors
-
Rader DJ, deGoma EM Future of cholesteryl ester transfer protein inhibitors. Annu Rev Med 2014, 65:385-403.
-
(2014)
Annu Rev Med
, vol.65
, pp. 385-403
-
-
Rader, D.J.1
deGoma, E.M.2
-
90
-
-
84938748425
-
Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial
-
Hovingh GK, Kastelein JJ, van Deventer SJ, et al. Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet 2015, 386:452-460.
-
(2015)
Lancet
, vol.386
, pp. 452-460
-
-
Hovingh, G.K.1
Kastelein, J.J.2
van Deventer, S.J.3
-
91
-
-
78549235583
-
Safety of anacetrapib in patients with or at high risk for coronary heart disease
-
Cannon CP, Shah S, Dansky HM, et al. Safety of anacetrapib in patients with or at high risk for coronary heart disease. N Engl J Med 2010, 363:2406-2415.
-
(2010)
N Engl J Med
, vol.363
, pp. 2406-2415
-
-
Cannon, C.P.1
Shah, S.2
Dansky, H.M.3
-
92
-
-
84928798085
-
Pharmacogenomic determinants of the cardiovascular effects of dalcetrapib
-
Tardif J-C, Rhéaume É, Lemieux Perreault L-P, et al. Pharmacogenomic determinants of the cardiovascular effects of dalcetrapib. Circ Cardiovasc Genet 2015, 8:372-382.
-
(2015)
Circ Cardiovasc Genet
, vol.8
, pp. 372-382
-
-
Tardif, J.-C.1
Rhéaume, É2
Lemieux Perreault, L.-P.3
-
93
-
-
64049099095
-
Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes
-
Baxter JD, Webb P Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nat Rev Drug Discov 2009, 8:308-320.
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 308-320
-
-
Baxter, J.D.1
Webb, P.2
-
94
-
-
15444357807
-
A novel compound that elevates high density lipoprotein and activates the peroxisome proliferator activated receptor
-
Bisgaier CL, Essenburg AD, Barnett BC, et al. A novel compound that elevates high density lipoprotein and activates the peroxisome proliferator activated receptor. J Lipid Res 1998, 39:17-30.
-
(1998)
J Lipid Res
, vol.39
, pp. 17-30
-
-
Bisgaier, C.L.1
Essenburg, A.D.2
Barnett, B.C.3
-
95
-
-
84963669572
-
-
Gemphire Therapeutics, (accessed Feb 20, 2016).
-
Differentiated product profile Gemphire Therapeutics, (accessed Feb 20, 2016). http://www.gemphire.com/products.php.
-
Differentiated product profile
-
-
-
98
-
-
84963651199
-
-
(accessed March 10, 2016).
-
Jefferies 2014 Global Healthcare Conference (accessed March 10, 2016). http://www.jefferies.com/CMSFiles/Jefferies.com/files/Conferences/060214/Presentations/Aegerion%20Pharma.pdf.
-
Jefferies 2014 Global Healthcare Conference
-
-
|