4,6-Diphenylpyridines as Promising Novel Anti-Influenza Agents Targeting the PA-PB1 Protein-Protein Interaction: Structure-Activity Relationships Exploration with the Aid of Molecular Modeling

Journal of Medicinal Chemistry

Volumn 59, Issue 6, 2016, Pages 2688-2703

  Trist, Iuni M L ^a   Nannetti, Giulio ^b   Tintori, Cristina ^a   Fallacara, Anna Lucia ^a   Deodato, Davide ^a   Mercorelli, Beatrice ^b   Palù, Giorgio ^b   Wijtmans, Maikel ^c   Gospodova, Tzveta ^d   Edink, Ewald ^c   Verheij, Mark ^c   De Esch, Iwan ^c   Viteva, Lilia ^d   Loregian, Arianna ^b   Botta, Maurizio ^a,e  

^a UNIVERSITY OF SIENA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

^c AMSTERDAM INSTITUTE FOR MOLECULES   (Netherlands)

^d INSTITUTE OF ORGANIC CHEMISTRY   (Bulgaria)

^e TEMPLE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (METHYLTHIO) 4,6 DIPHENYLNICOTINONITRILE; 2 CHLORO 1 MORPHOLINOETHAN 1 ONE; 2 CHLORO 4,6 BIS [4 (TRIFLUOROMETHYL)PHENYL]PYRIMIDINE; 2 CHLORO 4,6 DIPHENYLPYRIDINE; 2 CHLORO 4,6 DIPHENYLPYRIMIDINE; 2 [(2 MORPHOLINO 2 OXOETHYL)THIO] 4,6 DIPHENYLNICOTINONITRILE; 2 [(3 CYANO 4 PHENYLPYRIDIN 2 YL)THIO] (M TOLYL)ACETAMIDE; 2 [(3 CYANO 4,6 DIPHENYLPYRIDIN 2 YL)AMINO] (M TOLYL)ACETAMIDE; 2 [(3 CYANO 4,6 DIPHENYLPYRIDIN 2 YL)OXY] N (M TOLYL)ACETAMIDE; 2 [(3 CYANO 4,6 DIPHENYLPYRIDIN 2 YL)THIO] N (M TOLYL)ACETAMIDE; 2 [(3 CYANO 6 PHENYLPYRIDIN 2 YL)THIO] N (M TOLYL)ACETAMIDE; 2 [(4,6 DIPHENYLPYRIDIN 2 YL)THIO] N (M TOLYL)ACETAMIDE; 2 [(4,6 DIPHENYLPYRIMIDIN 2 YL)THIO] N (M TOLYL)ACETAMIDE; 3 (3 CYANO 4,6 DIPHENYLPYRIDIN 2 YL) N (M TOLYL)ACRYLAMIDE; 3 (3 CYANO 4,6 DIPHENYLPYRIDIN 2 YL) N (M TOLYL)PROPANAMIDE; 3 MERCAPTO N (M TOLYL)PROPANAMIDE; 3 [(3 CYANO 4,6 DIPHENYLPYRIDIN 2 YL)THIO] (M TOLYL)PROPANAMIDE; 4 MERCAPTO N (M TOLYL)BUTANAMIDE; 4 [(3 CYANO 4,6 DIPHENYLPYRIDIN 2 YL)THIO] N (M TOLYL)BUTANAMIDE; 4,6 DIPHENYLNICOTINONITRILE; ANTIVIRUS AGENT; BASIC PROTEIN 1; N (M TOLYL)ACRYLAMIDE; OSELTAMIVIR; POLYMERASE ACIDIC PROTEIN; PROTEIN; PYRIDINE DERIVATIVE; RIBAVIRIN; UNCLASSIFIED DRUG; DNA DIRECTED RNA POLYMERASE; INFLUENZA VIRUS POLYMERASE BASIC PROTEIN 1; VIRUS PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; ASSAY; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HYDROGEN BOND; HYDROPHOBICITY; INFLUENZA VIRUS; MOLECULAR DYNAMICS; MOLECULAR MODEL; NONHUMAN; NUCLEOPHILICITY; PLAQUE REDUCTION ASSAY; PROTEIN PROTEIN INTERACTION; SEQUENCE ALIGNMENT; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; DOG; DRUG DESIGN; DRUG EFFECTS; HEK293 CELL LINE; INFLUENZA A VIRUS; INFLUENZA, HUMAN; MDCK CELL LINE; MOLECULAR DOCKING; SYNTHESIS; VIRAL PLAQUE ASSAY; VIROLOGY; VIRUS REPLICATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIVIRAL AGENTS; CRYSTALLOGRAPHY, X-RAY; DNA-DIRECTED RNA POLYMERASES; DOGS; DRUG DESIGN; HEK293 CELLS; HUMANS; INFLUENZA A VIRUS; INFLUENZA, HUMAN; MADIN DARBY CANINE KIDNEY CELLS; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PLAQUE ASSAY; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 84962174298     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01935     Document Type: Article

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