Murine lung cancer increases CD4+ T cell apoptosis and decreases gut proliferative capacity in sepsis

PLoS ONE

Volumn 11, Issue 3, 2016, Pages

  Lyons, John D ^a   Mittal, Rohit ^a   Fay, Katherine T ^a   Chen, Ching Wen ^a   Liang, Zhe ^a   Margoles, Lindsay M ^a   Burd, Eileen M ^a   Farris, Alton B ^a   Ford, Mandy L ^a   Coopersmith, Craig M ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; CHEMOKINE RECEPTOR CXCR3; CXCR3 PROTEIN, MOUSE; PEROXIDASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL LOAD; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CECAL LIGATION AND PUNCTURE-INDUCED SEPSIS; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; FLOW CYTOMETRY; HISTOPATHOLOGY; IMMUNE RESPONSE; INTESTINE MUCOSA PERMEABILITY; KIDNEY DYSFUNCTION; LLC 1 CELL LINE; LUNG CANCER CELL LINE; LUNG CARCINOMA; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; MALE; MORTALITY; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PERITONEAL CAVITY; SEPSIS; SPLEEN CELL; SURVIVAL TIME; THIGH; ALLOTRANSPLANTATION; ANIMAL; BLOOD; BRONCHOALVEOLAR LAVAGE FLUID; C57BL MOUSE; CHEMISTRY; CYTOLOGY; DISEASE MODEL; ENZYMOLOGY; IMMUNOLOGY; INTESTINE MUCOSA; LIVER; LUNG; LUNG TUMOR; METABOLISM; PATHOLOGY; SURVIVAL RATE; TUMOR CELL LINE;

ANIMALS; APOPTOSIS; BRONCHOALVEOLAR LAVAGE FLUID; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE, TUMOR; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; INTESTINAL MUCOSA; LIVER; LUNG; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; PEROXIDASE; RECEPTORS, CXCR3; SEPSIS; SURVIVAL RATE; TRANSPLANTATION, HOMOLOGOUS;

EID: 84962171704     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0149069     Document Type: Article

References (37)

1. Gaieski DF, Edwards JM, Kallan MJ, Carr BG. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med 2013 May; 41(5):1167-74. doi: 10.1097/CCM. 0b013e31827c09f8 PMID: 23442987
2. Danai PA, Moss M, Mannino DM, Martin GS. The epidemiology of sepsis in patients with malignancy. Chest 2006 June; 129(6):1432-40. PMID: 16778259
3. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001 July; 29(7):1303-10. PMID: 11445675
4. Melamed A, Sorvillo FJ. The burden of sepsis-associated mortality in the United States from 1999 to 2005: an analysis of multiple-cause-of-death data. Crit Care 2009;13(1):R28. doi: 10.1186/cc7733 PMID: 19250547
5. Williams MD, Braun LA, Cooper LM, Johnston J, Weiss RV, Qualy RL, et al. Hospitalized cancer patients with severe sepsis: analysis of incidence, mortality, and associated costs of care. Crit Care 2004 October; 8(5):R291-R298. PMID: 15469571
6. Soares M, Caruso P, Silva E, Teles JM, Lobo SM, Friedman G, et al. Characteristics and outcomes of patients with cancer requiring admission to intensive care units: a prospective multicenter study. Crit Care Med 2010 January; 38(1):9-15. doi: 10.1097/CCM.0b013e3181c0349e PMID: 19829101
7. Rosolem MM, Rabello LS, Lisboa T, Caruso P, Costa RT, Leal JV, et al. Critically ill patients with cancer and sepsis: clinical course and prognostic factors. J Crit Care 2012 June; 27(3):301-7. doi: 10.1016/j. jcrc.2011.06.014 PMID: 21855281
8. De ME, Tandjaoui-Lambiotte Y, Legrand M, Lambert J, Mokart D, Kouatchet A, et al. Outcomes in critically ill cancer patients with septic shock of pulmonary origin. Shock 2013 March; 39(3):250-4. doi: 10. 1097/SHK.0b013e3182866d32 PMID: 23364436
9. Torres VB, Azevedo LC, Silva UV, Caruso P, Torelly AP, Silva E, et al. Sepsis-Associated Outcomes in Critically Ill Patients with Malignancies. Ann Am Thorac Soc 2015 Aug; 12(8):1185-92. doi: 10.1513/AnnalsATS.201501-046OC PMID: 26086679
10. Safdar A, Armstrong D. Infectious morbidity in critically ill patients with cancer. Crit Care Clin 2001 July; 17(3):531-viii. PMID: 11525048
11. Mittal R, Chen CW, Lyons JD, Margoles LM, Liang Z, Coopersmith CM, et al. Murine lung cancer induces generalized T-cell exhaustion. J Surg Res 2015 May 15; 195(2):541-9. doi: 10.1016/j.jss. 2015.02.004 PMID: 25748104
12. Mittal R, Wagener M, Breed ER, Liang Z, Yoseph BP, Burd EM, et al. Phenotypic T cell exhaustion in a murine model of bacterial infection in the setting of pre-existing malignancy. PLoS ONE 2014;9(5):e93523. doi: 10.1371/journal.pone.0093523 PMID: 24796533
13. Hotchkiss RS, Moldawer LL. Parallels between cancer and infectious disease. N Engl J Med 2014 July 24; 371(4):380-3. doi: 10.1056/NEJMcibr1404664 PMID: 25054723
14. Fox AC, Robertson CM, Belt B, Clark AT, Chang KC, Leathersich AM, et al. Cancer causes increased mortality and is associated with altered apoptosis in murine sepsis. Crit Care Med 2010 March; 38(3):886-93. doi: 10.1097/CCM.0b013e3181c8fdb1 PMID: 20009755
15. Fox AC, Breed ER, Liang Z, Clark AT, Zee-Cheng BR, Chang KC, et al. Prevention of Lymphocyte Apoptosis in Septic Mice with Cancer Increases Mortality. J Immunol 2011 August 15; 187(4):1950-6. doi: 10.4049/jimmunol.1003391 PMID: 21734077
16. Mittal R, Coopersmith CM. Redefining the gut as the motor of critical illness. Trends Mol Med 2014 April; 20(4):214-23. doi: 10.1016/j.molmed.2013.08.004 PMID: 24055446
17. Hotchkiss RS, Monneret G, Payen D. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat Rev Immunol 2013 December; 13(12):862-74. doi: 10.1038/nri3552 PMID: 24232462
18. Wiersinga WJ, Leopold SJ, Cranendonk DR, Van Der Poll T. Host innate immune responses to sepsis. Virulence 2014 January 1; 5(1):36-44. doi: 10.4161/viru.25436 PMID: 23774844
19. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, et al. Surviving Sepsis Campaign: International Guidelines for Management of Severe Sepsis and Septic Shock: 2012. Crit Care Med 2013 February; 41(2):580-637. doi: 10.1097/CCM.0b013e31827e83af PMID: 23353941
20. Baker CC, Chaudry IH, Gaines HO, Baue AE. Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 1983 August; 94(2):331-5. PMID: 6879447
21. Yoseph BP, Breed E, Overgaard CE, Ward CJ, Liang Z, Wagener ME, et al. Chronic alcohol ingestion increases mortality and organ injury in a murine model of septic peritonitis. PLoS ONE 2013;8(5):e62792. doi: 10.1371/journal.pone.0062792 PMID: 23717394
22. Clark JA, Gan H, Samocha AJ, Fox AC, Buchman TG, Coopersmith CM. Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis. Am J Physiol Gastrointest Liver Physiol 2009 September; 297(3):G471-G479. doi: 10.1152/ajpgi.00012.2009 PMID: 19571236
23. Liang Z, Xie Y, Dominguez JA, Breed ER, Yoseph BP, Burd EM, et al. Intestine-specific deletion of microsomal triglyceride transfer protein increases mortality in aged mice. PLoS ONE 2014;9(7):e101828. doi: 10.1371/journal.pone.0101828 PMID: 25010671
24. Dominguez JA, Xie Y, Dunne WM, Yoseph BP, Burd EM, Coopersmith CM, et al. Intestine-specific Mttp deletion decreases mortality and prevents sepsis-induced intestinal injury in a murine model of Pseudomonas aeruginosa pneumonia. PLoS ONE 2012;7(11):e49159. doi: 10.1371/journal.pone. 0049159 PMID: 23145105
25. Vyas D, Robertson CM, Stromberg PE, Martin JR, Dunne WM, Houchen CW, et al. Epithelial apoptosis in mechanistically distinct methods of injury in the murine small intestine. Histol Histopathol 2007 June; 22(6):623-30. PMID: 17357092
26. Dominguez JA, Samocha AJ, Liang Z, Burd EM, Farris AB, Coopersmith CM. Inhibition of IKKbeta in Enterocytes Exacerbates Sepsis-Induced Intestinal Injury and Worsens Mortality. Crit Care Med 2013 October; 41(10):e275-e285. doi: 10.1097/CCM.0b013e31828a44ed PMID: 23939348
27. McConnell KW, McDunn JE, Clark AT, Dunne WM, Dixon DJ, Turnbull IR, et al. Streptococcus pneumoniae and Pseudomonas aeruginosa pneumonia induce distinct host responses. Crit Care Med 2010 January; 38(1):223-41. doi: 10.1097/CCM.0b013e3181b4a76b PMID: 19770740
28. Fry DE. The generic septic response. Crit Care Med 2008 April; 36(4):1369-70. doi: 10.1097/CCM. 0b013e31816a11e9 PMID: 18379273
29. Yu SL, Chen HW, Yang PC, Peck K, Tsai MH, Chen JJ, et al. Differential gene expression in gram-negative and gram-positive sepsis. Am J Respir Crit Care Med 2004 May 15; 169(10):1135-43. PMID: 15001460
30. Hotchkiss RS, Tinsley KW, Swanson PE, Chang KC, Cobb JP, Buchman TG, et al. Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc Natl Acad Sci U S A 1999 December 7; 96(25):14541-6. PMID: 10588741
31. Hotchkiss RS, Swanson PE, Knudson CM, Chang KC, Cobb JP, Osborne DF, et al. Overexpression of Bcl-2 in transgenic mice decreases apoptosis and improves survival in sepsis. J Immunol 1999 April 1; 162(7):4148-56. PMID: 10201940
32. Hotchkiss RS, Coopersmith CM, McDunn JE, Ferguson TA. The sepsis seesaw: tilting toward immunosuppression. Nat Med 2009 May; 15(5):496-7. doi: 10.1038/nm0509-496 PMID: 19424209
33. Delano MJ, Scumpia PO, Weinstein JS, Coco D, Nagaraj S, Kelly-Scumpia KM, et al. MyD88-dependent expansion of an immature GR-1 (+) CD11b (+) population induces T cell suppression and Th2 polarization in sepsis. J Exp Med 2007 June 11; 204(6):1463-74. PMID: 17548519
34. Sertaridou E, Papaioannou V, Kolios G, Pneumatikos I. Gut failure in critical care: old school versus new school. Ann Gastroenterol 2015 July; 28(3):309-22. PMID: 26130136
35. Clark JA, Coopersmith CM. Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness. Shock 2007 October; 28(4):384-93. PMID: 17577136
36. Iskander KN, Craciun FL, Stepien DM, Duffy ER, Kim J, Moitra R, et al. Cecal ligation and punctureinduced murine sepsis does not cause lung injury. Crit Care Med 2013 January; 41(1):154-65.
37. Hotchkiss RS, Sherwood ER. Immunology. Getting sepsis therapy right. Science 2015 March 13; 347(6227):1201-2. doi: 10.1126/science.aaa8334 PMID: 25766219