메뉴 건너뛰기




Volumn 9, Issue 8, 2011, Pages

Scientific Opinion on Flavouring Group Evaluation 13, Revision 2 (FGE.13Rev2): Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14
[No Author Info available]

Author keywords

disulphide; FGE.13; flavourings; furan; Furfuryl; safety; sulphur substituted; thioester; trisulphide

Indexed keywords


EID: 84962143908     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2011.2313     Document Type: Article
Times cited : (19)

References (213)
  • 1
    • 0024339042 scopus 로고
    • The in vitro unscheduled DNA synthesis (UDS) assay in rat primary hepatocytes: Evaluation of 2-furoic acid and 7 drug candidates
    • Aaron CS, Harbach PR, Wiser SK, Grzegorczyk CR, Smith AL, 1989. The in vitro unscheduled DNA synthesis (UDS) assay in rat primary hepatocytes: Evaluation of 2-furoic acid and 7 drug candidates. Mutat. Res. 223 (2), 163–169.
    • (1989) Mutat. Res , vol.223 , Issue.2 , pp. 163-169
    • Aaron, C.S.1    Harbach, P.R.2    Wiser, S.K.3    Grzegorczyk, C.R.4    Smith, A.L.5
  • 2
    • 85078397363 scopus 로고    scopus 로고
    • An investigation of the effect of furfural on the unscheduled DNA synthesis in cultured human liver slices
    • Adams TB, Lake BG, Beamad JA, Price RJ, Ford RA, Goodman, J.I., 1998b. An investigation of the effect of furfural on the unscheduled DNA synthesis in cultured human liver slices. Toxicologist 42 (1-S), 79.
    • (1998) Toxicologist , vol.42 , Issue.1-S , pp. 79
    • Adams, T.B.1    Lake, B.G.2    Beamad, J.A.3    Price, R.J.4    Ford, R.A.5    Goodman, J.I.6
  • 6
    • 85078373818 scopus 로고
    • Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Bio-Research Laboratory, 1980. Ethyl-beta-furfural-alpha-thiopropionate (EFTP). Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1980) Ethyl-beta-furfural-alpha-thiopropionate (EFTP)
  • 7
    • 0027590958 scopus 로고
    • Biotransformation of furfural and 5-hydroxymethyl furfural by enteric bacteria
    • Boopathy R, Bokang H and Daniels L, 1993. Biotransformation of furfural and 5-hydroxymethyl furfural by enteric bacteria. J. Ind. Microbiol. 11 (3), 147–150.
    • (1993) J. Ind. Microbiol , vol.11 , Issue.3 , pp. 147-150
    • Boopathy, R.1    Bokang, H.2    Daniels, L.3
  • 8
    • 0002468844 scopus 로고
    • Mixed disulfides: Biological function and increase in oxidative stress
    • Sies, H., (ed.)., Academic Press, New York
    • Brigelius R, 1985. Mixed disulfides: Biological function and increase in oxidative stress. In: Sies, H. (ed.). Oxidative Stress. Academic Press, New York, 243–272.
    • (1985) Oxidative Stress , pp. 243-272
    • Brigelius, R.1
  • 11
    • 23244464769 scopus 로고    scopus 로고
    • Generation of reactive oxygen species by a persulfide (BnSSH)
    • Chatterji T, Keerthi K and Gates KS, 2005. Generation of reactive oxygen species by a persulfide (BnSSH). Bioorg. Med. Chem. Lett. 15, 3921–3924.
    • (2005) Bioorg. Med. Chem. Lett , vol.15 , pp. 3921-3924
    • Chatterji, T.1    Keerthi, K.2    Gates, K.S.3
  • 12
    • 85078369339 scopus 로고    scopus 로고
    • Steenwinkel, M.-J.S.T. Project 01044074. 1 May 2003. Unpublished report submitted to EFSA
    • CIVO-TNO, 2003. In vivo gene mutation by use of lambdaZ-transgenic mice with furfural. Steenwinkel, M.-J.S.T. Project no. 01044074. 1 May 2003. Unpublished report submitted to EFSA.
    • (2003) In vivo gene mutation by use of lambdaZ-transgenic mice with furfural
  • 13
    • 84899008427 scopus 로고
    • Flavouring substances and natural sources of flavourings
    • 4th Ed., Council of Europe, partial agreement in the social and public health field, Strasbourg
    • CoE, 1992. Flavouring substances and natural sources of flavourings. 4th Ed. vol. I. Chemically defined flavouring substances. Council of Europe, partial agreement in the social and public health field. Strasbourg.
    • (1992) Chemically defined flavouring substances , vol.I
  • 14
    • 0030952758 scopus 로고    scopus 로고
    • DNA-protein cross-links produced by various chemicals in cultured human lymphoma cells
    • Costa M, Zhitkovich A, Harris M, Paustenbach D and Gargas M, 1997. DNA-protein cross-links produced by various chemicals in cultured human lymphoma cells. J. Toxicol. Environ. Health 50 (5), 433–449.
    • (1997) J. Toxicol. Environ. Health , vol.50 , Issue.5 , pp. 433-449
    • Costa, M.1    Zhitkovich, A.2    Harris, M.3    Paustenbach, D.4    Gargas, M.5
  • 15
    • 84987484095 scopus 로고
    • Thiol-disulphide exchange: Physiological and toxicological aspects: Sulphur-containing drugs and related organic compounds
    • Damani, L.A., (ed.)., John Wiley & Sons, New York
    • Cotgreave IA, Atzori L and Moldéus P, 1989. Thiol-disulphide exchange: Physiological and toxicological aspects. In: Damani, L.A. (ed.). Sulphur-containing drugs and related organic compounds. Ellis Horwood Series in Biochem. Pharmacol. John Wiley & Sons, New York. pp. 101–119.
    • (1989) Ellis Horwood Series in Biochem. Pharmacol , pp. 101-119
    • Cotgreave, I.A.1    Atzori, L.2    Moldéus, P.3
  • 16
    • 0018079206 scopus 로고
    • Estimation of toxic hazard - a decision tree approach
    • Cramer GM, Ford RA and Hall RL, 1978. Estimation of toxic hazard - a decision tree approach. Food Cosmet. Toxicol. 16 (3), 255–276.
    • (1978) Food Cosmet. Toxicol , vol.16 , Issue.3 , pp. 255-276
    • Cramer, G.M.1    Ford, R.A.2    Hall, R.L.3
  • 17
    • 0014911117 scopus 로고
    • [Tolerance to 5-hydroxymethylfurfural (HMF). 2. Pharmacological properties]
    • (In German)
    • Czok G, 1970. [Tolerance to 5-hydroxymethylfurfural (HMF). 2. Pharmacological properties]. Z. Ernährungswissenschaft 10 (2), 103–110. (In German)
    • (1970) Z. Ernährungswissenschaft , vol.10 , Issue.2 , pp. 103-110
    • Czok, G.1
  • 18
    • 84903658736 scopus 로고    scopus 로고
    • Genotoxiciteten av HMF: s metabolit SMF studerad med det flödescytometerbaserade mikrokärntestet in vivo
    • University of Uppsala, Uppsala, (as cited by Glatt and Sommer 2006)
    • Dahlberg J, 2004. “Genotoxiciteten av HMF: s metabolit SMF studerad med det flödescytometerbaserade mikrokärntestet in vivo”, Examination work supervised by Abramsson-Zetterberg L, University of Uppsala, Uppsala, 34 pp. (as cited by Glatt and Sommer 2006).
    • (2004) Examination work supervised by Abramsson-Zetterberg L , pp. 34
    • Dahlberg, J.1
  • 19
    • 0343622296 scopus 로고
    • Metabolism of sulphur-containing drugs
    • Benford, D.J., Bridges, J.W., Gibson, G.G., (eds.)., Taylor & Francis, London, New York, Philadelphia
    • Damani LA, 1987. Metabolism of sulphur-containing drugs. In: Benford, D.J., Bridges, J.W., Gibson, G.G. (eds.). Drug metabolism - from molecules to man. Taylor & Francis, London, New York, Philadelphia, pp. 581–603.
    • (1987) Drug metabolism - from molecules to man , pp. 581-603
    • Damani, L.A.1
  • 20
    • 0027759818 scopus 로고
    • Metabolism of benzbromarone in man: structures of new oxidative metabolites, 6-hydroxy- and 1 ‘-oxo-benzbromarone, and the enantioselective formation and elimination of 1 ’-hydroxybenzbromarone
    • De Vries JX, Walter-Sack Voss A, Forster W, Ilisisteguipons P, Stoetzer F, Sprauls M, Ackermanns M and Moyna G, 1993. Metabolism of benzbromarone in man: structures of new oxidative metabolites, 6-hydroxy- and 1 ‘-oxo-benzbromarone, and the enantioselective formation and elimination of 1 ’-hydroxybenzbromarone. Xenobiotica, 23 (12), 1435–1450
    • (1993) Xenobiotica , vol.23 , Issue.12 , pp. 1435-1450
    • De Vries, J.X.1    Walter-Sack Voss, A.2    Forster, W.3    Ilisisteguipons, P.4    Stoetzer, F.5    Sprauls, M.6    Ackermanns, M.7    Moyna, G.8
  • 21
    • 0031972838 scopus 로고    scopus 로고
    • The effectiveness of Salmonella strains TA100, TA102 and TA104 for detecting mutagenicity of some aldehydes and peroxides
    • Dillon D, Combes R and Zeiger E, 1998. The effectiveness of Salmonella strains TA100, TA102 and TA104 for detecting mutagenicity of some aldehydes and peroxides. Mutagenesis 13 (1), 19–26.
    • (1998) Mutagenesis , vol.13 , Issue.1 , pp. 19-26
    • Dillon, D.1    Combes, R.2    Zeiger, E.3
  • 22
    • 36549030653 scopus 로고
    • Armed Services Technical Information Agency, Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Doull J, Plzak V and Brois SJ, 1962. A survey of compounds for radiation protection. Armed Services Technical Information Agency, 1–124. Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1962) A survey of compounds for radiation protection , pp. 1-124
    • Doull, J.1    Plzak, V.2    Brois, S.J.3
  • 23
    • 0032694761 scopus 로고    scopus 로고
    • p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing
    • Duerksen-Hughes PJ, Yang J and Ozcan O, 1999. p53 induction as a genotoxic test for twenty-five chemicals undergoing in vivo carcinogenicity testing. Environ. Health Perspect. 107 (10), 805–812.
    • (1999) Environ. Health Perspect , vol.107 , Issue.10 , pp. 805-812
    • Duerksen-Hughes, P.J.1    Yang, J.2    Ozcan, O.3
  • 24
    • 60849125078 scopus 로고    scopus 로고
    • Evaluation of the DNA damaging effect of the heat-induced food toxicant 5-hydroxymethylfurfural (HMF) in various cell lines with different activities of sulfotransferases
    • Durling LJK, Busk L and Hellman BE, 2009. Evaluation of the DNA damaging effect of the heat-induced food toxicant 5-hydroxymethylfurfural (HMF) in various cell lines with different activities of sulfotransferases. Food Chem Toxicol. 47, 880–884.
    • (2009) Food Chem Toxicol , vol.47 , pp. 880-884
    • Durling, L.J.K.1    Busk, L.2    Hellman, B.E.3
  • 27
    • 0015394311 scopus 로고
    • Mechanism of biosynthesis of thio-beta-D-glucuronides
    • Dutton GJ and Illing HPA, 1972. Mechanism of biosynthesis of thio-beta-D-glucuronides. Biochem. J., 129, 539–550.
    • (1972) Biochem. J , vol.129 , pp. 539-550
    • Dutton, G.J.1    Illing, H.P.A.2
  • 28
    • 1842651482 scopus 로고    scopus 로고
    • Regulation No 2232/96 of the European Parliament and of the Council of 28 October 1996
    • 23.11.1996
    • EC, 1996a. Regulation No 2232/96 of the European Parliament and of the Council of 28 October 1996. Official Journal of the European Communities 23.11.1996, L 299, 1–4.
    • (1996) Official Journal of the European Communities , vol.L 299 , pp. 1-4
  • 29
    • 9644266890 scopus 로고    scopus 로고
    • Commission Decision 1999/217/EC of 23 February 1999 adopting a register of flavouring substances used in or on foodstuffs
    • 27.3.1999
    • EC, 1999a. Commission Decision 1999/217/EC of 23 February 1999 adopting a register of flavouring substances used in or on foodstuffs. Official Journal of the European Communities 27.3.1999, L 84, 1–137.
    • (1999) Official Journal of the European Communities , vol.L 84 , pp. 1-137
  • 30
    • 9644264216 scopus 로고    scopus 로고
    • Commission Regulation No 1565/2000 of 18 July 2000 laying down the measures necessary for the adoption of an evaluation programme in application of Regulation (EC) No 2232/96
    • 19.7.2000
    • EC, 2000a. Commission Regulation No 1565/2000 of 18 July 2000 laying down the measures necessary for the adoption of an evaluation programme in application of Regulation (EC) No 2232/96. Official Journal of the European Communities 19.7.2000, L 180, 8–16.
    • (2000) Official Journal of the European Communities , vol.L 180 , pp. 8-16
  • 31
    • 85078395709 scopus 로고    scopus 로고
    • Commission Regulation No 622/2002 of 11 April 2002 establishing deadlines for the submission of information for the evaluation of chemically defined flavouring substances used in or on foodstuffs
    • 12.4.2002
    • EC, 2002b. Commission Regulation No 622/2002 of 11 April 2002 establishing deadlines for the submission of information for the evaluation of chemically defined flavouring substances used in or on foodstuffs. Official Journal of the European Communities 12.4.2002, L 95, 10–11.
    • (2002) Official Journal of the European Communities , vol.L 95 , pp. 10-11
  • 32
    • 84923341107 scopus 로고    scopus 로고
    • Commission Decision 2009/163/EC of 26 February 2009 amending Decision 1999/217/EC as regards the Register of flavouring substances used in or on foodstuffs
    • 27.2.2009
    • EC, 2009a. Commission Decision 2009/163/EC of 26 February 2009 amending Decision 1999/217/EC as regards the Register of flavouring substances used in or on foodstuffs. Official Journal of the European Union 27.2.2009, L 55, 41.
    • (2009) Official Journal of the European Union , vol.L 55 , pp. 41
  • 33
    • 0027512525 scopus 로고
    • The possible role of alpha, beta-unsaturated carbonyl compounds in mutagenesis and carcinogenesis
    • Eder E, Scheckenbach S, Deininger C and Hoffman C, 1993. The possible role of alpha, beta-unsaturated carbonyl compounds in mutagenesis and carcinogenesis. Toxicol. Lett. 67, 87–103.
    • (1993) Toxicol. Lett , vol.67 , pp. 87-103
    • Eder, E.1    Scheckenbach, S.2    Deininger, C.3    Hoffman, C.4
  • 36
    • 85078389925 scopus 로고    scopus 로고
    • Flavoring group evaluation of 19 flavoring substances (candidate chemicals) of the chemical group 14 (Annex I of 1565/2000/EC) structurally related to furfuryl alcohol and related substances [JECFA/WHO FAS 46/55] and sulfursubstituted furan derivates [JECFA/WHO FAS 50/59] used as flavoring substances. 31 January, 2003. Unpublished report submitted by EFFA to FLAVIS Secretariat. FLAVIS/8.21
    • EFFA, 2003g. Submission 2003–3. Flavoring group evaluation of 19 flavoring substances (candidate chemicals) of the chemical group 14 (Annex I of 1565/2000/EC) structurally related to furfuryl alcohol and related substances [JECFA/WHO FAS 46/55] and sulfursubstituted furan derivates [JECFA/WHO FAS 50/59] used as flavoring substances. 31 January, 2003. Unpublished report submitted by EFFA to FLAVIS Secretariat. FLAVIS/8.21.
    • (2003) Submission 2003–3
  • 38
    • 85078371672 scopus 로고    scopus 로고
    • Supplement of eight flavouring substances (candidate chemicals) to the flavouring group evaluation of chemical group 14 (Annex I of 1565/2000/EC) structurally related to furfuryl alcohol and related substances [JECFA/WHO FAS 46/55] and sulfursubstituted furan derivatives [JECFA/WHO FAS 50/59] used as flavouring substances 3 June 2004. Unpublished report submitted by EFFA to FLAVIS Secretariat. FLAVIS/8.68
    • EFFA, 2004y. Submission 2003–3 Addendum. Supplement of eight flavouring substances (candidate chemicals) to the flavouring group evaluation of chemical group 14 (Annex I of 1565/2000/EC) structurally related to furfuryl alcohol and related substances [JECFA/WHO FAS 46/55] and sulfursubstituted furan derivatives [JECFA/WHO FAS 50/59] used as flavouring substances 3 June 2004. Unpublished report submitted by EFFA to FLAVIS Secretariat. FLAVIS/8.68.
    • (2004) Submission 2003–3 Addendum
  • 40
    • 85078396854 scopus 로고    scopus 로고
    • Private communication from EFFA to the FLAVIS secretariat. 27 May 2011. FLAVIS/8.111
    • EFFA, 2011b. Poundage data on selected substances in FGE.66 and FGE.67. Private communication from EFFA to the FLAVIS secretariat. 27 May 2011. FLAVIS/8.111
    • (2011) Poundage data on selected substances in FGE.66 and FGE.67
  • 42
    • 85053822036 scopus 로고    scopus 로고
    • Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to furfural and furfural diethylacetal
    • Question number EFSA-Q-2003-236. Adopted by written procedure on 2 June 2004
    • EFSA, 2004c. Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with food on a request from the Commission related to furfural and furfural diethylacetal. Question number EFSA-Q-2003-236. Adopted by written procedure on 2 June 2004. The EFSA Journal 67, 1–27.
    • (2004) The EFSA Journal , vol.67 , pp. 1-27
  • 45
    • 85078390972 scopus 로고    scopus 로고
    • o., Adopted on 26 November 2009. EFSA-Q-2008-032S
    • th meeting). Adopted on 26 November 2009. EFSA-Q-2008-032S.
    • (2009) th meeting)
  • 46
    • 85078390453 scopus 로고    scopus 로고
    • p., Adopted 9 July 2008. EFSA-Q-2008-032R
    • th meeting). Adopted 9 July 2008. EFSA-Q-2008-032R
    • (2009) th meeting)
  • 47
    • 85078379881 scopus 로고    scopus 로고
    • c., Use of the benchmark dose approach in risk assessment. Guidance of the Scientific Committee (Question No EFSA-Q-2005-232). The EFSA Journal, Available online
    • EFSA, 2009bc. Opinion of the EFSA Scientific Committee. Use of the benchmark dose approach in risk assessment. Guidance of the Scientific Committee (Question No EFSA-Q-2005-232). The EFSA Journal (2009) 1150, 1–72. Available online: www.efsa.europa.eu/en/efsajournal/doc/1150.pdf.
    • (2009) Opinion of the EFSA Scientific Committee , vol.1150 , Issue.2009 , pp. 1-72
  • 50
    • 0003610530 scopus 로고    scopus 로고
    • Use of BMDS and PROAST software packages by EFSA Scientific Panels and Units for applying the Benchmark Dose (BMD) approach in risk assessment. Issued on 17 March 2010. EFSA-Q-2010-00897
    • EFSA, 2011g. Technical Report. Use of BMDS and PROAST software packages by EFSA Scientific Panels and Units for applying the Benchmark Dose (BMD) approach in risk assessment. Issued on 17 March 2010. EFSA-Q-2010-00897.
    • (2011) Technical Report
  • 52
    • 84870227385 scopus 로고
    • Reaction of glutathione with conjugated carbonyls
    • Esterbauer H, Zollner H, Scholz N, 1975. Reaction of glutathione with conjugated carbonyls. Z. Naturforsch. 30c, 466–473.
    • (1975) Z. Naturforsch , vol.30c , pp. 466-473
    • Esterbauer, H.1    Zollner, H.2    Scholz, N.3
  • 53
    • 0000635578 scopus 로고
    • The reaction of cysteine with alpha, beta-unsaturated aldehydes
    • Esterbauer H, Ertl A and Scholz N, 1976. The reaction of cysteine with alpha, beta-unsaturated aldehydes. Tetrahedron 32, 285–289.
    • (1976) Tetrahedron , vol.32 , pp. 285-289
    • Esterbauer, H.1    Ertl, A.2    Scholz, N.3
  • 54
    • 85078393221 scopus 로고    scopus 로고
    • Draft human health section. October, 2004. European Chemicals Bureau, Institute for Health and Consumer Protection, Ispra, Italy
    • EU-RAR (European Union Risk Assessment Report), 2004b. EU-RAR on furfural (CAS no: 98–01-1; EINECS no: 202–627-7). Draft human health section. October, 2004. European Chemicals Bureau, Institute for Health and Consumer Protection, Ispra, Italy.
    • (2004) EU-RAR on furfural (CAS no: 98–01-1; EINECS no: 202–627-7)
  • 55
    • 85070224875 scopus 로고    scopus 로고
    • Cited in Eurostat, 2004. The EU population, Total population. [Online]. Available, Population and social conditions, Population, Demography, Main demographic indicators, Total population. December 2008
    • Eurostat, 1998. Total population. Cited in Eurostat, 2004. The EU population, Total population. [Online]. Available: epp.eurostat.ec.europa.eu/portal/page?_pageid=1090,30070682,1090_33076576&_dad=dortal&_schema=aORTAL, Population and social conditions, Population, Demography, Main demographic indicators, Total population. December 2008.
    • (1998) Total population
  • 56
    • 0015252466 scopus 로고
    • Respiratory tract tumors in hamsters after intratracheal instillations of benzo[a]pyrene alone and with furfural
    • Feron VJ, 1972. Respiratory tract tumors in hamsters after intratracheal instillations of benzo[a]pyrene alone and with furfural. Cancer Res. 32, 28–36.
    • (1972) Cancer Res , vol.32 , pp. 28-36
    • Feron, V.J.1
  • 58
    • 0018187525 scopus 로고
    • The absorption, metabolism and excretion of furfural in man
    • Flek J, Sedivec V, 1978. The absorption, metabolism and excretion of furfural in man. Int. Arch. Occup. Environ. Health 41, 159–168.
    • (1978) Int. Arch. Occup. Environ. Health , vol.41 , pp. 159-168
    • Flek, J.1    Sedivec, V.2
  • 59
    • 0018822306 scopus 로고
    • Screening of tobacco smoke constituents for mutagenicity using the Ames' test
    • Florin I, Rutberg L, Curvall M and Enzell CR, 1980. Screening of tobacco smoke constituents for mutagenicity using the Ames' test. Toxicology. 18, 219–232.
    • (1980) Toxicology , vol.18 , pp. 219-232
    • Florin, I.1    Rutberg, L.2    Curvall, M.3    Enzell, C.R.4
  • 60
    • 85078393889 scopus 로고
    • Affiliated Medical Research, Inc. Contract 121–2079-93. October 23, 1973. Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Fogleman RW and Suppers L, 1973a. Acute oral toxicity in mice with 15129 (2,5-dimethyl-3-thiofuroylfuran). Affiliated Medical Research, Inc. Contract no. 121–2079-93. October 23, 1973. Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1973) Acute oral toxicity in mice with 15129 (2,5-dimethyl-3-thiofuroylfuran)
    • Fogleman, R.W.1    Suppers, L.2
  • 61
    • 85078393889 scopus 로고
    • Affiliated Medical Research, Inc. Contract 121–2079-93. October 23, 1973. Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Fogleman RW and Suppers L, 1973b. Acute oral toxicity in mice with 15124 (2,5-dimethyl-3-thiosovalerate). Affiliated Medical Research, Inc. Contract no. 121–2079-93. October 23, 1973. Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1973) Acute oral toxicity in mice with 15124 (2,5-dimethyl-3-thiosovalerate)
    • Fogleman, R.W.1    Suppers, L.2
  • 62
    • 85078393889 scopus 로고
    • Affiliated Medical Research, Inc. Contract 121–2079-93. February 11, 1974. Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Fogleman RW and Suppers L, 1974a. Acute oral toxicity in mice with 15124 (2,5-dimethyl-3-thioisovalerate). Affiliated Medical Research, Inc. Contract no. 121–2079-93. February 11, 1974. Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1974) Acute oral toxicity in mice with 15124 (2,5-dimethyl-3-thioisovalerate)
    • Fogleman, R.W.1    Suppers, L.2
  • 63
    • 85078393889 scopus 로고
    • Affiliated Medical Research, Inc. Contract 121–2079-93. February 11, 1974. Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Fogleman RW and Suppers L, 1974b. Acute oral toxicity in mice with 15129 (2,5-dimethyl-3-thiofuroylfuran). Affiliated Medical Research, Inc. Contract no. 121–2079-93. February 11, 1974. Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1974) Acute oral toxicity in mice with 15129 (2,5-dimethyl-3-thiofuroylfuran)
    • Fogleman, R.W.1    Suppers, L.2
  • 64
    • 0342954905 scopus 로고
    • Verhalten der furfuracrylsäure und der furoylessigsäure im tierkörper
    • (In German)
    • Friedmann E, 1911. Verhalten der furfuracrylsäure und der furoylessigsäure im tierkörper. Biochem. Z. 35, 40–48. (In German)
    • (1911) Biochem. Z , vol.35 , pp. 40-48
    • Friedmann, E.1
  • 66
    • 0021267155 scopus 로고
    • Toxicity-distribution relationships among 3-alkylfurans in the mouse lung
    • Gammal LM, Wiley RA, Traiger G, Haschek WM and Baraban S, 1984. Toxicity-distribution relationships among 3-alkylfurans in the mouse lung. Toxicology 30, 177–184.
    • (1984) Toxicology , vol.30 , pp. 177-184
    • Gammal, L.M.1    Wiley, R.A.2    Traiger, G.3    Haschek, W.M.4    Baraban, S.5
  • 67
    • 0023627123 scopus 로고
    • Rapid and complete urinary elimination of [14C]-5-hydroxymethyl-2-furaldehyde administered orally or intravenously to rats
    • Germond J-E, Philippossian G, Richli U, Bracco I and Arnaud MJ, 1987. Rapid and complete urinary elimination of [14C]-5-hydroxymethyl-2-furaldehyde administered orally or intravenously to rats. J. Toxicol. Environ. Health 22, 79–89.
    • (1987) J. Toxicol. Environ. Health , vol.22 , pp. 79-89
    • Germond, J.-E.1    Philippossian, G.2    Richli, U.3    Bracco, I.4    Arnaud, M.J.5
  • 69
    • 84903654575 scopus 로고    scopus 로고
    • Health risks by 5-hydroxymethylfurfural (HMF) and related compounds
    • K. Skog, J. Alexander, eds.),, Woodhead Publishing, Cambridge
    • Glatt HR and Sommer Y, 2006. Health risks by 5-hydroxymethylfurfural (HMF) and related compounds. In: Acrylamide and Other Health Hazardous Compounds in Heat-treated Foods (K. Skog, J. Alexander, eds.), Woodhead Publishing, Cambridge, 2006, 328–357.
    • (2006) Acrylamide and Other Health Hazardous Compounds in Heat-treated Foods , vol.2006 , pp. 328-357
    • Glatt, H.R.1    Sommer, Y.2
  • 70
    • 12744258127 scopus 로고    scopus 로고
    • V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals
    • Glatt H, Schneider H and Liu Y, 2005. V79-hCYP2E1-hSULT1A1, a cell line for the sensitive detection of genotoxic effects induced by carbohydrate pyrolysis products and other food-borne chemicals. Mutation Research 580, 41–52.
    • (2005) Mutation Research , vol.580 , pp. 41-52
    • Glatt, H.1    Schneider, H.2    Liu, Y.3
  • 71
    • 0030934879 scopus 로고    scopus 로고
    • Bioactivation of mutagens via sulfation
    • Glatt H, 1997. Bioactivation of mutagens via sulfation. The FASEB Journal 11, 314–321.
    • (1997) The FASEB Journal , vol.11 , pp. 314-321
    • Glatt, H.1
  • 72
    • 0033546127 scopus 로고    scopus 로고
    • Distribution and metabolism of (5-hydroxymethyl)furfural in male F344 rats and B6C3F1 mice after oral administration
    • Godfrey VB, Chen L-J, Griffin RJ, Lebetkin EH and Burka LT, 1999. Distribution and metabolism of (5-hydroxymethyl)furfural in male F344 rats and B6C3F1 mice after oral administration. J. Toxicol. Environ. Health, Part A 57, 199–210.
    • (1999) J. Toxicol. Environ. Health, Part A , vol.57 , pp. 199-210
    • Godfrey, V.B.1    Chen, L.-J.2    Griffin, R.J.3    Lebetkin, E.H.4    Burka, L.T.5
  • 74
    • 85078376894 scopus 로고    scopus 로고
    • to USEPA reporting results of acute oral toxicity study in rats with methyl-2-furoate, dated 2/5/1998. Methyl-2-furoate. Wil Research Laboratories, Inc. EPA Doc 88980000095, microfiche OTS0559247. February 5, 1998. Unpublished data submitted by EFFA to FLAVIS Secretariat
    • Great Lakes Chemical Corp., 1998. Initial submission: Letter from Lakes Chemical Corp. to USEPA reporting results of acute oral toxicity study in rats with methyl-2-furoate, dated 2/5/1998. Methyl-2-furoate. Wil Research Laboratories, Inc. EPA Doc 88980000095, microfiche no. OTS0559247. February 5, 1998. Unpublished data submitted by EFFA to FLAVIS Secretariat.
    • (1998) Initial submission: Letter from Lakes Chemical Corp
  • 75
    • 0027406059 scopus 로고
    • Dependence of glycine conjugation on availability of glycine: role of the glycine cleavage system
    • Gregus Z, Fekete T, Varga F and Klaassen CD, 1993. Dependence of glycine conjugation on availability of glycine: role of the glycine cleavage system. Xenobiotica 23, 141–153.
    • (1993) Xenobiotica , vol.23 , pp. 141-153
    • Gregus, Z.1    Fekete, T.2    Varga, F.3    Klaassen, C.D.4
  • 76
    • 85078387250 scopus 로고
    • Ethyl furfuryl alpha-thiopropionate. Food and Drug Research Laboratories, Inc. Lab. 5663a. October 10, 1977. Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Griffiths J and Babish JG, 1977a. Acute oral toxicity (LD50) of ethyl furfuryl alpha-thiopropionate in mice. Ethyl furfuryl alpha-thiopropionate. Food and Drug Research Laboratories, Inc. Lab. no. 5663a. October 10, 1977. Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1977) Acute oral toxicity (LD50) of ethyl furfuryl alpha-thiopropionate in mice
    • Griffiths, J.1    Babish, J.G.2
  • 77
    • 0017606482 scopus 로고
    • Toxicological assessment of flavouring esters
    • Grundschober F, 1977. Toxicological assessment of flavouring esters. Toxicology 8, 387–390.
    • (1977) Toxicology , vol.8 , pp. 387-390
    • Grundschober, F.1
  • 79
    • 0027535562 scopus 로고
    • The hypolipidemic effects of 2-furoic acid in Sprague-Dawley rats
    • Hall IH, Wong OT, Reynolds DJ and Chang JJ, 1993. The hypolipidemic effects of 2-furoic acid in Sprague-Dawley rats. Arch. Pharm. (Weinheim) 326 (1), 15–23.
    • (1993) Arch. Pharm. (Weinheim) , vol.326 , Issue.1 , pp. 15-23
    • Hall, I.H.1    Wong, O.T.2    Reynolds, D.J.3    Chang, J.J.4
  • 80
    • 0025731958 scopus 로고
    • The use of hepatocytes cultured from inducer-treated rats in the detection of cytochrome p-450-mediated cytotoxicity
    • Hammond AH and Fry JR, 1991. The use of hepatocytes cultured from inducer-treated rats in the detection of cytochrome p-450-mediated cytotoxicity. Toxicol. In Vitro 5 (2), 133–137.
    • (1991) Toxicol. In Vitro , vol.5 , Issue.2 , pp. 133-137
    • Hammond, A.H.1    Fry, J.R.2
  • 81
    • 33646777094 scopus 로고    scopus 로고
    • The nose revisited: A brief review of the comparative structure, function and toxicology pathology of the nose epithelium
    • 2006
    • Harkema JR, Carey SA and Wagner JG, 2006. The nose revisited: A brief review of the comparative structure, function and toxicology pathology of the nose epithelium. Toxicology Pathology 34.252–269, 2006.
    • (2006) Toxicology Pathology , vol.34 , pp. 252-269
    • Harkema, J.R.1    Carey, S.A.2    Wagner, J.G.3
  • 82
    • 0016810415 scopus 로고
    • Metabolism in the rat of some pyrazine derivatives having flavour importance in foods
    • Hawksworth G and Scheline RR, 1975. Metabolism in the rat of some pyrazine derivatives having flavour importance in foods. Xenobiotica 5 (7), 389–399.
    • (1975) Xenobiotica , vol.5 , Issue.7 , pp. 389-399
    • Hawksworth, G.1    Scheline, R.R.2
  • 83
    • 0000747053 scopus 로고
    • Carboxylesterases and amidases
    • Jakoby, W.B., (ed.)., 2nd Ed., Academic Press, New York
    • Heymann E, 1980. Carboxylesterases and amidases. In: Jakoby, W.B. (ed.). Enzymatic basis of detoxication. 2nd Ed. Academic Press, New York, pp. 291–323.
    • (1980) Enzymatic basis of detoxication , pp. 291-323
    • Heymann, E.1
  • 84
    • 25044455216 scopus 로고
    • Cytochrome P-450 and non-P-450 sulphoxidations
    • P
    • Hoodi AA and Damani LA, 1984. Cytochrome P-450 and non-P-450 sulphoxidations. Indian J. Pharm. Pharmacol. 36, 62P.
    • (1984) Indian J. Pharm. Pharmacol , vol.36 , pp. 62
    • Hoodi, A.A.1    Damani, L.A.2
  • 86
    • 0006343081 scopus 로고
    • IOFI, International Organization of the Flavor Industry, 1995
    • IOFI, 1995. European inquiry on volume of use. IOFI, International Organization of the Flavor Industry, 1995.
    • (1995) European inquiry on volume of use
  • 88
    • 0033889614 scopus 로고    scopus 로고
    • 5-Hydroxymethylfurfural: assessment of mutagenicity, DNA-damaging potential and reactivity towards cellular glutathione
    • Janzowski C, Glaab V, Samimi E, Schlatter J and Eisenbrand G, 2000. 5-Hydroxymethylfurfural: assessment of mutagenicity, DNA-damaging potential and reactivity towards cellular glutathione. Food Chem. Toxicol. 38 (9), 801–809.
    • (2000) Food Chem. Toxicol , vol.38 , Issue.9 , pp. 801-809
    • Janzowski, C.1    Glaab, V.2    Samimi, E.3    Schlatter, J.4    Eisenbrand, G.5
  • 89
    • 0003391968 scopus 로고    scopus 로고
    • Forty-fourth Meeting of the Joint FAO/WHO Expert Committee on Food Additives. 14–23 February 1995. WHO Technical Report Series, 859. Geneva
    • JECFA, 1995. Evaluation of certain food additives and contaminants. Forty-fourth Meeting of the Joint FAO/WHO Expert Committee on Food Additives. 14–23 February 1995. WHO Technical Report Series, no. 859. Geneva.
    • (1995) Evaluation of certain food additives and contaminants
  • 90
    • 0003391974 scopus 로고    scopus 로고
    • The forty-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives and contaminants. WHO Food Additives Series 35. IPCS, WHO, Geneva
    • JECFA, 1996a. Toxicological evaluation of certain food additives. The forty-fourth meeting of the Joint FAO/WHO Expert Committee on Food Additives and contaminants. WHO Food Additives Series: 35. IPCS, WHO, Geneva.
    • (1996) Toxicological evaluation of certain food additives
  • 91
    • 84937759317 scopus 로고    scopus 로고
    • Forty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives. Geneva, 6–15 February 1996. WHO Technical Report Series, 868. Geneva
    • JECFA, 1997a. Evaluation of certain food additives and contaminants. Forty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives. Geneva, 6–15 February 1996. WHO Technical Report Series, no. 868. Geneva.
    • (1997) Evaluation of certain food additives and contaminants
  • 92
    • 0003391968 scopus 로고    scopus 로고
    • Forty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives. Rome, 17–26 June 1997. WHO Technical Report Series, 884. Geneva
    • JECFA, 1999b. Evaluation of certain food additives and contaminants. Forty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives. Rome, 17–26 June 1997. WHO Technical Report Series, no. 884. Geneva.
    • (1999) Evaluation of certain food additives and contaminants
  • 93
    • 0003892297 scopus 로고    scopus 로고
    • Joint FAO/WHO Expert Committee of Food Additives. 55, meeting. Geneva, 6–15 June 2000. FAO Food and Nutrition paper 52 Add. 8
    • th meeting. Geneva, 6–15 June 2000. FAO Food and Nutrition paper 52 Add. 8.
    • (2000) Compendium of food additive specifications. Addendum 8
  • 94
    • 0012598758 scopus 로고    scopus 로고
    • Fifty-fifth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, 901. Geneva, 6–15 June 2000
    • JECFA, 2001a. Evaluation of certain food addtives and contaminants. Fifty-fifth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, no. 901. Geneva, 6–15 June 2000.
    • (2001) Evaluation of certain food addtives and contaminants
  • 95
    • 0003794616 scopus 로고    scopus 로고
    • Fifty-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series 46. IPCS, WHO, Geneva
    • JECFA, 2001b. Safety evaluation of certain food additives and contaminants. Fifty-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series: 46. IPCS, WHO, Geneva.
    • (2001) Safety evaluation of certain food additives and contaminants
  • 96
    • 67349135595 scopus 로고    scopus 로고
    • Addendum 9. Joint FAO/WHO Expert Committee of Food Additives 57th session. Rome, 5–14 June 2001. FAO Food and Nutrition paper 52 Add. 9
    • JECFA, 2001c. Compendium of food additive specifications. Addendum 9. Joint FAO/WHO Expert Committee of Food Additives 57th session. Rome, 5–14 June 2001. FAO Food and Nutrition paper 52 Add. 9.
    • (2001) Compendium of food additive specifications
  • 97
    • 0003391968 scopus 로고    scopus 로고
    • Fifty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, 913. Geneva, 4–13 June 2002
    • JECFA, 2002c. Evaluation of certain food additives. Fifty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, no. 913. Geneva, 4–13 June 2002.
    • (2002) Evaluation of certain food additives
  • 98
    • 85070229015 scopus 로고    scopus 로고
    • Addendum 10. Joint FAO/WHO Expert Committee of Food Additives 59, session. Geneva, 4–13 June 2002. FAO Food and Nutrition paper 52 Add. 10
    • th session. Geneva, 4–13 June 2002. FAO Food and Nutrition paper 52 Add. 10.
    • (2002) Compendium of food additive specifications
  • 99
    • 0003794616 scopus 로고    scopus 로고
    • Fifty-ninth meeting of the Joint FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series 50. IPCS, WHO, Geneva
    • JECFA, 2003a. Safety evaluation of certain food additives. Fifty-ninth meeting of the Joint FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series: 50. IPCS, WHO, Geneva.
    • (2003) Safety evaluation of certain food additives
  • 100
    • 0003391968 scopus 로고    scopus 로고
    • Sixty-fifth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, 934. Geneva, 7–16 June 2005
    • JECFA, 2006b. Evaluation of certain food additives. Sixty-fifth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, no. 934. Geneva, 7–16 June 2005.
    • (2006) Evaluation of certain food additives
  • 101
    • 0003391968 scopus 로고    scopus 로고
    • Sixty-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series 56. IPCS, WHO, Geneva
    • JECFA, 2006d. Safety evaluation of certain food additives and contaminants. Sixty-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series: 56. IPCS, WHO, Geneva.
    • (2006) Safety evaluation of certain food additives and contaminants
  • 102
    • 27144439707 scopus 로고    scopus 로고
    • Sixty-ninth meeting of the Joint FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series 60. IPCS, WHO, Geneva 2009, (May 2009)
    • JECFA, 2009a. Safety evaluation of certain food additives and contaminants. Sixty-ninth meeting of the Joint FAO/WHO Expert Committee on Food Additives, WHO Food Additives Series: 60. IPCS, WHO, Geneva 2009 whqlibdoc.who.int/publications/2009/9789241660600_eng.pdf (May 2009)
    • (2009) Safety evaluation of certain food additives and contaminants
  • 103
    • 0012598758 scopus 로고    scopus 로고
    • Sixty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, 952. Rome, 17–26 June 2008., (May 2009)
    • JECFA, 2009c. Evaluation of certain food additives. Sixty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives. WHO Technical Report Series, no. 952. Rome, 17–26 June 2008. whqlibdoc.who.int/trs/WHO_TRS_952_eng.pdf (May 2009)
    • (2009) Evaluation of certain food additives
  • 104
    • 0015862157 scopus 로고
    • The presence of furen derivates in patients receiving fructose-containing solutions intravenously
    • Jellum E, Borresen HC and Eldjarn L, 1973. The presence of furen derivates in patients receiving fructose-containing solutions intravenously. Clin. Chim. Acta 47, 191–201.
    • (1973) Clin. Chim. Acta , vol.47 , pp. 191-201
    • Jellum, E.1    Borresen, H.C.2    Eldjarn, L.3
  • 105
    • 85078371604 scopus 로고
    • Cz. I. Isolacja i identyfikacja 5-methylofuroiloglicyny. Bromatologiai Chemia Toksykologiczna XVIII, 219-223. (In Polish)
    • Jodynis-Liebert J, 1985. Badania metaboliszmu 5-methylfurfuralu u szczura. Cz. I. Isolacja i identyfikacja 5-methylofuroiloglicyny. Bromatologiai Chemia Toksykologiczna XVIII, 219-223. (In Polish)
    • (1985) Badania metaboliszmu 5-methylfurfuralu u szczura
    • Jodynis-Liebert, J.1
  • 106
    • 0023773116 scopus 로고
    • Metabolism of 5-methyl-2-furaldehyde in rat. III. Identification and determination of 5-methyl-2-furylmethylketone
    • Jodynis-Liebert J, 1988. Metabolism of 5-methyl-2-furaldehyde in rat. III. Identification and determination of 5-methyl-2-furylmethylketone. Xenobiotica 18 (8), 887–892.
    • (1988) Xenobiotica , vol.18 , Issue.8 , pp. 887-892
    • Jodynis-Liebert, J.1
  • 107
    • 85078392978 scopus 로고    scopus 로고
    • Sub-chronic (13-week) oral toxicity study in rats with micro-encapsulated furfural
    • Report V99.520. May, 1999
    • Jonker D, 2000b. Sub-chronic (13-week) oral toxicity study in rats with micro-encapsulated furfural. Report V99.520. May, 1999. TNO, Zeist, The Netherlands.
    • (2000) TNO, Zeist, The Netherlands
    • Jonker, D.1
  • 108
    • 0030596896 scopus 로고    scopus 로고
    • A comprehensive protocol for conducting the Syrian hamster embryo cell transformation assay at pH 6.70
    • Kerckaert GA, Isfort RJ, Carr GJ, Aardema MJ and LeBoeuf RA, 1996. A comprehensive protocol for conducting the Syrian hamster embryo cell transformation assay at pH 6.70. Mutat. Res. 356, 64–84.
    • (1996) Mutat. Res , vol.356 , pp. 64-84
    • Kerckaert, G.A.1    Isfort, R.J.2    Carr, G.J.3    Aardema, M.J.4    LeBoeuf, R.A.5
  • 109
    • 0023118576 scopus 로고
    • Desmutagenic effect of alpha-dicarbonyl and alpha-hydroxycarbonyl compounds against mutagenic heterocyclic amines
    • Kim SB, Hayase F and Kato H, 1987b. Desmutagenic effect of alpha-dicarbonyl and alpha-hydroxycarbonyl compounds against mutagenic heterocyclic amines. Mutat. Res. 177, 9–15.
    • (1987) Mutat. Res , vol.177 , pp. 9-15
    • Kim, S.B.1    Hayase, F.2    Kato, H.3
  • 110
    • 0018237603 scopus 로고
    • Relationship between biological activities and enzymatic reduction of nitrofuran derivatives
    • Kitamura S, Koga H, Tatsumi K, Yoshimura H and Horiuchi T, 1978. Relationship between biological activities and enzymatic reduction of nitrofuran derivatives. J. Pharm. Dyn. 1, 15–21.
    • (1978) J. Pharm. Dyn , vol.1 , pp. 15-21
    • Kitamura, S.1    Koga, H.2    Tatsumi, K.3    Yoshimura, H.4    Horiuchi, T.5
  • 111
    • 0025123209 scopus 로고
    • Xanthine dehydrogenase and 2-furoyl-coenzyme A dehydrogenase from Pseudomonas putida Fu1; two molybenum-containing dehydrogenases of novel structural composition
    • Koenig K and Andreesen JR, 1990. Xanthine dehydrogenase and 2-furoyl-coenzyme A dehydrogenase from Pseudomonas putida Fu1; two molybenum-containing dehydrogenases of novel structural composition. J. Bacteriol. 172, 5999–6009.
    • (1990) J. Bacteriol , vol.172 , pp. 5999-6009
    • Koenig, K.1    Andreesen, J.R.2
  • 112
    • 0035011866 scopus 로고    scopus 로고
    • In vitro prediction of carcinogenicity using a bovine papillomavirus DNA-carrying C3H/10T1/2 cell line (T1). II: Results from the testing of 100 chemicals
    • Kowalski LA, Assi KP, Wee RK-H and Madden Z, 2001. In vitro prediction of carcinogenicity using a bovine papillomavirus DNA-carrying C3H/10T1/2 cell line (T1). II: Results from the testing of 100 chemicals. Environ. Mol. Mutag. 37 (3), 231–240.
    • (2001) Environ. Mol. Mutag , vol.37 , Issue.3 , pp. 231-240
    • Kowalski, L.A.1    Assi, K.P.2    Wee, R.K.-H.3    Madden, Z.4
  • 113
    • 0026520072 scopus 로고
    • Inhibitory effects of 2-n-heptylfuran and 2-n-butylthiophene on benzo[a]pyrene-induced lung and forestomach tumorigenesis in A/J mice
    • Lam L and Zheng B, 1992. Inhibitory effects of 2-n-heptylfuran and 2-n-butylthiophene on benzo[a]pyrene-induced lung and forestomach tumorigenesis in A/J mice. Nutr. Cancer 17 (1), 19–26.
    • (1992) Nutr. Cancer , vol.17 , Issue.1 , pp. 19-26
    • Lam, L.1    Zheng, B.2
  • 114
    • 0014911585 scopus 로고
    • Tolerance of 5-hydroxymethylfurfural (HMF). 1. Chronic administration of HMF and metabolites of the substance
    • (In German)
    • Lang K, Kieckebusch W, Bässler KH, Griem W and Czok G, 1970. [Tolerance of 5-hydroxymethylfurfural (HMF). 1. Chronic administration of HMF and metabolites of the substance]. Z. Ernährungswissenschaft 10 (2), 97–101. (In German)
    • (1970) Z. Ernährungswissenschaft , vol.10 , Issue.2 , pp. 97-101
    • Lang, K.1    Kieckebusch, W.2    Bässler, K.H.3    Griem, W.4    Czok, G.5
  • 115
    • 0028002187 scopus 로고
    • Genotoxicity of 1,3-dithiane and 1,4-dithiane in the CHO/SCE assay and the Salmonella/microsomal test
    • Lee H, Bian SS and Chen YL, 1994a. Genotoxicity of 1,3-dithiane and 1,4-dithiane in the CHO/SCE assay and the Salmonella/microsomal test. Mutat. Res. 321, 213–218.
    • (1994) Mutat. Res , vol.321 , pp. 213-218
    • Lee, H.1    Bian, S.S.2    Chen, Y.L.3
  • 116
    • 0029049978 scopus 로고
    • Bioactivation of 5-hydroxylmethyl-2-furaldehyde to an electrophilic and mutagenic allylic sulfuric acid ester
    • Lee, Y.C., Shlyankevich, M., Jeong, H.K., Douglas, J.S., Surh, Y.J., 1995b. Bioactivation of 5-hydroxylmethyl-2-furaldehyde to an electrophilic and mutagenic allylic sulfuric acid ester. Biochem. Biophys. Res. Commun. 209 (3), 996–1002.
    • (1995) Biochem. Biophys. Res. Commun , vol.209 , Issue.3 , pp. 996-1002
    • Lee, Y.C.1    Shlyankevich, M.2    Jeong, H.K.3    Douglas, J.S.4    Surh, Y.J.5
  • 117
    • 0019379114 scopus 로고
    • Studies on the mutagenic constituents of apple brandy and various alcoholic beverages collected in western France, a high incidence area for oesophageal cancer
    • Loquet C, Toussaint G and LeTalaer JY, 1981. Studies on the mutagenic constituents of apple brandy and various alcoholic beverages collected in western France, a high incidence area for oesophageal cancer. Mutat. Res. 88, 155–164.
    • (1981) Mutat. Res , vol.88 , pp. 155-164
    • Loquet, C.1    Toussaint, G.2    LeTalaer, J.Y.3
  • 118
    • 0024508017 scopus 로고
    • Determination and metabolism of dithiol chelating agents VI. Isolation and identification of the mixed disulfides of meso-2, 3-dimercaptosuccinic acid with L-cysteine in human urine
    • Maiorino RM, Bruce DC and Aposhian HV, 1989. Determination and metabolism of dithiol chelating agents VI. Isolation and identification of the mixed disulfides of meso-2, 3-dimercaptosuccinic acid with L-cysteine in human urine. Toxicol. Appl. Pharmacol. 97, 338–349.
    • (1989) Toxicol. Appl. Pharmacol , vol.97 , pp. 338-349
    • Maiorino, R.M.1    Bruce, D.C.2    Aposhian, H.V.3
  • 119
    • 0026532372 scopus 로고
    • Effects of plate preparation on results in microbial mutation assays
    • Majeska JB and McGregor DB, 1992. Effects of plate preparation on results in microbial mutation assays. Environ. Molec. Mutagen. 19 (3), 244–252.
    • (1992) Environ. Molec. Mutagen , vol.19 , Issue.3 , pp. 244-252
    • Majeska, J.B.1    McGregor, D.B.2
  • 121
    • 0024906048 scopus 로고
    • The Bacillus Subtilis/Microsome rec-assay for the detection of DNA damaging substances which may occur in chlorinated and ozonated waters
    • Matsui S, Yamamoto R and Yamada H, 1989. The Bacillus Subtilis/Microsome rec-assay for the detection of DNA damaging substances which may occur in chlorinated and ozonated waters. Water Sci. Technol. 21, 875–887.
    • (1989) Water Sci. Technol , vol.21 , pp. 875-887
    • Matsui, S.1    Yamamoto, R.2    Yamada, H.3
  • 122
    • 0014578421 scopus 로고
    • S-methylation, oxidation, hydroxylation, and conjugation of thiophenol in the rat
    • McBain JB and Menn JJ, 1969. S-methylation, oxidation, hydroxylation, and conjugation of thiophenol in the rat. Biochem. Pharmacol. 18 (9), 2282–2285.
    • (1969) Biochem. Pharmacol , vol.18 , Issue.9 , pp. 2282-2285
    • McBain, J.B.1    Menn, J.J.2
  • 125
    • 0018756732 scopus 로고
    • Assay of 855 test chemicals in ten tester strains using a new modification of the ames test for bacterial mutagens
    • McMahon RE, Cline JC and Thompson CZ, 1979. Assay of 855 test chemicals in ten tester strains using a new modification of the ames test for bacterial mutagens. Cancer Res. 39, 682–693.
    • (1979) Cancer Res , vol.39 , pp. 682-693
    • McMahon, R.E.1    Cline, J.C.2    Thompson, C.Z.3
  • 126
    • 0017751555 scopus 로고
    • Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine
    • McMurtry RJ and Mitchell JR, 1977. Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine. Toxicol. Appl. Pharmacol. 42, 285–300.
    • (1977) Toxicol. Appl. Pharmacol , vol.42 , pp. 285-300
    • McMurtry, R.J.1    Mitchell, J.R.2
  • 127
    • 67349201797 scopus 로고    scopus 로고
    • Conversion of the common food constituent 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo
    • Monien BH, Frank H, Seidel A and Glatt H, 2009. Conversion of the common food constituent 5-hydroxymethylfurfural into a mutagenic and carcinogenic sulfuric acid ester in the mouse in vivo. Chem. Res. Toxicol. 22, 1123–1128.
    • (2009) Chem. Res. Toxicol , vol.22 , pp. 1123-1128
    • Monien, B.H.1    Frank, H.2    Seidel, A.3    Glatt, H.4
  • 128
    • 0019171249 scopus 로고
    • Acute oral toxicity of selected flavor chemicals
    • Moran EJ, Easterday DD and Oser BL, 1980. Acute oral toxicity of selected flavor chemicals. Drug Chem. Toxicol. 3 (3), 249–258.
    • (1980) Drug Chem. Toxicol , vol.3 , Issue.3 , pp. 249-258
    • Moran, E.J.1    Easterday, D.D.2    Oser, B.L.3
  • 129
    • 85078388156 scopus 로고
    • MB Research Laboratories. Project MB 77-2207. February 9, 1978. Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Moreno OM, 1978g. Acute oral toxicity of 5-methyl furfural in rats. MB Research Laboratories. Project no. MB 77-2207. February 9, 1978. Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1978) Acute oral toxicity of 5-methyl furfural in rats
    • Moreno, O.M.1
  • 130
    • 0003965104 scopus 로고
    • 90-Day feeding studies in rats with bis-(2-methyl-3-furyl)disulfide (31001)
    • Food and Drug Research Laboratories, Inc. Lab. 0028. August 24, 1970
    • Morgareidge K and Oser BL, 1970e. 90-Day feeding studies in rats with bis-(2-methyl-3-furyl)disulfide (31001). Food and Drug Research Laboratories, Inc. Lab. no. 0028. August 24, 1970. Report submitted by EFFA to FLAVIS Secretariat.
    • (1970) Report submitted by EFFA to FLAVIS Secretariat
    • Morgareidge, K.1    Oser, B.L.2
  • 131
    • 0003965104 scopus 로고
    • 90-Day feeding studies in rats with bis-(2-methyl-3-furyl)tetrasulfide (31058)
    • Food and Drug Research Laboratories, Inc. Lab. 0031. August 24, 1970
    • Morgareidge K and Oser BL, 1970f. 90-Day feeding studies in rats with bis-(2-methyl-3-furyl)tetrasulfide (31058). Food and Drug Research Laboratories, Inc. Lab. no. 0031. August 24, 1970. Report submitted by EFFA to FLAVIS Secretariat.
    • (1970) Report submitted by EFFA to FLAVIS Secretariat
    • Morgareidge, K.1    Oser, B.L.2
  • 132
    • 85078384914 scopus 로고
    • 90-Day feeding study in rats with compound 15124 (2,5-dimethyl-3-thioisovalerylfuran)
    • Food and Drug Research Laboratories, Inc. Lab. 2107g. December 30, 1974
    • Morgareidge K, Cox, GE and Bailey DE, 1974a. 90-Day feeding study in rats with compound 15124 (2,5-dimethyl-3-thioisovalerylfuran). Food and Drug Research Laboratories, Inc. Lab. no. 2107g. December 30, 1974. Report submitted by EFFA to FLAVIS Secretariat.
    • (1974) Report submitted by EFFA to FLAVIS Secretariat
    • Morgareidge, K.1    Cox, G.E.2    Bailey, D.E.3
  • 133
    • 85078373194 scopus 로고
    • 90-Day feeding study in rats with 2,5-dimethyl-3-thiofuroylfuran
    • Food and Drug Research Laboratories, Inc. Lab. 2107h. December 30, 1974
    • Morgareidge K, Cox, G.E., Bailey, D.E., 1974b. 90-Day feeding study in rats with 2,5-dimethyl-3-thiofuroylfuran. Food and Drug Research Laboratories, Inc. Lab. no. 2107h. December 30, 1974. Report submitted by EFFA to FLAVIS Secretariat.
    • (1974) Report submitted by EFFA to FLAVIS Secretariat
    • Morgareidge, K.1    Cox, G.E.2    Bailey, D.E.3
  • 135
  • 136
    • 85078367616 scopus 로고
    • Biological evaluation of dusmelline and DUS-5. Part 1. Palatability study in rats. Unilever Research Colworth/Welwyn. NCW 1387
    • Project CW 22390. July 11, 1972
    • Munday R and Gellatly JB, 1972. Biological evaluation of dusmelline and DUS-5. Part 1. Palatability study in rats. Unilever Research Colworth/Welwyn. NCW 1387. Project CW 22390. July 11, 1972. Report submitted by EFFA to FLAVIS Secretariat.
    • (1972) Report submitted by EFFA to FLAVIS Secretariat
    • Munday, R.1    Gellatly, J.B.2
  • 137
    • 85078396565 scopus 로고
    • Biological evaluation of feeding trial with DUS-5. Part 4. 13-week rat
    • Unilever Research Colworth/Welwyn. NCW 73 1159. Project CW 22390. July 11, 1972
    • Munday R and Gellatly JB, 1973a. Biological evaluation of feeding trial with DUS-5. Part 4. 13-week rat. Unilever Research Colworth/Welwyn. NCW 73 1159. Project CW 22390. July 11, 1972. Report submitted by EFFA to FLAVIS Secretariat.
    • (1973) Report submitted by EFFA to FLAVIS Secretariat
    • Munday, R.1    Gellatly, J.B.2
  • 138
    • 85078370162 scopus 로고
    • Biological evaluation of DUS-5. Part 5. Reversibility of toxic effects induced by the feeding of DUS-5
    • Unilever Research Colworth/Welwyn, NCW 73 1299. Project CW 22390. July 7, 1973
    • Munday R and Gellatly JB, 1973b. Biological evaluation of DUS-5. Part 5. Reversibility of toxic effects induced by the feeding of DUS-5. Unilever Research Colworth/Welwyn. NCW 73 1299. Project CW 22390. July 7, 1973. Report submitted by EFFA to SCF.
    • (1973) Report submitted by EFFA to SCF
    • Munday, R.1    Gellatly, J.B.2
  • 139
    • 85078389725 scopus 로고
    • Private communication to FEMA. Unilever Research Colworth/Welwyn. NCW 74 1104. Project CW 22390. February 7, 1974. Report submitted by EFFA to FLAVIS Secretariat
    • Munday R and Gellatly JB, 1974. Biological evaluation of DUS-5. Part 7. 1-year test with DUS-5 in rats. Private communication to FEMA. Unilever Research Colworth/Welwyn. NCW 74 1104. Project CW 22390. February 7, 1974. Report submitted by EFFA to FLAVIS Secretariat.
    • (1974) Biological evaluation of DUS-5. Part 7. 1-year test with DUS-5 in rats
    • Munday, R.1    Gellatly, J.B.2
  • 140
    • 0344131406 scopus 로고    scopus 로고
    • Meiotic nondisjunction induced by furfural in Drosophila melanogaster females
    • Muñoz ER and Barnett MB, 1999. Meiotic nondisjunction induced by furfural in Drosophila melanogaster females. Environ. Molec. Mutagen. 34 (1), 61–63.
    • (1999) Environ. Molec. Mutagen , vol.34 , Issue.1 , pp. 61-63
    • Muñoz, E.R.1    Barnett, M.B.2
  • 141
    • 0023472186 scopus 로고
    • SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals
    • Nakamura SI, Oda Y, Shimada T, Oki I and Sugimoto K, 1987. SOS-inducing activity of chemical carcinogens and mutagens in Salmonella typhimurium TA1535/pSK1002: examination with 151 chemicals. Mutat. Res. 192, 239–246.
    • (1987) Mutat. Res , vol.192 , pp. 239-246
    • Nakamura, S.I.1    Oda, Y.2    Shimada, T.3    Oki, I.4    Sugimoto, K.5
  • 144
    • 0028329532 scopus 로고
    • Fate of dipropyl sulphide and dipropyl sulphoxide in rat
    • Nickson RM and Mitchell SC, 1994. Fate of dipropyl sulphide and dipropyl sulphoxide in rat. Xenobiotica 24 (2), 157–168.
    • (1994) Xenobiotica , vol.24 , Issue.2 , pp. 157-168
    • Nickson, R.M.1    Mitchell, S.C.2
  • 145
  • 146
    • 0024456345 scopus 로고
    • Chromosome aberrations induced by pyrolysates of carbohydrates in Chinese hamster V79 cells
    • Nishi Y, Miyakawa Y and Kato K, 1989. Chromosome aberrations induced by pyrolysates of carbohydrates in Chinese hamster V79 cells. Mutat. Res. 227, 117–123.
    • (1989) Mutat. Res , vol.227 , pp. 117-123
    • Nishi, Y.1    Miyakawa, Y.2    Kato, K.3
  • 147
    • 0006381107 scopus 로고
    • The involvement of rat liver CYP2B1 and CYP2D1 in the microsomal sulphoxidation of 4-chlorophenyl methyl sulphide
    • Nnane P and Damani LA, 1995. The involvement of rat liver CYP2B1 and CYP2D1 in the microsomal sulphoxidation of 4-chlorophenyl methyl sulphide. ISSX Proceedings 8, 110.
    • (1995) ISSX Proceedings , vol.8 , pp. 110
    • Nnane, P.1    Damani, L.A.2
  • 148
    • 0026522110 scopus 로고
    • Comparative metabolism and disposition of furfural and furfuryl alcohol in rats
    • Nomeir AA, Silvena DM, McComish MF and Chadwick M, 1992. Comparative metabolism and disposition of furfural and furfuryl alcohol in rats. Drug Metab. Disposition 20 (2), 198–204.
    • (1992) Drug Metab. Disposition , vol.20 , Issue.2 , pp. 198-204
    • Nomeir, A.A.1    Silvena, D.M.2    McComish, M.F.3    Chadwick, M.4
  • 149
    • 85078392402 scopus 로고
    • NTP technical report on the toxicology and carcinogenesis studies of furfural (CAS 98–01-1) in F344/N rats and B6C3F1 mice (gavage studies). March 1990. NTP-TR 382. NIH Publication 90-2837
    • NTP, 1990a. NTP technical report on the toxicology and carcinogenesis studies of furfural (CAS no. 98–01-1) in F344/N rats and B6C3F1 mice (gavage studies). March 1990. NTP-TR 382. NIH Publication no. 90-2837.
    • (1990)
  • 150
    • 85078388066 scopus 로고    scopus 로고
    • Toxicology and carcinogenesis studies of furfuryl alcohol (CAS 98–00-0) in F344/N rats and B6C3F1 mice (inhalation studies). February 1999. NTP-TR 482. NIH Publication 99-3972. NC
    • NTP, 1999a. Toxicology and carcinogenesis studies of furfuryl alcohol (CAS no. 98–00-0) in F344/N rats and B6C3F1 mice (inhalation studies). February 1999. NTP-TR 482. NIH Publication no. 99-3972. NC.
    • (1999)
  • 151
    • 84856580692 scopus 로고    scopus 로고
    • Toxicology and carcinogenesis studies of 5-(hydroxymethyl)-2-furfural (CAS 67–47-0) in F344/N rats and B6C3F1 mice (gavage studies). National Toxicology Program, Research Triangle, NC, USA. TR-554. NIH Publication 10-5895. [Online]
    • NTP, 2010c. National Toxicology Program. Toxicology and carcinogenesis studies of 5-(hydroxymethyl)-2-furfural (CAS No. 67–47-0) in F344/N rats and B6C3F1 mice (gavage studies). National Toxicology Program, Research Triangle, NC, USA. TR-554. NIH Publication No. 10-5895. [Online] ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/TR554.pdf
    • (2010) National Toxicology Program
  • 152
    • 0028171299 scopus 로고
    • Metabolism of trans-cinnamic acid in the rat and the mouse and its variation with dose
    • Nutley BP, Farmer P and Caldwell J, 1994. Metabolism of trans-cinnamic acid in the rat and the mouse and its variation with dose. Food Chem. Toxicol. 32 (10), 877–886.
    • (1994) Food Chem. Toxicol , vol.32 , Issue.10 , pp. 877-886
    • Nutley, B.P.1    Farmer, P.2    Caldwell, J.3
  • 153
    • 0022260385 scopus 로고
    • Participation of active oxygen species in the induction of chromosomal aberrations by cadmium chloride in cultured Chinese hamster cells
    • Ochi T and Ohsawa M, 1985. Participation of active oxygen species in the induction of chromosomal aberrations by cadmium chloride in cultured Chinese hamster cells. Mutat. Res. 143, 137–142.
    • (1985) Mutat. Res , vol.143 , pp. 137-142
    • Ochi, T.1    Ohsawa, M.2
  • 154
    • 0001034126 scopus 로고
    • Formation of mutagens by the maillard reaction
    • Waller, G.R., Feather, M.S., (eds.)., ACS Symposium Series, 215., American Chemical Society, Washington D.C
    • Omura H, Jahan N, Shinohara K and Murakami H, 1983. Formation of mutagens by the maillard reaction. In: Waller, G.R., Feather, M.S. (eds.). The Maillard Reaction in Foods and Nutrition. ACS Symposium Series, 215. American Chemical Society, Washington D.C., pp. 537–563.
    • (1983) The Maillard Reaction in Foods and Nutrition , pp. 537-563
    • Omura, H.1    Jahan, N.2    Shinohara, K.3    Murakami, H.4
  • 155
    • 0001633736 scopus 로고
    • Mutagen formation in the reaction of nitrite with the food components analogous to sorbic acid
    • Osawa T and Namiki M, 1982. Mutagen formation in the reaction of nitrite with the food components analogous to sorbic acid. Agric. Biol. Chem. 45, 2299–2304.
    • (1982) Agric. Biol. Chem , vol.45 , pp. 2299-2304
    • Osawa, T.1    Namiki, M.2
  • 156
    • 85078394001 scopus 로고
    • Food and Drug Research Laboratories, Inc., Lab. 906. August 4, 1969. Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Oser BL, 1969a. Approximate acute oral LD50 in mice. 2-Methyl-3-furanthiol. Food and Drug Research Laboratories, Inc. Lab. no. 906. August 4, 1969. Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1969) Approximate acute oral LD50 in mice. 2-Methyl-3-furanthiol
    • Oser, B.L.1
  • 157
    • 85078379388 scopus 로고
    • Food and Drug Research Laboratories, Inc. Lab. 90606a. August 4, 1969. Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Oser BL, 1969b. The acute oral toxicity (LD50) to mice of bis-(2-methyl-3-furyl) disulfide. Food and Drug Research Laboratories, Inc. Lab. no. 90606a. August 4, 1969. Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1969) The acute oral toxicity (LD50) to mice of bis-(2-methyl-3-furyl) disulfide
    • Oser, B.L.1
  • 158
    • 0003965104 scopus 로고
    • Food and Drug Research Laboratories, Inc. Lab. 90616. January 22, 1970. Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Oser BL, 1970a. 90-Day feeding studies with bis-(2-methyl-3-furyl) disulfide in rats. Food and Drug Research Laboratories, Inc. Lab. no. 90616. January 22, 1970. Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1970) 90-Day feeding studies with bis-(2-methyl-3-furyl) disulfide in rats
    • Oser, B.L.1
  • 159
    • 0003965104 scopus 로고
    • Food and Drug Research Laboratories, Inc. Lab. 90615. January 22, 1970. Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Oser BL, 1970b. 90-Day feeding studies with 2-methyl-3-furanthiol in rats. Food and Drug Research Laboratories, Inc. Lab. no. 90615. January 22, 1970. Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1970) 90-Day feeding studies with 2-methyl-3-furanthiol in rats
    • Oser, B.L.1
  • 160
    • 85078384629 scopus 로고
    • Food and Drug Research Laboratories, Inc. Lab. 91115-91124. April 13, 1970. Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Oser BL, 1970c. The acute oral toxicity to mice of ten compounds. Food and Drug Research Laboratories, Inc. Lab. no. 91115-91124. April 13, 1970. Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1970) The acute oral toxicity to mice of ten compounds
    • Oser, B.L.1
  • 161
    • 0028171298 scopus 로고
    • Metabolism and excretion of [14C]-furfural in the rat and the mouse
    • Parkash MK and Caldwell J, 1994. Metabolism and excretion of [14C]-furfural in the rat and the mouse. Food Chem. Toxicol. 32 (10), 887–895.
    • (1994) Food Chem. Toxicol , vol.32 , Issue.10 , pp. 887-895
    • Parkash, M.K.1    Caldwell, J.2
  • 163
    • 0015408508 scopus 로고
    • The identification and metabolic origin of 2-furoylglycine and 2,5-furandicarboxylic acid in human urine
    • Pettersen JE and Jellum E, 1972. The identification and metabolic origin of 2-furoylglycine and 2,5-furandicarboxylic acid in human urine. Clin. Chim. Acta 41, 199–207.
    • (1972) Clin. Chim. Acta , vol.41 , pp. 199-207
    • Pettersen, J.E.1    Jellum, E.2
  • 164
    • 85078369336 scopus 로고
    • Toxicity and local anesthetic activity of alkyl esters of 2-furoic acid
    • Phatak NM and Emerson GA, 1936. Toxicity and local anesthetic activity of alkyl esters of 2-furoic acid. J. Pharmacol. Exp. Ther. 58, 405–407.
    • (1936) J. Pharmacol. Exp. Ther , vol.58 , pp. 405-407
    • Phatak, N.M.1    Emerson, G.A.2
  • 169
    • 0022298754 scopus 로고
    • Metabolic activation of 2-methylfuran by rat microsomal systems
    • Ravindranath V and Boyd MR, 1985. Metabolic activation of 2-methylfuran by rat microsomal systems. Toxicol. Appl. Pharmacol. 78, 370–376.
    • (1985) Toxicol. Appl. Pharmacol , vol.78 , pp. 370-376
    • Ravindranath, V.1    Boyd, M.R.2
  • 170
    • 0026061646 scopus 로고
    • Effect of modulators of glutathione synthesis on the hepatotoxicity of 2-methylfuran
    • Ravindranath V and Boyd MR, 1991. Effect of modulators of glutathione synthesis on the hepatotoxicity of 2-methylfuran. Biochem. Pharmacol. 41 (9), 1311–1318.
    • (1991) Biochem. Pharmacol , vol.41 , Issue.9 , pp. 1311-1318
    • Ravindranath, V.1    Boyd, M.R.2
  • 171
    • 84914340098 scopus 로고
    • Isolation and characterization of the reactive metabolites of 2-methylfuran (2-MF) and 3-methylfuran (3-MF)
    • Ravindranath V, Burka LT and Boyd MR, 1984. Isolation and characterization of the reactive metabolites of 2-methylfuran (2-MF) and 3-methylfuran (3-MF). Pharmacologist 25, 171.
    • (1984) Pharmacologist , vol.25 , pp. 171
    • Ravindranath, V.1    Burka, L.T.2    Boyd, M.R.3
  • 172
    • 0021235725 scopus 로고
    • Reactive metabolites from the bioactivation of toxic methylfurans
    • Ravindranath V, Burka LT and Boyd MR, 1984. Reactive metabolites from the bioactivation of toxic methylfurans. Science 224, 884–886.
    • (1984) Science , vol.224 , pp. 884-886
    • Ravindranath, V.1    Burka, L.T.2    Boyd, M.R.3
  • 175
    • 0026087565 scopus 로고
    • Metabolism in the rat of a model xenobiotic plant metabolite S-benzyl-N-malonyl-L-cysteine
    • Richardson KA, Edward VT, Jones BC and Hutson, D.H., 1991. Metabolism in the rat of a model xenobiotic plant metabolite S-benzyl-N-malonyl-L-cysteine. Xenobiotica 21 (3), 371–382.
    • (1991) Xenobiotica , vol.21 , Issue.3 , pp. 371-382
    • Richardson, K.A.1    Edward, V.T.2    Jones, B.C.3    Hutson, D.H.4
  • 176
    • 0024395595 scopus 로고
    • Evidence for the absence of mutagenic activity of furfuryl alcohol in tests of germ cells in Drosophila melanogaster
    • Rodriquez-Arnaiz R, Morales PR, Moctezuma RV and Salas RMB. 1989. Evidence for the absence of mutagenic activity of furfuryl alcohol in tests of germ cells in Drosophila melanogaster. Mutat. Res. 223, 309–311.
    • (1989) Mutat. Res , vol.223 , pp. 309-311
    • Rodriquez-Arnaiz, R.1    Morales, P.R.2    Moctezuma, R.V.3    Salas, R.M.B.4
  • 177
    • 85078377512 scopus 로고
    • Evaluation in Drosophila melanogaster of the mutagenic potential of furfual in the mei-9(a) test for chromosome loss in germ-line cells
    • Rodriquez-Arnaiz R., Morales PR and Zimmering S, 1992. Evaluation in Drosophila melanogaster of the mutagenic potential of furfual in the mei-9(a) test for chromosome loss in germ-line cells. Mutat. Res. 280, 75–80.
    • (1992) Mutat. Res , vol.280 , pp. 75-80
    • Rodriquez-Arnaiz, R.1    Morales, P.R.2    Zimmering, S.3
  • 180
    • 85078374900 scopus 로고
    • First annual report on chemically defined flavouring substances. May 1995, 2nd draft prepared by the SCF Working Group on Flavouring Substances (Submitted by the SCF Secretariat, 17 May 1995). CS/FLAV/FL/140-Rev2. Annex 6 to Document III/5611/95, European Commission, Directorate-General III, Industry
    • SCF, 1995. Scientific Committee for Food. First annual report on chemically defined flavouring substances. May 1995, 2nd draft prepared by the SCF Working Group on Flavouring Substances (Submitted by the SCF Secretariat, 17 May 1995). CS/FLAV/FL/140-Rev2. Annex 6 to Document III/5611/95, European Commission, Directorate-General III, Industry.
    • (1995) Scientific Committee for Food
  • 181
    • 0344125595 scopus 로고    scopus 로고
    • Scientific Committee on Food, SCF/CS/FLAV/TASK/11 Final 6/12/1999. Annex I the minutes of the 119th Plenary meeting. European Commission, Health & Consumer Protection Directorate-General
    • SCF, 1999a. Opinion on a programme for the evaluation of flavouring substances (expressed on 2 December 1999). Scientific Committee on Food. SCF/CS/FLAV/TASK/11 Final 6/12/1999. Annex I the minutes of the 119th Plenary meeting. European Commission, Health & Consumer Protection Directorate-General.
    • (1999) Opinion on a programme for the evaluation of flavouring substances (expressed on 2 December 1999)
  • 182
    • 73749087741 scopus 로고    scopus 로고
    • Genotoxic activities of the food contaminant 5-hydroxymethylfurfural using different in vitro bioassays
    • Severin I, Dumont C, Jondeau-Cabaton A, Graillot V and Chagnon M-C, 2010. Genotoxic activities of the food contaminant 5-hydroxymethylfurfural using different in vitro bioassays. Toxicology Letters 192, 189–194.
    • (2010) Toxicology Letters , vol.192 , pp. 189-194
    • Severin, I.1    Dumont, C.2    Jondeau-Cabaton, A.3    Graillot, V.4    Chagnon, M.-C.5
  • 183
    • 0023835788 scopus 로고
    • Comparative mutagenicity of nine brands of coffee to Salmonella typhimurium TA100, TA102, and TA104
    • Shane BS, Troxclair AM, McMillin DJ and Henry CB, 1988. Comparative mutagenicity of nine brands of coffee to Salmonella typhimurium TA100, TA102, and TA104. Environ. Mol. Mutag. 11, 195–206
    • (1988) Environ. Mol. Mutag , vol.11 , pp. 195-206
    • Shane, B.S.1    Troxclair, A.M.2    McMillin, D.J.3    Henry, C.B.4
  • 184
    • 0005469054 scopus 로고
    • Gulf South Research Institute, GSRI Project NC-403. January 4, 1971. Unpublished report submittec by EFFA to FLAVIS Secretariat
    • Shellenberger TE, 1971e. Subacute toxicity evaluation of 2-pentyl furan with rats. Gulf South Research Institute. GSRI Project NC-403. January 4, 1971. Unpublished report submittec by EFFA to FLAVIS Secretariat.
    • (1971) Subacute toxicity evaluation of 2-pentyl furan with rats
    • Shellenberger, T.E.1
  • 186
    • 0024834316 scopus 로고
    • Positive foci of glutathione S-transferase placental form in the liver of rats given furfural by oral administration
    • Shimizu A, Yoshiyasu N, Harada M, Ono T, Sato K, Inoue T and Kanisawa M, 1989. Positive foci of glutathione S-transferase placental form in the liver of rats given furfural by oral administration. Jap. J. Cancer Res. 80, 608–611.
    • (1989) Jap. J. Cancer Res , vol.80 , pp. 608-611
    • Shimizu, A.1    Yoshiyasu, N.2    Harada, M.3    Ono, T.4    Sato, K.5    Inoue, T.6    Kanisawa, M.7
  • 187
    • 25344467712 scopus 로고
    • Furans as the mutagens formed by amino-carbonyl reactions
    • Fujimaki, M., Namiki, M., Kato, H., (eds.)., Elsevier, New York
    • Shinohara K, Kim E and Omura H, 1986. Furans as the mutagens formed by amino-carbonyl reactions. In: Fujimaki, M., Namiki, M., Kato, H., (eds.). Amino-Carbonyl Reactions in Food and Biological Systems. Elsevier, New York.
    • (1986) Amino-Carbonyl Reactions in Food and Biological Systems
    • Shinohara, K.1    Kim, E.2    Omura, H.3
  • 188
    • 0023073336 scopus 로고
    • Hormones, glutathione status and protein S-thiolation
    • Sies H, Brigelius R and Graf P, 1987. Hormones, glutathione status and protein S-thiolation. Adv. Enzyme Regul. 26, 175–189.
    • (1987) Adv. Enzyme Regul , vol.26 , pp. 175-189
    • Sies, H.1    Brigelius, R.2    Graf, P.3
  • 189
    • 0014441988 scopus 로고
    • [Toxico-hygienic characteristics of hydroxymethylfurfural]
    • (In Russian)
    • Simonyan TA, 1969. [Toxico-hygienic characteristics of hydroxymethylfurfural]. Vopr. Pitan. 28 (1), 54–58. (In Russian)
    • (1969) Vopr. Pitan , vol.28 , Issue.1 , pp. 54-58
    • Simonyan, T.A.1
  • 190
    • 12744272865 scopus 로고    scopus 로고
    • Metabolism of 5-hydroxymethyl-2-furfural (HMF) to the mutagen, 5-sulfoxymethyl-2-furfural (SMF) by individual human sulfotransferases
    • Issue Supplement
    • Sommer Y, Hollnagel H, Schneider H and Glatt HR, 2003. Metabolism of 5-hydroxymethyl-2-furfural (HMF) to the mutagen, 5-sulfoxymethyl-2-furfural (SMF) by individual human sulfotransferases. Naunyn Schmiederberg's Arch. Pharmacol. 367, Issue Supplement 1, R166.
    • (2003) Naunyn Schmiederberg's Arch. Pharmacol , vol.367 , Issue.1 , pp. R166
    • Sommer, Y.1    Hollnagel, H.2    Schneider, H.3    Glatt, H.R.4
  • 192
    • 0033974965 scopus 로고    scopus 로고
    • Responses of transgenic mouse lines p53(+/-) and Tg.AC to agents tested in conventional carcinogenicity bioassays
    • Spalding JW, French JE, Stasiewicz S, Furedi-Machacek M, Conner F, Tice RR and Tennant RW, 2000. Responses of transgenic mouse lines p53(+/-) and Tg.AC to agents tested in conventional carcinogenicity bioassays. Toxicol. Sci. 53 (2), 213–223.
    • (2000) Toxicol. Sci , vol.53 , Issue.2 , pp. 213-223
    • Spalding, J.W.1    French, J.E.2    Stasiewicz, S.3    Furedi-Machacek, M.4    Conner, F.5    Tice, R.R.6    Tennant, R.W.7
  • 193
    • 85078382234 scopus 로고
    • [Toxicity of butyl 2-furancarboxylate and butyl 5-chloromethyl-2-furancarboxylate]
    • (In Russian)
    • Stasenkova KP and Shchirskaya VA, 1967. [Toxicity of butyl 2-furancarboxylate and butyl 5-chloromethyl-2-furancarboxylate]. Vopr. Pitan. 9, 118–126. (In Russian)
    • (1967) Vopr. Pitan , vol.9 , pp. 118-126
    • Stasenkova, K.P.1    Shchirskaya, V.A.2
  • 196
    • 0342954871 scopus 로고
    • Genotoxic assay of two dietary furans by some in vivo cytogenetic parameters
    • Subramanyam S, Sailaja D and Rathnaprabha D, 1989. Genotoxic assay of two dietary furans by some in vivo cytogenetic parameters. Environ. Mol. Mutag. 14 (15), 239.
    • (1989) Environ. Mol. Mutag , vol.14 , Issue.15 , pp. 239
    • Subramanyam, S.1    Sailaja, D.2    Rathnaprabha, D.3
  • 197
    • 0028198842 scopus 로고
    • Clastogenicity of furfuryl alcohol in a mouse bone marrow system
    • Sujatha PS and Subramanyam S, 1994. Clastogenicity of furfuryl alcohol in a mouse bone marrow system. Med. Sci. Res. 22 (4), 281–284.
    • (1994) Med. Sci. Res , vol.22 , Issue.4 , pp. 281-284
    • Sujatha, P.S.1    Subramanyam, S.2
  • 198
    • 0027437430 scopus 로고
    • Evaluation of the clastogenic potential of 2-furyl methyl ketone in an in vivo mouse system
    • Sujatha PS, Jayanthi A and Subramanyam S, 1993. Evaluation of the clastogenic potential of 2-furyl methyl ketone in an in vivo mouse system. Med. Sci. Res. 21 (18), 675–678.
    • (1993) Med. Sci. Res , vol.21 , Issue.18 , pp. 675-678
    • Sujatha, P.S.1    Jayanthi, A.2    Subramanyam, S.3
  • 199
    • 33846885049 scopus 로고    scopus 로고
    • Genotoxic evaluation of furfuryl alcohol and 2-furyl methyl ketone by sister chromatid exchange (SCE) analysis
    • Sujatha PS, 2007. Genotoxic evaluation of furfuryl alcohol and 2-furyl methyl ketone by sister chromatid exchange (SCE) analysis. J. Health Sci. 53 (1), 124–127.
    • (2007) J. Health Sci , vol.53 , Issue.1 , pp. 124-127
    • Sujatha, P.S.1
  • 200
    • 0028222204 scopus 로고
    • Activation of the Maillard reaction product 5-(hydroxymethyl)furfural to strong mutagens via allylic sulfonation and chlorination
    • Surh Y-J and Tannenbaum SR, 1994. Activation of the Maillard reaction product 5-(hydroxymethyl)furfural to strong mutagens via allylic sulfonation and chlorination. Chem. Res. Toxicol. 7, 313–318.
    • (1994) Chem. Res. Toxicol , vol.7 , pp. 313-318
    • Surh, Y.-J.1    Tannenbaum, S.R.2
  • 201
    • 0027973158 scopus 로고
    • 5-Sulfooxymethylfurfural as a possible ultimate mutagenic and carcinogenic metabolite of the Maillard reaction product, 5-hydroxymethylfurfural
    • Surh Y-J, Liem A, Miller JA and Tannenbaum SR, 1994. 5-Sulfooxymethylfurfural as a possible ultimate mutagenic and carcinogenic metabolite of the Maillard reaction product, 5-hydroxymethylfurfural. Carcinogenesis 15 (10), 2375–2377.
    • (1994) Carcinogenesis , vol.15 , Issue.10 , pp. 2375-2377
    • Surh, Y.-J.1    Liem, A.2    Miller, J.A.3    Tannenbaum, S.R.4
  • 202
    • 0027484078 scopus 로고
    • Metabolism and bioactivation of 3-methylindole by Clara cells, alveolar macrophages and subcellular fractions from rabbit lungs
    • Thornton-Manning JR, Nichols WK, Manning BW, Skiles GL and Yost GS, 1993. Metabolism and bioactivation of 3-methylindole by Clara cells, alveolar macrophages and subcellular fractions from rabbit lungs. Toxicol. Appl. Pharmacol. 122, 182–190.
    • (1993) Toxicol. Appl. Pharmacol , vol.122 , pp. 182-190
    • Thornton-Manning, J.R.1    Nichols, W.K.2    Manning, B.W.3    Skiles, G.L.4    Yost, G.S.5
  • 203
    • 1842771279 scopus 로고    scopus 로고
    • TNO Nutrition and Food Research Institute. Boelens Aroma Chemical Information Service BACIS, Zeist, The Netherlands
    • TNO, 2000. Volatile Compounds in Food - VCF Database. TNO Nutrition and Food Research Institute. Boelens Aroma Chemical Information Service BACIS, Zeist, The Netherlands.
    • (2000) Volatile Compounds in Food - VCF Database
  • 204
    • 85078378569 scopus 로고    scopus 로고
    • TNO Nutrition and Food Research Institute. Boelens Aroma Chemical Information Service BACIS, Zeist, The Netherlands
    • TNO, 2009. Volatile Compounds in Food - VCF Database. TNO Nutrition and Food Research Institute. Boelens Aroma Chemical Information Service BACIS, (Zeist, The Netherlands.
    • (2009) Volatile Compounds in Food - VCF Database
  • 205
    • 85078395771 scopus 로고
    • Quaker Oats Co. Warf Institute 7061313. Quaker Control 60. EPA Doc 88–920005429, microfiche OTS0544683. June 10, 1977. Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Warf Institute, 1977. Initial Submission: Acute oral LD50 study with hydroxymethylfurfural in rats with cover letter dated 07/31/92. Quaker Oats Co. Warf Institute no. 7061313. Quaker Control no. 60. EPA Doc 88–920005429, microfiche no. OTS0544683. June 10, 1977. Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1977) Initial Submission: Acute oral LD50 study with hydroxymethylfurfural in rats with cover letter dated 07/31/92
  • 206
    • 0021281831 scopus 로고
    • Toxicity-distribution relationships among 3-alkylfurans in mouse liver and kidney
    • Wiley RA, Traiger GJ, Baraban S and Gammal LM, 1984. Toxicity-distribution relationships among 3-alkylfurans in mouse liver and kidney. Toxicol. Appl. Pharmacol. 74, 1–9.
    • (1984) Toxicol. Appl. Pharmacol , vol.74 , pp. 1-9
    • Wiley, R.A.1    Traiger, G.J.2    Baraban, S.3    Gammal, L.M.4
  • 207
    • 85078388268 scopus 로고    scopus 로고
    • Product Safety Labs. Study 5212. July 21, 1997. Unpublished report submitted by EFFA to FLAVIS Secretariat
    • Wnorowski G, 1997d. 14-Day dietary study in rats: Furfuryl thiopentanone − 4.2. Product Safety Labs. Study no. 5212. July 21, 1997. Unpublished report submitted by EFFA to FLAVIS Secretariat.
    • (1997) 14-Day dietary study in rats: Furfuryl thiopentanone − 4.2
    • Wnorowski, G.1
  • 210
    • 0016436015 scopus 로고
    • [Hygienic standardization of oxymethylfurfurol in food products]
    • (In Russian)
    • Zaitzev AN, Simonyan TA and Pozdnyakov AL, 1975. [Hygienic standardization of oxymethylfurfurol in food products]. Vopr. Pitan. 1, 52–55. (In Russian)
    • (1975) Vopr. Pitan , vol.1 , pp. 52-55
    • Zaitzev, A.N.1    Simonyan, T.A.2    Pozdnyakov, A.L.3
  • 211
    • 0027196817 scopus 로고
    • Initiation and promotion of colonic aberrant crypt foci in rats by 5-hydroxymethyl-2-furaldehyde in thermolyzed sucrose
    • Zang XM, Chan CC, Stamp D, Minkin S, Archer MC and Bruce WR, 1993. Initiation and promotion of colonic aberrant crypt foci in rats by 5-hydroxymethyl-2-furaldehyde in thermolyzed sucrose. Carcinogenesis 14, 773–775.
    • (1993) Carcinogenesis , vol.14 , pp. 773-775
    • Zang, X.M.1    Chan, C.C.2    Stamp, D.3    Minkin, S.4    Archer, M.C.5    Bruce, W.R.6
  • 212
    • 0018075704 scopus 로고
    • Mutagenic activity of furfural in Salmonella typhimurium TA 100
    • Zdzienicka M, Tudek B, Zielenska M and Szymczyk T, 1978. Mutagenic activity of furfural in Salmonella typhimurium TA 100. Mutat. Res. 58, 205–209.
    • (1978) Mutat. Res , vol.58 , pp. 205-209
    • Zdzienicka, M.1    Tudek, B.2    Zielenska, M.3    Szymczyk, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.