RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated

Cancer Letters

Volumn 376, Issue 1, 2016, Pages 34-42

  Tanabe, Atsushi ^a   Tanikawa, Kenya ^a   Tsunetomi, Mai ^a   Takai, Kaori ^a   Ikeda, Hiroto ^a   Konno, Junpei ^a   Torigoe, Toshihiko ^b   Maeda, Hideki ^b   Kutomi, Goro ^b   Okita, Kenji ^b   Mori, Mitsuru ^b   Sahara, Hiroeki ^a  

^a AZABU UNIVERSITY   (Japan)

^b SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Colon tumor; HIF 1 ; Metastasis; RNA helicase

Indexed keywords

COMPLEMENTARY DNA; FIREFLY LUCIFERASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; RNA HELICASE; UNCLASSIFIED DRUG; YTH DOMAIN CONTAINING 2 PROTEIN; 5' UNTRANSLATED REGION; ADENOSINE TRIPHOSPHATASE; HIF1A PROTEIN, HUMAN; NUCLEAR PROTEIN; TWIST RELATED PROTEIN 1; TWIST1 PROTEIN, HUMAN; YTHDC2 PROTEIN, HUMAN;

5' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER STAGING; CANCER TISSUE; CARCINOMA CELL; COLON ADENOCARCINOMA; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER METASTASIS; MAJOR CLINICAL STUDY; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSLATION INITIATION; TUMOR XENOGRAFT; WESTERN BLOTTING; WOUND HEALING; ADENOCARCINOMA; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; CANCER TRANSPLANTATION; CELL MOTION; CHLOROCEBUS AETHIOPS; COLON TUMOR; COS CELL LINE; ENZYMOLOGY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; HCT 116 CELL LINE; HT-29 CELL LINE; METABOLISM; METASTASIS; NUDE MOUSE; PATHOLOGY; REPORTER GENE; RNA INTERFERENCE; SECONDARY; SIGNAL TRANSDUCTION; TIME FACTOR; TUMOR HYPOXIA; UPREGULATION; XENOGRAFT;

5' UNTRANSLATED REGIONS; ADENOCARCINOMA; ADENOSINE TRIPHOSPHATASES; ANIMALS; CELL MOVEMENT; CERCOPITHECUS AETHIOPS; COLONIC NEOPLASMS; COS CELLS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; HCT116 CELLS; HETEROGRAFTS; HT29 CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM METASTASIS; NEOPLASM STAGING; NEOPLASM TRANSPLANTATION; NUCLEAR PROTEINS; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; TUMOR HYPOXIA; TWIST-RELATED PROTEIN 1; UP-REGULATION;

EID: 84962130214     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2016.02.022     Document Type: Article

References (26)

1. Tanner N.K., Linder P. DExD/H box RNA helicases: from generic motors to specific dissociation functions. Mol. Cell 2001, 8:251-262.
2. Fuller-Pace F.V. DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation. Nucleic Acids Res 2006, 34:4206-4215.
3. Svitkin Y.V., Pause A., Haghighat A., Pyronnet S., Witherell G., Belsham G.J., et al. The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. RNA 2001, 7:382-394.
4. Marintchev A. Roles of helicases in translation initiation: a mechanistic view. Biochim. Biophys. Acta 1829, 2013:799-809.
5. Parsyan A., Shahbazian D., Martineau Y., Petroulakis E., Alain T., Larsson O., et al. The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:22217-22222.
6. Lai M.C., Chang W.C., Shieh S.Y., Tarn W.Y. DDX3 regulates cell growth through translational control of cyclin E1. Mol. Cell. Biol 2010, 30:5444-5453.
7. Caruthers J.M., McKay D.B. Helicase structure and mechanism. Curr. Opin. Struct. Biol 2002, 12:123-133.
8. Cordin O., Banroques J., Tanner N.K., Linder P. The DEAD-box protein family of RNA helicases. Gene 2006, 367:17-37.
9. Stoilov P., Rafalska I., Stamm S. YTH: a new domain in nuclear proteins. Trends Biochem. Sci 2002, 27:495-497.
10. Zhang Z., Theler D., Kaminska K.H., Hiller M., de la Grange P., Pudimat R., et al. The YTH domain is a novel RNA binding domain. J. Biol. Chem 2010, 285:14701-14710.
11. Morohashi K., Sahara H., Watashi K., Iwabata K., Sunoki T., Kuramochi K., et al. Cyclosporin A associated helicase-like protein facilitates the association of hepatitis C virus RNA polymerase with its cellular cyclophilin B. PLoS ONE 2011, 6:e18285.
12. Tanabe A., Konno J., Tanikawa K., Sahara H. Transcriptional machinery of TNF-α-inducible YTH domain containing 2 (YTHDC2) gene. Gene 2014, 535:24-32.
13. Thiery J.P., Acloque H., Huang R.Y.J., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
14. Valastyan S., Weinberg R.A. Tumor metastasis: molecular insights and evolving paradigms. Cell 2011, 147:275-292.
15. Yang M.H., Wu M.Z., Chiou S.H., Chen P.M., Chang S.Y., Liu C.J., et al. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat. Cell Biol 2008, 10:295-305.
16. Torigoe T., Asanuma H., Nakazawa E., Tamura Y., Hirohashi Y., Yamamoto E., et al. Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue: unusually high frequency of down-regulation in breast cancer tissues. Pathol. Int 2012, 62:303-308.
17. Chen H.H., Yu H.I., Cho W.C., Tarn W.Y. DDX3 modulates cell adhesion and motility and cancer cell metastasis via Rac1-mediated signaling pathway. Oncogene 2014, 34:2790-2800.
18. Maynard M.A., Ohh M. The role of hypoxia-inducible factors in cancer. Cell. Mol. Life Sci 2007, 64:2170-2180.
19. Majmundar A.J., Wong W.J., Simon M.C. Hypoxia-inducible factors and the response to hypoxic stress. Mol. Cell 2010, 40:294-309.
20. Lang K.J., Kappel A., Goodall G.J. Hypoxia-inducible factor-1 mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol. Biol. Cell 2002, 13:1792-1801.
21. Yasuda M., Hatanaka T., Shirato H., Nishioka T. Cell type-specific reciprocal regulation of HIF1A gene expression is dependent on 5'- and 3'-UTRs. Biochem. Biophys. Res. Commun 2014, 447:638-643.
22. Yang J., Mani S.A., Donaher J.L., Ramaswamy S., Itzykson R.A., Come C., et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004, 117:927-939.
23. Tsai J.H., Donaher J.L., Murphy D.A., Chau S., Yang J. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 2012, 22:725-736.
24. Chang L.H., Chen C.H., Huang D.Y., Pai H.C., Pan S.L., Teng C.M. Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1A translational pathway in colorectal cancer cells. J. Cell. Physiol 2011, 226:1060-1068.
25. An J., Liu H., Magyar C.E., Guo Y., Veena M.S., Srivatsan E.S., et al. Hyperactivated JNK is a therapeutic target in pVHL-deficient renal cell carcinoma. Cancer Res 2013, 73:1374-1385.
26. Zhao D., Besser A.H., Wander S.A., Sun J., Zhou W., Wang B., et al. Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation. Oncogene 2015, 34:5447-5459.