Different serum free fatty acid profiles in NAFLD subjects and healthy controls after oral fat load

International Journal of Molecular Sciences

Volumn 17, Issue 4, 2016, Pages

  Gambino, Roberto ^a   Bugianesi, Elisabetta ^a   Rosso, Chiara ^a   Mezzabotta, Lavinia ^a   Pinach, Silvia ^a   Alemanno, Natalina ^a   Saba, Francesca ^a   Cassader, Maurizio ^a  

^a UNIVERSITY OF TURIN   (Italy)

Author keywords

Free fatty acids; Insulin resistance; Nonalcoholic fatty liver disease

Indexed keywords

ALANINE AMINOTRANSFERASE; ARACHIDONIC ACID; ASPARTATE AMINOTRANSFERASE; FATTY ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ICOSATRIENOIC ACID; LAURIC ACID; LINOLEIC ACID; LINOLENIC ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MYRISTIC ACID; OLEIC ACID; PALMITIC ACID; PALMITOLEIC ACID; STEARIC ACID; TRIACYLGLYCEROL; CHOLESTEROL; GLUCOSE BLOOD LEVEL; INSULIN; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID;

ADULT; ARTICLE; BIOCHEMICAL ANALYSIS; BODY FAT; CLINICAL ARTICLE; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INSULIN RESISTANCE; INSULINEMIA; LIPID COMPOSITION; NONALCOHOLIC FATTY LIVER; NORMAL HUMAN; OBESITY; ANALYSIS; BLOOD; CASE CONTROL STUDY; COLORIMETRY; FEMALE; LIPID DIET; MALE; MIDDLE AGED; PATHOLOGY;

ADULT; BLOOD GLUCOSE; CASE-CONTROL STUDIES; CHOLESTEROL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLORIMETRY; DIET, HIGH-FAT; FATTY ACIDS, NONESTERIFIED; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FEMALE; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; NON-ALCOHOLIC FATTY LIVER DISEASE; TRIGLYCERIDES;

EID: 84962092520     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17040479     Document Type: Article

References (43)

1. Kooner, J.S.; Baliga, R.R.; Wilding, J.; Crook, D.; Packard, C.J.; Banks, L.M.; Peart, S.; Aitman, T.J.; Scott, J. Abdominal obesity, impaired nonesterified fatty acid suppression, and insulin-mediated glucose disposal are early metabolic abnormalities in families with premature myocardial infarction. Arterioscler. Thromb. Vasc. Biol. 1998, 18, 1021-1026. [CrossRef] [PubMed]
2. Zoratti, R.; Godsland, I.F.; Chaturvedi, N.; Crook, D.; Crook, D.; Stevenson, J.C.; McKeigue, P.M. Relation of plasma lipids to insulin resistance, nonesterified fatty acid levels, and body fat in men from three ethnic groups: Relevance to variation in risk of diabetes and coronary disease. Metabolism 2000, 49, 245-252. [CrossRef]
3. Musso, G.; Gambino, R.; Cassader, M. Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog. Lipid Res. 2009, 48, 1-26. [CrossRef] [PubMed]
4. Musso, G.; Gambino, R.; de Michieli, F.; Biroli, G.; Fagà, E.; Pagano, G.; Cassader, M. Association of liver disease with postprandial large intestinal triglyceride-rich lipoprotein accumulation and pro/antioxidant imbalance in normolipidemic non-alcoholic steatohepatitis. Ann. Med. 2008, 40, 383-394. [CrossRef] [PubMed]
5. De Almeida, I.T.; Cortez-Pinto, H.; Fidalgo, G.; Rodrigues, D.; Camilo, M.E. Plasma total and free fatty acids composition in human non-alcoholic steatohepatitis. Clin. Nutr. 2002, 21, 219-223. [CrossRef] [PubMed]
6. Seidelin, K.N.; Myrup, B.; Fischer-Hansen, B. n-3 fatty acids in adipose tissue and coronary artery disease are inversely related. Am. J. Clin. Nutr. 1992, 55, 1117-1119. [PubMed]
7. Musso, G.; Gambino, R.; Pacini, G.; de Michieli, F.; Cassader, M. Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: Dysregulated enteroadipocyte axis as a novel feature of fatty liver. Am. J. Clin. Nutr. 2009, 89, 558-567. [CrossRef] [PubMed]
8. Marinou, K.; Adiels, M.; Hodson, L.; Frayn, K.N.; Karpe, F.; Fielding, B.A. Young women partition fatty acids towards ketone body production rather than VLDL-TAG synthesis, compared with young men. Br. J. Nutr. 2011, 105, 857-865. [CrossRef] [PubMed]
9. Nelson, R.H.; Basu, R.; Johnson, C.M.; Rizza, R.A.; Miles, J.M. Splanchnic spillover of extracellular lipase-generated fatty acids in overweight and obese humans. Diabetes 2007, 56, 2878-2884. [CrossRef] [PubMed]
10. Hardy, S.; El-Assaad, W.; Przybytkowski, E.; Joly, E.; Prentki, M.; Langelier, Y. Saturated fatty acid induced-apoptosis in MDA-MB-231 breast cancer cells-A role for cardiolipin. J. Biol. Chem. 2003, 278, 31861-31870. [CrossRef] [PubMed]
11. Musso, G.; Gambino, R.; Durazzo, M.; Biroli, G.; Carello, M.; Faga, E.; Pacini, G.; de Michieli, F.; Rabbione, L.; Premoli, A.; et al. Adipokines in NASH: Postprandial lipid metabolism as a link between adiponectin and liver disease. Hepatology 2005, 42, 1175-1183. [CrossRef] [PubMed]
12. Okere, I.; Chandler, M.; McElfresh, T.; Rennison, J.H.; Sharov, V.; Sabbah, H.N.; Tserng, K.T.; Hoit, B.D.; Ernsberger, P.; Young, M.E.; et al. Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin. Am. J. Physiol. Heart Circ. Physiol. 2006, 291, H38-H44. [CrossRef] [PubMed]
13. Wang, D.;Wei, Y.R.; Pagliassotti, M.J. Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology 2006, 147, 943-951. [CrossRef] [PubMed]
14. Spector, A.A.; Yorek, M.A. Membrane lipid-composition and cellular function. J. Lipid Res. 1985, 26, 1015-1035. [PubMed]
15. Borradaile, N.M.; Han, X.; Harp, J.D.; Gale, S.E.; Ory, D.S.; Schaffer, J.E. Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J. Lipid Res. 2006, 47, 2726-2737. [CrossRef] [PubMed]
16. Satapati, S.; Sunny, N.E.; Kucejova, B.; Fu, X.; He, T.T.; Méndez-Lucas, A.; Shelton, J.M.; Perales, J.C.; Browning, J.D.; Burgess, S.C. Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver. J. Lipid Res. 2012, 53, 1080-1092. [CrossRef] [PubMed]
17. Sunny, N.E.; Parks, E.J.; Browning, J.D.; Burgess, S.C. Excessive hepatic mitochondrial TCA cycle and gluconeogenesis in humans with nonalcoholic fatty liver disease. Cell Metab. 2011, 14, 804-810. [CrossRef] [PubMed]
18. Nakamura, S.; Takamura, T.; Matsuzawa-Nagata, N.; Takayama, H.; Misu, H.; Noda, H.; Nabemoto, S.; Kurita, S.; Ota, T.; Ando, H.; et al. Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria. J. Biol. Chem. 2009, 284, 14809-14818. [CrossRef] [PubMed]
19. Paumen, M.B.; Ishida, Y.; Muramatsu, M.; Yamamoto, M.; Honjo, T. Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis. J. Biol. Chem. 1997, 272, 3324-3329. [CrossRef] [PubMed]
20. Summers, S.A. Ceramides in insulin resistance and lipotoxicity. Prog. Lipid Res. 2006, 45, 42-72. [CrossRef] [PubMed]
21. Maeda, K.; Cao, H.; Kono, K.; Gorgun, C.Z.; Furuhashi, M.; Uysal, K.T.; Cao, Q.; Atsumi, G.; Malone, H.; Krishnan, B.; et al. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. Cell Metab. 2005, 1, 107-119. [CrossRef] [PubMed]
22. Yli-Jama, P.; Meyer, H.E.; Ringstad, J.; Pedersen, J.I. Serum free fatty acid pattern and risk of myocardial infarction: A case-control study. J. Intern. Med. 2002, 251, 19-28. [CrossRef] [PubMed]
23. Miles, J.M.; Park, Y.S.;Walewicz, D.; Russell-Lopez, C.;Windsor, S.; Isley,W.L.; Coppack, S.W.; Harris,W.S. Systemic and forearm triglyceride metabolism: Fate of lipoprotein lipase-generated glycerol and free fatty acids. Diabetes 2004, 53, 521-527. [CrossRef] [PubMed]
24. Havel, R.J.; Hamilton, R.L. Hepatic catabolism of remnant lipoproteins: Where the action is. Arterioscler. Thromb. Vasc. Biol. 2004, 24, 213-215. [PubMed]
25. Griffiths, A.J.; Humphreys, S.M.; Clark, M.L.; Fielding, B.A.; Frayn, K.N. Immediate metabolic availability of dietary fat in combination with carbohydrate. Am. J. Clin. Nutr. 1994, 59, 53-59. [PubMed]
26. Weiss, E.P.; Fields, D.A.; Mittendorfer, B.; Dorien Haverkort, A.M.; Klein, S. Reproducibility of postprandial lipemia test and validity of an abbreviated 4-h test. Metabolism 2008, 57, 1479-1485. [CrossRef] [PubMed]
27. Musso, G.; Gambino, R.; De Michieli, F.; Cassader, M.; Rizzetto, M.; Durazzo, M.; Fagà, E.; Silli, B.; Pagano, G. Dietary habits and their relation to insulin resistance in nonalcoholic steatohepatitis. Hepatology 2003, 37, 909-916. [CrossRef] [PubMed]
28. Cassader, M.; Gambino, R.; Musso, G.; Depetris, N.; Mecca, F.; Cavallo-Perin, P.; Pacini, G.; Rizzetto, M.; Pagano, G. Postprandial triglyceride-rich lipoprotein metabolism and insulin sensitivity in nonalcoholic steatohepatitis patients. Lipids 2001, 36, 1117-1124. [CrossRef] [PubMed]
29. Ntambi, J.M.; Miyazaki, M. Regulation of stearoyl-CoA desaturases and role in metabolism. Prog. Lipid Res. 2004, 43, 91-104. [CrossRef]
30. Inagaki, K.; Aki, T.; Fukuda, Y.; Kawamoto, S.; Shigeta, S.; Ono, K.; Suzuki, O. Identification and expression of a rat fatty acid elongase involved in the biosynthesis of C18 fatty acids. Biosci. Biotechnol. Biochem. 2002, 66, 613-621. [CrossRef] [PubMed]
31. Sampath, H.; Ntambi, J.M. The fate and intermediary metabolism of stearic acid. Lipids 2005, 40, 1187-1191. [CrossRef] [PubMed]
32. Sun, Y.; Hao, M.M.; Luo, Y.; Liang, C.P.; Silver, D.L.; Cheng, C.; Maxfield, F.R.; Tall, A.R. Stearoyl-CoA desaturase inhibits ATP-binding cassette transporter A1-mediated cholesterol efflux and modulates membrane domain structure. J. Biol. Chem. 2003, 278, 5813-5820. [CrossRef] [PubMed]
33. Attie, A.D.; Krauss, R.M.; Gray-Keller, M.P.; Brownlie, A.; Miyazaki, M.; Kastelein, J.J.; Lusis, A.J.; Stalenhoef, A.F.; Stoehr, J.P.; Hayden, M.R.; et al. Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia. J. Lipid Res. 2002, 43, 1899-1907. [CrossRef] [PubMed]
34. Le, H.D.; Meisel, J.A.; de Meijer, V.E.; Gura, K.M.; Puder, M. The essentiality of arachidonic acid and docosahexaenoic acid. Prostaglandins Leukot. Essent. Fatty Acids 2009, 81, 165-170. [CrossRef] [PubMed]
35. Brenna, J.T.; Salem, N., Jr.; Sinclair, A.J.; Cunnane, S.C. α-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans. Prostaglandins Leukot. Essent. Fatty Acids 2009, 80, 85-91. [CrossRef] [PubMed]
36. Roche, H.M.; Gibney, M.J. Effect of long-chain n-3 polyunsaturated fatty acids on fasting and postprandial triacylglycerol metabolism. Am. J. Clin. Nutr. 2000, 71, 232s-237s. [PubMed]
37. Tulk, H.; Robinson, L. Modifying the n-6/n-3 polyunsaturated fatty acid ratio of a high-saturated fat challenge does not acutely attenuate postprandial changes in inflammatory markers in men with metabolic syndrome. Metabolism 2009, 58, 1709-1716. [CrossRef] [PubMed]
38. Song, Z.; Yang, L.; Shu, G.; Lu, H.; Sun, G. Effects of the n-6/n-3 polyunsaturated fatty acids ratio on postprandial metabolism in hypertriacylglycerolemia patients. Lipids Health Dis. 2013, 12, 181-188. [CrossRef] [PubMed]
39. Warnick, G.R.; Albers, J.J. A comprehensive evolution of the heparin manganese precipitation procedure for estimating high density lipoprotein cholesterol. J. Lipid Res. 1978, 29, 65-76.
40. Gidez, L.I.; Miller, G.J.; Burnstein, M.; Slagle, S.; Eder, H.A. Separation and quantitation of subclasses of human plasma HDL by a single precipitation procedure. J. Lipid Res. 1982, 23, 1206-1216. [PubMed]
41. Katz, A.; Nambi, S.S.; Mather, K.; Baron, A.D.; Follmann, D.A.; Sullivan, G.; Quon, M.J. Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans. J. Clin. Endocrinol. Metab. 2000, 85, 2402-2410. [CrossRef] [PubMed]
42. Matthews, D.R.; Hosker, J.P.; Rudenski, A.S.; Naylor, B.A.; Treacher, D.F.; Turner, R.C. Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28, 412-419. [CrossRef] [PubMed]
43. Matsuzawa, T.; Mishima, K.; Nishii, M.; Ito, M. Serum fatty acids analysis by high performance liquid chromatography, after enzymatic hydrolysis and isolation by Sep-Pak C18 minicolumn. Biochem. Int. 1987, 15, 693-702. [PubMed]