CGG Repeat-Associated Non-AUG Translation Utilizes a Cap-Dependent Scanning Mechanism of Initiation to Produce Toxic Proteins

Molecular Cell

Volumn 62, Issue 2, 2016, Pages 314-322

  Kearse, Michael G ^a   Green, Katelyn M ^a   Krans, Amy ^a,b   Rodriguez, Caitlin M ^a   Linsalata, Alexander E ^a   Goldstrohm, Aaron C ^a,c   Todd, Peter K ^a,b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRAGILE X MENTAL RETARDATION PROTEIN; INITIATION FACTOR; INITIATION FACTOR 4A; MESSENGER RNA; SIGNAL PEPTIDE; FMR1 PROTEIN, HUMAN; INITIATION FACTOR 4E;

ARTICLE; CGG REPEAT; CONTROLLED STUDY; DROSOPHILA; FEMALE; HELA CELL LINE; HUMAN; HUMAN CELL; KINETICS; NONHUMAN; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; PROTEIN SECONDARY STRUCTURE; REPEAT ASSOCIATED NON AUG TRANSLATION; START CODON; STOP CODON; TRANSLATION INITIATION; TRANSLATION REGULATION; BIOSYNTHESIS; FRAGILE X SYNDROME; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETICS; METABOLISM; NERVE CELL; NERVE DEGENERATION; OPEN READING FRAME; PATHOLOGY; PHENOTYPE; PROTEIN SYNTHESIS; REPORTER GENE; RIBOSOMAL FRAMESHIFTING; RIBOSOME; TRANSCRIPTION INITIATION SITE; TRINUCLEOTIDE REPEAT;

EUKARYOTIC INITIATION FACTOR-4E; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; FRAMESHIFTING, RIBOSOMAL; GENES, REPORTER; GENETIC PREDISPOSITION TO DISEASE; HELA CELLS; HUMANS; NERVE DEGENERATION; NEURONS; OPEN READING FRAMES; PHENOTYPE; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA, MESSENGER; TRANSCRIPTION INITIATION SITE; TRANSFECTION; TRINUCLEOTIDE REPEAT EXPANSION; TRINUCLEOTIDE REPEATS;

EID: 84962090260     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.02.034     Document Type: Article

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