The impact of the modified Atkins diet on lipid profiles in adults with epilepsy

Nutritional Neuroscience

Volumn 19, Issue 3, 2016, Pages 131-137

  Cervenka, Mackenzie C ^a   Patton, Katlyn ^a,c   Eloyan, Ani ^b   Henry, Bobbie ^a   Kossoff, Eric H ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c VILLANOVA UNIVERSITY   (United States)

Author keywords

Cholesterol; Epilepsy; Hyperlipidemia; Ketogenic diet; Lipoprotein; Modified Atkins diet; Seizure; Triglycerides

Indexed keywords

ANTICONVULSIVE AGENT; CARNITINE; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; KETONE; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; BIOLOGICAL MARKER; EDIBLE OIL;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; DIET THERAPY; DISEASE COURSE; EPILEPSY; FAT INTAKE; FEMALE; HUMAN; ISCHEMIC HEART DISEASE; KETOACIDOSIS; LIPID ANALYSIS; MALE; MODEL; MODIFIED ATKINS DIET; MULTIPLE REGRESSION; PRIORITY JOURNAL; PROSPECTIVE STUDY; URINALYSIS; ADOLESCENT; ADVERSE EFFECTS; BLOOD; CORONARY DISEASE; HYPERCHOLESTEROLEMIA; KETOGENIC DIET; LONGITUDINAL STUDY; MARYLAND; MIDDLE AGED; PATHOPHYSIOLOGY; PATIENT COMPLIANCE; PATIENT EDUCATION; RISK FACTOR; URINE; YOUNG ADULT;

ADOLESCENT; ADULT; BALTIMORE; BIOMARKERS; CHOLESTEROL; CORONARY DISEASE; DIETARY FATS, UNSATURATED; EPILEPSY; FEMALE; HUMANS; HYPERCHOLESTEROLEMIA; KETOGENIC DIET; KETONES; LIPOPROTEINS, LDL; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; PATIENT COMPLIANCE; PATIENT EDUCATION AS TOPIC; PROSPECTIVE STUDIES; RISK FACTORS; YOUNG ADULT;

EID: 84962048235     PISSN: 1028415X     EISSN: 14768305     Source Type: Journal    
DOI: 10.1179/1476830514Y.0000000162     Document Type: Article

References (25)

1. Cervenka MC, Kossoff EH. Dietary treatment of intractable epilepsy. Continuum (Minneap Minn) 2013;19(3 Epilepsy):756–66.
2. Payne NE, Cross JH, Sander JW, Sisodiya SM. The ketogenic and related diets in adolescents and adults – a review. Epilepsia 2011;52(11):1941–8.
3. Chen W, Kossoff EH. Long-term follow-up of children treated with the modified Atkins diet. J Child Neurol 2012;27(6):754–8.
4. Kossoff EH, Cervenka MC, Henry BJ, Haney CA, Turner Z. A decade of the modified Atkins diet (2003–2013): results, insights, and future directions. Epilepsy Behav 2013;29(3):437–42.
5. Kwiterovich PO, Jr., Vining EP, Pyzik P, Skolasky R, Jr., Freeman JM. Effect of a high-fat ketogenic diet on plasma levels of lipids, lipoproteins, and apolipoproteins in children. JAMA 2003;290(7):912–20.
6. Nizamuddin J, Turner Z, Rubenstein JE, Pyzik PL, Kossoff EH. Management and risk factors for dyslipidemia with the ketogenic diet. J Child Neurol 2008;23(7):758–61.
7. Coppola G, Natale F, Torino A, Capasso R, D’Aniello A, Pironti E, et al. The impact of the ketogenic diet on arterial morphology and endothelial function in children and young adults with epilepsy: a case-control study. Seizure 2014;23(4):260–5.
8. Groesbeck DK, Bluml RM, Kossoff EH. Long-term use of the ketogenic diet in the treatment of epilepsy. Dev Med Child Neurol 2006;48(12):978–81.
9. Kapetanakis M, Liuba P, OdermarskyM, Lundgren J, Hallbook T. Effects of ketogenic diet on vascular function. Eur J Paediatr Neurol 2014;18(4):489–94.
10. Kossoff EH, Henry BJ, Cervenka MC. Transitioning pediatric patients receiving ketogenic diets for epilepsy into adulthood. Seizure 2013;22(6):487–9.
11. Stone NJ, Robinson J, Lichtenstein AH, Bairey Merz CN, Lloyd-Jones DM, Blum CB, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013;63(25 Pt B): 2889–934.
12. Cervenka MC, Terao NN, Bosarge JL, Henry BJ, Klees AA, Morrison PF, et al. E-mail management of the modified Atkins diet for adults with epilepsy is feasible and effective. Epilepsia 2012;53(4):728–32.
13. Third Report of the National Cholesterol Education Program (NCEP). Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 2002;106(25):3143–421.
14. Stone NJ, Robinson JG, Lichtenstein AH, Goff DC, Jr., Lloyd- Jones DM, Smith SC, Jr., et al. Treatment of blood cholesterol to reduce atherosclerotic cardiovascular disease risk in adults: synopsis of the 2013 ACC/AHA cholesterol guideline. Ann Intern Med 2014;160(5):339–43.
15. Keaney JF, Jr., Curfman GD, Jarcho JA. A pragmatic view of the new cholesterol treatment guidelines. N Engl J Med 2014; 370(3):275–8.
16. Kossoff EH, Rowley H, Sinha SR, Vining EP. A prospective study of the modified Atkins diet for intractable epilepsy in adults. Epilepsia 2008;49(2):316–9.
17. Forsythe CE, Phinney SD, Feinman RD, Volk BM, Freidenreich D, Quann E, et al. Limited effect of dietary saturated fat on plasma saturated fat in the context of a low carbohydrate diet. Lipids 2010;45(10):947–62.
18. Volek JS, Phinney SD, Forsythe CE, Quann EE, Wood RJ, Puglisi MJ, et al. Carbohydrate restriction has a more favorable impact on the metabolic syndrome than a low fat diet. Lipids 2009;44(4):297–309.
19. Volek JS, Fernandez ML, Feinman RD, Phinney SD. Dietary carbohydrate restriction induces a unique metabolic state positively affecting atherogenic dyslipidemia, fatty acid partitioning, and metabolic syndrome. Prog Lipid Res 2008;47(5): 307–18.
20. Dashti HM, Al-Zaid NS, Mathew TC, Al-Mousawi M, Talib H, Asfar SK, et al. Long term effects of ketogenic diet in obese subjects with high cholesterol level. Mol Cell Biochem 2006; 286(1–2):1–9.
21. Dahlin M, Hjelte L, Nilsson S, Amark P. Plasma phospholipid fatty acids are influenced by a ketogenic diet enriched with n-3 fatty acids in children with epilepsy. Epilepsy Res 2007;73(2): 199–207.
22. Dell CA, Likhodii SS, Musa K, Ryan MA, Burnham WM, Cunnane SC. Lipid and fatty acid profiles in rats consuming different high-fat ketogenic diets. Lipids 2001;36(4):373–8.
23. Fraser DD, Whiting S, Andrew RD, Macdonald EA, Musa- Veloso K, Cunnane SC. Elevated polyunsaturated fatty acids in blood serum obtained from children on the ketogenic diet. Neurology 2003;60(6):1026–9.
24. Seo JH, Lee YM, Lee JS, Kang HC, Kim HD. Efficacy and tolerability of the ketogenic diet according to lipid: nonlipid ratios – comparison of 3:1 with 4:1 diet. Epilepsia 2007;48(4):801–5.
25. Mudd JO, Borlaug BA, Johnston PV, Kral BG, Rouf R, Blumenthal RS, et al. Beyond low-density lipoprotein cholesterol: defining the role of low-density lipoprotein heterogeneity in coronary artery disease. J Am Coll Cardiol 2007;50(18): 1735–41.