Potential of neuropeptide Y for preventing or treating post-traumatic stress disorder

Neuropeptides

Volumn 56, Issue , 2016, Pages 19-24

  Sabban, Esther L ^a   Alaluf, Lishay G ^a   Serova, Lidia I ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

Depression; Intranasal; PTSD; Resilience; Single prolonged stress

Indexed keywords

NEUROPEPTIDE Y;

AIRWAY RESISTANCE; AMYGDALOID NUCLEUS; ARTICLE; BEHAVIORAL STRESS; BLOOD VESSEL PERMEABILITY; BRAIN FUNCTION; BRAIN REGION; COPING BEHAVIOR; CYCLIC AMP RESPONSIVE ELEMENT; DRUG MECHANISM; DRUG RELEASE; EMOTIONALITY; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; HYPOTHALAMUS; LOCUS CERULEUS; NEUROMODULATION; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROPHYLAXIS; ANIMAL; BRAIN; DRUG EFFECTS; METABOLISM; STRESS DISORDERS, POST-TRAUMATIC;

ANIMALS; BRAIN; HUMANS; NEUROPEPTIDE Y; STRESS DISORDERS, POST-TRAUMATIC;

EID: 84962016028     PISSN: 01434179     EISSN: 15322785     Source Type: Journal    
DOI: 10.1016/j.npep.2015.11.004     Document Type: Review

References (90)

1. A dose escalation study of intranasal neuropeptide Y in post-traumatic stress disorder (PTSD). U.S. National Institutes of Health; James Murrough, Mount Sinai School of Medicine. Bethesda, MD: National Library of Medicine (US), 2013. Available at . NLM Identifier: NCT01533519. http://clinicaltrials.gov/ct2/show/NCT01533519?term=NCT+01533519&rank=1.
2. Bannon A.W., Seda J., Carmouche M., Francis J.M., Norman M.H., Karbon B., McCaleb M.L. Behavioral characterization of neuropeptide Y knockout mice. Brain Res. 2000, 868:79-87.
3. Bournat J.C., Allen J.M. Regulation of the Y1 neuropeptide Y receptor gene expression in PC12 cells. Brain Res. Mol. Brain Res. 2001, 90:149-164.
4. Bowers M.E., Choi D.C., Ressler K.J. Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide Y. Physiol. Behav. 2012, 107:699-710.
5. Brothers S.P., Wahlestedt C. Therapeutic potential of neuropeptide Y (NPY) receptor ligands. EMBO Mol. Med. 2010, 2:429-439.
6. Brothers S.P., Saldanha S.A., Spicer T.P., Cameron M., Mercer B.A., Chase P., McDonald P., Wahlestedt C., Hodder P.S. Selective and brain penetrant neuropeptide y y2 receptor antagonists discovered by whole-cell high-throughput screening. Mol. Pharmacol. 2010, 77:46-57.
7. Caberlotto L., Fuxe K., Overstreet D.H., Gerrard P., Hurd Y.L. Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment. Brain Res. Mol. Brain Res. 1998, 59:58-65.
8. Cervin A., Onnerfalt J., Edvinsson L., Grundemar L. Functional effects of neuropeptide Y receptors on blood flow and nitric oxide levels in the human nose. Am. J. Respir. Crit. Care Med. 1999, 160:1724-1728.
9. Chapman C.D., Frey W.H., Craft S., Danielyan L., Hallschmid M., Schiöth H.B., Benedict C. Intranasal treatment of central nervous system dysfunction in humans. Pharm. Res. 2012.
10. Christiansen S.H., Olesen M.V., Gøtzsche C.R., Woldbye D.P. Anxiolytic-like effects after vector-mediated overexpression of neuropeptide Y in the amygdala and hippocampus of mice. Neuropeptides 2014, 48:335-344.
11. Cohen H., Liu T., Kozlovsky N., Kaplan Z., Zohar J., Mathé A.A. The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stress exposure in an animal model of post-traumatic stress disorder. Neuropsychopharmacology 2011.
12. Conrad C.D., McEwen B.S. Acute stress increases neuropeptide Y mRNA within the arcuate nucleus and hilus of the dentate gyrus. Brain Res. Mol. Brain Res. 2000, 79:102-109.
13. Dhuria S.V., Hanson L.R., Frey W.H. Intranasal delivery to the central nervous system: mechanisms and experimental considerations. J. Pharm. Sci. 2010, 99:1654-1673.
14. Dimitrov E.L., DeJoseph M.R., Brownfield M.S., Urban J.H. Involvement of neuropeptide Y Y1 receptors in the regulation of neuroendocrine corticotropin-releasing hormone neuronal activity. Endocrinology 2007, 148:3666-3673.
15. Domschke K., Dannlowski U., Hohoff C., et al. Neuropeptide Y (NPY) gene: impact on emotional processing and treatment response in anxious depression. Eur. Neuropsychopharmacol. 2010, 20:301-309.
16. Eaton K., Sallee F.R., Sah R. Relevance of neuropeptide Y (NPY) in psychiatry. Curr. Top. Med. Chem. 2007, 7:1645-1659.
17. Edvinsson L., Ekblad E., Håkanson R., Wahlestedt C. Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels. Br. J. Pharmacol. 1984, 83:519-525.
18. Enman N.M., Sabban E.L., McGonigle P., Van Bockstaele E.J. Targeting the neuropeptide Y system in stress-related psychiatric disorders. Neurobiol. Stress 2015, 1:33-43.
19. Eva C., Serra M., Mele P., Panzica G., Oberto A. Physiology and gene regulation of the brain NPY Y1 receptor. Front. Neuroendocrinol. 2006, 27:308-339.
20. Finta E.P., Regenold J.T., Illes P. Depression by neuropeptide Y of noradrenergic inhibitory postsynaptic potentials of locus coeruleus neurones. Naunyn Schmiedeberg's Arch. Pharmacol. 1992, 346:472-474.
21. Foote S.L., Bloom F.E., Aston-Jones G. Nucleus locus ceruleus: new evidence of anatomical and physiological specificity. Physiol. Rev. 1983, 63:844-914.
22. Füzesi T., Wittmann G., Liposits Z., Lechan R.M., Fekete C. Contribution of noradrenergic and adrenergic cell groups of the brainstem and agouti-related protein-synthesizing neurons of the arcuate nucleus to neuropeptide-y innervation of corticotropin-releasing hormone neurons in hypothalamic paraventricular nucleus of the rat. Endocrinology 2007, 148:5442-5450.
23. Giesbrecht C.J., Mackay J.P., Silveira H.B., Urban J.H., Colmers W.F. Countervailing modulation of Ih by neuropeptide Y and corticotrophin-releasing factor in basolateral amygdala as a possible mechanism for their effects on stress-related behaviors. J Neurosci 2010, 30:16970-16982.
24. Gutman A.R., Yang Y., Ressler K.J., Davis M. The role of neuropeptide Y in the expression and extinction of fear-potentiated startle. J. Neurosci 2008, 28:12682-12690.
25. Hallschmid M., Gais S., Meinert S., Born J. NPY attenuates positive cortical DC-potential shift upon food intake in man. Psychoneuroendocrinology 2003, 28:529-539.
26. Hallschmid M., Benedict C., Born J., Fehm H.L., Kern W. Manipulating central nervous mechanisms of food intake and body weight regulation by intranasal administration of neuropeptides in man. Physiol. Behav. 2004, 83:55-64.
27. Heilig M. The NPY system in stress, anxiety and depression. Neuropeptides 2004, 38:213-224.
28. Heilig M., Thorsell A. Brain neuropeptide Y (NPY) in stress and alcohol dependence. Rev. Neurosci. 2002, 13:85-94.
29. Heilig M., Widerlöv E. Neuropeptide Y: an overview of central distribution, functional aspects, and possible involvement in neuropsychiatric illnesses. Acta Psychiatr. Scand. 1990, 82:95-114.
30. Heilig M., Söderpalm B., Engel J.A., Widerlöv E. Centrally administered neuropeptide Y (NPY) produces anxiolytic-like effects in animal anxiety models. Psychopharmacology 1989, 98:524-529.
31. Heilig M., Koob G.F., Ekman R., Britton K.T. Corticotropin-releasing factor and neuropeptide Y: role in emotional integration. Trends Neurosci. 1994, 17:80-85.
32. Hirsch D., Zukowska Z. NPY and stress 30 years later: the peripheral view. Cell. Mol. Neurobiol. 2012, 32:645-659.
33. Horvath T.L., Bechmann I., Naftolin F., Kalra S.P., Leranth C. Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations. Brain Res. 1997, 756:283-286.
34. Hou C., Jia F., Liu Y., Li L. CSF serotonin, 5-hydroxyindolacetic acid and neuropeptide Y levels in severe major depressive disorder. Brain Res. 2006, 1095:154-158.
35. Illes P., Finta E.P., Nieber K. Neuropeptide Y potentiates via Y2-receptors the inhibitory effect of noradrenaline in rat locus coeruleus neurones. Naunyn Schmiedeberg's Arch. Pharmacol. 1993, 348:546-548.
36. Ionescu I.A., Dine J., Yen Y.C., Buell D.R., Herrmann L., Holsboer F., Eder M., Landgraf R., Schmidt U. Intranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons. Neuropsychopharmacology 2012, 37:1323-1337.
37. Kash T.L., Winder D.G. Neuropeptide Y and corticotropin-releasing factor bi-directionally modulate inhibitory synaptic transmission in the bed nucleus of the stria terminalis. Neuropharmacology 2006, 51:1013-1022.
38. Kask A., Rägo L., Harro J. Anxiolytic-like effect of neuropeptide Y (NPY) and NPY13-36 microinjected into vicinity of locus coeruleus in rats. Brain Res. 1998, 788:345-348.
39. Kask A., Harro J., von Horsten S., Redrobe J.P., Dumont Y., Quirion R. The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. Neurosci. Biobehav. Rev. 2002, 26:259-283.
40. Kastin A.J., Akerstrom V. Nonsaturable entry of neuropeptide Y into brain. Am. J. Phys. 1999, 276:E479-E482.
41. Kohda K., Harada K., Kato K., Hoshino A., Motohashi J., Yamaji T., Morinobu S., Matsuoka N., Kato N. Glucocorticoid receptor activation is involved in producing abnormal phenotypes of single-prolonged stress rats: a putative post-traumatic stress disorder model. Neuroscience 2007, 148:22-33.
42. Kormos V., Gaszner B. Role of neuropeptides in anxiety, stress, and depression: from animals to humans. Neuropeptides 2013, 47:401-419.
43. Kuo L.E., Kitlinska J.B., Tilan J.U., et al. Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat. Med. 2007, 13:803-811.
44. Lacroix J.S., Mosimann B.L. Attenuation of allergen-evoked nasal responses by local pretreatment with exogenous neuropeptide Y in atopic patients. J. Allergy Clin. Immunol. 1996, 98:611-616.
45. Lacroix J.S., Ricchetti A.P., Morel D., Mossimann B., Waeber B., Grouzmann E. Intranasal administration of neuropeptide Y in man: systemic absorption and functional effects. Br. J. Pharmacol. 1996, 118:2079-2084.
46. Laukova M., Alaluf L.G., Serova L.I., Arango V., Sabban E.L. Early intervention with intransala NPY prevents single prolonged stress-triggered impairments in hypothalamus and ventral hippocampus in male rats. Endocrinology 2014, 155:3920-3933.
47. Li M., Han F., Shi Y. Expression of locus coeruleus mineralocorticoid receptor and glucocorticoid receptor in rats under single-prolonged stress. Neurol. Sci. 2011, 32:625-631.
48. Liberzon I., López J.F., Flagel S.B., Vázquez D.M., Young E.A. Differential regulation of hippocampal glucocorticoid receptors mRNA and fast feedback: relevance to post-traumatic stress disorder. J. Neuroendocrinol. 1999, 11:11-17.
49. Lindell S.G., Schwandt M.L., Sun H., et al. Functional NPY variation as a factor in stress resilience and alcohol consumption in rhesus macaques. Arch. Gen. Psychiatry 2010, 67:423-431.
50. Liposits Z., Sievers L., Paull W.K. Neuropeptide-Y and ACTH-immunoreactive innervation of corticotropin releasing factor (CRF)-synthesizing neurons in the hypothalamus of the rat. An immunocytochemical analysis at the light and electron microscopic levels. Histochemistry 1988, 88:227-234.
51. Makino S., Hashimoto K., Gold P.W. Multiple feedback mechanisms activating corticotropin-releasing hormone system in the brain during stress. Pharmacol. Biochem. Behav. 2002, 73:147-158.
52. McGuire J.L., Larke L.E., Sallee F.R., Herman J.P., Sah R. Differential regulation of neuropeptide Y in the amygdala and prefrontal cortex during recovery from chronic variable stress. Front. Behav. Neurosci. 2011, 5:54.
53. Melas P.A., Lennartsson A., Vakifahmetoglu-Norberg H., et al. Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression. Transcult. Psychiatry 2013, 3.
54. Michel M.C., Beck-Sickinger A., Cox H., Doods H.N., Herzog H., Larhammar D., Quirion R., Schwartz T., Westfall T. XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev. 1998, 50:143-150.
55. Mickey B.J., Zhou Z., Heitzeg M.M., et al. Emotion processing, major depression, and functional genetic variation of neuropeptide Y. Arch. Gen. Psychiatry 2011, 68:158-166.
56. Morgan C.A., Wang S., Rasmusson A., Hazlett G., Anderson G., Charney D.S. Relationship among plasma cortisol, catecholamines, neuropeptide Y, and human performance during exposure to uncontrollable stress. Psychosom. Med. 2001, 63:412-422.
57. Morgan C.A., Rasmusson A.M., Wang S., Hoyt G., Hauger R.L., Hazlett G. Neuropeptide-Y, cortisol, and subjective distress in humans exposed to acute stress: replication and extension of previous report. Biol. Psychiatry 2002, 52:136-142.
58. Nilsson C., Karlsson G., Blennow K., Heilig M., Ekman R. Differences in the neuropeptide Y-like immunoreactivity of the plasma and platelets of human volunteers and depressed patients. Peptides 1996, 17:359-362.
59. Palkovits M. Stress-induced activation of neurons in the ventromedial arcuate nucleus: a blood-brain-CSF interface of the hypothalamus. Ann. N. Y. Acad. Sci. 2008, 1148:57-63.
60. Pedrazzini T., Pralong F., Grouzmann E. Neuropeptide Y: the universal soldier. Cell. Mol. Life Sci. 2003, 60:350-377.
61. Pitman R.K., Rasmusson A.M., Koenen K.C., Shin L.M., Orr S.P., Gilbertson M.W., Milad M.R., Liberzon I. Biological studies of post-traumatic stress disorder. Nat. Rev. Neurosci. 2012, 13:769-787.
62. Primeaux S.D., Wilson S.P., Cusick M.C., York D.A., Wilson M.A. Effects of altered amygdalar neuropeptide Y expression on anxiety-related behaviors. Neuropsychopharmacology 2005, 30:1589-1597.
63. Pronchuk N., Beck-Sickinger A.G., Colmers W.F. Multiple NPY receptors Inhibit GABA(A) synaptic responses of rat medial parvocellular effector neurons in the hypothalamic paraventricular nucleus. Endocrinology 2002, 143:535-543.
64. Rasmusson A.M., Hauger R.L., Morgan C.A., Bremner J.D., Charney D.S., Southwick S.M. Low baseline and yohimbine-stimulated plasma neuropeptide Y (NPY) levels in combat-related PTSD. Biol. Psychiatry 2000, 47:526-539.
65. Rasmusson A.M., Schnurr P.P., Zukowska Z., Scioli E., Forman D.E. Adaptation to extreme stress: post-traumatic stress disorder, neuropeptide Y and metabolic syndrome. Exp. Biol. Med. (Maywood) 2010, 235:1150-1162.
66. Redrobe J.P., Dumont Y., Fournier A., Quirion R. The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neuropsychopharmacology 2002, 26:615-624.
67. Reichmann F., Holzer P. Neuropeptide Y: A stressful review. Neuropeptides 2015.
68. Sabban E., Laukova M., Alalaluf L., Olsson E., Serova L. Locus coeruleus response to single prolonged stress and early intervention with intranasal neuropeptide Y. J. Neurochem. 2015, (Epub ahead of print). 10.1111/jnc.13347.
69. Sah R., Geracioti T.D. Neuropeptide y and posttraumatic stress disorder. Mol. Psychiatry 2013, 18:646-655.
70. Sah R., Ekhator N.N., Strawn J.R., Sallee F.R., Baker D.G., Horn P.S., Geracioti T.D. Low cerebrospinal fluid neuropeptide Y concentrations in posttraumatic stress disorder. Biol. Psychiatry 2009, 66:705-707.
71. Sajdyk T.J., Schober D.A., Gehlert D.R. Neuropeptide Y receptor subtypes in the basolateral nucleus of the amygdala modulate anxiogenic responses in rats. Neuropharmacology 2002, 43:1165-1172.
72. Sajdyk T.J., Schober D.A., Smiley D.L., Gehlert D.R. Neuropeptide Y-Y2 receptors mediate anxiety in the amygdala. Pharmacol. Biochem. Behav. 2002, 71:419-423.
73. Sajdyk T.J., Shekhar A., Gehlert D.R. Interactions between NPY and CRF in the amygdala to regulate emotionality. Neuropeptides 2004, 38:225-234.
74. Serova L.I., Tillinger A., Alaluf L.G., Laukova M., Keegan K., Sabban E.L. Single intranasal neuropeptide Y infusion attenuates development of PTSD-like symptoms to traumatic stress in rats. Neuroscience 2013, 236:298-312.
75. Serova L., Laukova M., Alaluf L., Pucillo L., Sabban E. Intranasal neuropeptide Y reverses anxiety and depressive-like behavior impaired by single prolonged stress PTSD model. Euro. Neuropsychopharmacology 2014, 24:142-147.
76. Shoblock J.R., Welty N., Nepomuceno D., et al. In vitro and in vivo characterization of JNJ-31020028 (N-(4-4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor. Psychopharmacology 2010, 208:265-277.
77. Suda T., Tozawa F., Iwai I., Sato Y., Sumitomo T., Nakano Y., Yamada M., Demura H. Neuropeptide Y increases the corticotropin-releasing factor messenger ribonucleic acid level in the rat hypothalamus. Brain Res. Mol. Brain Res. 1993, 18:311-315.
78. Sweerts B.W., Jarrott B., Lawrence A.J. The effect of acute and chronic restraint on the central expression of prepro-neuropeptide Y mRNA in normotensive and hypertensive rats. J. Neuroendocrinol. 2001, 13:608-617.
79. Thorne R.G., Emory C.R., Ala T.A., Frey W.H. Quantitative analysis of the olfactory pathway for drug delivery to the brain. Brain Res. 1995, 692:278-282.
80. Thorne R.G., Pronk G.J., Padmanabhan V., Frey W.H. Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration. Neuroscience 2004, 127:481-496.
81. Thorsell A. Brain neuropeptide Y and corticotropin-releasing hormone in mediating stress and anxiety. Exp. Biol. Med. (Maywood) 2010, 235:1163-1167.
82. Thorsell A., Svensson P., Wiklund L., Sommer W., Ekman R., Heilig M. Suppressed neuropeptide Y (NPY) mRNA in rat amygdala following restraint stress. Regul. Pept. 1998, 75-76:247-254.
83. Thorsell A., Carlsson K., Ekman R., Heilig M. Behavioral and endocrine adaptation, and up-regulation of NPY expression in rat amygdala following repeated restraint stress. Neuroreport 1999, 10:3003-3007.
84. Thorsell A., Michalkiewicz M., Dumont Y., Quirion R., Caberlotto L., Rimondini R., Mathé A.A., Heilig M. Behavioral insensitivity to restraint stress, absent fear suppression of behavior and impaired spatial learning in transgenic rats with hippocampal neuropeptide Y overexpression. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:12852-12857.
85. Valentino R.J., Van Bockstaele E. Convergent regulation of locus coeruleus activity as an adaptive response to stress. Eur. J. Pharmacol. 2008.
86. Wahlestedt C., Skagerberg G., Ekman R., Heilig M., Sundler F., Håkanson R. Neuropeptide Y (NPY) in the area of the hypothalamic paraventricular nucleus activates the pituitary-adrenocortical axis in the rat. Brain Res. 1987, 417:33-38.
87. Wu G., Feder A., Wegener G., Bailey C., Saxena S., Charney D., Mathé A.A. Central functions of neuropeptide Y in mood and anxiety disorders. Expert Opin. Ther. Targets 2011, 15:1317-1331.
88. Yehuda R., Brand S., Yang R.K. Plasma neuropeptide Y concentrations in combat exposed veterans: relationship to trauma exposure, recovery from PTSD, and coping. Biol. Psychiatry 2006, 59:660-663.
89. Zhou Z., Zhu G., Hariri A.R., et al. Genetic variation in human NPY expression affects stress response and emotion. Nature 2008, 452:997-1001.
90. Zukowska-Grojec Z. Neuropeptide Y. A novel sympathetic stress hormone and more. Ann. N. Y. Acad. Sci. 1995, 771:219-233.