DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1857, Issue 8, 2016, Pages 1267-1276

  Oettinghaus, Björn ^a   D'Alonzo, Donato ^a   Barbieri, Elisa ^b   Restelli, Lisa Michelle ^a   Savoia, Claudia ^b   Licci, Maria ^a,c   Tolnay, Markus ^a   Frank, Stephan ^a   Scorrano, Luca ^b,d  

^a UNIVERSITY HOSPITAL BASEL   (Switzerland)

^b UNIVERSITY OF PADOVA   (Italy)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d VENETIAN INSTITUTE OF MOLECULAR MEDICINE   (Italy)

Author keywords

Apoptosis; Apoptosome; Bax Bak; Cristae remodeling; Cytochrome c release; Mitochondrial fission

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE; CYTOCHROME C; DYNAMIN RELATED PROTEIN 1; GUANINE NUCLEOTIDE BINDING PROTEIN; HYDROGEN PEROXIDE; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID; STAUROSPORINE; THAPSIGARGIN; UNCLASSIFIED DRUG; APAF1 PROTEIN, MOUSE; BAK1 PROTEIN, MOUSE; BAX PROTEIN, MOUSE; BID PROTEIN, MOUSE; DNM1L PROTEIN, MOUSE; DYNAMIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DEATH; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL PROTECTION; CELL ULTRASTRUCTURE; FIBROBLAST; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; OUTER MEMBRANE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SECRETION; ANIMAL; CYTOLOGY; DEFICIENCY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRIAL DYNAMICS; MOUSE; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CELL LINE; CYTOCHROMES C; DYNAMINS; FIBROBLASTS; GENE EXPRESSION REGULATION; HYDROGEN PEROXIDE; MICE; MICE, KNOCKOUT; MITOCHONDRIAL DYNAMICS; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; STAUROSPORINE; THAPSIGARGIN;

EID: 84961900214     PISSN: 00052728     EISSN: 18792650     Source Type: Journal    
DOI: 10.1016/j.bbabio.2016.03.016     Document Type: Article

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