-
1
-
-
33846472391
-
Fifteen-year cumulative incidence of age-related macular degeneration: The Beaver Dam Eye Study
-
Klein, R. et al. Fifteen-year cumulative incidence of age-related macular degeneration: the Beaver Dam Eye Study. Ophthalmology. 114, 253-262 (2007).
-
(2007)
Ophthalmology
, vol.114
, pp. 253-262
-
-
Klein, R.1
-
2
-
-
78650938849
-
Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration
-
Karunadharma, P. P., Nordgaard, C. L., Olsen, T. W. & Ferrington, D. A. Mitochondrial DNA damage as a potential mechanism for age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 51, 5470-5479 (2010).
-
(2010)
Invest. Ophthalmol. Vis. Sci
, vol.51
, pp. 5470-5479
-
-
Karunadharma, P.P.1
Nordgaard, C.L.2
Olsen, T.W.3
Ferrington, D.A.4
-
3
-
-
80051749739
-
Mitochondrial DNA damage and repair in RPE associated with aging and age-related macular degeneration
-
Lin, H. et al. Mitochondrial DNA damage and repair in RPE associated with aging and age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 52, 3521-3529 (2011).
-
(2011)
Invest. Ophthalmol. Vis. Sci
, vol.52
, pp. 3521-3529
-
-
Lin, H.1
-
4
-
-
84929353725
-
Investigating mitochondria as a target for treating age-related macular degeneration
-
Terluk, M. R. et al. Investigating mitochondria as a target for treating age-related macular degeneration. J. Neurosci. 35, 7304-7311 (2015).
-
(2015)
J. Neurosci
, vol.35
, pp. 7304-7311
-
-
Terluk, M.R.1
-
5
-
-
0036355070
-
Measuring oxidative mtDNA damage and repair using quantitative PCR
-
Santos, J. H., Mandavilli, B. S. & Van Houten, B. Measuring oxidative mtDNA damage and repair using quantitative PCR. Methods Mol. Biol. 197, 159-176 (2002).
-
(2002)
Methods Mol. Biol
, vol.197
, pp. 159-176
-
-
Santos, J.H.1
Mandavilli, B.S.2
Van Houten, B.3
-
6
-
-
67651097456
-
In Current Protocols in Human Genetics
-
Kovalenko, O. A. & Santos, J. H. In Current Protocols in Human Genetics. Suppl. 62, 19.1.1-19.1.13 (2009).
-
(2009)
Suppl
, vol.62
, pp. 1911-19113
-
-
Kovalenko, O.A.1
Santos, J.H.2
-
7
-
-
0031032817
-
Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
-
Yakes, F. M. & Van Houten, B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl. Acad. Sci. USA 94, 514-519 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 514-519
-
-
Yakes, F.M.1
Van Houten, B.2
-
8
-
-
0021118509
-
Transcription of the mammalian mitochondrial genome
-
Clayton, D. A. Transcription of the mammalian mitochondrial genome. Annu. Rev. Biochem. 53, 573-594 (1984).
-
(1984)
Annu. Rev. Biochem
, vol.53
, pp. 573-594
-
-
Clayton, D.A.1
-
9
-
-
0036591855
-
Free radical-induced damage to DNA: Mechanisms and measurement
-
Dizdaroglu, M., Jaruga, P., Birincioglu, M. & Rodriguez, H. Free radical-induced damage to DNA: mechanisms and measurement. Free Radic. Biol. Med. 32, 1102-1115 (2002).
-
(2002)
Free Radic. Biol. Med
, vol.32
, pp. 1102-1115
-
-
Dizdaroglu, M.1
Jaruga, P.2
Birincioglu, M.3
Rodriguez, H.4
-
10
-
-
33646839960
-
Genetic effects of oxidative DNA damages: Comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells
-
Kalam, M. A. et al. Genetic effects of oxidative DNA damages: comparative mutagenesis of the imidazole ring-opened formamidopyrimidines (Fapy lesions) and 8-oxo-purines in simian kidney cells. Nucleic Acids Res. 34, 2305-2315 (2006).
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 2305-2315
-
-
Kalam, M.A.1
-
11
-
-
0034597669
-
Simultaneous measurement of 8-oxo-2-deoxyguanosine and 8-oxo-2-deoxyadenosine by HPLC-MS/MS
-
Podmore, I. D., Cooper, D., Evans, M. D., Wood, M. & Lunec, J. Simultaneous measurement of 8-oxo-2-deoxyguanosine and 8-oxo-2-deoxyadenosine by HPLC-MS/MS. Biochem. Biophys. Res. Commun. 277, 764-770 (2000).
-
(2000)
Biochem. Biophys. Res. Commun
, vol.277
, pp. 764-770
-
-
Podmore, I.D.1
Cooper, D.2
Evans, M.D.3
Wood, M.4
Lunec, J.5
-
12
-
-
0035313577
-
Measurement of 8-oxo-2-deoxyguanosine and 8-oxo-2-deoxyadenosine in DNA and human urine by high performance liquid chromatography-electrospray tandem mass spectrometry
-
Weimann, A., Belling, D. & Poulsen, H. E. Measurement of 8-oxo-2-deoxyguanosine and 8-oxo-2-deoxyadenosine in DNA and human urine by high performance liquid chromatography-electrospray tandem mass spectrometry. Free Radic. Biol. Med. 30, 757-764 (2001).
-
(2001)
Free Radic. Biol. Med
, vol.30
, pp. 757-764
-
-
Weimann, A.1
Belling, D.2
Poulsen, H.E.3
-
13
-
-
34248632229
-
Effects of environmental air pollution on endogenous oxidative DNA damage in humans
-
Singh, R. et al. Effects of environmental air pollution on endogenous oxidative DNA damage in humans. Mutat. Res. 620, 71-82 (2007).
-
(2007)
Mutat. Res
, vol.620
, pp. 71-82
-
-
Singh, R.1
-
14
-
-
66649095844
-
Glutathione depletion by buthionine sulfoximine induces oxidative damage to DNA in organs of rabbits in vivo
-
Gokce, G. et al. Glutathione depletion by buthionine sulfoximine induces oxidative damage to DNA in organs of rabbits in vivo. Biochemistry. 48, 4980-4987 (2009).
-
(2009)
Biochemistry
, vol.48
, pp. 4980-4987
-
-
Gokce, G.1
-
15
-
-
0034867530
-
An improved (32)P-postlabeling assay for the sensitive detection of 8-oxodeoxyguanosine in tissue DNA
-
Gupta, R. C. & Arif, J. M. An improved (32)P-postlabeling assay for the sensitive detection of 8-oxodeoxyguanosine in tissue DNA. Chem. Res. Toxicol. 14, 951-957 (2001).
-
(2001)
Chem. Res. Toxicol.
, vol.14
, pp. 951-957
-
-
Gupta, R.C.1
Arif, J.M.2
-
16
-
-
0037462609
-
Determination of 8-hydroxy-2-deoxyguanosine in untreated urine by capillary electrophoresis with UV detection
-
Kvasnicova, V., Samcova, E., Jursova, A. & Jelinek, I. Determination of 8-hydroxy-2-deoxyguanosine in untreated urine by capillary electrophoresis with UV detection. J. Chromatogr. A. 985, 513-517 (2003).
-
(2003)
J. Chromatogr. A
, vol.985
, pp. 513-517
-
-
Kvasnicova, V.1
Samcova, E.2
Jursova, A.3
Jelinek, I.4
-
17
-
-
2942738870
-
A high-throughput and sensitive methodology for the quantification of urinary 8-hydroxy-2-deoxyguanosine: Measurement with gas chromatography-mass spectrometry after single solid-phase extraction
-
Lin, H. S. et al. A high-throughput and sensitive methodology for the quantification of urinary 8-hydroxy-2-deoxyguanosine: measurement with gas chromatography-mass spectrometry after single solid-phase extraction. Biochem. J. 380, 541-548 (2004).
-
(2004)
Biochem. J
, vol.380
, pp. 541-548
-
-
Lin, H.S.1
-
18
-
-
84908119442
-
Analysis of a malondialdehyde-deoxyguanosine adduct in human leukocyte DNA by liquid chromatography nanoelectrospray-high-resolution tandem mass spectrometry
-
Ma, B., Villalta, P. W., Balbo, S. & Stepanov, I. Analysis of a malondialdehyde-deoxyguanosine adduct in human leukocyte DNA by liquid chromatography nanoelectrospray-high-resolution tandem mass spectrometry. Chem. Res. Toxicol. 27, 1829-1836 (2014).
-
(2014)
Chem. Res. Toxicol
, vol.27
, pp. 1829-1836
-
-
Ma, B.1
Villalta, P.W.2
Balbo, S.3
Stepanov, I.4
-
19
-
-
0037487098
-
Effect of different solution flow rates on analyte ion signals in nano-ESI MS, or: When does ESI turn into nano-ESI J
-
Schmidt, A., Karas, M. & Dulcks, T. Effect of different solution flow rates on analyte ion signals in nano-ESI MS, or: when does ESI turn into nano-ESI J. Am. Soc. Mass Spectrom. 14, 492-500 (2003).
-
(2003)
Am. Soc. Mass Spectrom
, vol.14
, pp. 492-500
-
-
Schmidt, A.1
Karas, M.2
Dulcks, T.3
-
20
-
-
0032775166
-
Mitochondrial mutagenesis in human cells and tissues
-
Marcelino, L. A. & Thilly, W. G. Mitochondrial mutagenesis in human cells and tissues. Mutat. Res. 434, 177-203 (1999).
-
(1999)
Mutat. Res
, vol.434
, pp. 177-203
-
-
Marcelino, L.A.1
Thilly, W.G.2
-
21
-
-
38149019198
-
Prevention of artifactual oxidation in determination of cellular 8-oxo-7,8-dihydro-2-deoxyguanosine by isotope-dilution LC-MS/MS with automated solid-phase extraction
-
Chao, M. R., Yen, C. C. & Hu, C. W. Prevention of artifactual oxidation in determination of cellular 8-oxo-7,8-dihydro-2-deoxyguanosine by isotope-dilution LC-MS/MS with automated solid-phase extraction. Free Radic. Biol. Med. 44, 464-473 (2008).
-
(2008)
Free Radic. Biol. Med
, vol.44
, pp. 464-473
-
-
Chao, M.R.1
Yen, C.C.2
Hu, C.W.3
-
22
-
-
0037234459
-
An improved liquid chromatography/tandem mass spectrometry method for the determination of 8-oxo-7,8-dihydro-2-deoxyguanosine in DNA samples using immunoaffinity column purification
-
Singh, R., McEwan, M., Lamb, J. H., Santella, R. M. & Farmer, P. B. An improved liquid chromatography/tandem mass spectrometry method for the determination of 8-oxo-7,8-dihydro-2-deoxyguanosine in DNA samples using immunoaffinity column purification. Rapid Commun. Mass Spectrom. 17, 126-134 (2003).
-
(2003)
Rapid Commun. Mass Spectrom
, vol.17
, pp. 126-134
-
-
Singh, R.1
McEwan, M.2
Lamb, J.H.3
Santella, R.M.4
Farmer, P.B.5
-
23
-
-
0032544392
-
Isotope dilution high-performance liquid chromatography-electrospray tandem mass spectrometry assay for the measurement of 8-oxo-7,8-dihydro-2-deoxyguanosine in biological samples
-
Ravanat, J. L., Duretz, B., Guiller, A., Douki, T. & Cadet, J. Isotope dilution high-performance liquid chromatography-electrospray tandem mass spectrometry assay for the measurement of 8-oxo-7,8-dihydro-2-deoxyguanosine in biological samples. J. Chromatogr. B. Biomed. Sci. Appl. 715, 349-356 (1998).
-
(1998)
J. Chromatogr. B. Biomed. Sci. Appl
, vol.715
, pp. 349-356
-
-
Ravanat, J.L.1
Duretz, B.2
Guiller, A.3
Douki, T.4
Cadet, J.5
-
24
-
-
62249112082
-
Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
-
Stepanov, I. & Hecht, S. S. Mitochondrial DNA adducts in the lung and liver of F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and (S)-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chem. Res. Toxicol. 22, 406-414 (2009).
-
(2009)
Chem. Res. Toxicol
, vol.22
, pp. 406-414
-
-
Stepanov, I.1
Hecht, S.S.2
-
25
-
-
84878619863
-
Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease
-
Santos, R. X. et al. Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease. Antioxid. Redox Signal. 18, 2444-2457 (2013).
-
(2013)
Antioxid. Redox Signal
, vol.18
, pp. 2444-2457
-
-
Santos, R.X.1
-
26
-
-
0037452679
-
Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations
-
Mambo, E. et al. Electrophile and oxidant damage of mitochondrial DNA leading to rapid evolution of homoplasmic mutations. Proc. Natl. Acad. Sci. USA 100, 1838-1843 (2003).
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 1838-1843
-
-
Mambo, E.1
-
27
-
-
0030842414
-
Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain
-
Mecocci, P. et al. Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain. Mol. Chem. Neuropathol. 31, 53-64 (1997).
-
(1997)
Mol. Chem. Neuropathol
, vol.31
, pp. 53-64
-
-
Mecocci, P.1
-
28
-
-
0033972463
-
Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals
-
Barja, G. & Herrero, A. Oxidative damage to mitochondrial DNA is inversely related to maximum life span in the heart and brain of mammals. FASEB J. 14, 312-318 (2000).
-
(2000)
FASEB J
, vol.14
, pp. 312-318
-
-
Barja, G.1
Herrero, A.2
-
29
-
-
33947166345
-
Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
-
Lao, Y., Yu, N., Kassie, F., Villalta, P. W. & Hecht, S. S. Formation and accumulation of pyridyloxobutyl DNA adducts in F344 rats chronically treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol. Chem. Res. Toxicol. 20, 235-245 (2007).
-
(2007)
Chem. Res. Toxicol
, vol.20
, pp. 235-245
-
-
Lao, Y.1
Yu, N.2
Kassie, F.3
Villalta, P.W.4
Hecht, S.S.5
-
30
-
-
0024352214
-
The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: Cryptic signals revealed by comparative analysis between vertebrates
-
Gadaleta, G. et al. The complete nucleotide sequence of the Rattus norvegicus mitochondrial genome: cryptic signals revealed by comparative analysis between vertebrates. J. Mol. Evol. 28, 497-516 (1989).
-
(1989)
J. Mol. Evol
, vol.28
, pp. 497-516
-
-
Gadaleta, G.1
-
31
-
-
74049108269
-
Analysis of 8-oxo-7,8-dihydro-2-deoxyguanosine by ultra high pressure liquid chromatography-heat assisted electrospray ionization-tandem mass spectrometry
-
Boysen, G. et al. Analysis of 8-oxo-7,8-dihydro-2-deoxyguanosine by ultra high pressure liquid chromatography-heat assisted electrospray ionization-tandem mass spectrometry. J. Chromatogr. B. Biomed. Sci. Appl. 878, 375-380 (2010).
-
(2010)
J. Chromatogr. B. Biomed. Sci. Appl
, vol.878
, pp. 375-380
-
-
Boysen, G.1
-
32
-
-
0003484310
-
-
U.S. Food and Drug Administration Available at (Accessed: 4th November 2015
-
U.S. Food and Drug Administration, Guidance for Industry: Bioanalytical Method Validation (2001). Available at: www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm070107.pdf. (Accessed: 4th November 2015).
-
(2001)
Guidance for Industry: Bioanalytical Method Validation
-
-
|