-
1
-
-
79959216005
-
Genetics and pathogenesis of inflammatory bowel disease
-
Khor B, Gardet A, & Xavier R.J. Genetics and pathogenesis of inflammatory bowel disease. Nature. 474, 307-317 (2011).
-
(2011)
Nature
, vol.474
, pp. 307-317
-
-
Khor, B.1
Gardet, A.2
Xavier, R.J.3
-
2
-
-
33344478734
-
Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease
-
Adams D.H, & Eksteen B. Aberrant homing of mucosal T cells and extra-intestinal manifestations of inflammatory bowel disease. Nat. Rev. Immunol. 6, 244-251 (2006).
-
(2006)
Nat. Rev. Immunol
, vol.6
, pp. 244-251
-
-
Adams, D.H.1
Eksteen, B.2
-
3
-
-
0034122116
-
Phagocytosis, killing, lymphocyte-mediated antibacterial activity, serum autoantibodies, and plasma endotoxins in inflammatory bowel disease
-
Caradonna L, Amati L, Lella P, Jirillo E, & Caccavo D. Phagocytosis, killing, lymphocyte-mediated antibacterial activity, serum autoantibodies, and plasma endotoxins in inflammatory bowel disease. Am. J. Gastroenterol. 95, 1495-1502 (2000).
-
(2000)
Am. J. Gastroenterol
, vol.95
, pp. 1495-1502
-
-
Caradonna, L.1
Amati, L.2
Lella, P.3
Jirillo, E.4
Caccavo, D.5
-
4
-
-
23344446570
-
Intestinal macrophages: Unique effector cells of the innate immune system
-
Smith P.D, Ochsenbauer-Jambor C, & Smythies L.E. Intestinal macrophages: unique effector cells of the innate immune system. Immunol. Rev. 206, 149-159 (2005).
-
(2005)
Immunol. Rev
, vol.206
, pp. 149-159
-
-
Smith, P.D.1
Ochsenbauer-Jambor, C.2
Smythies, L.E.3
-
5
-
-
84862297537
-
Dextran sodium sulphate colitis mouse model: Traps and tricks
-
Perse M, & Cerar A. Dextran sodium sulphate colitis mouse model: traps and tricks. J. Biomed. Biotechnol. 2012, 718617 (2012).
-
(2012)
J. Biomed. Biotechnol
, vol.2012
, pp. 718617
-
-
Perse, M.1
Cerar, A.2
-
6
-
-
0025181580
-
A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
-
Okayasu I, et al. A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology. 98, 694-702 (1990).
-
(1990)
Gastroenterology
, vol.98
, pp. 694-702
-
-
Okayasu, I.1
-
7
-
-
84870900504
-
Ly6C(hi) monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells
-
Zigmond E, et al. Ly6C(hi) monocytes in the inflamed colon give rise to proinflammatory effector cells and migratory antigen-presenting cells. Immunity. 37, 1076-1090 (2012).
-
(2012)
Immunity
, vol.37
, pp. 1076-1090
-
-
Zigmond, E.1
-
8
-
-
0034133163
-
The key role of macrophages in the immunopathogenesis of inflammatory bowel disease
-
Mahida Y.R. The key role of macrophages in the immunopathogenesis of inflammatory bowel disease. Inflamm. Bowel Dis. 6, 21-33 (2000).
-
(2000)
Inflamm. Bowel Dis
, vol.6
, pp. 21-33
-
-
Mahida, Y.R.1
-
9
-
-
84921313153
-
Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice.Nat
-
Bain C.C, et al. Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice.Nat. Immunol. 15, 929-937 (2014).
-
(2014)
Immunol
, vol.15
, pp. 929-937
-
-
Bain, C.C.1
-
10
-
-
0030995158
-
Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel disease
-
Rugtveit J, et al. Cytokine profiles differ in newly recruited and resident subsets of mucosal macrophages from inflammatory bowel disease. Gastroenterology. 112, 1493-1505 (1997).
-
(1997)
Gastroenterology
, vol.112
, pp. 1493-1505
-
-
Rugtveit, J.1
-
11
-
-
34948821265
-
TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases
-
Schenk M, Bouchon A, Seibold F, & Mueller C. TREM-1-expressing intestinal macrophages crucially amplify chronic inflammation in experimental colitis and inflammatory bowel diseases. J. Clin. Invest. 117, 3097-3106 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, pp. 3097-3106
-
-
Schenk, M.1
Bouchon, A.2
Seibold, F.3
Mueller, C.4
-
12
-
-
84876800337
-
Macrophage biology in development, homeostasis and disease
-
Wynn T.A, Chawla A, & Pollard J.W. Macrophage biology in development, homeostasis and disease. Nature. 496, 445-455 (2013).
-
(2013)
Nature
, vol.496
, pp. 445-455
-
-
Wynn, T.A.1
Chawla, A.2
Pollard, J.W.3
-
13
-
-
77956128040
-
Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome
-
Bauer C, et al. Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome. Gut. 59, 1192-1199 (2010).
-
(2010)
Gut
, vol.59
, pp. 1192-1199
-
-
Bauer, C.1
-
14
-
-
84877795283
-
An entirely automated method to score DSS-induced colitis in mice by digital image analysis of pathology slides
-
Kozlowski C, et al. An entirely automated method to score DSS-induced colitis in mice by digital image analysis of pathology slides. Dis. Model Mech. 6, 855-865 (2013).
-
(2013)
Dis. Model Mech
, vol.6
, pp. 855-865
-
-
Kozlowski, C.1
-
15
-
-
70350343544
-
Induction of intestinal Th17 cells by segmented filamentous bacteria
-
Ivanov I.I, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell. 139, 485-498 (2009).
-
(2009)
Cell
, vol.139
, pp. 485-498
-
-
Ivanov, I.I.1
-
16
-
-
84861318436
-
Targeting leukocyte migration and adhesion in Crohn's disease and ulcerative colitis
-
Thomas S, & Baumgart D.C. Targeting leukocyte migration and adhesion in Crohn's disease and ulcerative colitis. Inflammopharmacology. 20, 1-18 (2012).
-
(2012)
Inflammopharmacology
, vol.20
, pp. 1-18
-
-
Thomas, S.1
Baumgart, D.C.2
-
17
-
-
78650724558
-
Cation-pi interaction regulates ligand-binding affinity and signaling of integrin alpha4beta7
-
Pan Y, et al. Cation-pi interaction regulates ligand-binding affinity and signaling of integrin alpha4beta7. Proc. Natl Acad. Sci. USA. 107, 21388-21393 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 21388-21393
-
-
Pan, Y.1
-
18
-
-
0031092633
-
Monoclonal antibodies specific for beta(7) integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RB(high) CD4(+) T cells
-
Picarella D, et al. Monoclonal antibodies specific for beta(7) integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RB(high) CD4(+) T cells. J. Immunol. 158, 2099-2106 (1997).
-
(1997)
J. Immunol
, vol.158
, pp. 2099-2106
-
-
Picarella, D.1
-
19
-
-
79953067215
-
A humanized monoclonal antibody targeting the beta7 integrin selectively blocks intestinal homing of T lymphocytes
-
Stefanich E.G, et al. A humanized monoclonal antibody targeting the beta7 integrin selectively blocks intestinal homing of T lymphocytes. Br. J. Pharmacol. 162, 1855-1870 (2011).
-
(2011)
Br. J. Pharmacol
, vol.162
, pp. 1855-1870
-
-
Stefanich, E.G.1
-
20
-
-
78149484171
-
Beta7 integrin deficiency suppresses B cell homing and attenuates chronic ileitis in SAMP1/YitFc mice
-
Gorfu G, et al. Beta7 integrin deficiency suppresses B cell homing and attenuates chronic ileitis in SAMP1/YitFc mice. J. Immunol. 185, 5561-5568 (2010).
-
(2010)
J. Immunol
, vol.185
, pp. 5561-5568
-
-
Gorfu, G.1
-
21
-
-
20444469332
-
Treatment of ulcerative colitiswith a humanized antibody to the alpha4beta7 integrin
-
Feagan, B.G, et al. Treatment of ulcerative colitiswith a humanized antibody to the alpha4beta7 integrin. N. Engl. J. Med. 352, 2499-2507 (2005).
-
(2005)
N. Engl. J. Med
, vol.352
, pp. 2499-2507
-
-
Feagan, B.G.1
-
22
-
-
84880254401
-
A randomised phase i study of etrolizumab (rhuMAb beta7) in moderate to severe ulcerative colitis
-
Rutgeerts P.J, et al. A randomised phase I study of etrolizumab (rhuMAb beta7) in moderate to severe ulcerative colitis. Gut. 62, 1122-1130 (2013).
-
(2013)
Gut
, vol.62
, pp. 1122-1130
-
-
Rutgeerts, P.J.1
-
23
-
-
84904857048
-
Etrolizumab as induction therapy for ulcerative colitis: A randomised, controlled, phase 2 trial
-
Vermeire S, et al. Etrolizumab as induction therapy for ulcerative colitis: a randomised, controlled, phase 2 trial. Lancet. 384, 309-318 (2014).
-
(2014)
Lancet
, vol.384
, pp. 309-318
-
-
Vermeire, S.1
-
24
-
-
0029665856
-
Critical role for beta7 integrins in formation of the gutassociated lymphoid tissue
-
Wagner N, et al. Critical role for beta7 integrins in formation of the gutassociated lymphoid tissue. Nature. 382, 366-370 (1996).
-
(1996)
Nature
, vol.382
, pp. 366-370
-
-
Wagner, N.1
-
25
-
-
81255158784
-
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner
-
Ramirez-Carrozzi V, et al. IL-17C regulates the innate immune function of epithelial cells in an autocrine manner. Nat. Immunol. 12, 1159-1166 (2011).
-
(2011)
Nat. Immunol
, vol.12
, pp. 1159-1166
-
-
Ramirez-Carrozzi, V.1
-
26
-
-
25444461358
-
Involvement of innate immunity in the development of inflammatory and autoimmune diseases
-
Tlaskalova-Hogenova H, et al. Involvement of innate immunity in the development of inflammatory and autoimmune diseases. Ann. N Y Acad. Sci. 1051, 787-798 (2005).
-
(2005)
Ann. N y Acad. Sci
, vol.1051
, pp. 787-798
-
-
Tlaskalova-Hogenova, H.1
-
27
-
-
0036786219
-
ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease
-
Rijcken E, et al. ICAM-1 and VCAM-1 antisense oligonucleotides attenuate in vivo leucocyte adherence and inflammation in rat inflammatory bowel disease. Gut. 51, 529-535 (2002).
-
(2002)
Gut
, vol.51
, pp. 529-535
-
-
Rijcken, E.1
-
28
-
-
0030017256
-
Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion
-
Huang G.T, Eckmann L, Savidge T.C, & Kagnoff M.F. Infection of human intestinal epithelial cells with invasive bacteria upregulates apical intercellular adhesion molecule-1 (ICAM)-1) expression and neutrophil adhesion. J. Clin. Invest. 98, 572-583 (1996).
-
(1996)
J. Clin. Invest
, vol.98
, pp. 572-583
-
-
Huang, G.T.1
Eckmann, L.2
Savidge, T.C.3
Kagnoff, M.F.4
-
29
-
-
0033851841
-
Comparative studies of the colonic in situ expression of intercellular adhesion molecules (ICAM-1, -2, and -3), beta2 integrins (LFA-1, Mac-1, and p150, 95), and PECAM-1 in ulcerative colitis and Crohn's disease
-
Vainer B, Nielsen O.H, & Horn T. Comparative studies of the colonic in situ expression of intercellular adhesion molecules (ICAM-1, -2, and -3), beta2 integrins (LFA-1, Mac-1, and p150, 95), and PECAM-1 in ulcerative colitis and Crohn's disease. Am. J. Surg. Pathol. 24, 1115-1124 (2000).
-
(2000)
Am. J. Surg. Pathol
, vol.24
, pp. 1115-1124
-
-
Vainer, B.1
Nielsen, O.H.2
Horn, T.3
-
30
-
-
48749130978
-
Glucosamine suppresses interleukin-8 production and ICAM-1 expression by TNFalpha-stimulated human colonic epithelial HT-29 cells
-
Yomogida S, Hua J, Sakamoto K, & Nagaoka I. Glucosamine suppresses interleukin-8 production and ICAM-1 expression by TNFalpha-stimulated human colonic epithelial HT-29 cells. Int. J. Mol. Med. 22, 205-211 (2008).
-
(2008)
Int. J. Mol. Med
, vol.22
, pp. 205-211
-
-
Yomogida, S.1
Hua, J.2
Sakamoto, K.3
Nagaoka, I.4
-
31
-
-
33644602142
-
Colonic epithelial cell expression of ICAM-1 relates to loss of surface continuity: A comparative study of inflammatory bowel disease and colonic neoplasms
-
Vainer B, Horn T, & Nielsen O.H. Colonic epithelial cell expression of ICAM-1 relates to loss of surface continuity: a comparative study of inflammatory bowel disease and colonic neoplasms. Scand. J. Gastroenterol. 41, 318-325 (2006).
-
(2006)
Scand. J. Gastroenterol
, vol.41
, pp. 318-325
-
-
Vainer, B.1
Horn, T.2
Nielsen, O.H.3
-
32
-
-
78649557780
-
Efficient Treg depletion induces T-cell infiltration and rejection of large tumors
-
Li X, Kostareli E, Suffner J, Garbi N, & Hammerling G.J. Efficient Treg depletion induces T-cell infiltration and rejection of large tumors. Eur. J. Immunol. 40, 3325-3335 (2010).
-
(2010)
Eur. J. Immunol
, vol.40
, pp. 3325-3335
-
-
Li, X.1
Kostareli, E.2
Suffner, J.3
Garbi, N.4
Hammerling, G.J.5
-
33
-
-
34548564632
-
In vitro generation ofCD4+CD25+regulatory cells from murine naive Tcells
-
Fantini M.C, Dominitzki S, Rizzo A, Neurath M.F, & Becker C. In vitro generation ofCD4+CD25+regulatory cells from murine naive Tcells. Nat. Protoc. 2, 1789-1794 (2007).
-
(2007)
Nat. Protoc
, vol.2
, pp. 1789-1794
-
-
Fantini, M.C.1
Dominitzki, S.2
Rizzo, A.3
Neurath, M.F.4
Becker, C.5
-
34
-
-
85027091098
-
Synthesis and activity of new aryl- and heteroarylsubstituted 5, 6-dihydro-4H-pyrrolo[1, 2-B]pyrazole inhibitors of the transforming growth factor-beta type i receptor kinase domain
-
Sawyer J.S, et al. Synthesis and activity of new aryl- And heteroarylsubstituted 5, 6-dihydro-4H-pyrrolo[1, 2-B]pyrazole inhibitors of the transforming growth factor-beta type I receptor kinase domain. Abstr. Pap. Am. Chem. S. 226, U13-U13 (2003).
-
(2003)
Abstr. Pap. Am. Chem. S
, vol.226
, pp. U13-U13
-
-
Sawyer, J.S.1
-
35
-
-
16644376635
-
Isolation and culture of murine macrophages
-
Davies J.Q, & Gordon S. Isolation and culture of murine macrophages. Methods Mol. Biol. 290, 91-103 (2005).
-
(2005)
Methods Mol. Biol
, vol.290
, pp. 91-103
-
-
Davies, J.Q.1
Gordon, S.2
-
36
-
-
84860580137
-
Adoptive transfer with in vitro expanded human regulatory Tcells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice
-
Yi S, et al. Adoptive transfer with in vitro expanded human regulatory Tcells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice. Diabetes. 61, 1180-1191 (2012).
-
(2012)
Diabetes
, vol.61
, pp. 1180-1191
-
-
Yi, S.1
-
37
-
-
84905594747
-
Beta 7 integrins are required to give rise to intestinal mononuclear phagocytes with tolerogenic potential
-
Villablanca E.J, et al. Beta 7 integrins are required to give rise to intestinal mononuclear phagocytes with tolerogenic potential. Gut. 63, 1431-1440 (2014).
-
(2014)
Gut
, vol.63
, pp. 1431-1440
-
-
Villablanca, E.J.1
-
38
-
-
20444414184
-
Cutting edge: CD4(+)CD25(+) for intestinal homing can regulatory T cells impaired prevent colitis
-
Denning T.L, Kim G, & Kronenberg M. Cutting edge: CD4(+)CD25(+) for intestinal homing can regulatory T cells impaired prevent colitis. J. Immunol. 174, 7487-7491 (2005).
-
(2005)
J. Immunol
, vol.174
, pp. 7487-7491
-
-
Denning, T.L.1
Kim, G.2
Kronenberg, M.3
-
39
-
-
0842324613
-
Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
-
Ogawa A, Andoh A, Araki Y, Bamba T, & Fujiyama Y. Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice. Clin. Immunol. 110, 55-62 (2004).
-
(2004)
Clin. Immunol
, vol.110
, pp. 55-62
-
-
Ogawa, A.1
Andoh, A.2
Araki, Y.3
Bamba, T.4
Fujiyama, Y.5
-
40
-
-
77954143695
-
Innate IL-17-producing cells: The sentinels of the immune system
-
Cua D.J, & Tato C.M. Innate IL-17-producing cells: the sentinels of the immune system. Nat. Rev. Immunol. 10, 479-489 (2010).
-
(2010)
Nat. Rev. Immunol
, vol.10
, pp. 479-489
-
-
Cua, D.J.1
Tato, C.M.2
-
41
-
-
75949084489
-
Methods of inducing inflammatory bowel disease in mice
-
Unit5 58
-
Maxwell J.R, Brown, W.A, Smith C.L, Byrne F.R, & Viney J.L. Methods of inducing inflammatory bowel disease in mice. Curr. Protoc. Pharmacol. Chapter. 5, Unit5 58 (2009).
-
(2009)
Curr. Protoc. Pharmacol. Chapter
, vol.5
-
-
Maxwell, J.R.1
Brown, W.A.2
Smith, C.L.3
Byrne, F.R.4
Viney, J.L.5
-
42
-
-
0032793928
-
Inhibition of dextran sulphate sodium (DSS)-induced colitis in mice by intracolonically administered antibodies against adhesion molecules (endothelial leucocyte adhesion molecule-1 (ELAM-1) or intercellular adhesion molecule-1 (ICAM-1
-
Hamamoto N, et al. Inhibition of dextran sulphate sodium (DSS)-induced colitis in mice by intracolonically administered antibodies against adhesion molecules (endothelial leucocyte adhesion molecule-1 (ELAM-1) or intercellular adhesion molecule-1 (ICAM-1)). Clin. Exp. Immunol. 117, 462-468 (1999).
-
(1999)
Clin. Exp. Immunol
, vol.117
, pp. 462-468
-
-
Hamamoto, N.1
-
43
-
-
38449084962
-
Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue
-
Weigmann B, et al. Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue. Nat. Protoc. 2, 2307-2311 (2007).
-
(2007)
Nat. Protoc
, vol.2
, pp. 2307-2311
-
-
Weigmann, B.1
-
44
-
-
33751343683
-
A general method for bead-enhanced quantitation by flow cytometry
-
Montes M, Jaensson E.A, Rozco A.F, Lewis D.E, & Corry D.B. A general method for bead-enhanced quantitation by flow cytometry. J. Immunol. Methods. 317, 45-55 (2006).
-
(2006)
J. Immunol. Methods
, vol.317
, pp. 45-55
-
-
Montes, M.1
Jaensson, E.A.2
Rozco, A.F.3
Lewis, D.E.4
Corry, D.B.5
-
45
-
-
57349143302
-
Cytotoxic-T-lymphocyte-Associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis
-
Watanabe K, et al. Cytotoxic-T-lymphocyte-Associated antigen 4 blockade abrogates protection by regulatory T cells in a mouse model of microbially induced innate immune-driven colitis. Infect. Immun. 76, 5834-5842 (2008).
-
(2008)
Infect. Immun
, vol.76
, pp. 5834-5842
-
-
Watanabe, K.1
|