Comparative studies of the colonic in situ expression of intercellular adhesion molecules (ICAM-1, -2, and -3), β2 integrins (LFA-1, Mac-1, and p150,95), and PECAM-1 in ulcerative colitis and Crohn's disease

American Journal of Surgical Pathology

Volumn 24, Issue 8, 2000, Pages 1115-1124

  Vainer, Ben ^a   Nielsen, Ole Haagen ^b   Horn, Thomas ^b  

^a GLOSTRUP UNIVERSITY HOSPITAL   (Denmark)

^b NONE

Author keywords

2 Integrins; Colon; Crohn's disease; Immunoelectron microscopy; Immunohistochemistry; Inflammatory bowel disease; Intercellular adhesion molecules; PECAM 1; Ulcerative colitis

Indexed keywords

CD31 ANTIGEN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 2; INTERCELLULAR ADHESION MOLECULE 3;

ARTICLE; COLON MUCOSA; CONTROLLED STUDY; CROHN DISEASE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; LEUKOCYTE MIGRATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; ULCERATIVE COLITIS;

ANTIGENS, CD18; ANTIGENS, CD31; CELL ADHESION MOLECULES; COLITIS, ULCERATIVE; COLON; CROHN DISEASE; EPITHELIAL CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHAXBETA2; LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; MACROPHAGES; NEUTROPHIL INFILTRATION; NEUTROPHILS; T-LYMPHOCYTES;

EID: 0033851841     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200008000-00009     Document Type: Article

References (33)

1. Allan RN, Rhodes JM, Hanauer SB, Keighley MRB, Alexander-Williams J, Fazio VW, eds. Inflammatory Bowel Diseases, 3rd ed. New York, NY: Churchill Livingstone, 1997.
2. Arber N, Berliner S, Hallak A, et al. Increased leukocyte adhesiveness/aggregation is a most useful indicator of disease activity in patients with inflammatory bowel disease. Gut 1995;37:77-80.
3. Balsitis M, Morrell K, Mahida YR, Hawkey CJ. Cell adhesion molecule expression by colonic mucosa in ulcerative colitis. Eur J Gastroenterol Hepatol 1994;6:351-8.
4. 2 Integrin/ICAM expression in Crohn's disease. Clin Immunol Immunopathol 1998; 86:147-60.
5. Binder V. A comparison between clinical state, macroscopic and microscopic appearances of rectal mucosa, and cytologic picture of mucosal exudate in ulcerative colitis. Scand J Gastroenterol 1970; 5:627-32.
6. Burgio VL. Fais S, Boirivant M, Perrone A, Pallone F. Peripheral monocyte and naive T-cell recruitment and activation in Crohn's disease. Gastroenterology 1995;109:1029-38.
7. Cellier C, Patey N, Fromont-Hankard G, et al. In-situ endothelial cell adhesion molecule expression in ulcerative colitis. E-selectin in-situ expression correlates with clinical, endoscopie and histologic activity and outcome. Eur J Gastroenterol Hepatol 1997;9: 1197-203.
8. Colgan SP, Parkos CA, Delp C, Arnaout MA, Madara JL. Neutrophil migration across cultured intestinal epithelial monolayers is modulated by epithelial exposure to IFN-gamma in a highly polarized fashion. J Cell Biol 1993;120:785-98.
9. D'Amelio R, Pallone F, Le Moli S, et al. Humoral inhibition of neutrophil chemotaxis in Crohn's disease. Scand J Immunol 1985; 22:597-602.
10. Dean PA, Ramsey PS, Nelson H. Differential expression of cell adhesion molecules in Crohn's and ulcerative colitis [Abstract]. Gastroenterology 1993;104:A689.
11. Dippold W, Wittig B, Schwaeble W, Mayet W, Meyer zum Büschenfelde K-H. Expression of intercellular adhesion molecule 1 (ICAM-1, CD54) on colonic epithelial cells. Gut 1993;34:1593-7.
12. Grisham MB, Kvietys PR. Role of neutrophils in the pathogenesis of inflammatory bowel disease. In: Allan RN, Rhodes JM, Hanauer SB, Keighley MRB, Alexander-Williams J, Fazio VW, eds. Inflammatory Bowel Disease, 3rd ed. New York, NY: Churchill Livingstone, 1997:73-80.
13. Hogg N. CD11a workshop panel report. In: Kishimoto T, Kikutani H, von dem Borne AEG, et al., eds. Leucocyte Typing VI - White Cell Differentiation Antigens. New York. NY: Garland Publishing, 1997:343-5.
14. Jones SC, Banks RE, Haidar A. Adhesion molecules in inflammatory bowel disease. Gut 1995;36:724-30.
15. Kusugami K, Haruta J, Ieda M, et al. Phenotypic and functional characterization of T-cell lines generated from colonoscopic biopsy specimens in patients with ulcerative colitis. Dig Dis Sci 1995;40:198-210.
16. Kvale D, Krajci P, Brandtzaeg P. Expression and regulation of adhesion molecules ICAM-1 (CD54) and LFA-3 (CD58) in human intestinal epithelial cell lines. Scand J Immunol 1992;35:669-86.
17. Malizia G, Calabrese A, Cottone M, et al. Expression of leukocyte adhesion molecules by mucosal mononuclear phagocytes in inflammatory bowel disease. Gastroenterology 1991;100:150-9.
18. Mishra L, Mishra BB, Harris M, Bayless TM, Muchmore AV. In vitro cell aggregation and cell adhesion molecules in Crohn's disease. Clin Exp Immunol 1994;96:432-6.
19. Nakamura S, Ohtani H, Watanabe Y, et al. In situ expression of the cell adhesion molecules in inflammatory bowel disease: evidence of immunologic activation of vascular endothelial cells. Lab Invest 1993;69:77-85.
20. Nielsen OH, Brynskov J, Vainer B. Increased mucosal concentrations of soluble intercellular adhesion molecule-1 (sICAM-1), sE-selectin, and interleukin-8 in active ulcerative colitis. Dig Dis Sci 1996;41:1780-5.
21. Oshitani N, Campbell A, Kitano A, Kobayashi K, Jewell DP. In situ comparison of phenotypical and functional activity of infiltrating cells in ulcerative colitis mucosa. J Pathol 1996;178:95-9.
22. Oshitani N, Sawa Y, Hara J, et al. Functional and phenotypical activation of leukocytes in inflamed human colonie mucosa. J Gastroenterol Hepatol 1997;12:809-14.
23. Parkos CA, Colgan SP, Diamond MS, et al. Expression and polarization of intercellular adhesion molecule-1 on human intestinal epithelia: consequences for CD11b/CD18-mediated interactions with neutrophils. Mol Med 1996;2:489-505.
24. Petruzzelli L, Maduzia L, Springer TA. Differential requirements for LFA-1 binding to ICAM-1 and LFA-1-mediated cell aggregation. J Immunol 1998;160:4208-16.
25. Pooley N, Ghosh L, Sharon P. Up-regulation of E-selectin and intercellular adhesion molecule-1 differs between Crohn's disease and ulcerative colitis. Dig Dis Sci 1995;40:219-25.
26. Rhodes JM, Potter BJ, Brown DJC, Jewell DP. Serum inhibitors of leukocyte chemotaxis in Crohn's disease and ulcerative colitis. Gastroenterology 1982;82:1327-34.
27. Rogler G, Andus T, Aschenbrenner E, et al. Alterations of the phenotype of colonic macrophages in inflammatory bowel disease. Eur J Gastroenterol Hepatol 1997;9:893-9.
28. Saverymuttu SH, Peters AM, Lavender JP, Chadwick VS, Hodgson HJ. In vivo assessment of granulocyte migration of diseased bowel in Crohn's disease. Gut 1985;26:379-83.
29. Schürmann GM, Aber-Bishop AE, Facer P, et al. Altered expression of cell adhesion molecules in uninvolved gut in inflammatory bowel disease. Clin Exp Immunol 1993;94:341-7.
30. Simmons DL, Walker C, Power C, Pigott R. Molecular cloning of CD31, a putative intercellular adhesion molecule closely related to carcinoembryonic antigen. J Exp Med 1990;171:2147-52.
31. Squarcia O, Fais S, Boirivant M, et al. Phenotypes and spontaneous immunoglobulin production in mononuclear cell suspensions isolated from colonie biopsies of patients with mild active and quiescent ulcerative colitis. Gastroenterol Clin Biol 1991;15:194-8.
32. Wandall JH, Binder V. Leucocyte function in Crohn's disease. Studies on mobilisation using a quantitative skin window technique and on the function of circulating polymorphonuclear leukocytes in vitro. Gut 1982;23:173-80.
33. Wandall JH, Binder V. Leucocyte function in ulcerative colitis. Quantitative leukocyte mobilisation to skin windows and in vitro function of blood leukocytes. Gut 1982;23:758-65.