An entirely automated method to score DSS-induced colitis in mice by digital image analysis of pathology slides

DMM Disease Models and Mechanisms

Volumn 6, Issue 3, 2013, Pages 855-865

  Kozlowski, Cleopatra ^a   Jeet, Surinder ^a   Beyer, Joseph ^a   Guerrero, Steve ^a   Lesch, Justin ^a   Wang, Xiaoting ^a   DeVoss, Jason ^a   Diehl, Lauri ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXTRAN SULFATE;

ALGORITHM; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOMATION; B LYMPHOCYTE; CELL INFILTRATION; COLITIS; COMPUTER PROGRAM; EFFECT SIZE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; INTERNAL CONSISTENCY; MACROPHAGE; META ANALYSIS (TOPIC); MORPHOLOGY; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; SCORING SYSTEM; T LYMPHOCYTE;

ANIMALS; AUTOMATION; CELL MOVEMENT; COLITIS; COLON; DEXTRAN SULFATE; IMAGE PROCESSING, COMPUTER-ASSISTED; INFLAMMATION; INTERLEUKINS; META-ANALYSIS AS TOPIC; MICE; MICE, INBRED C57BL;

EID: 84877795283     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.011759     Document Type: Article

References (23)

1. Abraham, C. and Cho, J. H. (2009). Inflammatory bowel disease. N. Engl. J. Med. 361, 2066-2078.
2. Baatz, M., Zimmermann, J. and Blackmore, C. G. (2009). Automated analysis and detailed quantification of biomedical images using Definiens Cognition Network Technology. Comb. Chem. High Throughput Screen. 12, 908-916.
3. Baatz, M. and Schape, A. (2000). Multiresolution Segmentation: an optimization approach for high quality multi-scale image segmentation. In Angewandte Geographische Informationsverarbeitung XII. Beiträge zum AGIT-Symposium Salzburg 2000 (ed. J. Strobl). Karlsruhe: Herbert Wichmann Verlag.
4. Cox, J. H., Kljavin, N. M., Ota, N., Leonard, J., Roose-Girma, M., Diehl, L., Ouyang, W. and Ghilardi, N. (2012). Opposing consequences of IL-23 signaling mediated by innate and adaptive cells in chemically induced colitis in mice. Mucosal Immunol. 5, 99-109.
5. Diaz, D., Allamneni, K., Tarrant, J. M., Lewin-Koh, S. C., Pai, R., Dhawan, P., Cain, G. R., Kozlowski, C., Hiraragi, H., La, N. et al. (2012). Phosphorous dysregulation induced by MEK small molecule inhibitors in the rat involves blockade of FGF-23 signaling in the kidney. Toxicol. Sci. 125, 187-195.
6. Diaz-Granados, N., Howe, K., Lu, J. and McKay, D. M. (2000). Dextran sulfate sodium-induced colonic histopathology, but not altered epithelial ion transport, is reduced by inhibition of phosphodiesterase activity. Am. J. Pathol. 156, 2169-2177.
7. Dieleman, L. A., Palmen, M. J., Akol, H., Bloemena, E., Peña, A. S., Meuwissen, S. G. and Van Rees, E. P. (1998). Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin. Exp. Immunol. 114, 385-391.
8. Esgiar, A. N., Naguib, R. N., Sharif, B. S., Bennett, M. K. and Murray, A. (2002). Fractal analysis in the detection of colonic cancer images. IEEE Trans. Inf. Technol. Biomed. 6, 54-58.
9. Hall, L. J., Faivre, E., Quinlan, A., Shanahan, F., Nally, K. and Melgar, S. (2011). Induction and activation of adaptive immune populations during acute and chronic phases of a murine model of experimental colitis. Dig. Dis. Sci. 56, 79-89.
10. Hamilton, P. W., Bartels, P. H., Thompson, D., Anderson, N. H., Montironi, R. and Sloan, J. M. (1997). Automated location of dysplastic fields in colorectal histology using image texture analysis. J. Pathol. 182, 68-75.
11. Johansson, M. E., Gustafsson, J. K., Sjöberg, K. E., Petersson, J., Holm, L., Sjövall, H. and Hansson, G. C. (2010). Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model. PLoS ONE 5, e12238.
12. Ota, N., Wong, K., Valdez, P. A., Zheng, Y., Crellin, N. K., Diehl, L. and Ouyang, W. (2011). IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium. Nat. Immunol. 12, 941-948.
13. Pastorelli, L., Pizarro, T. T., Cominelli, F. and Vecchi, M. (2009). Emerging drugs for the treatment of ulcerative colitis. Expert Opin. Emerg. Drugs 14, 505-521.
14. Paul, S. M., Mytelka, D. S., Dunwiddie, C. T., Persinger, C. C., Munos, B. H., Lindborg, S. R. and Schacht, A. L. (2010). How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat. Rev. Drug Discov. 9, 203-214.
15. Persohn, E., Seewald, W., Bauer, J. and Schreiber, J. (2007). Cell proliferation measurement in cecum and colon of rats using scanned images and fully automated image analysis: validation of method. Exp. Toxicol. Pathol. 58, 411-418.
16. Sugimoto, K., Ogawa, A., Mizoguchi, E., Shimomura, Y., Andoh, A., Bhan, A. K., Blumberg, R. S., Xavier, R. J. and Mizoguchi, A. (2008). IL-22 ameliorates intestinal inflammation in a mouse model of ulcerative colitis. J. Clin. Invest. 118, 534-544.
17. Taylor, C. R. and Levenson, R. M. (2006). Quantification of immunohistochemistry - issues concerning methods, utility and semiquantitative assessment II. Histopathology 49, 411-424.
18. Walker, R. A. (2006). Quantification of immunohistochemistry - issues concerning methods, utility and semiquantitative assessment I. Histopathology 49, 406-410.
19. Wirtz, S., Neufert, C., Weigmann, B. and Neurath, M. F. (2007). Chemically induced mouse models of intestinal inflammation. Nat. Protoc. 2, 541-546.
20. Xavier, R. J. and Podolsky, D. K. (2007). Unravelling the pathogenesis of inflammatory bowel disease. Nature 448, 427-434.
21. Yan, Y., Kolachala, V., Dalmasso, G., Nguyen, H., Laroui, H., Sitaraman, S. V. and Merlin, D. (2009). Temporal and spatial analysis of clinical and molecular parameters in dextran sodium sulfate induced colitis. PLoS ONE 4, e6073.
22. Zhang, Y., Dubé, P. E., Washington, M. K., Yan, F. and Polk, D. B. (2012). ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival. Lab. Invest. 92, 437-450.
23. Zheng, Y., Valdez, P. A., Danilenko, D. M., Hu, Y., Sa, S. M., Gong, Q., Abbas, A. R., Modrusan, Z., Ghilardi, N., de Sauvage, F. J. et al. (2008). Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens. Nat. Med. 14, 282-289.