Comparative analysis of human mesenchymal stem cells from fetal-bone marrow, adipose tissue, and Warton’s jelly as sources of cell immunomodulatory therapy

Human Vaccines and Immunotherapeutics

Volumn 12, Issue 1, 2016, Pages 85-96

  Wang, Qiushi ^a   Yang, Qiaoni ^a   Wang, Zhe ^a   Tong, Haixia ^a   Ma, Liangyan ^a   Zhang, Yi ^a   Shan, Fengping ^a   Meng, Yiming ^a   Yuan, Zhengwei ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Adipose tissue; Fetal bone marrow; Gene expression; Mesenchymal stem cells; Wharton s jelly

Indexed keywords

CD14 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; CXCL11 CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; NOTCH RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A; MEMBRANE ANTIGEN;

ADIPOSE TISSUE CELL; ARTICLE; BONE MARROW DERIVED MESENCHYMAL STEM CELL; CELL DIFFERENTIATION; CELL GROWTH; CELL IMMUNOMODULATORY THERAPY; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; FLOW CYTOMETRY; GENE EXPRESSION; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; IMMUNOTHERAPY; MESENCHYMAL STEM CELL; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WHARTON JELLY; ADIPOSE TISSUE; BONE MARROW CELL; COCULTURE; COMPARATIVE STUDY; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION PROFILING; IMMUNOLOGY; IMMUNOMODULATION; MESENCHYMAL STROMA CELL; METABOLISM; MONONUCLEAR CELL; PHYSIOLOGY; UMBILICAL CORD;

ADIPOSE TISSUE; ANTIGENS, SURFACE; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL PROLIFERATION; COCULTURE TECHNIQUES; GENE EXPRESSION PROFILING; HUMANS; IMMUNOMODULATION; INTERFERON-GAMMA; LEUKOCYTES, MONONUCLEAR; MESENCHYMAL STROMAL CELLS; REAL-TIME POLYMERASE CHAIN REACTION; UMBILICAL CORD;

EID: 84961827503     PISSN: 21645515     EISSN: 2164554X     Source Type: Journal    
DOI: 10.1080/21645515.2015.1030549     Document Type: Article

References (44)

1. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP, Hedrick MH. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 2001; 7(2):211-28; PMID:11304456; http://dx.doi.org/10.1089/107632701300062859
2. Sottile V, Halleux C, Bassilana F, Keller H, Seuwen K. Stem cell characteristics of human trabecular bonederived cells. Bone 2002; 30(5):699-704; PMID:11996907; http://dx.doi.org/10.1016/S8756-3282(02)00674-9
3. Friedenstein AJ, Petrakova KV, Kurolesova AI, Frolova GP. Heterotopic of bone marrow. Analysis of precursor cells for osteogenic and hematopoietic tissues. Transplantation 1968; 6(2):230-47; PMID:5654088; http://dx.doi.org/10.1097/00007890-196803000-00009
4. Bassi EJ, Aita CA, Câmara NO. Immune regulatory properties of multipotent mesenchymal stromal cells: where do we stand? World J Stem Cells 2011; 3(1):1-8; PMID:21607131; http://dx.doi.org/10.4252/wjsc.v3.i1.1
5. Krampera M, Glennie S, Dyson J, Scott D, Laylor R, Simpson E, Dazzi F. Bone marrow mesenchymal stem cells inhibit the response of naive and memoryantigenspecific T cells to their cognate peptide. Blood 2003; 101(9):3722-9; PMID:12506037; http://dx.doi.org/10.1182/blood-2002-07-2104
6. Tse WT, Pendleton JD, Beyer WM, Egalka MC, Guinan EC. Suppression of allogeneic T-cell proliferation by human marrow stromal cells: implicationsin transplantation. Transplantation 2003; 75(3):389-97; PMID:12589164; http://dx.doi.org/10.1097/01.TP.0000045055.63901.A9
7. Polchert D, Sobinsky J, Douglas G, Kidd M, Moadsiri A, Reina E, Genrich K, Mehrotra S, Setty S, Smith B, et al. IFN-γ activation of mesenchymal stem cells for treatment and prevention of graft versus host disease. Eur J Immunol 2008; 38:1745-55; PMID:18493986; http://dx.doi.org/10.1002/eji.200738129
8. Krampera M, Cosmi L, Angeli R, Pasini A, Liotta F, Andreini A, Santarlasci V, Mazzinghi B, Pizzolo G, Vinante F, et al. Role for interferon-g in the immunomodulatory activity of human bone marrow mesenchymal stem cells. Stem Cells 2006; 24(2):386-98; PMID:16123384; http://dx.doi.org/10.1634/stemcells.2005-0008
9. Stenderup K, Justesen J, Clausen C, Kassem M. Aging is associated with decreased maximal life span and accelerated senescence of bone marrow stromal cells. Bone 2003; 33(6):919-26; PMID:14678851; http://dx.doi.org/10.1016/j.bone.2003.07.005
10. Rubinstein P, Rosenfield RE, Adamson JW, Stevens CE. Stored placental blood for unrelated bone marrow reconstitution. Blood 1993; 81(7):1679-90; PMID:8096404
11. Da Silva Meirelles L, Chagastelles P C, Nardi N B. Mesenchymal stem cells reside invirtually all post-natal organs and tissues. J Cell Sci 2006; 119(Pt11):2204-13; PMID:16684817; http://dx.doi.org/10.1242/jcs.02932
12. Hoogduijn MJ, Crop MJ, Peeters AM, Van Osch GJ, Balk AH, Ijzermans JN, Weimar W, Baan CC. Human heart, spleen, and perirenal fat-derived mesenchymal stem cells have immunomodulatory capacities. Stem Cells 2007; 16(4):597-604; PMID:17784833; http://dx.doi.org/10.1089/scd.2006.0110
13. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP, Hedrick MH. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 2001; 7(2):211-28; PMID:11304456; http://dx.doi.org/10.1089/107632701300062859
14. Yen BL, Huang HI, Chien CC, Jui HY, Ko BS, Yao M, Shun CT, Yen ML, Lee MC, Chen YC. Isolation of multipotent cells from human term placenta. Stem Cells 2005; 23(1):3-9; PMID:15625118; http://dx.doi.org/10.1634/stemcells.2004-0098
15. Wang HS, Hung SC, Peng ST, Huang CC, Wei HM, Guo YJ, Fu YS, Lai MC, Chen CC. Mesenchymal stem cells in the Wharton’s jelly of the human umbilical cord. Stem Cells 2004; 22(7):1330-7; PMID:15579650; http://dx.doi.org/10.1634/stemcells.2004-0013
16. Gotherstrom C, Ringden O, Tammik C, Zetterberg E, Westgren M, Le Blanc K. Immunologic properties of human fetal mesenchymal stem cells. Am J Obstet Gynecol 2004; 190(1):239-45; PMID:14749666; http://dx.doi.org/10.1016/j.ajog.2003.07.022
17. Campagnoli C, Roberts IA, Kumar S, Bennett PR, Bellantuono I, Fisk NM. Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood 2001; 98 (8):2396-402; PMID:11588036; http://dx.doi.org/10.1182/blood.V98.8.2396
18. Deuse T, Stubbendorff M, Tang-Quan K, Phillips N, Kay MA, Eiermann T, Phan TT, Volk HD, Reichenspurner H, Robbins RC, et al. Immunogenicity and immunomodulatory properties of umbilical cord lining mesenchymal stem cells. Cell Trans 2011; 20(5):655-67; PMID:21054940; http://dx.doi.org/10.3727/096368910X536473
19. Mitchell KE, Weiss ML, Mitchell BM, Martin P, Davis D, Morales L, Helwig B, Beerenstrauch M, Abou-Easa K, Hildreth T, et al. Matrix cells from Wharton’s jelly form neurons and glia. Stem Cells 2003; 21(1):50-60; PMID:12529551; http://dx.doi.org/10.1634/stemcells.21-1-50
20. Guo Z, Zheng C, Chen Z, Gu D, Du W, Ge J, Han Z, Yang R. Fetal BM-derived mesenchymal stem cells promote the expansion of human Th17 cells, but inhibit the production of Th1 cells. Eur J Immunol 2009; 39 (10):2840-9; PMID:19637224; http://dx.doi.org/10.1002/eji.200839070
21. Yoo KH, Jang IK, Lee MW, Kim HE, Yang MS, Eom Y, Lee JE, Kim YJ, Yang SK, Jung HL, et al. Comparison of immunomodulatory properties of mesenchymal stem cells derived from adult human tissues. Cell Immunol. 2009; 259(2):150-6; PMID:19608159; http://dx.doi.org/10.1016/j.cellimm.2009.06.010
22. Nakanishi C, Nagaya N, Ohnishi S, Yamahara K, Takabatake S, Konno T, Hayashi K, Kawashiri MA, Tsubokawa T, Yamagishi M. Gene and protein expression analysis of mesenchymal stem cells derived from rat adipose tissue and bone marrow. Circ J 2011; 75 (9):2260-8; PMID:21747191; http://dx.doi.org/10.1253/circj.CJ-11-0246
23. Munn DH, Zhou M, Attwood JT, Bondarev I, Conway SJ, Marshall B, Brown C, Mellor AL. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998; 281(5380):1191-3; PMID:9712583; http://dx.doi.org/10.1126/science.281.5380.1191
24. Meisel R, Zibert A, Laryea M, Göbel U, Däubener W, Dilloo D. Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2, 3-dioxygenase- mediated tryptophan degradation. Blood 2004; 103(12):4619-21; http://dx.doi.org/10.1182/blood-2003-11-3909
25. Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts AI, Zhao RC, Shi Y. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2008; 2 (2):141-50; PMID:18371435; http://dx.doi.org/10.1016/j.stem.2007.11.014
26. Crop MJ, Baan CC, Korevaar SS, Ijzermans JN, Pescatori M, Stubbs AP, van Ijcken WF, Dahlke MH, Eggenhofer E, Weimar W, et al. Inflammatory conditions affect gene expression and function of human adipose tissue-derived mesenchymal stem cells. Clin Exp Immunol 2010; 162(3):474-86; PMID:20846162; http://dx.doi.org/10.1111/j.1365-2249.2010.04256.x
27. Najar M, Rouas R, Raicevic G, Boufker HI, Lewalle P, Meuleman N, Bron D, Toungouz M, Martiat P, Lagneaux L. Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: the importance of low cell ratio and role of interleukin-6. Cytotherapy 2009; 11 (5):570-83; PMID:19565371; http://dx.doi.org/10.1080/14653240903079377
28. Hemeda H, Jakob M, Ludwig A, Giebe B, Lang S, Brandau S. Interferon-gamma and tumor necrosis factor- alpha differentially affect cytokine expression and migration properties of mesenchymal stem cells. Stem Cells Dev 2010; 19(5):693-706; PMID:20067407; http://dx.doi.org/10.1089/scd.2009.0365
29. Nasef A, Mathieu N, Chapel A, Frick J, François S, Mazurier C, Boutarfa A, Bouchet S, Gorin NC, Thierry D, et al. Immunosuppressive effects of mesenchymal stem cells: involvement of HLA-G. Transplantation 2007; 84(2):231-7; PMID:17667815; http://dx.doi.org/10.1097/01.tp.0000267918.07906.08
30. Kadri T, Lataillade JJ, Doucet C, Marie A, Ernou I, Bourin P, Joubert-Caron R, Caron M, Lutomski D. Proteomic study of Galectin-1 expression in human mesenchymal stem cells. Stem Cells Dev 2005; 14 (2):204-12; PMID:15910247; http://dx.doi.org/10.1089/scd.2005.14.204
31. Sioud M, Mobergslien A, Boudabous A, Floisand Y. Evidence for the involvement of galectin-3 in mesenchymal stem cell suppression of allogeneic T-cell proliferation. Scan J Immun 2010; 71(2):267-74; http://dx.doi.org/10.1111/j.1365-3083.2010.02378.x
32. Yang RY, Hsu DK, Liu FT. Expression of galectin-3 modulates T-cell growth and apoptosis. Proc Natl Acad Sci USA 1996; 93(13):6737-42; PMID:8692888; http://dx.doi.org/10.1073/pnas.93.13.6737
33. Rice CM. Scolding NJ. Adult human mesenchymal cells proliferate and migrate in response to chemokines expressed in demyelination. Cell Adh Migr 2010; 4 (2):235-40; PMID:20234187; http://dx.doi.org/10.4161/cam.4.2.11404
34. Ren G, Zhao X, Zhang L, Zhang J, L’Huillier A, Ling W, Roberts AI, Le AD, Shi S, Shao C, et al. Inflammatory cytokine-induced intercellular adhesion molecule- 1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression. J Immunol 2010; 184(5):2321-8; PMID:20130212; http://dx.doi.org/10.4049/jimmunol.0902023
35. Najar M, Raicevic G, Id Boufker H, Stamatopoulos B, De Bruyn C, Meuleman N, Bron D, Toungouz M, Lagneaux L. Modulated expression of adhesion molecules and galectin-1: role during mesenchymal stromal cell immunoregulatory functions. Exp Hematol 2010; 38(10):922-32; PMID:20570633; http://dx.doi.org/10.1016/j.exphem.2010.05.007
36. Isobe M, Suzuki J, Yamazaki S, Yazaki Y, Horie S, Okubo Y, Maemura K, Yazaki Y, Sekiguchi M. Regulation by differential development of Th1 and Th2 cells in peripheral tolerance to cardiac allograft induced by blocking ICAM-1/LFA-1 adhesion. Circulation 1997; 96(7):2247-53; PMID:9337197; http://dx.doi.org/10.1161/01.CIR.96.7.2247
37. Shimada Y, Hasegawa M, Kaburagi Y, Hamaguchi Y, Komura K, Saito E, Takehara K, Steeber DA, Tedder TF, Sato S. L-selectin or ICAM- 1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity. J Immunol 2003; 170(8):4325-34; PMID:12682269; http://dx.doi.org/10.4049/jimmunol.170.8.4325
38. Caplan AI, Dennis JE. Mesenchymal stem cells astrophic mediators. J Cell Biochem 2006; 98(5):1076-84; http://dx.doi.org/10.1002/jcb.20886
39. Cheng H, Qiu L, Ma J, Zhang H, Cheng M, Li W, Zhao X, Liu K. Replicative senescence of human bone marrow and umbilical cord derived mesenchymal stem cells and their differentiation to adipocytes and osteoblasts. Mol Biol Rep 2011; 38:5161-8; PMID:21188535; http://dx.doi.org/10.1007/s11033-010-0665-2
40. Prasanna SJ, Gopalakrishnan D, Shankar SR, Vasandan AB. Pro-inflammatory cytokines, IFNg and TNFa, influence immune properties of human bone marrow and Wharton jelly mesenchymal stem cells differentially. PLoS One 2010; 5(2):e9016; http://dx.doi.org/10.1371/journal.pone.0009016
41. Kassis I, Grigoriadis N, Gowda-Kurkalli B, et al. Neuroprotection and immunomodulation with mesenchymal stem cells in chronic experimental autoimmune encephalomyelitis[J]. ARCH NEUROL 2008; 65(6):753-761
42. Oreja-Guevara C, Sindern E, Raulf-Heimsoth M, Malin JP. Analysis of lymphocyte subpopulations in cerebrospinal fluid and peripheral blood inpatients with multiple sclerosis and inflammatory diseases of the nervous system[J]. Acta Neurol Scand, 1998; 98(5):310-313
43. Rafei M, Campeau PM, Aguilar-Mahecha A. Mesenchymal stromal cells ameliorate experimental autoimmune encephalomyelitis by inhibiting CD4 Th17 T cells in a CC chemokine ligand 2-dependent manner. J Immunol 2009; 182(10):5994-6002
44. Eljaafari A, Tartelin ML, Aissaoui H, Chevrel G, Osta B, Lavocat F, Miossec P. Bone marrow-derived and synovium-derived mesenchymal cells promote Th17 cell expansion and activation through caspase 1 activation: Contribution to the chronicity of rheumatoid arthritis. Arthritis Rheum 2012; 64(7):2147-2157