-
1
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
PID: 19339720
-
Van Cutsem E, Kohne CH, Hitre E, Zaluski J, Chang Chien CR, Makhson A, et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med. 2009;360(14):1408–17. doi:10.1056/NEJMoa0805019.
-
(2009)
N Engl J Med
, vol.360
, Issue.14
, pp. 1408-1417
-
-
Van Cutsem, E.1
Kohne, C.H.2
Hitre, E.3
Zaluski, J.4
Chang Chien, C.R.5
Makhson, A.6
-
2
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
COI: 1:CAS:528:DC%2BD2cXks1Gjt74%3D, PID: 15175435
-
Hurwitz H, Fehrenbacher L, Novotny W, Cartwright T, Hainsworth J, Heim W, et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med. 2004;350(23):2335–42. doi:10.1056/NEJMoa032691.
-
(2004)
N Engl J Med
, vol.350
, Issue.23
, pp. 2335-2342
-
-
Hurwitz, H.1
Fehrenbacher, L.2
Novotny, W.3
Cartwright, T.4
Hainsworth, J.5
Heim, W.6
-
3
-
-
42949149159
-
Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study
-
COI: 1:CAS:528:DC%2BD1cXlvFaqs7g%3D
-
Saltz LB, Clarke S, Diaz-Rubio E, Scheithauer W, Figer A, Wong R, et al. Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study. J Clin Oncol Off J Am Soc Clin Oncol. 2008;26(12):2013–9. doi:10.1200/JCO.2007.14.9930.
-
(2008)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.26
, Issue.12
, pp. 2013-2019
-
-
Saltz, L.B.1
Clarke, S.2
Diaz-Rubio, E.3
Scheithauer, W.4
Figer, A.5
Wong, R.6
-
4
-
-
56749169353
-
Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE)
-
COI: 1:CAS:528:DC%2BD1MXhslCmtw%3D%3D
-
Grothey A, Sugrue MM, Purdie DM, Dong W, Sargent D, Hedrick E, et al. Bevacizumab beyond first progression is associated with prolonged overall survival in metastatic colorectal cancer: results from a large observational cohort study (BRiTE). J Clin Oncol Off J Am Soc Clin Oncol. 2008;26(33):5326–34. doi:10.1200/JCO.2008.16.3212.
-
(2008)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.26
, Issue.33
, pp. 5326-5334
-
-
Grothey, A.1
Sugrue, M.M.2
Purdie, D.M.3
Dong, W.4
Sargent, D.5
Hedrick, E.6
-
5
-
-
84862026304
-
Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials
-
COI: 1:CAS:528:DC%2BC38XkvFSlsro%3D, PID: 22446022
-
Bokemeyer C, Van Cutsem E, Rougier P, Ciardiello F, Heeger S, Schlichting M, et al. Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials. Eur J Cancer. 2012;48(10):1466–75. doi:10.1016/j.ejca.2012.02.057.
-
(2012)
Eur J Cancer
, vol.48
, Issue.10
, pp. 1466-1475
-
-
Bokemeyer, C.1
Van Cutsem, E.2
Rougier, P.3
Ciardiello, F.4
Heeger, S.5
Schlichting, M.6
-
6
-
-
1342290189
-
FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study
-
COI: 1:CAS:528:DC%2BD2cXpsVKit7w%3D
-
Tournigand C, Andre T, Achille E, Lledo G, Flesh M, Mery-Mignard D, et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol Off J Am Soc Clin Oncol. 2004;22(2):229–37. doi:10.1200/JCO.2004.05.113.
-
(2004)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.22
, Issue.2
, pp. 229-237
-
-
Tournigand, C.1
Andre, T.2
Achille, E.3
Lledo, G.4
Flesh, M.5
Mery-Mignard, D.6
-
7
-
-
84872921660
-
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
-
COI: 1:CAS:528:DC%2BC38Xhslarsr%2FE, PID: 23177514
-
Grothey A, Van Cutsem E, Sobrero A, Siena S, Falcone A, Ychou M, et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet. 2013;381(9863):303–12. doi:10.1016/S0140-6736(12)61900-X.
-
(2013)
Lancet
, vol.381
, Issue.9863
, pp. 303-312
-
-
Grothey, A.1
Van Cutsem, E.2
Sobrero, A.3
Siena, S.4
Falcone, A.5
Ychou, M.6
-
8
-
-
20044372154
-
MGMT gene silencing and benefit from temozolomide in glioblastoma
-
COI: 1:CAS:528:DC%2BD2MXit1Wktro%3D, PID: 15758010
-
Hegi ME, Diserens AC, Gorlia T, Hamou MF, de Tribolet N, Weller M, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005;352(10):997–1003. doi:10.1056/NEJMoa043331.
-
(2005)
N Engl J Med
, vol.352
, Issue.10
, pp. 997-1003
-
-
Hegi, M.E.1
Diserens, A.C.2
Gorlia, T.3
Hamou, M.F.4
de Tribolet, N.5
Weller, M.6
-
9
-
-
33747168829
-
New trends in the medical management of glioblastoma multiforme: the role of temozolomide chemotherapy
-
PID: 16709037
-
Dehdashti AR, Hegi ME, Regli L, Pica A, Stupp R. New trends in the medical management of glioblastoma multiforme: the role of temozolomide chemotherapy. Neurosurg Focus. 2006;20(4):E6. doi:10.3171/foc.2006.20.4.3.
-
(2006)
Neurosurg Focus
, vol.20
, Issue.4
, pp. E6
-
-
Dehdashti, A.R.1
Hegi, M.E.2
Regli, L.3
Pica, A.4
Stupp, R.5
-
10
-
-
51649117107
-
Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
-
COI: 1:CAS:528:DC%2BD1cXhtFKisb7M
-
Hegi ME, Liu L, Herman JG, Stupp R, Wick W, Weller M, et al. Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J Clin Oncol Off J Am Soc Clin Oncol. 2008;26(25):4189–99. doi:10.1200/JCO.2007.11.5964.
-
(2008)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.26
, Issue.25
, pp. 4189-4199
-
-
Hegi, M.E.1
Liu, L.2
Herman, J.G.3
Stupp, R.4
Wick, W.5
Weller, M.6
-
11
-
-
0026575413
-
Chromosomal localization of human O6-methylguanine-DNA methyltransferase (MGMT) gene by in situ hybridization
-
COI: 1:CAS:528:DyaK38Xit12gs7s%3D, PID: 1635460
-
Natarajan AT, Vermeulen S, Darroudi F, Valentine MB, Brent TP, Mitra S, et al. Chromosomal localization of human O6-methylguanine-DNA methyltransferase (MGMT) gene by in situ hybridization. Mutagenesis. 1992;7(1):83–5.
-
(1992)
Mutagenesis
, vol.7
, Issue.1
, pp. 83-85
-
-
Natarajan, A.T.1
Vermeulen, S.2
Darroudi, F.3
Valentine, M.B.4
Brent, T.P.5
Mitra, S.6
-
12
-
-
1942469956
-
MGMT: its role in cancer aetiology and cancer therapeutics
-
COI: 1:CAS:528:DC%2BD2cXis1Gmt70%3D, PID: 15057289
-
Gerson SL. MGMT: its role in cancer aetiology and cancer therapeutics. Nat Rev Cancer. 2004;4(4):296–307. doi:10.1038/nrc1319.
-
(2004)
Nat Rev Cancer
, vol.4
, Issue.4
, pp. 296-307
-
-
Gerson, S.L.1
-
13
-
-
79954443733
-
Response to temozolomide in patients with metastatic colorectal cancer with loss of MGMT expression: a new approach in the era of personalized medicine?
-
Shacham-Shmueli E, Beny A, Geva R, Blachar A, Figer A, Aderka D. Response to temozolomide in patients with metastatic colorectal cancer with loss of MGMT expression: a new approach in the era of personalized medicine? J Clin Oncol Off J Am Soc Clin Oncol. 2011;29(10):e262–5. doi:10.1200/JCO.2010.32.0242.
-
(2011)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.29
, Issue.10
, pp. e262-e265
-
-
Shacham-Shmueli, E.1
Beny, A.2
Geva, R.3
Blachar, A.4
Figer, A.5
Aderka, D.6
-
14
-
-
0025196019
-
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents
-
COI: 1:CAS:528:DyaK3cXlt1OqsLk%3D, PID: 2164681
-
Dolan ME, Moschel RC, Pegg AE. Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic alkylating agents. Proc Natl Acad Sci U S A. 1990;87(14):5368–72.
-
(1990)
Proc Natl Acad Sci U S A
, vol.87
, Issue.14
, pp. 5368-5372
-
-
Dolan, M.E.1
Moschel, R.C.2
Pegg, A.E.3
-
15
-
-
0025924488
-
Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents
-
COI: 1:CAS:528:DyaK3MXkvVCrtr4%3D, PID: 1647266
-
Dolan ME, Mitchell RB, Mummert C, Moschel RC, Pegg AE. Effect of O6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents. Cancer Res. 1991;51(13):3367–72.
-
(1991)
Cancer Res
, vol.51
, Issue.13
, pp. 3367-3372
-
-
Dolan, M.E.1
Mitchell, R.B.2
Mummert, C.3
Moschel, R.C.4
Pegg, A.E.5
-
16
-
-
0022032204
-
Altering gene expression with 5-azacytidine
-
COI: 1:CAS:528:DyaL2MXhvFyktr8%3D, PID: 2578884
-
Jones PA. Altering gene expression with 5-azacytidine. Cell. 1985;40(3):485–6.
-
(1985)
Cell
, vol.40
, Issue.3
, pp. 485-486
-
-
Jones, P.A.1
-
17
-
-
0021309561
-
5-Azacytidine, DNA methylation, and differentiation
-
COI: 1:CAS:528:DyaL2cXksV2hu7g%3D, PID: 6201321
-
Taylor SM, Constantinides PA, Jones PA. 5-Azacytidine, DNA methylation, and differentiation. Curr Top Microbiol Immunol. 1984;108:115–27.
-
(1984)
Curr Top Microbiol Immunol
, vol.108
, pp. 115-127
-
-
Taylor, S.M.1
Constantinides, P.A.2
Jones, P.A.3
-
18
-
-
0023266684
-
Biochemistry of azacitidine: a review
-
COI: 1:CAS:528:DyaL2sXmtFWgs7Y%3D, PID: 2443243
-
Glover AB, Leyland-Jones B. Biochemistry of azacitidine: a review. Cancer Treat Rep. 1987;71(10):959–64.
-
(1987)
Cancer Treat Rep
, vol.71
, Issue.10
, pp. 959-964
-
-
Glover, A.B.1
Leyland-Jones, B.2
-
19
-
-
42549125175
-
Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis
-
COI: 1:CAS:528:DC%2BD1cXltlaitbY%3D
-
Nagasaka T, Goel A, Notohara K, Takahata T, Sasamoto H, Uchida T, et al. Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis. Int J Cancer J Int Cancer. 2008;122(11):2429–36. doi:10.1002/ijc.23398.
-
(2008)
Int J Cancer J Int Cancer
, vol.122
, Issue.11
, pp. 2429-2436
-
-
Nagasaka, T.1
Goel, A.2
Notohara, K.3
Takahata, T.4
Sasamoto, H.5
Uchida, T.6
-
20
-
-
45749127481
-
Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial
-
COI: 1:CAS:528:DC%2BD1cXnvVOhsb4%3D
-
Braun MS, Richman SD, Quirke P, Daly C, Adlard JW, Elliott F, et al. Predictive biomarkers of chemotherapy efficacy in colorectal cancer: results from the UK MRC FOCUS trial. J Clin Oncol Off J Am Soc Clin Oncol. 2008;26(16):2690–8. doi:10.1200/JCO.2007.15.5580.
-
(2008)
J Clin Oncol Off J Am Soc Clin Oncol
, vol.26
, Issue.16
, pp. 2690-2698
-
-
Braun, M.S.1
Richman, S.D.2
Quirke, P.3
Daly, C.4
Adlard, J.W.5
Elliott, F.6
-
21
-
-
0029843950
-
Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands
-
COI: 1:CAS:528:DyaK28XlsFeht7Y%3D, PID: 8790415
-
Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci U S A. 1996;93(18):9821–6.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, Issue.18
, pp. 9821-9826
-
-
Herman, J.G.1
Graff, J.R.2
Myohanen, S.3
Nelkin, B.D.4
Baylin, S.B.5
-
22
-
-
65349121788
-
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial
-
COI: 1:CAS:528:DC%2BD1MXlsVKhs74%3D, PID: 19269895
-
Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol. 2009;10(5):459–66. doi:10.1016/S1470-2045(09)70025-7.
-
(2009)
Lancet Oncol
, vol.10
, Issue.5
, pp. 459-466
-
-
Stupp, R.1
Hegi, M.E.2
Mason, W.P.3
van den Bent, M.J.4
Taphoorn, M.J.5
Janzer, R.C.6
-
23
-
-
0029002319
-
Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression
-
COI: 1:CAS:528:DyaK2MXlvFeru7g%3D, PID: 7538900
-
Ferguson AT, Lapidus RG, Baylin SB, Davidson NE. Demethylation of the estrogen receptor gene in estrogen receptor-negative breast cancer cells can reactivate estrogen receptor gene expression. Cancer Res. 1995;55(11):2279–83.
-
(1995)
Cancer Res
, vol.55
, Issue.11
, pp. 2279-2283
-
-
Ferguson, A.T.1
Lapidus, R.G.2
Baylin, S.B.3
Davidson, N.E.4
-
24
-
-
79951726143
-
MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers
-
PID: 21140203
-
Shima K, Morikawa T, Baba Y, Nosho K, Suzuki M, Yamauchi M, et al. MGMT promoter methylation, loss of expression and prognosis in 855 colorectal cancers. Cancer Causes Control CCC. 2011;22(2):301–9. doi:10.1007/s10552-010-9698-z.
-
(2011)
Cancer Causes Control CCC
, vol.22
, Issue.2
, pp. 301-309
-
-
Shima, K.1
Morikawa, T.2
Baba, Y.3
Nosho, K.4
Suzuki, M.5
Yamauchi, M.6
-
25
-
-
84863498717
-
Loss of heterozygosity, aberrant methylation, BRAF mutation and KRAS mutation in colorectal signet ring cell carcinoma
-
COI: 1:CAS:528:DC%2BC38XpvVSjsrg%3D
-
Kakar S, Deng G, Smyrk TC, Cun L, Sahai V, Kim YS. Loss of heterozygosity, aberrant methylation, BRAF mutation and KRAS mutation in colorectal signet ring cell carcinoma. Mod Pathol Off J US Can Acad Pathol Inc. 2012;25(7):1040–7. doi:10.1038/modpathol.2012.44.
-
(2012)
Mod Pathol Off J US Can Acad Pathol Inc
, vol.25
, Issue.7
, pp. 1040-1047
-
-
Kakar, S.1
Deng, G.2
Smyrk, T.C.3
Cun, L.4
Sahai, V.5
Kim, Y.S.6
-
26
-
-
25144518262
-
MGMT promoter methylation and field defect in sporadic colorectal cancer
-
COI: 1:CAS:528:DC%2BD2MXhtVKhsrjM, PID: 16174854
-
Shen L, Kondo Y, Rosner GL, Xiao L, Hernandez NS, Vilaythong J, et al. MGMT promoter methylation and field defect in sporadic colorectal cancer. J Natl Cancer Inst. 2005;97(18):1330–8. doi:10.1093/jnci/dji275.
-
(2005)
J Natl Cancer Inst
, vol.97
, Issue.18
, pp. 1330-1338
-
-
Shen, L.1
Kondo, Y.2
Rosner, G.L.3
Xiao, L.4
Hernandez, N.S.5
Vilaythong, J.6
-
27
-
-
0035117307
-
Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability
-
COI: 1:CAS:528:DC%2BD3MXhsFSrtLw%3D, PID: 11221863
-
Whitehall VL, Walsh MD, Young J, Leggett BA, Jass JR. Methylation of O-6-methylguanine DNA methyltransferase characterizes a subset of colorectal cancer with low-level DNA microsatellite instability. Cancer Res. 2001;61(3):827–30.
-
(2001)
Cancer Res
, vol.61
, Issue.3
, pp. 827-830
-
-
Whitehall, V.L.1
Walsh, M.D.2
Young, J.3
Leggett, B.A.4
Jass, J.R.5
-
28
-
-
0036160987
-
O(6)-methylguanine-DNA methyltransferase (MGMT) as a determinant of resistance to camptothecin derivatives
-
COI: 1:CAS:528:DC%2BD38XisVKmurY%3D
-
Okamoto R, Takano H, Okamura T, Park JS, Tanimoto K, Sekikawa T, et al. O(6)-methylguanine-DNA methyltransferase (MGMT) as a determinant of resistance to camptothecin derivatives. Japanese J Cancer Res Gann. 2002;93(1):93–102.
-
(2002)
Japanese J Cancer Res Gann
, vol.93
, Issue.1
, pp. 93-102
-
-
Okamoto, R.1
Takano, H.2
Okamura, T.3
Park, J.S.4
Tanimoto, K.5
Sekikawa, T.6
-
29
-
-
31144478509
-
DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors
-
COI: 1:CAS:528:DC%2BD28XhtlWqtLc%3D, PID: 16258022
-
Kuo CC, Liu JF, Chang JY. DNA repair enzyme, O6-methylguanine DNA methyltransferase, modulates cytotoxicity of camptothecin-derived topoisomerase I inhibitors. J Pharmacol Exp Ther. 2006;316(2):946–54. doi:10.1124/jpet.105.095919.
-
(2006)
J Pharmacol Exp Ther
, vol.316
, Issue.2
, pp. 946-954
-
-
Kuo, C.C.1
Liu, J.F.2
Chang, J.Y.3
|