Chronic skin inflammation leads to bone loss by IL-17-mediated inhibition of Wnt signaling in osteoblasts

Science Translational Medicine

Volumn 8, Issue 330, 2016, Pages

  Uluçkan, Özge ^a   Jimenez, Maria ^a   Karbach, Susanne ^b,c   Jeschke, Anke ^d   Graña, Osvaldo ^a   Keller, Johannes ^d   Busse, Björn ^d   Croxford, Andrew L ^c   Finzel, Stephanie ^e   Koenders, Marije ^f   Van Den Berg, Wim ^f   Schinke, Thorsten ^d   Amling, Michael ^d   Waisman, Ari ^c   Schett, Georg ^e   Wagner, Erwin F ^a  

^a Structural Biology and Biocomputing Programme   (Spain)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

^d UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^e UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^f RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17; TRANSCRIPTION FACTOR JUNB; WNT PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE DEFECT; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GAMMA DELTA T LYMPHOCYTE; GENE EXPRESSION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; KERATINOCYTE; LYMPHOID CELL; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; SIGNAL TRANSDUCTION; ANIMAL; BIOLOGICAL MODEL; BONE DEVELOPMENT; C57BL MOUSE; CELL LINEAGE; CHRONIC DISEASE; EPITHELIUM; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; OSTEOCYTE; PATHOLOGY; SKIN; WNT SIGNALING PATHWAY;

ANIMALS; BONE RESORPTION; CELL LINEAGE; CHRONIC DISEASE; EPITHELIUM; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; INTERLEUKIN-17; MALE; MICE, INBRED C57BL; MIDDLE AGED; MODELS, BIOLOGICAL; OSTEOBLASTS; OSTEOCYTES; OSTEOGENESIS; PSORIASIS; SKIN; WNT SIGNALING PATHWAY;

EID: 84961784866     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aad8996     Document Type: Article

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