IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions

Journal of Investigative Dermatology

Volumn 134, Issue 3, 2014, Pages 728-735

  Croxford, Andrew L ^a,b   Karbach, Susanne ^a   Kurschus, Florian C ^a   Wörtge, Simone ^a   Nikolaev, Alexei ^a   Yogev, Nir ^a   Klebow, Sabrina ^e   Schüler, Rebecca ^a   Reissig, Sonja ^a   Piotrowski, Carolin ^c   Brylla, Elke ^c   Bechmann, Ingo ^c   Scheller, Jürgen ^a   Rose John, Stefan ^d   Wunderlich, F Thomas ^e   Münzel, Thomas ^a   Von Stebut, Esther ^a   Waisman, Ari ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF LEIPZIG   (Germany)

^d UNIVERSITY OF KIEL   (Germany)

^e UNIVERSITY OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ENHANCED GREEN FLUORESCENT PROTEIN; INTERLEUKIN 17; INTERLEUKIN 6;

ABSCESS; ALLELE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DERMATITIS; GRANULOCYTE; GRANULOPOIESIS; HYPERKERATOSIS; INFLAMMATORY INFILTRATE; LEUKOCYTE MIGRATION; MACROPHAGE; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PSORIASIS; PSORIASIS AREA AND SEVERITY INDEX; T LYMPHOCYTE; UPREGULATION; ANIMAL TISSUE; CELL MIGRATION; DISEASE EXACERBATION; EFFECTOR CELL; GENE EXPRESSION; LYMPHOCYTIC INFILTRATION; NEUTROPHIL MICROABSCESS; SIGNAL TRANSDUCTION;

ABSCESS; ANIMALS; DISEASE MODELS, ANIMAL; EPIDERMIS; GENE EXPRESSION; GRANULOCYTES; INTERLEUKIN-17; INTERLEUKIN-6; MACROPHAGES; MICE; MICE, KNOCKOUT; NEUTROPHILS; PSORIASIS; RECEPTORS, INTERLEUKIN-6; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 84894054890     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2013.404     Document Type: Article

References (56)

1. Aggarwal S, Ghilardi N, Xie MH et al. (2003) Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin- 17. J Biol Chem 278:1910-44
2. Albanesi C, Scarponi C, Cavani A et al. (2000) Interleukin-17 is produced by both Th1 and Th2 lymphocytes, and modulates interferon-gamma- and interleukin-4-induced activation of human keratinocytes. J Invest Dermatol 115:81-77
3. Arican O, Aral M, Sasmaz S et al. (2005) Serum levels of TNF-alpha, IFNgamma, IL-6, IL-8, IL-12, IL-17, and IL-18 in patients with active psoriasis and correlation with disease severity. Mediators inflammation 2005:273-99
4. Aujla SJ, Dubin PJ, Kolls JK (2007) Interleukin-17 in pulmonary host defense. Exp Lung Res 33:507-188
5. Bartoccioni E, Scuderi F, Marino M et al. (2003) IL-6, monocyte infiltration and parenchymal cells. Trends Immunol 24:299-300. author reply 300-2911
6. Becher B, Pantelyushin S (2012) Hiding under the skin: interleukin-17- producing gammadelta T cells go under the skin? Nat Med 18:1748-500
7. Castells-Rodellas A, Castell JV, Ramirez-Bosca A et al. (1992) Interleukin-6 in normal skin and psoriasis. Acta Derm Venereol 72:165-88
8. Chalaris A, Rabe B, Paliga K et al. (2007) Apoptosis is a natural stimulus of IL6R shedding and contributes to the proinflammatory trans-signaling function of neutrophils. Blood 110:1748-555
9. Cho JS, Pietras EM, Garcia NC et al. (2010) IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice. J Clin Invest 120:1762-733
10. Di Cesare A, Di Meglio P, Nestle FO (2009) The IL-23/Th17 axis in the immunopathogenesis of psoriasis. J Invest Dermatol 129:1339-500
11. El Malki K, Karbach SH, Huppert J et al. (2013) An alternative pathway of imiquimod-induced psoriasis-like skin inflammation in the absence of interleukin-17 receptor a signaling. J Invest Dermatol 133:441-511
12. Ellinghaus E, Ellinghaus D, Stuart PE et al. (2010) Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2. Nat Genet 42:991-55
13. Farley E, Menter A (2011) Psoriasis: comorbidities and associations. G Ital Dermatol Venereol 146:9-155
14. Fujishima S, Watanabe H, Kawaguchi M et al. (2010) Involvement of IL-17F via the induction of IL-6 in psoriasis. Arch Dermatol Res 302:499-5055
15. Girolomoni G, Mrowietz U, Paul C (2012) Psoriasis: rationale for targeting interleukin-17. Br J Dermatol 167:717-244
16. Greaves MW, Weinstein GD (1995) Treatment of psoriasis. N Engl J Med 332:581-88
17. Grossman RM, Krueger J, Yourish D et al. (1989) Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc Natl Acad Sci USA 86:6367-711
18. Gudjonsson JE, Johnston A, Dyson M et al. (2007) Mouse models of psoriasis. J Invest Dermatol 127:1292-3088
19. Haak S, Croxford AL, Kreymborg K et al. (2009) IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice. J Clin Invest 119:61-99
20. Hafner M, Wenk J, Nenci A et al. (2004) Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte-expressed protein. Genesis 38:176-811
21. Harper EG, Guo C, Rizzo H et al. (2009) Th17 cytokines stimulate CCL200 expression in keratinocytes in vitro and in vivo: implications for psoriasis pathogenesis. J Invest Dermatol 129:2175-833
22. Harrison OJ, Foley J, Bolognese BJ et al. (2008) Airway infiltration of CD4-CCR6-Th17 type cells associated with chronic cigarette smoke induced airspace enlargement. Immunol Lett 121:13-211
23. Hedrick MN, Lonsdorf AS, Shirakawa AK et al. (2009) CCR6 is required for IL- 23-induced psoriasis-like inflammation in mice. J Clin Invest 119:2317-299
24. Hirota K, Yoshitomi H, Hashimoto M et al. (2007) Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med 204:2803-122
25. Hoeve MA, Savage ND, de Boer T et al. (2006) Divergent effects of IL-122 and IL-23 on the production of IL-17 by human T cells. Eur J Immunol 36:661-700
26. Hoge J, Yan I, Janner N et al. (2013) IL-6 controls the innate immune response against Listeria monocytogenes via classical IL-6 signaling. J Immunol 190:703-111
27. Kaplanski G, Marin V, Montero-Julian F et al. (2003) IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol 24:25-99
28. Kelly MN, Kolls JK, Happel K et al. (2005) Interleukin-17/interleukin-177 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection. Infect Immun 73:617-211
29. Kishimoto T, Hibi M, Murakami M et al. (1992) The molecular biology of interleukin 6 and its receptor. Ciba Found Symp 167:5-16; discussion 16-233
30. Koga C, Kabashima K, Shiraishi N et al. (2008) Possible pathogenic role of Th17 cells for atopic dermatitis. J Invest Dermatol 128:2625-300
31. Kolls JK, Linden A (2004) Interleukin-17 family members and inflammation. Immunity 21:467-766
32. Lambert JR, Wright V (1976) Eye inflammation in psoriatic arthritis. Ann Rheum Dis 35:354-66
33. Lillard JW Jr, Singh UP, Boyaka PN et al. (2003) MIP-1alpha and MIP-1beta differentially mediate mucosal and systemic adaptive immunity. Blood 101:807-144
34. Lowes MA, Kikuchi T, Fuentes-Duculan J et al. (2008) Psoriasis vulgaris lesions contain discrete populations of Th1 and Th17 T cells. J Invest Dermatol 128:1207-111
35. Maini RN, Taylor PC, Szechinski J et al. (2006) Double-blind randomized controlled clinical trial of the interleukin-6 receptor antagonist, tocilizumab, in European patients with rheumatoid arthritis who had an incomplete response to methotrexate. Arthritis Rheum 54:2817-299
36. McLoughlin RM, Witowski J, Robson RL et al. (2003) Interplay between IFNgamma and IL-6 signaling governs neutrophil trafficking and apoptosis during acute inflammation. J Clin Invest 112:598-6077
37. Nestle FO, Conra C (2004) The IL-12 family member p40 chain as a master switch and novel therapeutic target in psoriasis. J Invest Dermatol 123: xiv-xv Neurath MF, Finotto S (2011) IL-6 signaling in autoimmunity, chronic inflammation and inflammation-associated cancer. Cytokine Growth Factor Rev 22:83-99
38. Nograles KE, Brasington RD, Bowcock AM (2009) New insights into the pathogenesis and genetics of psoriatic arthritis. Nat Clin Pract Rheumatol 5:83-911
39. Ogura H, Murakami M, Okuyama Y et al. (2008) Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-66 induction. Immunity 29:628-366
40. Pantelyushin S, Haak S, Ingold B et al. (2012) Rorgammat-innate lymphocytes and gammadelta T cells initiate psoriasiform plaque formation in mice. J Clin Invest 122:2252-66
41. Patel DD, Lee DM, Kolbinger F et al. (2013) Effect of IL-17A blockade with secukinumab in autoimmune diseases. Ann Rheum Dis 72 Suppl 2:ii116-233
42. Rincon M. (2012) Interleukin-6: from an inflammatory marker to a target for inflammatory diseases. Trends Immunol 33:571-77
43. Romano M, Sironi M, Toniatti C et al. (1997) Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment. Immunity 6:315-255
44. Sano S, Chan KS, Carbajal S et al. (2005) Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med 11:43-99
45. Schall TJ, Bacon K, Camp RD et al. (1993) Human macrophage inflammatory protein alpha (MIP-1 alpha) and MIP-1 beta chemokines attract distinct populations of lymphocytes. J Exp Med 177:1821-66
46. Shear NH, Prinz J, Papp K et al. (2008) Targeting the interleukin-12/23 cytokine family in the treatment of psoriatic disease. J Cutan Med Surg 12(Suppl 1):S1-100
47. Taub DD, Conlon K, Lloyd AR et al. (1993) Preferential migration of activated CD4-and CD8-T cells in response to MIP-1 alpha and MIP-1 beta. Science 260:355-88
48. Teunissen MB, Koomen CW, deWaal Malefyt R et al. (1998) Interleukin-17 and interferon-gamma synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J Invest Dermatol 111:645-99
49. Toruniowa B, Krasowska D, Koziol M et al. (1995) Serum levels of IL-6 in mycosis fungoides, psoriasis, and lichen planus. Ann N Y Acad Sci 762:432-44
50. Turner JE, Paust HJ, Steinmetz OM et al. (2010) CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis. J Am Soc Nephrol 21:974-855
51. van der Fits L, Mourits S, Voerman JS et al. (2009) Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23/IL-17 axis. J Immunol 182:5836-455
52. Waisman A (2012) To be 17 again-anti-interleukin-17 treatment for psoriasis. N Engl J Med 366:1251-22
53. Walter A, Schafer M, Cecconi V et al. (2013) Aldara activates TLR7- independent immune defence. Nat Commun 4:15600
54. Wang C, Kang SG, Lee J et al. (2009) The roles of CCR6 in migration of Th177 cells and regulation of effector T-cell balance in the gut. Mucosal Immunol 2:173-833
55. Zenz R, Eferl R, Kenner L et al. (2005) Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. Nature 437:369-755
56. Zhou X, Chen Q, Moore J et al. (2009) Critical role of the interleukin-17/ interleukin-17 receptor axis in regulating host susceptibility to respiratory infection with Chlamydia species. Infect Immun 77:5059-700