A wearable biochemical sensor for monitoring alcohol consumption lifestyle through Ethyl glucuronide (EtG) detection in human sweat

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Panneer Selvam, Anjan ^a,b   Muthukumar, Sriram ^b   Kamakoti, Vikramshankar ^a   Prasad, Shalini ^a  

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b ENLISENSE LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; BIOLOGICAL MARKER; ETHYL GLUCURONIDE; GLUCURONIC ACID;

DEVICES; DIAGNOSTIC EQUIPMENT; DRINKING BEHAVIOR; DRUG MONITORING; GENETIC PROCEDURES; HUMAN; IMPEDANCE; LIFESTYLE; METABOLISM; SWEAT;

ALCOHOL DRINKING; BIOMARKERS; BIOSENSING TECHNIQUES; DIAGNOSTIC EQUIPMENT; DRUG MONITORING; ELECTRIC IMPEDANCE; ETHANOL; GLUCURONATES; HUMANS; LIFE STYLE; SWEAT;

EID: 84961773087     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep23111     Document Type: Article

References (53)

1. Roerecke, M., Rehm, J. Alcohol use disorders and mortality: a systematic review and meta-analysis. Addiction 108, 1562-1578, doi: 10.1111/add.12231 (2013).
2. McPherson, S., Lucey, M. R., Moriarty, K. J. Decompensated alcohol related liver disease: acute management. BMJ 352, i124 (2016).
3. Kendrick, S., Day, C. Risk factors for alcoholrelated liver disease. Alcohol Abuse and Liver Disease, 47-55 (2015).
4. Substance Abuse and Mental Health Services Administration 2012 Newsletter. The Role of Biomarkers in the Treatment of Alcohol Use Disorders, 2012 Revision. Advisory, 11(2), 1-8 (2012).
5. Cabarcos, P., lvarez, I., Tabernero, M., Bermejo, A. Determination of direct alcohol markers: a review. Anal Bioanal Chem 407, 4907-4925, doi: 10.1007/s00216-015-8701-7 (2015).
6. Joya, X. et al. Determination of maternal-fetal biomarkers of prenatal exposure to ethanol: A review. J.Pharm Biomed Anal 69, 209-222 (2012).
7. Lande, R. G., Marin, B. Biomarker Characteristics of Alcohol Use in the U.S. Army. J. Addict Dis 28, 158-163, doi: 10.1080/10550880902772506 (2009).
8. McDonell, M. G. et al. Evaluation of Ethyl Glucuronide Immunoassay Urinalysis in Five Alcohol Dependent Outpatients. Am J. Addict. 20, 482-484, doi: 10.1111/j.1521-0391.2011.00157.x (2011).
9. Staufer, K. et al. Urinary ethyl glucuronide as a novel screening tool in patients pre-and post-liver transplantation improves detection of alcohol consumption. Hepatology 54, 1640-1649, doi: 10.1002/hep.24596 (2011).
10. Wright, T. H., Ferslew, K. E. Biotransformation of ethanol to ethyl glucuronide in a rat model after a single high oral dosage. Alcohol 46, 159-164 (2012).
11. Tabakoff, B., Catherine, C., Gelpke, B. Biochemical Pharmacology of Ethanol. Advances in Experimental Medicine and Biology 56, 141-164 (2013).
12. Cederbaum, A. I. Alcohol metabolism. Clin liver dis. 16, 667-685 (2012).
13. Ramchandani, V., Bosron, W., Li, T. Research advances in ethanol metabolism. Pathol Biol. 49, 676-682 (2001).
14. Jatlow, P., O'Malley, S. S. Clinical (Non-forensic) Application Of Ethylglucuronide Measurement: Are We Ready Alcohol Clin Exp Res. 34, 968-975, doi: 10.1111/j.1530-0277.2010.01171.x (2010).
15. Jatlow, P. I. et al. Ethyl glucuronide and ethyl sulfate assays in clinical trials, interpretation, and limitations: results of a dose ranging alcohol challenge study and 2 clinical trials. Alcohol Clin Exp Res. 38, 2056-2065 (2014).
16. Crunelle, C. L. et al. Hair ethyl glucuronide levels as a marker for alcohol use and abuse: a review of the current state of the art. Drug Alcohol Depend. 134, 1-11 (2014).
17. Hseth, G., Yttredal, B., Karinen, R., Gjerde, H., Christophersen, A. Levels of ethyl glucuronide and ethyl sulfate in oral fluid, blood, and urine after use of mouthwash and ingestion of nonalcoholic wine. J. Anal Toxicol. 34(2), 84-88 (2010).
18. Hseth, G. et al. Ethyl glucuronide concentrations in oral fluid, blood, and urine after volunteers drank 0.5 and 1.0 g/kg doses of ethanol. J. Anal Toxicol. 34, 319-324 (2010).
19. Hseth, G., Morini, L., Polettini, A., Christophersen, A., Mland, J. Blood kinetics of ethyl glucuronide and ethyl sulphate in heavy drinkers during alcohol detoxification. Forensic Sci Int. 188, 52-56 (2009).
20. Stewart, S. H., Koch, D. G., Burgess, D. M., Willner, I. R., Reuben, A. Sensitivity and specificity of urinary ethyl glucuronide and ethyl sulfate in liver disease patients. Alcohol Clin Exp Res. 37, 150-155 (2013).
21. McDonell, M. G. et al. Using ethyl glucuronide in urine to detect light and heavy drinking in alcohol dependent outpatients. Drug Alcohol Depend. 157, 184-187 (2015).
22. Crunelle, C. L. et al. Ethyl glucuronide concentrations in hair: a controlled alcohol-dosing study in healthy volunteers. Anal Bioanal Chem, 1-7 (2015).
23. Stewart, S. H., Koch, D. G., Willner, I. R., Randall, P. K., Reuben, A. Hair ethyl glucuronide is highly sensitive and specific for detecting moderate-to-heavy drinking in patients with liver disease. Alcohol Alcohol. 48, 83-87 (2013).
24. Concheiro, M. et al. Ethylglucuronide determination in urine and hair from alcohol withdrawal patients. J. Anal Toxicol. 33, 155-161 (2009).
25. Patel, S., Park, H., Bonato, P., Chan, L., Rodgers, M. A review of wearable sensors and systems with application in rehabilitation. J. Neuroeng Rehabil. 9, 1-17 (2012).
26. Pantelopoulos, A., Bourbakis, N. G. A Survey on Wearable Sensor-Based Systems for Health Monitoring and Prognosis. Systems, Man, and Cybernetics, Part C: Applications and Reviews, IEEE Transactions on 40, 1-12, doi: 10.1109/TSMCC.2009.2032660 (2010).
27. Gong, S. et al. A wearable and highly sensitive pressure sensor with ultrathin gold nanowires. Nat Commun 5, doi: 10.1038/ncomms4132 (2014).
28. Gebel, E., Anatomy of a test strip. (2012) Available at : http://www.diabetesforecast.org/2012/jul/anatomy-of-a-test-strip.html. (Accessed: 16th October 2015).
29. Phillips, J. C. Bonds and Bands in Semiconductors. Science 169, 1035, doi: 10.1126/science.169.3950.1035 (1970).
30. Rogers, J. A., Bao, Z. Printed plastic electronics and paperlike displays. J. Polym. Sci. A Polym. Chem. 40, 3327-3334, doi: 10.1002/pola.10405 (2002).
31. Liao, C., Mak, C., Zhang, M., Chan, H. L., Yan, F. Flexible organic electrochemical transistors for highly selective enzyme biosensors and used for saliva testing. Adv Mater. 27, 676-681 (2015).
32. Shafiee, H. et al. Paper and flexible substrates as materials for biosensing platforms to detect multiple biotargets. Sci Rep. 5, doi: 10.1038/srep08719 (2015).
33. Gandhiraman, R. P., Nordlund, D., Jayan, V., Meyyappan, M., Koehne, J. E. Scalable Low-Cost Fabrication of Disposable Paper Sensors for DNA Detection. ACS Appl Mater Interfaces. 6, 22751-22760 (2014).
34. Pavinatto, F. J., Paschoal, C. W., Arias, A. C. Printed and flexible biosensor for antioxidants using interdigitated ink-jetted electrodes and gravure-deposited active layer. Biosens Bioelectron. 67, 553-559 (2015).
35. Wang, Y., Ping, J., Ye, Z., Wu, J., Ying, Y. Impedimetric immunosensor based on gold nanoparticles modified graphene paper for label-free detection of Escherichia coli O157: H7. Biosens Bioelectron. 49, 492-498 (2013).
36. Dong, S. et al. High loading MnO2 nanowires on graphene paper: facile electrochemical synthesis and use as flexible electrode for tracking hydrogen peroxide secretion in live cells. Anal Chim Acta. 853, 200-206 (2015).
37. Panneer Selvam, A., Prasad, S. Nanosensor electrical immunoassay for quantitative detection of NT-pro brain natriuretic peptide. Future Cardiol. 9, 137-147 (2013).
38. Panneer Selvam, A., Prasad, S., Barrett, T. W., Kazmierczak, S. C. Electrical nanowell diagnostics sensors for rapid and ultrasensitive detection of prostate-specific antigen. Nanomedicine 10, 2527-2536 (2015).
39. Panneer Selvam, A., Vattipalli, K. M., Prasad, S. Design of a high sensitive non-faradaic impedimetric sensor. Paper presented at 2012 Annual International Conference of the IEEE: Engineering in Medicine and Biology Society (EMBC) San Diego, USA. San Diego: IEEE. 3251-3254 (2012, August 20).
40. Daniels, J. S., Pourmand, N. Labelfree impedance biosensors: Opportunities and challenges. Electroanalysis 19, 1239-1257 (2007).
41. Koryta, J., Dvo, J., Kavan, L. Principles of electrochemistry. (John Wiley & Sons Inc, 1993).
42. Oldham, K. B. A Gouy-Chapman-Stern model of the double layer at a (metal)/(ionic liquid) interface. J. Electroanal Chem. 613, 131-138 (2008).
43. Franks, W., Schenker, I., Schmutz, P., Hierlemann, A. Impedance characterization and modeling of electrodes for biomedical applications. Biomedical Engineering, IEEE Transactions on 52, 1295-1302, doi: 10.1109/TBME.2005.847523 (2005).
44. Schummer, C., Appenzeller, B. M., Wennig, R. Quantitative determination of ethyl glucuronide in sweat. Ther Drug Monit. 30, 536-539 (2008).
45. Alcohol and Public Health., (2015), Available at: http://www.cdc.gov/alcohol/. (Accessed: 16th October 2015).
46. Liu, J., Lu, C.-Y., Zhou, H., Xu, J.-J., Chen, H.-Y. Flexible gold electrode array for multiplexed immunoelectrochemical measurement of three protein biomarkers for prostate cancer. ACS applied materials & interfaces 6, 20137-20143 (2014).
47. Hsu, M.-S., Chen, Y.-L., Lee, C.-Y., Chiu, H.-T. Gold nanostructures on flexible substrates as electrochemical dopamine sensors. ACS Appl Mater Interfaces. 4, 5570-5575 (2012).
48. Luo, X., Davis, J. J. Electrical biosensors and the label free detection of protein disease biomarkers. Chem Soc Rev. 42, 5944-5962 (2013).
49. Nesakumar, N., Thandavan, K., Sethuraman, S., Krishnan, U. M., Rayappan, J. B. B. An electrochemical biosensor with nanointerface for lactate detection based on lactate dehydrogenase immobilized on zinc oxide nanorods. J. Colloid Interface Sci. 414, 90-96 (2014).
50. Ali, M. A., Mondal, K., Singh, C., Malhotra, B. D., Sharma, A. Anti-epidermal growth factor receptor conjugated mesoporous zinc oxide nanofibers for breast cancer diagnostics. Nanoscale 7, 7234-7245 (2015).
51. Israr, M. Q. et al. Potentiometric cholesterol biosensor based on ZnO nanorods chemically grown on Ag wire. Thin Solid Films 519, 1106-1109 (2010).
52. Pradhan, D., Niroui, F., Leung, K. High-performance, flexible enzymatic glucose biosensor based on ZnO nanowires supported on a gold-coated polyester substrate. ACS Appl Mater Interfaces. 2, 2409-2412 (2010).
53. Jacobs, M., Muthukumar, S., Panneer Selvam, A., Engel Craven, J., Prasad, S. Ultra-sensitive electrical immunoassay biosensors using nanotextured zinc oxide thin films on printed circuit board platforms. Biosens Bioelectron. 55, 7-13 (2014).