Brain, hormone and appetite responses to glucose versus fructose

Current Opinion in Behavioral Sciences

Volumn 9, Issue , 2016, Pages 111-117

  Page, Kathleen A ^a   Melrose, A James ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; FRUCTOSE; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; LEPTIN;

APPETITE; BRAIN FUNCTION; BRAIN REGION; FEEDING BEHAVIOR; FOOD INTAKE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HYPOTHALAMUS; MOTIVATION; NEUROENDOCRINE SYSTEM; NEUROIMAGING; REVIEW; SATIETY;

EID: 84961658172     PISSN: None     EISSN: 23521546     Source Type: Journal    
DOI: 10.1016/j.cobeha.2016.03.002     Document Type: Review

References (52)

1. Ogden C.L., Carroll M.D., Kit B.K., Flegal K.M. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 2014, 311:806-814.
2. Bray G.A. Potential health risks from beverages containing fructose found in sugar or high-fructose corn syrup. Diab Care 2013, 36:11-12.
3. Malik V.S., Fructose Hu F.B., Cardiometabolic Health What the evidence from sugar-sweetened beverages tells us. J Am Coll Cardiol 2015, 66:1615-1624.
4. Nagai Y., Nishio Y., Nakamura T., Maegawa H., Kikkawa R., Kashiwagi A. Amelioration of high fructose-induced metabolic derangements by activation of PPARalpha. Am J Physiol Endocrinol Metab 2002, 282:E1180-E1190.
5. Tappy L., Lê K-A. Metabolic effects of fructose and the worldwide increase in obesity. Physiol Rev 2010, 90:23-46.
6. Cha S.H., Lane M.D. Central lactate metabolism suppresses food intake via the hypothalamic AMP kinase/malonyl-CoA signaling pathway. Biochem Biophys Res Commun 2009, 386:212-216.
7. Cha S.H., Wolfgang M., Tokutake Y., Chohnan S., Lane M.D. Differential effects of central fructose and glucose on hypothalamic malonyl-CoA and food intake. Proc Natl Acad Sci 2008, 105:16871-16875.
8. Jürgens H., Haass W., Castañeda T.R., Schürmann A., Koebnick C., Dombrowski F., et al. Consuming fructose-sweetened beverages increases body adiposity in mice. Obes Res 2005, 13:1146-1156.
9. Miller C.C., Martin R.J., Whitney M.L., Edwards G.L. Intracerebroventricular injection of fructose stimulates feeding in rats. Nutr Neurosci 2002, 5:359-362.
10. Page K.A., Chan O., Arora J., et al. Effects of fructose vs glucose on regional cerebral blood flow in brain regions involved with appetite and reward pathways. JAMA 2013, 309:63-70.
11. Luo S., Monterosso J.R., Sarpelleh K., Page K.A. Differential effects of fructose versus glucose on brain and appetitive responses to food cues and decisions for food rewards. Proc Natl Acad Sci 2015, 112:6509-6514.
12. Wölnerhanssen B.K., Meyer-Gerspach A.C., Schmidt A., Zimak N., Peterli R., Beglinger C., et al. Dissociable behavioral, physiological and neural effects of acute glucose and fructose ingestion: a pilot study. PloS One 2015, 10:e0130280.
13. Hanover L.M., White J.S. Manufacturing, composition, and applications of fructose. Am J Clin Nutr 1993, 58:724S-732S.
14. Havel P.J., Dietary Fructose Implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr Rev 2005, 63:133-157.
15. Figlewicz D.P., Benoit S.C. Insulin, leptin, and food reward: update 2008. Am J Physiol Regul Integr Comp Physiol 2009, 296:R9-R19.
16. Woods S.C., Chavez M., Park C.R., Riedy C., Kaiyala K., Richardson R.D., et al. The evaluation of insulin as a metabolic signal influencing behavior via the brain. Neurosci Biobehav Rev 1996, 20:139-144.
17. Mebel D.M., Wong J.C.Y., Dong Y.J., Borgland S.L. Insulin in the ventral tegmental area reduces hedonic feeding and suppresses dopamine concentration via increased reuptake. Eur J Neurosci 2012, 36:2336-2346.
18. Labouèbe G., Liu S., Dias C., Zou H., Wong J.C.Y., Karunakaran S., et al. Insulin induces long-term depression of ventral tegmental area dopamine neurons via endocannabinoids. Nat Neurosci 2013, 16:300-308.
19. Curry D.L. Effects of mannose and fructose on the synthesis and secretion of insulin. Pancreas 1989, 4:2-9.
20. Teff K.L., Grudziak J., Townsend R.R., Dunn T.N., Grant R.W., Adams S.H., et al. Endocrine and metabolic effects of consuming fructose- and glucose-sweetened beverages with meals in obese men and women: influence of insulin resistance on plasma triglyceride responses. J Clin Endocrinol Metab 2009, 94:1562-1569.
21. Figlewicz D.P., Benoit S.C. Insulin, leptin, and food reward: update 2008. Am J Physiol: Regul Integr Comp Physiol 2009, 296:R9-R19.
22. Lindqvist A., Baelemans A., Erlanson-Albertsson C. Effects of sucrose, glucose and fructose on peripheral and central appetite signals. Regul Pept 2008, 150:26-32.
23. Kong M-F., Chapman I., Goble E., Wishart J., Wittert G., Morris H., et al. Effects of oral fructose and glucose on plasma GLP-1 and appetite in normal subjects. Peptides 1999, 20:545-551.
24. Ogawa S., Lee T.M., Kay A.R., Tank D.W. Brain magnetic resonance imaging with contrast dependent on blood oxygenation. Proc Natl Acad Sci U S A 1990, 87:9868-9872.
25. Arthurs O.J., Boniface S. How well do we understand the neural origins of the fMRI BOLD signal?. Trends Neurosci 2002, 25:27-31.
26. Matsuda M., DeFronzo R.A. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diab Care 1999, 22:1462-1470.
27. Levin B.E., Routh V.H., Kang L., Sanders N.M., Dunn-Meynell A.A. Neuronal glucosensing: what do we know after 50 years?. Diabetes 2004, 53:2521-2528.
28. Page K.A., Arora J., Qiu M., Relwani R., Constable R.T., Sherwin R.S. Small decrements in systemic glucose provoke increases in hypothalamic blood flow prior to the release of counterregulatory hormones. Diabetes 2009, 58:448-452.
29. Liu Y., Gao J.H., Liu H.L., Fox P.T. The temporal response of the brain after eating revealed by functional MRI. Nature 2000, 405:1058-1062.
30. Matsuda M., Liu Y., Mahankali S., Pu Y., Mahankali A., Wang J., et al. Altered hypothalamic function in response to glucose ingestion in obese humans. Diabetes 1999, 48:1801-1806.
31. Smeets P.A.M., de Graaf C., Stafleu A., van Osch M.J.P., van der Grond J. Functional MRI of human hypothalamic responses following glucose ingestion. NeuroImage 2005, 24:363-368.
32. Smeets P.A.M., de Graaf C., Stafleu A., van Osch M.J.P., van der Grond J. Functional magnetic resonance imaging of human hypothalamic responses to sweet taste and calories. Am J Clin Nutr 2005, 82:1011-1016.
33. Smeets P.A.M., Vidarsdottir S., de Graaf C., Stafleu A., van Osch M.J.P., Viergever M.A., et al. Oral glucose intake inhibits hypothalamic neuronal activity more effectively than glucose infusion. Am J Physiol Endocrinol Metab 2007, 293:E754-E758.
34. Vidarsdottir S., Smeets P.A.M., Eichelsheim D.L., van Osch M.J.P., Viergever M.A., Romijn J.A., et al. Glucose ingestion fails to inhibit hypothalamic neuronal activity in patients with type 2 diabetes. Diabetes 2007, 56:2547-2550.
35. van de Sande-Lee S., Pereira F.R.S., Cintra D.E., Fernandes P.T., Cardoso A.R., Garlipp C.R., et al. Partial reversibility of hypothalamic dysfunction and changes in brain activity after body mass reduction in obese subjects. Diabetes 2011, 60:1699-1704.
36. Teeuwisse W.M., Widya R.L., Paulides M., Lamb H.J., Smit J.W.A., de Roos A., et al. Short-term caloric restriction normalizes hypothalamic neuronal responsiveness to glucose ingestion in patients with type 2 diabetes. Diabetes 2012, 61:3255-3259.
37. Purnell J.Q., Klopfenstein B.A., Stevens A.A., Havel P.J., Adams S.H., Dunn T.N., et al. Brain functional magnetic resonance imaging response to glucose and fructose infusions in humans. Diabetes Obes Metab 2011, 13:229-234.
38. Little T.J., McKie S., Jones R.B., D'Amato M., Smith C., Kiss O., et al. Mapping glucose-mediated gut-to-brain signalling pathways in humans. NeuroImage 2014, 96:1-11.
39. Batterham R.L., Cowley M.A., Small C.J., Herzog H., Cohen M.A., Dakin C.L., et al. Gut hormone PYY3-36 physiologically inhibits food intake. Nature 2002, 418:650-654.
40. De Silva A., Salem V., Long C.J., Makwana A., Newbould R.D., Rabiner E.A., et al. The gut hormones PYY 3-36 and GLP-1 7-36 amide reduce food intake and modulate brain activity in appetite centers in humans. Cell Metab 2011, 14:700-706.
41. Malik S., McGlone F., Bedrossian D., Dagher A. Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab 2008, 7:400-409.
42. Musen G., Simonson D.C., Bolo N.R., Driscoll A., Weinger K., Raji A., et al. Regional brain activation during hypoglycemia in type 1 diabetes. J Clin Endocrinol Metab 2008, 93:1450-1457.
43. Page K.A., Seo D., Belfort-DeAguiar R., Lacadie C., Dzuira J., Naik S., et al. Circulating glucose levels modulate neural control of desire for high-calorie foods in humans. J Clin Invest 2011, 121:4161-4169.
44. Kroemer N.B., Krebs L., Kobiella A., Grimm O., Vollstädt-Klein S., Wolfensteller U., et al. (Still) longing for food: Insulin reactivity modulates response to food pictures. Hum Brain Mapp 2013, 34:2367-2380.
45. Heni M., Kullmann S., Ketterer C., Guthoff M., Bayer M., Staiger H., et al. Differential effect of glucose ingestion on the neural processing of food stimuli in lean and overweight adults. Hum Brain Mapp 2014, 35:918-928.
46. Van Vugt D.A., Krzemien A., Alsaadi H., Frank T.C., Reid R.L. Glucose-induced inhibition of the appetitive brain response to visual food cues in polycystic ovary syndrome patients. Brain Res 2014, 1558:44-56.
47. Adam T.C., Tsao S., Page K.A., Hu H., Hasson R.E., Goran M.I. Insulin sensitivity and brain reward activation in overweight Hispanic girls: a pilot study. Pediatr Obes 2015, 10:30-36.
48. Guthoff M., Stingl K., Tschritter O., Rogic M., Heni M., Stingl K., et al. The insulin-mediated modulation of visually evoked magnetic fields is reduced in obese subjects. PLoS ONE 2011, 6:e19482.
49. Jastreboff A.M., Sinha R., Lacadie C., Small D.M., Sherwin R.S., Potenza M.N. Neural correlates of stress- and food cue-induced food craving in obesity association with insulin levels. Diab Care 2013, 36:394-402.
50. Anthony K., Reed L.J., Dunn J.T., Bingham E., Hopkins D., Marsden P.K., et al. Attenuation of insulin-evoked responses in brain networks controlling appetite and reward in insulin resistance: the cerebral basis for impaired control of food intake in metabolic syndrome?. Diabetes 2006, 55:2986-2992.
51. Petcharunpaisan S., Ramalho J., Castillo M. Arterial spin labeling in neuroimaging. World J Radiol 2010, 2:384-398.
52. Friston K.J. Functional and effective connectivity: a review. Brain Connect 2011, 1:13-36.