How well do we understand the neural origins of the fMRI BOLD signal?

Trends in Neurosciences

Volumn 25, Issue 1, 2002, Pages 27-31

  Arthurs, Owen J ^a   Boniface, Simon ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTION POTENTIAL; BLOOD FLOW; BLOOD OXYGENATION; BRAIN FUNCTION; HUMAN; NERVE CELL; NUCLEAR MAGNETIC RESONANCE IMAGING; POPULATION; PRIORITY JOURNAL; REVIEW; SYNAPSE;

ACTION POTENTIALS; ANIMALS; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; HUMANS; MAGNETIC RESONANCE IMAGING; NEURAL INHIBITION; NEURONS; SYNAPTIC TRANSMISSION;

EID: 0036153119     PISSN: 01662236     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-2236(00)01995-0     Document Type: Review

References (36)

1. Brain magnetic resonance imaging with contrast dependent on blood oxygenation
2. The magnetic properties and structure of haemoglobin, oxyhaemoglobin and carbon monoxyhaemoglobin
3. Oxygenation dependence of the transverse relaxation time of water protons in whole blood at high field
4. The concept of coupling blood flow to brain function: Revision required?
5. Coupling of brain activity and cerebral blood flow: Basis of functional neuroimaging
6. Neurophysiological investigation of the basis of the fMRI signal
7. Linear coupling between functional magnetic resonance imaging and evoked potential amplitude in human somatosensory cortex
8. An approach to probe some neural systems interaction by functional MRI at neural time scale down to milliseconds
9. Changes in local cerebral blood flow and neuronal activity during sensory stimulation in normal and sympathectomised cats
10. Frequency-dependent changes in cerebral blood flow and evoked potentials during somatosensory stimulation in the rat
11. Modification of activity-dependent increases of cerebral blood flow by excitatory synaptic activity and spikes in rat cerebellar cortex
12. Simultaneous recording of evoked potentials and T2*-weighted MR images during somatosensory stimulation of rat
13. Coupling and uncoupling of activity-dependent increases of neuronal activity and blood flow in rat somatosensory cortex
14. Potentials evoked in human and monkey cerebral cortex by stimulation of the median nerve. A review of scalp and intracranial recordings
15. Interpretation of action potentials evoked in the cerebral cortex
16. The cortical alpha rhythm in dog: The depth and surface profile of phase
17. Neural mechanisms underlying brain waves: From neural membranes to networks
18. Spikes versus BOLD: What does neuroimaging tell us about neuronal activity?
19. A direct quantitative relationship between the functional properties of human and macaque V5
20. Effect of alpha-chloralose, halothane, pentobarbital and nitrous oxide anesthesia on metabolic coupling in somatosensory cortex of rat
21. Coupling of neural activation to blood flow in the somatosensory cortex of rats is time-intensity separable, but not linear
22. Characterizing the relationship between BOLD contrast and regional cerebral blood flow measurements by varying the stimulus presentation rate
23. Neurophysiological correlates of different functional states of the brain
24. Frequency-dependent activation of glucose utilization in the superior cervical ganglion by electrical stimulation of cervical sympathetic trunk
25. Circulatory and metabolic correlates of brain function in normal humans
26. Role of sodium and potassium ions in regulation of glucose metabolism in cultured astroglia
27. Directly gated transmission at central synapses
28. Effects of antidromic stimulation of the ventral root on glucose utilization in the ventral horn of the spinal cord in the rat
29. Interactions between electrical activity and cortical microcirculation revealed by imaging spectroscopy: Implications for functional brain mapping
30. High-resolution mapping of iso-orientation columns by fMRI
31. Neuronal population activity and functional imaging
32. On the relation between brain images and brain neural networks
33. Effects of sleep and arousal on the processing of visual information in the cat
34. The relationship between synchronization among neuronal populations and their mean activity levels
35. Increased activity in human visual cortex during directed attention in the absence of visual stimulation