CD4 T cell defects in the aged: Causes, consequences and strategies to circumvent

Experimental Gerontology

Volumn 54, Issue , 2014, Pages 67-70

  Zhang, Wenliang ^a   Brahmakshatriya, Vinayak ^a   Swain, Susan L ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Ab production; Aging; CD4 T cell help; CD4 T cells; IL 6

Indexed keywords

CYTOKINE; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 6;

ADAPTIVE IMMUNITY; AGED; AGING; ANIMAL; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL COMMUNICATION; HELPER CELL; HUMAN; IMMUNOLOGY; METABOLISM; MOUSE; PHYSIOLOGY; T LYMPHOCYTE SUBPOPULATION;

ADAPTIVE IMMUNITY; ADJUVANTS, IMMUNOLOGIC; AGED; AGING; ANIMALS; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CYTOKINES; HUMANS; INTERLEUKIN-6; MICE; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 84898783099     PISSN: 05315565     EISSN: 18736815     Source Type: Journal    
DOI: 10.1016/j.exger.2014.01.002     Document Type: Review

References (38)

1. Allison A.C., Byars N.E. Immunological adjuvants: desirable properties and side-effects. Mol. Immunol. 1991, 28:279-284.
2. Brown D.M., Lee S., Garcia-Hernandez Mde L., Swain S.L. Multifunctional CD4 cells expressing gamma interferon and perforin mediate protection against lethal influenza virus infection. J. Virol. 2012, 86:6792-6803.
3. Cancro M.P., Hao Y., Scholz J.L., Riley R.L., Frasca D., Dunn-Walters D.K., Blomberg B.B. B cells and aging: molecules and mechanisms. Trends Immunol. 2009, 30:313-318.
4. Carlson B.C., Jansson A.M., Larsson A., Bucht A., Lorentzen J.C. The endogenous adjuvant squalene can induce a chronic T-cell-mediated arthritis in rats. Am. J. Pathol. 2000, 156:2057-2065.
5. Channappanavar R., Twardy B.S., Krishna P., Suvas S. Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells. Mech. Ageing Dev. 2009, 130:709-712.
6. Del Giudice G., Hilbert A.K., Bugarini R., Minutello A., Popova O., Toneatto D., Schoendorf I., Borkowski A., Rappuoli R., Podda A. An MF59-adjuvanted inactivated influenza vaccine containing A/Panama/1999 (H3N2) induced broader serological protection against heterovariant influenza virus strain A/Fujian/2002 than a subunit and a split influenza vaccine. Vaccine 2006, 24:3063-3065.
7. + T cells with a naive phenotype in the periphery. Dev. Immunol. 1992, 2:141-150.
8. Eaton S.M., Burns E.M., Kusser K., Randall T.D., Haynes L. Age-related defects in CD4 T cell cognate helper function lead to reductions in humoral responses. J. Exp. Med. 2004, 200:1613-1622.
9. Franceschi C., Olivieri F., Marchegiani F., Cardelli M., Cavallone L., Capri M., Salvioli S., Valensin S., De Benedictis G., Di Iorio A., Caruso C., Paolisso G., Monti D. Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech. Ageing Dev. 2005, 126:351-361.
10. Frasca D., Landin A.M., Riley R.L., Blomberg B.B. Mechanisms for decreased function of B cells in aged mice and humans. J. Immunol. 2008, 180:2741-2746.
11. Frey S., Poland G., Percell S., Podda A. Comparison of the safety, tolerability, and immunogenicity of a MF59-adjuvanted influenza vaccine and a non-adjuvanted influenza vaccine in non-elderly adults. Vaccine 2003, 21:4234-4237.
12. Garcia G.G., Miller R.A. Age-related defects in the cytoskeleton signaling pathways of CD4 T cells. Ageing Res. Rev. 2011, 10:26-34.
13. Garcia F., Climent N., Guardo A.C., Gil C., Leon A., Autran B., Lifson J.D., Martinez-Picado J., Dalmau J., Clotet B., Gatell J.M., Plana M., Gallart T. A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication. Sci. Transl. Med. 2013, 5:166ra162.
14. Garcia F., Plana M., Climent N., Leon A., Gatell J.M., Gallart T. Dendritic cell based vaccines for HIV infection: the way ahead. Hum. Vaccines Immunother. 2013, 9.
15. Goronzy J.J., Weyand C.M. Understanding immunosenescence to improve responses to vaccines. Nat. Immunol. 2013, 14:428-436.
16. Haynes L., Linton P.J., Eaton S.M., Tonkonogy S.L., Swain S.L. Interleukin 2, but not other common gamma chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice. J. Exp. Med. 1999, 190:1013-1024.
17. Haynes L., Eaton S.M., Burns E.M., Rincon M., Swain S.L. Inflammatory cytokines overcome age-related defects in CD4 T cell responses in vivo. J. Immunol. 2004, 172:5194-5199.
18. Jones S.C., Brahmakshatriya V., Huston G., Dibble J., Swain S.L. TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism. J. Immunol. 2010, 185:6783-6794.
19. Klinman N.R., Kline G.H. The B-cell biology of aging. Immunol. Rev. 1997, 160:103-114.
20. Kreutz M., Tacken P.J., Figdor C.G. Targeting dendritic cells - why bother?. Blood 2013, 121:2836-2844.
21. Lambrecht B.N., Kool M., Willart M.A., Hammad H. Mechanism of action of clinically approved adjuvants. Curr. Opin. Immunol. 2009, 21:23-29.
22. LeMaoult J., Szabo P., Weksler M.E. Effect of age on humoral immunity, selection of the B-cell repertoire and B-cell development. Immunol. Rev. 1997, 160:115-126.
23. Lien E., Golenbock D.T. Adjuvants and their signaling pathways: beyond TLRs. Nat. Immunol. 2003, 4:1162-1164.
24. Marshall N.B., Swain S.L. Cytotoxic CD4 T cells in antiviral immunity. J. Biomed. Biotechnol. 2011, 2011:954602.
25. Maue A.C., Eaton S.M., Lanthier P.A., Sweet K.B., Blumerman S.L., Haynes L. Proinflammatory adjuvants enhance the cognate helper activity of aged CD4 T cells. J. Immunol. 2009, 182:6129-6135.
26. + helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. Nat. Immunol. 2013, 14:281-289.
27. Nikolich-Zugich J. The aging immune system: challenges for the 21st century. Semin. Immunol. 2012, 24:301-302.
28. Petrovsky N.H., Susanne, Honda Yoshikazu, Lyons A.Bruce New-age vaccine adjuvants: friend or foe?. BioPharm Int. 2007, 20.
29. Podda A., Del Giudice G. MF59-adjuvanted vaccines: increased immunogenicity with an optimal safety profile. Expert Rev. Vaccines 2003, 2:197-203.
30. Sprent J., Surh C.D. Normal T cell homeostasis: the conversion of naive cells into memory-phenotype cells. Nat. Immunol. 2011, 12:478-484.
31. Steger M.M., Maczek C., Berger P., Grubeck-Loebenstein B. Vaccination against tetanus in the elderly: do recommended vaccination strategies give sufficient protection. Lancet 1996, 348:762.
32. + T-cell-mediated protection depends on secondary effectors that are distinct from and superior to primary effectors. Proc. Natl. Acad. Sci. U. S. A. 2012, 109:E2551-E2560.
33. Tacken P.J., de Vries I.J., Torensma R., Figdor C.G. Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting. Nat. Rev. Immunol. 2007, 7:790-802.
34. Tsukamoto H., Clise-Dwyer K., Huston G.E., Duso D.K., Buck A.L., Johnson L.L., Haynes L., Swain S.L. Age-associated increase in lifespan of naive CD4 T cells contributes to T-cell homeostasis but facilitates development of functional defects. Proc. Natl. Acad. Sci. U. S. A. 2009, 106:18333-18338.
35. Tsukamoto H., Huston G.E., Dibble J., Duso D.K., Swain S.L. Bim dictates naive CD4 T cell lifespan and the development of age-associated functional defects. J. Immunol. 2010, 185:4535-4544.
36. Weinberger B., Herndler-Brandstetter D., Schwanninger A., Weiskopf D., Grubeck-Loebenstein B. Biology of immune responses to vaccines in elderly persons. Clin. Infect. Dis. 2008, 46:1078-1084.
37. Weksler M.E., Szabo P. The effect of age on the B-cell repertoire. J. Clin. Immunol. 2000, 20:240-249.
38. Yager E.J., Ahmed M., Lanzer K., Randall T.D., Woodland D.L., Blackman M.A. Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J. Exp. Med. 2008, 205:711-723.