A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity

Diabetologia

Volumn 59, Issue 6, 2016, Pages 1307-1317

  Kitada, Munehiro ^a   Ogura, Yoshio ^a   Suzuki, Taeko ^a   Sen, Shi ^a   Lee, Seon Myeong ^a   Kanasaki, Keizo ^a   Kume, Shinji ^b   Koya, Daisuke ^a  

^a KANAZAWA MEDICAL UNIVERSITY   (Japan)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Autophagy; Diabetic nephropathy; Low protein diet; Mammalian target of rapamycin complex 1; Wistar fatty rat

Indexed keywords

CASPASE 3; CD68 ANTIGEN; CHOLESTEROL; COLLAGEN TYPE 3; CREATININE; CYSTATIN C; FATTY ACID BINDING PROTEIN; FIBROBLAST GROWTH FACTOR 21; HEMOGLOBIN A1C; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN KINASE B; PROTEIN P62; PROTEIN S6; TOLL LIKE RECEPTOR 2; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE;

ALBUMINURIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CALORIC RESTRICTION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETIC NEPHROPATHY; FEMALE; GLOMERULUS BASEMENT MEMBRANE; HEMOGLOBIN BLOOD LEVEL; HISTOLOGY; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; KIDNEY CORTEX; KIDNEY FIBROSIS; KIDNEY FUNCTION; KIDNEY MASS; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE CELL; MALE; MITOCHONDRION; NEPHRITIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PODOCYTE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN RESTRICTION; RAT; RENAL PROTECTION; TREATMENT DURATION; TRIACYLGLYCEROL BLOOD LEVEL; URINARY EXCRETION; VERY LOW PROTEIN DIET; ANIMAL; DIET THERAPY; DISEASE MODEL; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TRANSMISSION ELECTRON MICROSCOPY; WISTAR RAT;

ANIMALS; AUTOPHAGY; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DIET, PROTEIN-RESTRICTED; DISEASE MODELS, ANIMAL; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; MULTIPROTEIN COMPLEXES; OBESITY; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; TOR SERINE-THREONINE KINASES;

EID: 84961613490     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-3925-4     Document Type: Article

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