H3K9me3 inhibition improves memory, promotes spine formation, and increases BDNF levels in the aged hippocampus

Journal of Neuroscience

Volumn 36, Issue 12, 2016, Pages 3611-3622

  Snigdha, Shikha ^a   Aleph Prieto, G ^a   Petrosyan, Arpine ^a   Loertscher, Brad M ^a   Dieskau, André P ^a   Overman, Larry E ^a   Cotman, Carl W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aging; ETP69; H3k9me3; Memory; SUV39H1; Synaptic function

Indexed keywords

6 [BENZO(D)(1,3)DIOXOL 5 YL] 2,3,7 TRIMETHYL 1,4 DIOXOHEXAHYDRO 6H 3,8A EPIDITHIOPYRROLO(1,2 A)PYRAZINE 7 CARBONITRILE; BRAIN DERIVED NEUROTROPHIC FACTOR; HISTONE LYSINE METHYLTRANSFERASE INHIBITOR; HISTONE METHYLTRANSFERASE; NITRILE; UNCLASSIFIED DRUG; HISTONE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; BRAIN SYNAPTOSOME; CLINICAL TRIAL (TOPIC); COGNITIVE DEFECT; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENE SILENCING; GENETIC TRANSCRIPTION; HIPPOCAMPUS; IMMUNOPRECIPITATION; LEARNING AND MEMORY TEST; MALE; MEMORY; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPATIAL MEMORY; TRAINING; AGING; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; DENDRITIC SPINE; METABOLISM; PHYSIOLOGY; UPREGULATION;

AGING; ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; DENDRITIC SPINES; HIPPOCAMPUS; HISTONES; MALE; MEMORY; MICE; MICE, INBRED C57BL; UP-REGULATION;

EID: 84961572452     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.2693-15.2016     Document Type: Article

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