Impact of e-cigarette refill liquid with or without nicotine on liver function in adult rats

Toxicology Mechanisms and Methods

Volumn 26, Issue 6, 2016, Pages 419-426

  El Golli, Narges ^a   Jrad Lamine, Aicha ^a   Neffati, Hajira ^a   Rahali, Dalila ^a   Dallagi, Yosra ^a   Dkhili, Houssem ^a   Ba, Nathalie ^b   El May, Michele V ^c   El Fazaa, Saloua ^a  

^a FACULTÉ DES SCIENCES DE TUNIS   (Tunisia)

^b BICÊTRE HOSPITAL   (France)

^c UNIVERSITY OF TUNIS   (Tunisia)

Author keywords

E liquid; histopathology; liver injury; nicotine; oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CATALASE; GLUTATHIONE TRANSFERASE; GLYCEROL; GLYCOGEN; LACTATE DEHYDROGENASE; MACROGOL 400; MALONALDEHYDE; NICOTINE; PROPYLENE GLYCOL; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; BIOLOGICAL MARKER;

ADULT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL DEATH; CELL INFILTRATION; CONTROLLED STUDY; ELECTRONIC CIGARETTE; ENZYME ACTIVITY; GLYCOGEN ANALYSIS; GLYCOGEN LIVER LEVEL; HISTOPATHOLOGY; INFLAMMATORY CELL; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID PEROXIDATION; LIQUID; LIVER FUNCTION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; ADVERSE EFFECTS; ANIMAL; BLOOD; DRUG EFFECTS; ENZYMOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; LIVER; LIVER FUNCTION TEST; ORGAN SIZE; PATHOLOGY; WISTAR RAT;

ANIMALS; BIOMARKERS; ELECTRONIC CIGARETTES; INJECTIONS, INTRAPERITONEAL; LIPID PEROXIDATION; LIVER; LIVER FUNCTION TESTS; MALE; NICOTINE; ORGAN SIZE; OXIDATIVE STRESS; RATS, WISTAR;

EID: 84961390702     PISSN: 15376516     EISSN: 15376524     Source Type: Journal    
DOI: 10.3109/15376516.2016.1160963     Document Type: Article

References (36)

1. H.Aebi (1984). Catalase in vitro. Methods Enzymol 105:121–6
2. K.A.Amin, H.Abdel Hameid2nd, A.H.Abd Elsttar (2010). Effect of food azo dyes tartrazine and carmoisine on biochemical parameters related to renal, hepatic function and oxidative stress biomarkers in young male rats. Food Chem Toxicol 48:2994–9
3. M.Bagchi, D.Bagchi, E.Adickes, (1995). Chronic effects of smokeless tobacco extract on rat liver histopathology and production of HSP-90. J Environ Pathol Toxicol Oncol 14:61–8
4. V.Bahl, S.Lin, N.Xu, (2012). Comparison of electronic cigarette refill fluid cytotoxicity using embryonic and adult models. Reprod Toxicol 34:529–37
5. A.Balakrishnan, V.P.Menon (2007). Protective effect of hesperidin on nicotine induced toxicity in rats. Indian J Exp Biol 45:194–202
6. G.Bandyopadhyaya, S.Sinha, B.D.Chattopadhyay, (2008). Protective role of curcumin against nicotine-induced genotoxicity on rat liver under restricted dietary protein. Eur J Pharmacol 588:151–7
7. L.N.Bell, R.Vuppalanchi, P.B.Watkins, (2012). Serum proteomic profiling in patients with drug-induced liver injury. Aliment Pharmacol Ther 35:600–12
8. A.Besaratinia, S.Tommasi (2014). Electronic cigarettes:the road ahead. Prev Med 66:65–7
9. M.F.Borgerding, J.A.Bodnar, G.M.Curtin, (2012). The chemical composition of smokeless tobacco:a survey of products sold in the United States in 2006 and 2007. Regul Toxicol Pharmacol 64:367–87
10. J.A.Buege, S.D.Aust. (1978). Microsomal lipid peroxidation. Methods Enzymol 52:302–10
11. I.Celik, Z.Yilmaz, V.Turkoglu (2009). Hematotoxic and hepatotoxic effects of dichlorvos at sublethal dosages in rats. Environ Toxicol 24:128–32
12. F.Cervellati, X.M.Muresan, C.Sticozzi, (2014). Comparative effects between electronic and cigarette smoke in human keratinocytes and epithelial lung cells. Toxicol in Vitro 28:999–1005
13. K.Chattopadhyay, S.Mondal, B.Chattopadhyay, (2010). Ameliorative effect of sesame lignans on nicotine toxicity in rats. Food Chem Toxicol 48:3215–20
14. N.El Golli, H.Dkhili, Y.Dallagi, (2016). Comparison between electronic cigarette refill liquid and nicotine on metabolic parameters in rats. Life Sci 146:131–8
15. A.R.El-Zayadi (2006). Heavy smoking and liver. World J Gastroenterol 12:6098–101
16. K.E.Farsalinos, G.Romagna, E.Allifranchini, (2013). Comparison of the cytotoxic potential of cigarette smoke and electronic cigarette vapour extract on cultured myocardial cells. Int J Environ Res Public Health 10:5146–62
17. W.H.Habig, M.J.Pabst, W.B.Jakoby. (1974). Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130–9
18. K.Husain, B.R.Scott, S.K.Reddy, (2001). Chronic ethanol and nicotine interaction on rat tissue antioxidant defense system. Alcohol 25:89–97
19. M.L.Hu (1994). Measurement of protein thiol groups and glutathione in plasma. Methods Enzymol 233:380–5
20. JECFA. (1976). Evaluation of certain food additives. Twentieth report of the Joint FAO/WHO Expert Committee on Food Additives. World Health Organ Tech Rep Ser, 1–32
21. M.Kaur, R.Sandhir (2006). Comparative effects of acute and chronic carbofuran exposure on oxidative stress and drug-metabolizing enzymes in liver. Drug Chem Toxicol 29:415–21
22. A.L.Klatsky, M.A.Armstrong (1992). Alcohol, smoking, coffee, and cirrhosis. Am J Epidemiol 136:1248–57
23. C.A.Lerner, I.K.Sundar, H.Yao, (2015). Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung. PLoS One 10:e0116732. DOI:10.1371/journal.pone.0116732
24. H.B.Lim, S.H.Kim (2014). Inhallation of e-cigarette cartridge solution aggravates allergen-induced airway inflammation and hyper-responsiveness in mice. Toxicol Res 30:13–8
25. O.H.Lowry, N.J.Rosebrough, A.L.Farr, (1951). Protein measurement with the folin phenol reagent. J Biol Chem 193:265–75
26. J.M.McCord (1993). Human disease, free radicals, and the oxidant/antioxidant balance. Clin Biochem 26:351–7
27. H.P.Misra, I.Fridovich (1972). The role of superoxide anion in the autoxidation of epinephrine and a simple assay for superoxide dismutase. J Biol Chem 247:3170–5
28. M.Mori, M.Hara, I.Wada, (2000). Prospective study of hepatitis B and C viral infections, cigarette smoking, alcohol consumption, and other factors associated with hepatocellular carcinoma risk in Japan. Am J Epidemiol 151:131–9
29. G.Romagna, E.Allifranchini, E.Bocchietto, (2013). Cytotoxicity evaluation of electronic cigarette vapor extract on cultured mammalian fibroblasts (ClearStream-LIFE):comparison with tobacco cigarette smoke extract. Inhal Toxicol 25:354–61
30. S.Sancilio, M.Gallorini, A.Cataldi, (2015). Cytotoxicity and apoptosis induction by e-cigarette fluids in human gingival fibroblasts. Clin Oral Investig. [Epub ahead of print]. DOI:10.1007/s00784-015-1537-x
31. S.Scheffler, H.Dieken, O.Krischenowski, (2015). Evaluation of e-cigarette liquid vapor and mainstream cigarette smoke after direct exposure of primary human bronchial epithelial cells. Int J Environ Res Public Health 12:3915–25
32. H.Suleyman, K.Gumustekin, S.Taysi, (2002). Beneficial effects of Hippophae rhamnoides L. on nicotine induced oxidative stress in rat blood compared with vitamin E. Biol Pharm Bull 25:1133–6
33. T.E.Sussan, S.Gajghate, R.K.Thimmulappa, (2015). Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model. PLoS One 10:e0116861
34. USDHHS. (2014). The health consequences of smoking—50 years of progress. A Report of the Surgeon General. Atlanta:U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health
35. M.Williams, A.Villarreal, K.Bozhilov, (2013). Metal and silicate particles including nanoparticles are present in electronic cigarette cartomizer fluid and aerosol. PLoS One 8:e57987
36. D.Willis, M.Popovech, F.Gany, (2012). Toxicology of smokeless tobacco:implications for immune, reproductive, and cardiovascular systems. J Toxicol Environ Health B Crit Rev 15:317–31