How compelling are the data for Epstein-Barr virus being a trigger for systemic lupus and other autoimmune diseases?

Current Opinion in Rheumatology

Volumn 28, Issue 4, 2016, Pages 398-404

  Draborg, Anette ^a   Izarzugaza, Jose M G ^b   Houen, Gunnar ^a  

^a STATENS SERUM INSTITUT   (Denmark)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Epstein Barr virus; immunodeficiencies; infections; systemic lupus erythematosus

Indexed keywords

ANTIBODY;

ANTIBODY BLOOD LEVEL; AUTOIMMUNE DISEASE; DISEASE ACTIVITY; DISEASE ASSOCIATION; EPSTEIN BARR VIRUS; EPSTEIN BARR VIRUS INFECTION; HUMAN; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SJOEGREN SYNDROME; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; VIRUS REACTIVATION; COMPLICATION; EVIDENCE BASED MEDICINE; IMMUNOLOGY; ISOLATION AND PURIFICATION; PHYSIOLOGY; PROCEDURES; VIROLOGY; VIRUS ACTIVATION;

ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; EPSTEIN-BARR VIRUS INFECTIONS; EVIDENCE-BASED MEDICINE; HERPESVIRUS 4, HUMAN; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; SJOGREN'S SYNDROME; VIRUS ACTIVATION;

EID: 84961223628     PISSN: 10408711     EISSN: 15316963     Source Type: Journal    
DOI: 10.1097/BOR.0000000000000289     Document Type: Review

References (50)

1. Rahman A, Isenberg DA. Systemic lupus erythematosus. N Engl J Med 2008; 358: 929-939
2. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40: 1725
3. Stern R, Fishman J, Brusman H, et al. Systemic lupus erythematosus associated with Klinefelter's syndrome. Arthritis Rheum 1977; 20: 18-22
4. Tiffin N, Adeyemo A, Okpechi I. A diverse array of genetic factors contribute to the pathogenesis of systemic lupus erythematosus. Orphanet J Rare Dis 2013; 8: 2
5. Draborg AH, Lydolph MC, Westergaard M, et al. Elevated concentrations of serum immunoglobulin free light chains in systemic lupus erythematosus patients in relation to disease activity, inflammatory status, B-cell activity and Epstein-Barr virus antibodies. PLoS One 2015; 10: e0138753
6. Amon W, Farrell PJ. Reactivation of Epstein-Barr virus from latency. Rev Med Virol 2005; 15: 149-156
7. Farrell PJ. Epstein-Barr virus. The B95-8 strain map. Methods Mol Biol 2001; 174: 3-12
8. Thorley-Lawson DA. Epstein-Barr virus: exploiting the immune system. Nat Rev Immunol 2001; 1: 75-82
9. Draborg AH, Duus K, Houen G. Epstein-Barr virus in systemic autoimmune diseases. Clin Dev Immunol 2013; 2013: 535738
10. Tattevin P, Le TY, Minjolle S, et al. Increasing incidence of severe Epstein-Barr virus-related infectious mononucleosis: surveillance study. J Clin Microbiol 2006; 44: 1873-1874
11. Draborg AH, Duus K, Houen G. Epstein-Barr virus and systemic lupus erythematosus. Clin Dev Immunol 2012; 2012: 370516
12. Jenson HB. Acute complications of Epstein-Barr virus infectious mononucleosis. Curr Opin Pediatr 2000; 12: 263-268
13. Straus SE, Cohen JI, Tosato G, et al. NIH conference. Epstein-Barr virus infections: biology, pathogenesis, and management. Ann Intern Med 1993; 118: 45-58
14. Rigante D, Mazzoni MB, Esposito S. The cryptic interplay between systemic lupus erythematosus and infections. Autoimmun Rev 2014; 13: 96-102
15. Esposito S, Bosis S, Semino M, et al. Infections and systemic lupus erythematosus. Eur J Clin Microbiol Infect Dis 2014; 33: 1467-1475
16. Toussirot E, Roudier J. Epstein-Barr virus in autoimmune diseases. Best Pract Res Clin Rheumatol 2008; 22: 883-896
17. Evans ASEB. virus antibody in systemic lupus erythematosus. Lancet 1971; 1: 1023-1024
18. Hanlon P, Avenell A, Aucott L, et al. Systematic review and meta-analysis of the sero-epidemiological association between Epstein-Barr virus and systemic lupus erythematosus. Arthritis Res Ther 2015; 16: 274
19. Rasmussen NS, Draborg AH, Nielsen CT, et al. Antibodies to early EBV, CMV, and HHV6 antigens in systemic lupus erythematosus patients. Scand J Rheumatol 2015; 44: 143-149
20. Fattal I, Shental N, Molad Y, et al. Epstein-Barr virus antibodies mark systemic lupus erythematosus and scleroderma patients negative for anti-DNA. Immunology 2014; 141: 276-285
21. Westergaard MW, Draborg AH, Troelsen L, et al. Isotypes of Epstein-Barr virus antibodies in rheumatoid arthritis: association with rheumatoid factors and citrulline-dependent antibodies. Biomed Res Int 2015; 2015: 472174
22. Yu XX, Yao CW, Tao JL, et al. The expression of renal Epstein-Barr virus markers in patients with lupus nephritis. Exp Ther Med 2014; 7: 1135-1140
23. Ding Y, He X, Liao W, et al. The expression of EBV-encoded LMP1 in young patients with lupus nephritis. Int J Clin Exp Med 2015; 8: 6073-6078
24. Minamitani T, Yasui T, Ma Y, et al. Evasion of affinity-based selection in germinal centers by Epstein-Barr virus LMP2A. Proc Natl Acad Sci USA 2015; 112: 11612-11617
25. Draborg AH, Jacobsen S, Westergaard M, et al. Reduced response to Epstein-Barr virus antigens by T-cells in systemic lupus erythematosus patients. Lupus Sci Med 2014; 1: e000015
26. Mohamed AE, Hasen AM, Mohammed GF, et al. Real-Time PCR of cytomegalovirus and Epstein-Barr virus in adult Egyptian patients with systemic lupus erythematosus. Int J Rheum Dis 2015; 18: 452-458
27. Yamashita H, Shimizu A, Tsuchiya H, et al. Chronic active Epstein-Barr virus infection mimicking autoimmune hepatitis exacerbation in a patient with systemic lupus erythematosus. Lupus 2014; 23: 833-836
28. Haramura T, Haraguchi M, Irie J, et al. Case of plasmablastic lymphoma of the sigmoid colon and literature review. World J Gastroenterol 2015; 21: 7598-7603
29. Kim TH, Lee JH, Kim YC, et al. Hydroa vacciniforme-like lymphoma misdiagnosed as cutaneous lupus erythematosus. J Cutan Pathol 2015; 42: 229-231
30. Plaza JA, Sangueza M. Hydroa vacciniforme-like lymphoma with primarily periorbital swelling: 7 cases of an atypical clinical manifestation of this rare cutaneous T-cell lymphoma. Am J Dermatopathol 2015; 37: 20-25
31. Chen J, Zhang H, Chen P, et al. Correlation between systemic lupus erythematosus and cytomegalovirus infection detected by different methods. Clin Rheumatol 2015; 34: 691-698
32. Rondaan C, De HA, Horst G, et al. Altered cellular and humoral immunity to varicella-zoster virus in patients with autoimmune diseases. Arthritis Rheumatol 2014; 66: 3122-3128
33. Fali T, Le DC, Thabet Y, et al. DNA methylation modulates HRES1/p28 expression in B-cell from patients with Lupus. Autoimmunity 2014; 47: 265-271
34. Wu Z, Mei X, Zhao D, et al. DNA methylation modulates HERV-E expression in CD4+ T-cells from systemic lupus erythematosus patients. J Dermatol Sci 2015; 77: 110-116
35. Pasoto SG, Ribeiro AC, Bonfa E. Update on infections and vaccinations in systemic lupus erythematosus and Sjogren's syndrome. Curr Opin Rheumatol 2014; 26: 528-537
36. Fox RI. Sjogren's syndrome. Lancet 2005; 366: 321-331
37. McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med 2011; 365: 2205-2219
38. Fitzner B, Hecker M, Zettl UK. Molecular biomarkers in cerebrospinal fluid of multiple sclerosis patients. Autoimmun Rev 2015; 14: 903-913
39. Croia C, Astorri E, Murray-Brown W, et al. Implication of Epstein-Barr virus infection in disease-specific autoreactive B-cell activation in ectopic lymphoid structures of Sjogren's syndrome. Arthritis Rheumatol 2014; 66: 2545-2557
40. Kivity S, Arango MT, Ehrenfeld M, et al. Infection and autoimmunity in Sjogren's syndrome: a clinical study and comprehensive review. J Autoimmun 2014; 51: 17-22
41. Cornillet M, Verrouil E, Cantagrel A, et al. In ACPA-positive RA patients, antibodies to EBNA35-58Cit, a citrullinated peptide from the Epstein-Barr nuclear antigen-1, strongly cross-react with the peptide beta60-74Cit which bears the immunodominant epitope of citrullinated fibrin. Immunol Res 2015; 61: 117-125
42. Erre GL, Mameli G, Cossu D, et al. Increased Epstein-Barr virus DNA load and antibodies against EBNA1 and EA in sardinian patients with rheumatoid arthritis. Viral Immunol 2015; 28: 385-390
43. Pender MP, Burrows SR. Epstein-Barr virus and multiple sclerosis: potential opportunities for immunotherapy. Clin Transl Immunology 2014; 3: e27
44. van Nierop GP, Mautner J, Mitterreiter JG, et al. Intrathecal CD8 T-cells of multiple sclerosis patients recognize lytic Epstein-Barr virus proteins. Mult Scler 2015; 46: 347-353
45. Nejati A, Shoja Z, Shahmahmoodi S, et al. EBV and vitamin D status in relapsing-remitting multiple sclerosis patients with a unique cytokine signature. Med Microbiol Immunol 2015. [Epub ahead of print
46. Kvistad S, Myhr KM, Holmoy T, et al. Antibodies to Epstein-Barr virus and MRI disease activity in multiple sclerosis. Mult Scler 2014; 20: 1833-1840
47. Pfuhl C, Oechtering J, Rasche L, et al. Association of serum Epstein-Barr nuclear antigen-1 antibodies and intrathecal immunoglobulin synthesis in early multiple sclerosis. J Neuroimmunol 2015; 285: 156-160
48. Ruprecht K, Wunderlich B, Giess R, et al. Multiple sclerosis: the elevated antibody response to Epstein-Barr virus primarily targets, but is not confined to, the glycine-alanine repeat of Epstein-Barr nuclear antigen-1. J Neuroimmunol 2014; 272: 56-61
49. Zivadinov R, Cerza N, Hagemeier J, et al. Humoral response to EBV is associated with cortical atrophy and lesion burden in patients with MS. Neurol Neuroimmunol Neuroinflamm 2016; 3: e190
50. Mok CC. Current role of rituximab in systemic lupus erythematosus. Int J Rheum Dis 2015; 18: 154-163