Annealing as a tool for the optimization of lyophilization and ensuring of the stability of protein-loaded PLGA nanoparticles

International Journal of Pharmaceutics

Volumn 503, Issue 1-2, 2016, Pages 163-173

  Fonte, Pedro ^a,b   Lino, Paulo Roque ^c   Seabra, Vítor ^b   Almeida, António J ^c   Reis, Salette ^a   Sarmento, Bruno ^a,b,d  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY INSTITUTE OF HEALTH SCIENCES IUCS   (Portugal)

^c RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^d UNIVERSITY OF PORTO   (Portugal)

Author keywords

Annealing; FTIR; Insulin; Lyophilization; Nanoparticle; PLGA; Protein

Indexed keywords

INSULIN; NANOPARTICLE; POLYGLACTIN; THIOFLAVINE; TREHALOSE; CRYOPROTECTIVE AGENT; DRUG CARRIER; LACTIC ACID; POLYGLYCOLIC ACID; POLYLACTIC ACID-POLYGLYCOLIC ACID COPOLYMER;

ARTICLE; CIRCULAR DICHROISM; CONTROLLED STUDY; CRYSTAL; DRUG RETENTION; FLUORESCENCE SPECTROSCOPY; FREEZE DRYING; FREEZING; INFRARED SPECTROSCOPY; LYOPHILISATE; MECHANICAL STRESS; MOISTURE; NANOENCAPSULATION; PARTICLE SIZE; PHOTON CORRELATION SPECTROSCOPY; PHYSICAL CHEMISTRY; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN STABILITY; SCANNING ELECTRON MICROSCOPY; SURFACE CHARGE; ZETA POTENTIAL; CHEMISTRY; MEDICINAL CHEMISTRY; ULTRASTRUCTURE;

CHEMISTRY, PHARMACEUTICAL; CIRCULAR DICHROISM; CRYOPROTECTIVE AGENTS; DRUG CARRIERS; FREEZE DRYING; INSULIN; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; NANOPARTICLES; PARTICLE SIZE; POLYGLYCOLIC ACID; PROTEIN STABILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TREHALOSE;

EID: 84961218502     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2016.03.011     Document Type: Article

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