메뉴 건너뛰기




Volumn 24, Issue 4, 2016, Pages 249-256

Evolutionary Rationale for Phages as Complements of Antibiotics

Author keywords

Antibiotic resistance; Combined therapies; Evolution; Phage therapy

Indexed keywords

ANTIBIOTIC AGENT; CEFOTAXIME; CEFTRIAXONE; CIPROFLOXACIN; ENROFLOXACIN; GENTAMICIN; KANAMYCIN; LINEZOLID; MEROPENEM; STREPTOMYCIN; TETRACYCLINE; ANTIINFECTIVE AGENT;

EID: 84961213584     PISSN: 0966842X     EISSN: 18784380     Source Type: Journal    
DOI: 10.1016/j.tim.2015.12.011     Document Type: Review
Times cited : (214)

References (60)
  • 1
    • 84961227916 scopus 로고    scopus 로고
    • Dramatic rise seen in antibiotic use
    • Published online September 17, 2015
    • Reardon S. Dramatic rise seen in antibiotic use. Nature 2015, Published online September 17, 2015. 10.1038/nature.2015.18383.
    • (2015) Nature
    • Reardon, S.1
  • 2
    • 84887627398 scopus 로고    scopus 로고
    • Antibiotic resistance - the need for global solutions
    • Laxminarayan R., et al. Antibiotic resistance - the need for global solutions. Lancet Infect. Dis. 2013, 13:1057-1098.
    • (2013) Lancet Infect. Dis. , vol.13 , pp. 1057-1098
    • Laxminarayan, R.1
  • 3
    • 82655177026 scopus 로고    scopus 로고
    • Poverty and root causes of resistance in developing countries
    • Springer, A. Sosa, J. de (Eds.)
    • Okeke I.N. Poverty and root causes of resistance in developing countries. Antimicrobial Resistance in Developing Countries 2010, 27-35. Springer. A. Sosa, J. de (Eds.).
    • (2010) Antimicrobial Resistance in Developing Countries , pp. 27-35
    • Okeke, I.N.1
  • 4
    • 84899927894 scopus 로고    scopus 로고
    • Antibiotic resistance sweeping developing world
    • Reardon S. Antibiotic resistance sweeping developing world. Nature 2014, 509:141-142.
    • (2014) Nature , vol.509 , pp. 141-142
    • Reardon, S.1
  • 5
    • 84922937832 scopus 로고    scopus 로고
    • A new antibiotic kills pathogens without detectable resistance
    • Ling L.L., et al. A new antibiotic kills pathogens without detectable resistance. Nature 2015, 517:455-459.
    • (2015) Nature , vol.517 , pp. 455-459
    • Ling, L.L.1
  • 6
    • 84923349774 scopus 로고    scopus 로고
    • The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine
    • Cociancich S., et al. The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine. Nat. Chem. Biol. 2015, 11:195-197.
    • (2015) Nat. Chem. Biol. , vol.11 , pp. 195-197
    • Cociancich, S.1
  • 7
    • 84919668838 scopus 로고    scopus 로고
    • Cystobactamids: Myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity
    • Baumann S., et al. Cystobactamids: Myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity. Angew. Chem. Int. Ed. Egl. 2014, 53:14605-14609.
    • (2014) Angew. Chem. Int. Ed. Egl. , vol.53 , pp. 14605-14609
    • Baumann, S.1
  • 8
    • 0023808730 scopus 로고
    • Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium
    • Leclercq R., et al. Plasmid-mediated resistance to vancomycin and teicoplanin in Enterococcus faecium. N. Engl. J. Med. 1988, 319:157-161.
    • (1988) N. Engl. J. Med. , vol.319 , pp. 157-161
    • Leclercq, R.1
  • 9
    • 79960648350 scopus 로고    scopus 로고
    • The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy
    • Read A.F., et al. The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:10871-10877.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 10871-10877
    • Read, A.F.1
  • 10
    • 84875920923 scopus 로고    scopus 로고
    • A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments
    • Masui K. A tale of two approaches: complementary mechanisms of cytotoxic and targeted therapy resistance may inform next-generation cancer treatments. Carcinogenesis 2013, 34:725-738.
    • (2013) Carcinogenesis , vol.34 , pp. 725-738
    • Masui, K.1
  • 11
    • 77954734865 scopus 로고    scopus 로고
    • Antiretroviral therapy and management of HIV infection
    • Volberding P.A., Deeks S.G. Antiretroviral therapy and management of HIV infection. Lancet 2010, 376:49-62.
    • (2010) Lancet , vol.376 , pp. 49-62
    • Volberding, P.A.1    Deeks, S.G.2
  • 12
    • 84875261410 scopus 로고    scopus 로고
    • Combination approaches to combat multidrug-resistant bacteria
    • Worthington R.J., Melander C. Combination approaches to combat multidrug-resistant bacteria. Trends Biotechnol. 2013, 31:177-184.
    • (2013) Trends Biotechnol. , vol.31 , pp. 177-184
    • Worthington, R.J.1    Melander, C.2
  • 13
    • 84885773922 scopus 로고    scopus 로고
    • Back to the future: evolving bacteriophages to increase their effectiveness against the pathogen Pseudomonas aeruginosa PAO1
    • Betts A., et al. Back to the future: evolving bacteriophages to increase their effectiveness against the pathogen Pseudomonas aeruginosa PAO1. Evol. Appl. 2013, 6:1054-1063.
    • (2013) Evol. Appl. , vol.6 , pp. 1054-1063
    • Betts, A.1
  • 14
    • 84862860490 scopus 로고    scopus 로고
    • Phage therapy-history from Twort and d'Herelle through Soviet experience to current approaches
    • Chanishvili N. Phage therapy-history from Twort and d'Herelle through Soviet experience to current approaches. Adv. Virus Res. 2012, 83:3-40.
    • (2012) Adv. Virus Res. , vol.83 , pp. 3-40
    • Chanishvili, N.1
  • 15
    • 78149468115 scopus 로고    scopus 로고
    • Bacteriophages as potential new therapeutics to replace or supplement antibiotics
    • Kutateladze M., Adamia R. Bacteriophages as potential new therapeutics to replace or supplement antibiotics. Trends Biotechnol. 2010, 28:591-595.
    • (2010) Trends Biotechnol. , vol.28 , pp. 591-595
    • Kutateladze, M.1    Adamia, R.2
  • 16
    • 84897693673 scopus 로고    scopus 로고
    • Phage therapy in the food industry
    • Endersen L., et al. Phage therapy in the food industry. Annu. Rev. Food Sci. Technol. 2014, 5:327-349.
    • (2014) Annu. Rev. Food Sci. Technol. , vol.5 , pp. 327-349
    • Endersen, L.1
  • 17
    • 9744223697 scopus 로고    scopus 로고
    • Therapeutic efficacy of bacteriophage and baytril (enrofloxacin) individually and in combination to treat colibacillosis in broilers
    • Huff W.E., et al. Therapeutic efficacy of bacteriophage and baytril (enrofloxacin) individually and in combination to treat colibacillosis in broilers. Poult. Sci. 2004, 83:1944-1947.
    • (2004) Poult. Sci. , vol.83 , pp. 1944-1947
    • Huff, W.E.1
  • 18
    • 27744503831 scopus 로고    scopus 로고
    • P100 for control of Listeria monocytogenes in foods: Genome sequence, bioinformatic analyses, oral toxicity study, and application
    • Carlton R.M., et al. P100 for control of Listeria monocytogenes in foods: Genome sequence, bioinformatic analyses, oral toxicity study, and application. Regul. Toxicol. Pharm. 2005, 43:301-312.
    • (2005) Regul. Toxicol. Pharm. , vol.43 , pp. 301-312
    • Carlton, R.M.1
  • 19
    • 84937781711 scopus 로고    scopus 로고
    • Biopreservative methods to control the growth of foodborne pathogens on fresh-cut lettuce
    • Oliveira M., et al. Biopreservative methods to control the growth of foodborne pathogens on fresh-cut lettuce. Int. J. Food Microbiol. 2015, 214:4-11.
    • (2015) Int. J. Food Microbiol. , vol.214 , pp. 4-11
    • Oliveira, M.1
  • 20
    • 84948949452 scopus 로고    scopus 로고
    • Phage therapy redux - What is to be done?
    • Young R., Gill J.J. Phage therapy redux - What is to be done?. Science 2015, 350:1163-1164.
    • (2015) Science , vol.350 , pp. 1163-1164
    • Young, R.1    Gill, J.J.2
  • 21
    • 84925860108 scopus 로고    scopus 로고
    • Revisiting phage therapy: new applications for old resources
    • Nobrega F.L., et al. Revisiting phage therapy: new applications for old resources. Trends Microbiol. 2015, 23:185-191.
    • (2015) Trends Microbiol. , vol.23 , pp. 185-191
    • Nobrega, F.L.1
  • 22
    • 68349154135 scopus 로고    scopus 로고
    • A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy
    • Wright A., et al. A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy. Clin. Otolaryngol. 2009, 34:349-357.
    • (2009) Clin. Otolaryngol. , vol.34 , pp. 349-357
    • Wright, A.1
  • 23
    • 84938408259 scopus 로고    scopus 로고
    • Bacteriophage therapies re-enter clinical trials
    • Kingwell K. Bacteriophage therapies re-enter clinical trials. Nat. Rev. Drug Discov. 2015, 14:515-516.
    • (2015) Nat. Rev. Drug Discov. , vol.14 , pp. 515-516
    • Kingwell, K.1
  • 24
    • 55749103348 scopus 로고    scopus 로고
    • Interactive and cumulative effects of multiple human stressors in marine systems
    • Crain C.M., et al. Interactive and cumulative effects of multiple human stressors in marine systems. Ecol. Lett. 2008, 11:1304-1315.
    • (2008) Ecol. Lett. , vol.11 , pp. 1304-1315
    • Crain, C.M.1
  • 25
    • 84926418142 scopus 로고    scopus 로고
    • Reconceptualizing synergism and antagonism among multiple stressors
    • Piggott J.J., et al. Reconceptualizing synergism and antagonism among multiple stressors. Ecol. Evol. 2015, 5:1538-1547.
    • (2015) Ecol. Evol. , vol.5 , pp. 1538-1547
    • Piggott, J.J.1
  • 26
    • 60649100656 scopus 로고    scopus 로고
    • Aligning antimicrobial drug discovery with complex and redundant host-pathogen interactions
    • Lebeis S.L., Kalman D. Aligning antimicrobial drug discovery with complex and redundant host-pathogen interactions. Cell Host Microbe 2009, 5:114-122.
    • (2009) Cell Host Microbe , vol.5 , pp. 114-122
    • Lebeis, S.L.1    Kalman, D.2
  • 27
    • 76249117473 scopus 로고    scopus 로고
    • Restricting ciprofloxacin-induced resistant variant formation in biofilm of Klebsiella pneumoniae B5055 by complementary bacteriophage treatment
    • Verma V., et al. Restricting ciprofloxacin-induced resistant variant formation in biofilm of Klebsiella pneumoniae B5055 by complementary bacteriophage treatment. Biofouling 2010, 64:1212-1218.
    • (2010) Biofouling , vol.64 , pp. 1212-1218
    • Verma, V.1
  • 28
    • 84873910294 scopus 로고    scopus 로고
    • Co-therapy using lytic bacteriophage and linezolid: effective treatment in eliminating methicillin resistant Staphylococcus aureus (MRSA) from diabetic foot infections
    • Chhibber S., et al. Co-therapy using lytic bacteriophage and linezolid: effective treatment in eliminating methicillin resistant Staphylococcus aureus (MRSA) from diabetic foot infections. PLoS ONE 2013, 8:e56022.
    • (2013) PLoS ONE , vol.8 , pp. e56022
    • Chhibber, S.1
  • 29
    • 84866036607 scopus 로고    scopus 로고
    • Phages limit the evolution of bacterial antibiotic resistance in experimental microcosms
    • Zhang Q.G., Buckling A. Phages limit the evolution of bacterial antibiotic resistance in experimental microcosms. Evol. Appl. 2012, 5:575-582.
    • (2012) Evol. Appl. , vol.5 , pp. 575-582
    • Zhang, Q.G.1    Buckling, A.2
  • 30
    • 84870606574 scopus 로고    scopus 로고
    • Synergistic action of gentamicin and bacteriophage in a continuous culture population of Staphylococcus aureus
    • Kirby A.E. Synergistic action of gentamicin and bacteriophage in a continuous culture population of Staphylococcus aureus. PLoS ONE 2012, 7:e51017.
    • (2012) PLoS ONE , vol.7 , pp. e51017
    • Kirby, A.E.1
  • 31
    • 84987813254 scopus 로고    scopus 로고
    • Phage-host interplay: examples from tailed phages and Gram-negative bacterial pathogens
    • Chaturongakul S., Ounjai P. Phage-host interplay: examples from tailed phages and Gram-negative bacterial pathogens. Front. Microbiol. 2014, 5:442.
    • (2014) Front. Microbiol. , vol.5 , pp. 442
    • Chaturongakul, S.1    Ounjai, P.2
  • 32
    • 84907916701 scopus 로고    scopus 로고
    • A window of opportunity to control the bacterial pathogen Pseudomonas aeruginosa combining antibiotics and phages
    • Torres-Barceló C., et al. A window of opportunity to control the bacterial pathogen Pseudomonas aeruginosa combining antibiotics and phages. PLoS ONE 2014, 9:e106628.
    • (2014) PLoS ONE , vol.9 , pp. e106628
    • Torres-Barceló, C.1
  • 33
    • 84940460691 scopus 로고    scopus 로고
    • The potential impact of coinfection on antimicrobial chemotherapy and drug resistance
    • Birger R.B., et al. The potential impact of coinfection on antimicrobial chemotherapy and drug resistance. Trends Microbiol. 2015, 23:537-544.
    • (2015) Trends Microbiol. , vol.23 , pp. 537-544
    • Birger, R.B.1
  • 34
    • 84895730300 scopus 로고    scopus 로고
    • Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention
    • McVicker G., et al. Clonal expansion during Staphylococcus aureus infection dynamics reveals the effect of antibiotic intervention. PLoS Pathog. 2014, 10:e1003959.
    • (2014) PLoS Pathog. , vol.10 , pp. e1003959
    • McVicker, G.1
  • 35
    • 84921917258 scopus 로고    scopus 로고
    • Bacteriophage-mediated control of a two-species biofilm formed by microorganisms causing catheter-associated urinary tract infections in an in vitro urinary catheter model
    • Lehman S.M., Donlan R.M. Bacteriophage-mediated control of a two-species biofilm formed by microorganisms causing catheter-associated urinary tract infections in an in vitro urinary catheter model. Antimicrob. Agents Chemother. 2015, 59:1127-1137.
    • (2015) Antimicrob. Agents Chemother. , vol.59 , pp. 1127-1137
    • Lehman, S.M.1    Donlan, R.M.2
  • 36
    • 69149086768 scopus 로고
    • Observations on the effect of penicillin on the reaction between phage and staphylococci
    • Krueger A.P., et al. Observations on the effect of penicillin on the reaction between phage and staphylococci. J. Gen. Physiol. 1948, 31:477-488.
    • (1948) J. Gen. Physiol. , vol.31 , pp. 477-488
    • Krueger, A.P.1
  • 37
    • 40749128501 scopus 로고    scopus 로고
    • Phage-antibiotic synergy (PAS): β-lactam and quinolone antibiotics stimulate virulent phage growth
    • Comeau A.M., et al. Phage-antibiotic synergy (PAS): β-lactam and quinolone antibiotics stimulate virulent phage growth. PLoS ONE 2007, 2:e799.
    • (2007) PLoS ONE , vol.2 , pp. e799
    • Comeau, A.M.1
  • 38
    • 84862687253 scopus 로고    scopus 로고
    • Synergistic phage-antibiotic combinations for the control of Escherichia coli biofilms in vitro
    • Ryan E.M., et al. Synergistic phage-antibiotic combinations for the control of Escherichia coli biofilms in vitro. FEMS Immunol. Med. Microbiol. 2012, 65:395-398.
    • (2012) FEMS Immunol. Med. Microbiol. , vol.65 , pp. 395-398
    • Ryan, E.M.1
  • 39
    • 84870768710 scopus 로고    scopus 로고
    • Methicillin-resistant Staphylococcus aureus phage plaque size enhancement using sublethal concentrations of antibiotics
    • Kaur S., et al. Methicillin-resistant Staphylococcus aureus phage plaque size enhancement using sublethal concentrations of antibiotics. Appl. Environ. Microbiol. 2012, 78:8227-8233.
    • (2012) Appl. Environ. Microbiol. , vol.78 , pp. 8227-8233
    • Kaur, S.1
  • 40
    • 84921326551 scopus 로고    scopus 로고
    • Burkholderia cepacia complex phage-antibiotic synergy (PAS): Antibiotics stimulate lytic phage activity
    • Kamal F., Dennis J.J. Burkholderia cepacia complex phage-antibiotic synergy (PAS): Antibiotics stimulate lytic phage activity. Appl. Environ. Microbiol. 2015, 81:1132-1138.
    • (2015) Appl. Environ. Microbiol. , vol.81 , pp. 1132-1138
    • Kamal, F.1    Dennis, J.J.2
  • 41
    • 84871718658 scopus 로고    scopus 로고
    • Phage-antibiotic synergism: a possible approach to combatting Pseudomonas aeruginosa
    • Knezevic P., et al. Phage-antibiotic synergism: a possible approach to combatting Pseudomonas aeruginosa. Res. Microbiol. 2013, 164:55-60.
    • (2013) Res. Microbiol. , vol.164 , pp. 55-60
    • Knezevic, P.1
  • 42
    • 84908138374 scopus 로고    scopus 로고
    • The path of least resistance: aggressive or moderate treatment?
    • Kouyos R.D., et al. The path of least resistance: aggressive or moderate treatment?. Proc. Biol. Sci. 2014, 281:20140566.
    • (2014) Proc. Biol. Sci. , vol.281 , pp. 20140566
    • Kouyos, R.D.1
  • 43
    • 84876955225 scopus 로고    scopus 로고
    • When the most potent combination of antibiotics selects for the greatest bacterial load: the smile-frown transition
    • Pena-Miller R., et al. When the most potent combination of antibiotics selects for the greatest bacterial load: the smile-frown transition. PLoS Biol. 2013, 11:e1001540.
    • (2013) PLoS Biol. , vol.11 , pp. e1001540
    • Pena-Miller, R.1
  • 44
    • 79955527229 scopus 로고    scopus 로고
    • Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance
    • Baharoglu Z., Mazel D. Vibrio cholerae triggers SOS and mutagenesis in response to a wide range of antibiotics: a route towards multiresistance. Antimicrob. Agents Chemother. 2011, 55:2438-2441.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 2438-2441
    • Baharoglu, Z.1    Mazel, D.2
  • 45
    • 84867049470 scopus 로고    scopus 로고
    • Staphylococcal pathogenicity island interference with helper phage reproduction is a paradigm of molecular parasitism
    • Ram G., et al. Staphylococcal pathogenicity island interference with helper phage reproduction is a paradigm of molecular parasitism. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:16300-16305.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 16300-16305
    • Ram, G.1
  • 46
    • 84937252354 scopus 로고    scopus 로고
    • Fluoroquinolone induction of phage-mediated gene transfer in multidrug-resistant Salmonella
    • Bearson B.L., Brunelle B.W. Fluoroquinolone induction of phage-mediated gene transfer in multidrug-resistant Salmonella. Int. J. Antimicrob. Agents 2015, 46:201-204.
    • (2015) Int. J. Antimicrob. Agents , vol.46 , pp. 201-204
    • Bearson, B.L.1    Brunelle, B.W.2
  • 47
    • 63849290890 scopus 로고    scopus 로고
    • Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy
    • Lu T.K., Collins J.J. Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:4629-4634.
    • (2009) Proc. Natl. Acad. Sci. U.S.A. , vol.106 , pp. 4629-4634
    • Lu, T.K.1    Collins, J.J.2
  • 48
    • 1842455969 scopus 로고    scopus 로고
    • Population and evolutionary dynamics of phage therapy
    • Levin B.R., Bull J.J. Population and evolutionary dynamics of phage therapy. Nat. Rev. Microbiol. 2004, 2:166-173.
    • (2004) Nat. Rev. Microbiol. , vol.2 , pp. 166-173
    • Levin, B.R.1    Bull, J.J.2
  • 49
    • 84943537607 scopus 로고    scopus 로고
    • Steering evolution with sequential therapy to prevent the emergence of bacterial antibiotic resistance
    • Nichol D., et al. Steering evolution with sequential therapy to prevent the emergence of bacterial antibiotic resistance. PLoS Comput. Biol. 2015, 11:e1004493.
    • (2015) PLoS Comput. Biol. , vol.11 , pp. e1004493
    • Nichol, D.1
  • 50
    • 56349139534 scopus 로고    scopus 로고
    • The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria
    • Pages J.M., et al. The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria. Nat. Rev. Microbiol. 2008, 6:893-903.
    • (2008) Nat. Rev. Microbiol. , vol.6 , pp. 893-903
    • Pages, J.M.1
  • 51
    • 84894263511 scopus 로고    scopus 로고
    • Cooperation, quorum sensing, and evolution of virulence in Staphylococcus aureus
    • Pollitt E.J.G., et al. Cooperation, quorum sensing, and evolution of virulence in Staphylococcus aureus. Infect. Immun. 2014, 82:1045-1051.
    • (2014) Infect. Immun. , vol.82 , pp. 1045-1051
    • Pollitt, E.J.G.1
  • 52
    • 67549109702 scopus 로고    scopus 로고
    • Predators promote defence of rhizosphere bacterial populations by selective feeding on non-toxic cheaters
    • Jousset A., et al. Predators promote defence of rhizosphere bacterial populations by selective feeding on non-toxic cheaters. ISME J. 2009, 3:666-674.
    • (2009) ISME J. , vol.3 , pp. 666-674
    • Jousset, A.1
  • 53
    • 84908038336 scopus 로고    scopus 로고
    • Antibiotic treatment selects for cooperative virulence of Salmonella Typhimurium
    • Diard M., et al. Antibiotic treatment selects for cooperative virulence of Salmonella Typhimurium. Curr. Biol. 2014, 24:2000-2005.
    • (2014) Curr. Biol. , vol.24 , pp. 2000-2005
    • Diard, M.1
  • 54
    • 2442673189 scopus 로고    scopus 로고
    • Main features on tailed phage, host recognition and DNA uptake
    • Letellier L., et al. Main features on tailed phage, host recognition and DNA uptake. Front. Biosci. 2004, 9:1228-1339.
    • (2004) Front. Biosci. , vol.9 , pp. 1228-1339
    • Letellier, L.1
  • 55
    • 84937950366 scopus 로고    scopus 로고
    • Fitness cost of antibiotic susceptibility during bacterial infection
    • 297ra114
    • Roux D., et al. Fitness cost of antibiotic susceptibility during bacterial infection. Sci. Transl. Med. 2015, 7:297ra114.
    • (2015) Sci. Transl. Med. , vol.7
    • Roux, D.1
  • 56
    • 80255131401 scopus 로고    scopus 로고
    • Attenuated virulence of a slow-growing pandrug-resistant Acinetobacter baumannii is associated with decreased expression of genes encoding the porins CarO and OprD-like
    • Fernandez-Cuenca F., et al. Attenuated virulence of a slow-growing pandrug-resistant Acinetobacter baumannii is associated with decreased expression of genes encoding the porins CarO and OprD-like. Int. J. Antimicrob. Agents 2011, 38:548-549.
    • (2011) Int. J. Antimicrob. Agents , vol.38 , pp. 548-549
    • Fernandez-Cuenca, F.1
  • 57
    • 84871769684 scopus 로고    scopus 로고
    • Phage-driven loss of virulence in a fish pathogenic bacterium
    • Laanto E., et al. Phage-driven loss of virulence in a fish pathogenic bacterium. PLoS ONE 2012, 7:e53157.
    • (2012) PLoS ONE , vol.7 , pp. e53157
    • Laanto, E.1
  • 58
    • 74049138668 scopus 로고    scopus 로고
    • Exploitation of a new flagellatropic phage of Erwinia for positive selection of bacterial mutants attenuated in plant virulence: towards phage therapy
    • Evans T.J., et al. Exploitation of a new flagellatropic phage of Erwinia for positive selection of bacterial mutants attenuated in plant virulence: towards phage therapy. J. Appl. Microbiol. 2010, 108:676-685.
    • (2010) J. Appl. Microbiol. , vol.108 , pp. 676-685
    • Evans, T.J.1
  • 59
    • 84927162177 scopus 로고    scopus 로고
    • Evolutionary consequences of intra-patient phage predation on microbial populations
    • Seed K.D., et al. Evolutionary consequences of intra-patient phage predation on microbial populations. Elife 2014, 26:e03497.
    • (2014) Elife , vol.26 , pp. e03497
    • Seed, K.D.1
  • 60
    • 84875703277 scopus 로고    scopus 로고
    • Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?
    • Beceiro A., et al. Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?. Clin. Microbiol. Rev. 2013, 26:185-230.
    • (2013) Clin. Microbiol. Rev. , vol.26 , pp. 185-230
    • Beceiro, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.