Cystobactamids: Myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity

Angewandte Chemie - International Edition

Volumn 53, Issue 52, 2014, Pages 14605-14609

  Baumann, Sascha ^a,c   Herrmann, Jennifer ^a,c   Raju, Ritesh ^a,c   Steinmetz, Heinrich ^b,c   Mohr, Kathrin I ^b,c   Hüttel, Stephan ^a,c   Harmrolfs, Kirsten ^a,c   Stadler, Marc ^b,c   Müller, Rolf ^a,c  

^a SAARLAND UNIVERSITY   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c Deutsches Zentrum für Infektionsforschung DZIF Standort Hannover Braunschweig   (Germany)

Author keywords

Antibiotics; Myxobacteria; Natural products; NRPS; Topoisomerase inhibitors

Indexed keywords

BIOSYNTHESIS; SCAFFOLDS;

BIOSYNTHETIC ENGINEERINGS; BIOSYNTHETIC GENE CLUSTER; IDENTIFICATION AND ANNOTATION; MINIMUM INHIBITORY CONCENTRATION; MYXOBACTERIA; NATURAL PRODUCTS; NRPS; TOPOISOMERASES;

ANTIBIOTICS;

ANTI-BACTERIAL AGENTS; ASPARAGINE; BACTERIAL PROTEINS; CYSTOBACTAMID 919-2; DNA TOPOISOMERASES, TYPE I; NITRO COMPOUNDS; NON-RIBOSOMAL PEPTIDE SYNTHASE; PEPTIDE SYNTHASES; TOPOISOMERASE INHIBITORS;

ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CHEMICAL SYNTHESIS; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; METABOLISM; MICROBIAL SENSITIVITY TESTS; MYXOCOCCALES;

ANTI-BACTERIAL AGENTS; ASPARAGINE; BACTERIAL PROTEINS; DNA TOPOISOMERASES, TYPE I; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS; MYXOCOCCALES; NITRO COMPOUNDS; PEPTIDE SYNTHASES; TOPOISOMERASE INHIBITORS;

EID: 84919668838     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201409964     Document Type: Article

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