An in vitro human skin test for assessing sensitization potential

Journal of Applied Toxicology

Volumn 36, Issue 5, 2016, Pages 669-684

  Ahmed, S S ^a   Wang, X N ^b   Fielding, M ^b   Kerry, A ^b   Dickinson, I ^b   Munuswamy, R ^b   Kimber, I ^c   Dickinson, A M ^a,b  

^a ALCYOMICS LTD   (United Kingdom)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Antigen specific priming; in vitro alternative to animal testing; Interferon ; Local lymph node assay; Potency; Skin sensitization; T cell proliferation

Indexed keywords

4 HYDROXYBENZOIC ACID; CINNAMYL ALCOHOL; DODECYL SULFATE SODIUM; GAMMA INTERFERON; GLUTARALDEHYDE; NICKEL SULFATE; OXAZOLONE; PROPYLENE GLYCOL; ZINC SULFATE; ALLERGEN; HAPTEN; IRRITANT AGENT;

ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; EXPLANT; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IN VITRO STUDY; INTERFERON PRODUCTION; LOCAL LYMPH NODE ASSAY; LYMPHOCYTE PROLIFERATION; NORMAL HUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SKIN EXPLANT TEST; SKIN SENSITIZATION; SKIN TEST; T LYMPHOCYTE; ANIMAL; ANIMAL TESTING ALTERNATIVE; CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MONONUCLEAR CELL; MOUSE; SKIN;

ALLERGENS; ANIMAL TESTING ALTERNATIVES; ANIMALS; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HAPTENS; HUMANS; IN VITRO TECHNIQUES; INTERFERON-GAMMA; IRRITANTS; LEUKOCYTES, MONONUCLEAR; LOCAL LYMPH NODE ASSAY; MICE; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SKIN; SKIN TESTS; T-LYMPHOCYTES;

EID: 84961210989     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.3197     Document Type: Article

References (51)

1. Akiba H, Kehren J, Ducluzeau MT, Krasteva M, Horand F, Kaiserlian D, Kaneko F, Nicolas JF. 2002. Skin inflammation during contact hypersensitivity is mediated by early recruitment of CD8+ T cytotoxic 1 cells inducing keratinocyte apoptosis. J. Immunol. 168: 3079-3087.
2. Arts JH, De Jong WH, Van Triel JJ, Schijf MA, De Klerk A, Van Loveren H, Kuper CF. 2008. The respiratory local lymph node assay as a tool to study respiratory sensitizers. Toxicol. Sci. 106: 423-434.
3. Ashikaga T, Yoshida Y, Hirota M, Yoneyama K, Itagaki H, Sakaguchi H, Miyazawa M, Ito Y, Suzuki H, Toyoda H. 2006. Development of an in vitro skin sensitization test using human cell lines: the human Cell Line Activation Test (h-CLAT). I. Optimization of the h-CLAT protocol. Toxicol. In Vitro 20: 767-773.
4. Azam P, Peiffer JL, Chamousset D, Tissier MH, Bonnet PA, Vian L, Fabre I, Ourlin JC. 2006. The cytokine-dependent MUTZ-3 cell line as an in vitro model for the screening of contact sensitizers. Toxicol. Appl. Pharmacol. 212: 14-23.
5. Bender A, Sapp M, Schuler G, Steinman RM, Bhardwaj N. 1996. Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood. J. Immunol. Methods 196: 121-135.
6. Buehler EV. 1965. Delayed Contact Hypersensitivity in the Guinea Pig. Arch. Dermatol. 91: 171-177.
7. Burdek M, Spranger S, Wilde S, Frankenberger B, Schendel DJ, Geiger C. 2010. Three-day dendritic cells for vaccine development: antigen uptake, processing and presentation. J. Transl. Med. 8: 90.
8. Casati S, Aeby P, Kimber I, Maxwell G, Ovigne JM, Roggen E, Rovida C, Tosti L, Basketter D. 2009. Selection of chemicals for the development and evaluation of in vitro methods for skin sensitisation testing. Altern. Lab. Anim. 37: 305-312.
9. Chaudhry Q, Piclin N, Cotterill J, Pintore M, Price NR, Chretien JR, Roncaglioni A. 2010. Global QSAR models of skin sensitisers for regulatory purposes. Chem. Cent. J. 4(Suppl 1): S5.
10. Christiansen J, Farm G, Eid-Forest R, Anderson C, Cederbrant K, Hultman P. 2006. Interferon-gamma secreted from peripheral blood mononuclear cells as a possible diagnostic marker for allergic contact dermatitis to gold. Contact Dermatitis 55: 101-112.
11. Dhabhar FS, Satoskar AR, Bluethmann H, David JR, Mcewen BS. 2000. Stress-induced enhancement of skin immune function: A role for gamma interferon. Proc. Natl. Acad. Sci. U. S. A. 97: 2846-2851.
12. Dickinson A, Hromadnikova I, Sviland L, Jackson G, Taylor P, Vavrinec J, Sedlacek P, Cermakova M, Stary J, Vitek A, Sajdova J, Proctor S. 1999. Use of a skin explant model for predicting GVHD in HLA-matched bone marrow transplants - effect of GVHD prophylaxis. Bone Marrow Transplant. 24: 857-863.
13. Dickinson AM, Sviland L, Carey P, Reid MM, Hamilton PJ, Pearson AJ, Proctor SJ. 1988. Skin explant culture as a model for cutaneous graft-versus-host disease in humans. Bone Marrow Transplant. 3: 323-329.
14. Dickinson AM, Sviland L, Dunn J, Carey P, Proctor, SJ, 1991. Demonstration of direct involvement of cytokines in graft-versus-host reactions using an in vitro human skin explant model. Bone Marrow Transplant. 7: 209-216.
15. Dickinson AM, Wang XN, Sviland L, Vyth-Dreese FA, Jackson GH, Schumacher TN, Haanen JB, Mutis T, Goulmy E. 2002. In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens. Nat. Med. 8: 410-414.
16. Dimitrov SD, Low LK, Patlewicz GY, Kern PS, Dimitrova GD, Comber MH, Phillips RD, Niemela J, Bailey PT, Mekenyan OG. 2005. Skin sensitization: modeling based on skin metabolism simulation and formation of protein conjugates. Int. J. Toxicol. 24: 189-204.
17. Divkovic M, Pease CK, Gerberick GF, Basketter DA. 2005. Hapten-protein binding: from theory to practical application in the in vitro prediction of skin sensitization. Contact Dermatitis 53: 189-200.
18. Emter R, Ellis G, Natsch A. 2010. Performance of a novel keratinocyte-based reporter cell line to screen skin sensitizers in vitro. Toxicol. Appl. Pharmacol. 245: 281-290.
19. Faulkner L, Martinsson K, Santoyo-Castelazo A, Cederbrant K, Schuppe-Koistinen I, Powell H, Tugwood J, Naisbitt DJ, Park BK. 2012. The development of in vitro culture methods to characterize primary T-cell responses to drugs. Toxicol. Sci. 127: 150-158.
20. Gafvert E, Shao LP, Karlberg AT, Nilsson U, Nilsson JL. 1994. Contact allergy to resin acid hydroperoxides. Hapten binding via free radicals and epoxides. Chem. Res. Toxicol. 7: 260-266.
21. Gerberick GF, Ryan CA, Dearman RJ, Kimber I. 2007. Local lymph node assay (LLNA) for detection of sensitization capacity of chemicals. Methods 41: 54-60.
22. Gerberick GF, Vassallo JD, Bailey RE, Chaney JG, Morrall SW, Lepoittevin JP. 2004. Development of a peptide reactivity assay for screening contact allergens. Toxicol. Sci. 81: 332-343.
23. Gonzalo MA, De Argila D, Garcia JM, Alvarado MI. 1999. Allergic contact dermatitis to propylene glycol. Allergy 54: 82-83.
24. Jarvis M, Schulz U, Dickinson AM, Sviland L, Jackson G, Konur A, Wang XN, Hromadnikova I, Kolb HJ, Eissner G, Holler E 2002. The detection of apoptosis in a human in vitro skin explant assay for graft versus host reactions. J. Clin. Pathol. 55: 127-132.
25. Kimber I, Basketter DA, Butler M, Gamer A, Garrigue JL, Gerberick GF, Newsome C, Steiling W, Vohr HW. 2003. Classification of contact allergens according to potency: proposals. Food Chem. Toxicol. 41: 1799-1809.
26. Kimber I, Hilton J, Botham PA, Basketter DA, Scholes EW, Miller K, Robbins MC, Harrison PT, Gray TJ, Waite SJ. 1991. The murine local lymph node assay: results of an inter-laboratory trial. Toxicol. Lett. 55: 203-213.
27. Kimber I, Hilton J, Weisenberger C. 1989. The murine local lymph node assay for identification of contact allergens: a preliminary evaluation of in situ measurement of lymphocyte proliferation. Contact Dermatitis 21: 215-220.
28. Kvistborg P, Boegh M, Pedersen AW, Claesson MH, Zocca MB. 2009. Fast generation of dendritic cells. Cell. Immunol. 260: 56-62.
29. Lerner KG, Kao GF, Storb R, Buckner CD, Clift RA, Thomas ED. 1974. Histopathology of graft-vs.-host reaction (GvHR) in human recipients of marrow from HL-A-matched sibling donors. Transplant. Proc. 6: 367-371.
30. Magnusson B, Kligman AM. 1969. The identification of contact allergens by animal assay. The guinea pig maximization test. J. Invest. Dermatol. 52: 268-276.
31. Miyazawa M, Ito Y, Yoshida Y, Sakaguchi H & Suzuki H. 2007. Phenotypic alterations and cytokine production in THP-1 cells in response to allergens. Toxicol. In Vitro 21: 428-437.
32. Molls RR, Ahluwalia N, Fick T, Mastro AM, Wagstaff D, Handte G, Ball R. 2003. Inter- and intra-individual variation in tests of cell-mediated immunity in young and old women. Mech. Ageing Dev. 124: 619-627.
33. OECD. 2012a. The adverse outcome pathway for skin sensitisation initiated by covalent binding to proteins - Part 1: Scientific evidence. OECD Environment, Health and Safety Publications Series on Testing and Assessment 168: 1-59.
34. Patlewicz G, Aptula AO, Uriarte E, Roberts DW, Kern PS, Gerberick GF, Kimber I, Dearman RJ, Ryan CA, Basketter DA. 2007. An evaluation of selected global (Q)SARs/expert systems for the prediction of skin sensitisation potential. SAR QSAR Environ. Res. 18: 515-541.
35. Python F, Goebel C, Aeby P. 2007. Assessment of the U937 cell line for the detection of contact allergens. Toxicol. Appl. Pharmacol. 220: 113-124.
36. Randolph GJ, Beaulieu S, Lebecque S, Steinman RM, Muller WA. 1998. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science 282: 480-483.
37. Romani N, Reider D, Heuer M, Ebner S, Kampgen E, Eibl B, Niederwieser D, Schuler G. 1996. Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J. Immunol. Methods 196: 137-151.
38. Ruffin N, Ahmed SS, Osorio LM, Wang XN, Jackson GH, Collin MP, Ekre HP, Chiodi F, Dickinson AM. 2011. The involvement of epithelial Fas in a human model of graft versus host disease. Transplantation 91: 946-951.
39. Saint-Mezard P, Berard F, Dubois B, Kaiserlian D, Nicolas JF. 2004. The role of CD4+ and CD8+ T cells in contact hypersensitivity and allergic contact dermatitis. Eur. J. Dermatol. 14: 131-138.
40. Sviland L, Dickinson AM. 1999. A human skin explant model for predicting graft-versus-host disease following bone marrow transplantation. J. Clin. Pathol. 52: 910-913.
41. Sviland L, Dickinson AM, Carey PJ, Pearson AD. Proctor SJ 1990. An in vitro predictive test for clinical graft-versus-host disease in allogeneic bone marrow transplant recipients. Bone Marrow Transplant. 5: 105-109.
42. Takigawa T, Endo Y. 2006. Effects of glutaraldehyde exposure on human health. J. Occup. Health 48: 75-87.
43. Ulfgren AK, Klareskog L, Lindberg M 2000. An immunohistochemical analysis of cytokine expression in allergic and irritant contact dermatitis. Acta Derm. Venereol. 80: 167-170.
44. Van Den Broeke LT, Heffler LC, Tengvall Linder M, Nilsson JL, Karlberg AT, Scheynius A. 1999. Direct Ni2+ antigen formation on cultured human dendritic cells. Immunology 96: 578-585.
45. Vocanson M, Hennino A, Chavagnac C, Saint-Mezard P, Dubois B, Kaiserlian D, Nicolas JF. 2005. Contribution of CD4(+)and CD8(+) T-cells in contact hypersensitivity and allergic contact dermatitis. Expert Rev. Clin. Immunol. 1: 75-86.
46. Vocanson M, Hennino A, Rozieres A, Poyet G, Nicolas JF, 2009. Effector and regulatory mechanisms in allergic contact dermatitis. Allergy 64: 1699-1714.
47. Vogelsang GB, Hess AD, Berkman AW, Tutschka PJ, Farmer ER, Converse PJ, Santos GW. 1985. An in vitro predictive test for graft versus host disease in patients with genotypic HLA-identical bone marrow transplants. N. Engl. J. Med. 313: 645-650.
48. Wang XN, Haniffa MA, Holtick U, Collin MP, Jackson G, Hilkens CM, Holler E, Edinger M, Hoffmann P, Dickinson AM. 2009. Regulatory T-cell suppression of CD8+ T-cell-mediated graft-versus-host reaction requires their presence during priming. Transplantation 88: 188-197.
49. Webb EF, Tzimas MN, Newsholme SJ, Griswold DE. 1998. Intralesional cytokines in chronic oxazolone-induced contact sensitivity suggest roles for tumor necrosis factor alpha and interleukin-4. J. Invest. Dermatol. 111: 86-92.
50. Weibel H, Hansen J. 1989. Penetration of the fragrance compounds, cinnamaldehyde and cinnamyl alcohol, through human skin in vitro. Contact Dermatitis 20: 167-172.
51. Xu H, Diiulio NA, Fairchild RL. 1996. T cell populations primed by hapten sensitization in contact sensitivity are distinguished by polarized patterns of cytokine production: interferon gamma-producing (Tc1) effector CD8+ T cells and interleukin (Il) 4/Il-10-producing (Th2) negative regulatory CD4+ T cells. J. Exp. Med. 183: 1001-1012.