Enhanced Aβ1-40 Production in Endothelial Cells Stimulated with Fibrillar Aβ1-42

PLoS ONE

Volumn 8, Issue 3, 2013, Pages

  Rajadas, Jayakumar ^b   Sun, Wenchao ^b   Li, Hai ^b   Inayathullah, Mohammed ^b   Cereghetti, Damiano ^b   Tan, Aaron ^c   de Mello Coelho, Valeria ^a   Chrest, Francis J ^a   Kusiak, John W ^a   Smith, Wanli Wei ^a   Taub, Dennis ^a   Wu, Joseph C ^b   Rifkind, Joseph M ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ARTICLE; AUTOPHAGY; CELL SIZE; CELL STIMULATION; CELL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOTHELIUM CELL; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; MOLECULAR WEIGHT; PROTEIN EXPRESSION; PROTEIN SYNTHESIS; UPREGULATION; WESTERN BLOTTING;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AUTOPHAGY; CELL LINE; ENDOTHELIAL CELLS; HUMANS; NITRIC OXIDE SYNTHASE TYPE III; PEPTIDE FRAGMENTS;

EID: 84874751327     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0058194     Document Type: Article

References (56)

1. Goedert M, Spillantini MG, (2006) A century of Alzheimer's disease. Science 314: 777-781.
2. Zlokovic BV, (2011) Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat Rev Neurosci 12: 723-738.
3. Dewachter I, Van Dorpe J, Smeijers L, Gilis M, Kuiperi C, et al. (2000) Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1. J Neurosci 20: 6452-6458.
4. Guo Q, Wang Z, Li H, Wiese M, Zheng H, (2012) APP physiological and pathophysiological functions: insights from animal models. Cell Res 22: 78-89.
5. Mawuenyega KG, Sigurdson W, Ovod V, Munsell L, Kasten T, et al. (2010) Decreased clearance of CNS beta-amyloid in Alzheimer's disease. Science 330: 1774.
6. Armstrong RA, (2006) Classic beta-amyloid deposits cluster around large diameter blood vessels rather than capillaries in sporadic Alzheimer's disease. Curr Neurovasc Res 3: 289-294.
7. Cullen KM, Kocsi Z, Stone J, (2006) Microvascular pathology in the aging human brain: evidence that senile plaques are sites of microhaemorrhages. Neurobiol Aging 27: 1786-1796.
8. Biffi A, Greenberg SM, (2011) Cerebral amyloid angiopathy: a systematic review. J Clin Neurol 7: 1-9.
9. Thomas T, Thomas G, McLendon C, Sutton T, Mullan M, (1996) beta-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380: 168-171.
10. Yu D, Corbett B, Yan Y, Zhang GX, Reinhart P, et al. (2012) Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease. Neurobiol Aging.
11. Vinters HV, Farag ES, (2003) Amyloidosis of cerebral arteries. Adv Neurol 92: 105-112.
12. Mattson MP, (2002) Involvement of superoxide in pathogenic action of mutations that cause Alzheimer's disease. Methods Enzymol 352: 455-474.
13. Ansari MA, Scheff SW, (2011) NADPH-oxidase activation and cognition in Alzheimer disease progression. Free Radic Biol Med 51: 171-178.
14. Kisilevsky R, (2000) Amyloids: tombstones or triggers? Nat Med 6: 633-634.
15. Saido T, Leissring MA, (2012) Proteolytic Degradation of Amyloid beta-Protein. Cold Spring Harb Perspect Med 2: a006379.
16. Husemann J, Silverstein SC, (2001) Expression of scavenger receptor class B, type I, by astrocytes and vascular smooth muscle cells in normal adult mouse and human brain and in Alzheimer's disease brain. Am J Pathol 158: 825-832.
17. Thomas T, McLendon C, Sutton ET, Thomas G, (1997) Cerebrovascular endothelial dysfunction mediated by beta-amyloid. Neuroreport 8: 1387-1391.
18. Iadecola C, Zhang F, Niwa K, Eckman C, Turner SK, et al. (1999) SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Nat Neurosci 2: 157-161.
19. Yan Y, Wang C, (2006) Abeta42 is more rigid than Abeta40 at the C terminus: implications for Abeta aggregation and toxicity. J Mol Biol 364: 853-862.
20. Eisenhauer PB, Johnson RJ, Wells JM, Davies TA, Fine RE, (2000) Toxicity of various amyloid beta peptide species in cultured human blood-brain barrier endothelial cells: increased toxicity of dutch-type mutant. J Neurosci Res 60: 804-810.
21. Cecchi C, Fiorillo C, Baglioni S, Pensalfini A, Bagnoli S, et al. (2007) Increased susceptibility to amyloid toxicity in familial Alzheimer's fibroblasts. Neurobiol Aging 28: 863-876.
22. Beeg M, Stravalaci M, Bastone A, Salmona M, Gobbi M, (2011) A modified protocol to prepare seed-free starting solutions of amyloid-beta (Abeta)(1)(-)(4)(0) and Abeta(1)(-)(4)(2) from the corresponding depsipeptides. Anal Biochem 411: 297-299.
23. Evin G, Cappai R, Li QX, Culvenor JG, Small DH, et al. (1995) Candidate gamma-secretases in the generation of the carboxyl terminus of the Alzheimer's disease beta A4 amyloid: possible involvement of cathepsin D. Biochemistry (Mosc). 34: 14185-14192.
24. Kuo YM, Webster S, Emmerling MR, De Lima N, Roher AE, (1998) Irreversible dimerization/tetramerization and post-translational modifications inhibit proteolytic degradation of A beta peptides of Alzheimer's disease. Biochim Biophys Acta 1406: 291-298.
25. Majumdar A, Chung H, Dolios G, Wang R, Asamoah N, et al. (2007) Degradation of fibrillar forms of Alzheimer's amyloid beta-peptide by macrophages. Neurobiol Aging.
26. Vinters HV, Natte R, Maat-Schieman ML, van Duinen SG, Hegeman-Kleinn I, et al. (1998) Secondary microvascular degeneration in amyloid angiopathy of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D). Acta Neuropathol 95: 235-244.
27. Rockenstein E, Adame A, Mante M, Larrea G, Crews L, et al. (2005) Amelioration of the cerebrovascular amyloidosis in a transgenic model of Alzheimer's disease with the neurotrophic compound cerebrolysin. J Neural Transm 112: 269-282.
28. Austin SA, Santhanam AV, Katusic ZS, (2010) Endothelial nitric oxide modulates expression and processing of amyloid precursor protein. Circ Res 107: 1498-1502.
29. Zhang H, Ma Q, Zhang YW, Xu H, (2012) Proteolytic processing of Alzheimer's beta-amyloid precursor protein. J Neurochem 120 (Suppl 1):: 9-21.
30. Davis-Salinas J, Saporito-Irwin SM, Cotman CW, Van Nostrand WE, (1995) Amyloid beta-protein induces its own production in cultured degenerating cerebrovascular smooth muscle cells. J Neurochem 65: 931-934.
31. Naiki H, Nakakuki K, (1996) First-order kinetic model of Alzheimer's beta-amyloid fibril extension in vitro. Lab Invest 74: 374-383.
32. Hasegawa K, Yamaguchi I, Omata S, Gejyo F, Naiki H, (1999) Interaction between A beta(1-42) and A beta(1-40) in Alzheimer's beta-amyloid fibril formation in vitro. Biochemistry (Mosc) 38: 15514-15521.
33. Heffelfinger SC, Hawkins HH, Barrish J, Taylor L, Darlington GJ, (1992) SK HEP-1: a human cell line of endothelial origin. In Vitro Cell Dev Biol 28A: 136-142.
34. Olivieri G, Brack C, Muller-Spahn F, Stahelin HB, Herrmann M, et al. (2000) Mercury induces cell cytotoxicity and oxidative stress and increases beta-amyloid secretion and tau phosphorylation in SHSY5Y neuroblastoma cells. J Neurochem 74: 231-236.
35. Ju H, Zou R, Venema VJ, Venema RC, (1997) Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity. J Biol Chem 272: 18522-18525.
36. Jaeger PA, Pickford F, Sun CH, Lucin KM, Masliah E, et al. (2010) Regulation of amyloid precursor protein processing by the Beclin 1 complex. PLoS One 5: e11102.
37. Altman R, Rutledge JC, (2010) The vascular contribution to Alzheimer's disease. Clin Sci (Lond) 119: 407-421.
38. Bell RD, Zlokovic BV, (2009) Neurovascular mechanisms and blood-brain barrier disorder in Alzheimer's disease. Acta Neuropathol 118: 103-113.
39. Reed-Cossairt A, Zhu X, Lee HG, Reed C, Perry G, et al. (2012) Alzheimer's disease and vascular deficiency: lessons from imaging studies and down syndrome. Curr Gerontol Geriatr Res 2012: 929734.
40. Francis P, (2006) Targeting cell death in dementia. Alzheimer Dis Assoc Disord 20: S3-7.
41. Zlokovic BV, Ghiso J, Mackic JB, McComb JG, Weiss MH, et al. (1993) Blood-brain barrier transport of circulating Alzheimer's amyloid beta. Biochem Biophys Res Commun 197: 1034-1040.
42. Ueno M, Nakagawa T, Wu B, Onodera M, Huang CL, et al. (2010) Transporters in the brain endothelial barrier. Curr Med Chem 17: 1125-1138.
43. Deane R, Du Yan S, Submamaryan RK, LaRue B, Jovanovic S, et al. (2003) RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain. Nat Med 9: 907-913.
44. Yan SD, Chen X, Fu J, Chen M, Zhu H, et al. (1996) RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature 382: 685-691.
45. Yan SD, Zhu H, Zhu A, Golabek A, Du H, et al. (2000) Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis. Nat Med 6: 643-651.
46. Origlia N, Arancio O, Domenici L, Yan SS, (2009) MAPK, beta-amyloid and synaptic dysfunction: the role of RAGE. Expert Rev Neurother 9: 1635-1645.
47. Bar-Am O, Weinreb O, Amit T, Youdim MB, (2005) Regulation of Bcl-2 family proteins, neurotrophic factors, and APP processing in the neurorescue activity of propargylamine. Faseb J 19: 1899-1901.
48. LeBlanc A, (1995) Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: possible involvement of apoptosis. J Neurosci 15: 7837-7846.
49. Cook DG, Forman MS, Sung JC, Leight S, Kolson DL, et al. (1997) Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells. Nat Med 3: 1021-1023.
50. Parvathy S, Rajadas J, Ryan H, Vaziri S, Anderson L, et al. (2009) Abeta peptide conformation determines uptake and interleukin-1alpha expression by primary microglial cells. Neurobiol Aging 30: 1792-1804.
51. Rogers JT, Leiter LM, McPhee J, Cahill CM, Zhan SS, et al. (1999) Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences. J Biol Chem 274: 6421-6431.
52. Cai Z, Zhao B, Ratka A, (2011) Oxidative stress and beta-amyloid protein in Alzheimer's disease. Neuromolecular Medicine 13: 223-250.
53. Nicoll JA, Wilkinson D, Holmes C, Steart P, Markham H, et al. (2003) Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat Med 9: 448-452.
54. Drummond GR, Cai H, Davis ME, Ramasamy S, Harrison DG, (2000) Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Circ Res 86: 347-354.
55. Breton-Romero R, Gonzalez de Orduna C, Romero N, Sanchez-Gomez FJ, de Alvaro C, et al. (2012) Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress. Free Radic Biol Med 52: 1093-1100.
56. Cai H, Harrison DG, (2000) Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 87: 840-844.