Oral delivery of Lactococcus lactis that secretes bioactive heme oxygenase-1 alleviates development of acute colitis in mice

Microbial Cell Factories

Volumn 14, Issue 1, 2015, Pages

  Shigemori, Suguru ^a,b   Watanabe, Takafumi ^a   Kudoh, Kai ^a   Ihara, Masaki ^a   Nigar, Shireen ^a   Yamamoto, Yoshinari ^a   Suda, Yoshihito ^c   Sato, Takashi ^d   Kitazawa, Haruki ^e   Shimosato, Takeshi ^a  

^a SHINSHU UNIVERSITY   (Japan)

^b JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^c MIYAGI UNIVERSITY   (Japan)

^d YOKOHAMA CITY UNIVERSITY   (Japan)

^e TOHOKU UNIVERSITY   (Japan)

Author keywords

Acute colitis; Heme oxygenase 1; Inflammatory bowel disease; Interleukin 10; Lactococcus lactis; Mice

Indexed keywords

HEME OXYGENASE 1; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 6; DEXTRAN SULFATE; NISIN; RECOMBINANT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COLITIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ACTIVITY SCORE; DRUG DETERMINATION; ENZYME RELEASE; FEMALE; HISTOPATHOLOGY; LACTOCOCCUS LACTIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; ACUTE DISEASE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; INTESTINE MUCOSA; METABOLISM; MICROBIOLOGY; ORAL DRUG ADMINISTRATION; PATHOLOGY;

ACUTE DISEASE; ADMINISTRATION, ORAL; ANIMALS; COLITIS; DEXTRAN SULFATE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION REGULATION, BACTERIAL; HEME OXYGENASE-1; INTERLEUKIN-10; INTERLEUKIN-1ALPHA; INTERLEUKIN-6; INTESTINAL MUCOSA; LACTOCOCCUS LACTIS; MICE; MICE, INBRED C57BL; NISIN; RECOMBINANT PROTEINS;

EID: 84961185950     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/s12934-015-0378-2     Document Type: Article

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