Fed-batch production and secretion of streptavidin by Hansenula polymorpha: Evaluation of genetic factors and bioprocess development

Journal of Biotechnology

Volumn 225, Issue , 2016, Pages 3-9

  Wetzel, David ^a   Müller, Jakob M ^a   Flaschel, Erwin ^a   Friehs, Karl ^a   Risse, Joe M ^a  

^a BIELEFELD UNIVERSITY   (Germany)

Author keywords

Bioreactor cultivation; Biotin blocked binding sites; Chain length of streptavidin; FMD promoter; Methanol free production; MOX promoter

Indexed keywords

BACTERIA; BINDING SITES; BINS; BIOREACTORS; COENZYMES; FEEDING; GENE EXPRESSION; GENES; GLUCOSE; METHANOL;

BIOPROCESS DEVELOPMENT; EXTRACELLULAR CONCENTRATION; FMD PROMOTER; HANSENULA POLYMORPHA; HETEROLOGOUS PRODUCTION; MOX PROMOTER; PRODUCT CONCENTRATION; STREPTAVIDIN;

PROTEINS;

GLUCOSE; GLYCEROL; METHANOL; OXYGEN; STREPTAVIDIN; TETRAMER; CULTURE MEDIUM; FUNGAL PROTEIN;

ARTICLE; BIOMASS PRODUCTION; BIOPROCESS; BIOREACTOR; CONTROLLED STUDY; FED BATCH FERMENTATION; FEEDING; FUNGAL GENE; FUNGAL STRAIN; GENE; HEREDITY; NONHUMAN; OGATAEA ANGUSTA; PRIORITY JOURNAL; PROMOTER REGION; BATCH CELL CULTURE; BIOMASS; CHEMISTRY; CULTURE MEDIUM; FERMENTATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PHARMACOLOGY; PICHIA; SECRETION (PROCESS);

BATCH CELL CULTURE TECHNIQUES; BIOMASS; CULTURE MEDIA; FERMENTATION; FUNGAL PROTEINS; GLYCEROL; METHANOL; PICHIA; PROMOTER REGIONS, GENETIC; STREPTAVIDIN;

EID: 84961184841     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2016.03.017     Document Type: Article

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