Improved processing of secretory proteins in Hansenula polymorpha by sequence variation near the processing site of the alpha mating factor prepro sequence

Journal of Biotechnology

Volumn 167, Issue 2, 2013, Pages 94-100

  Eilert, Eva ^a   Rolf, Theresa ^a   Heumaier, Andreas ^b   Hollenberg, Cornelis P ^a,c   Piontek, Michael ^a   Suckow, Manfred ^a  

^a ARTES Biotechnology GmbH   (Germany)

^b UNIVERSITY OF HAMBURG   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Alpha mating factor; Hansenula polymorpha; Interferon 2a; Interleukin 6; Kex2p; Processing; Secretion; Signal sequence

Indexed keywords

ALPHA MATING FACTOR; HANSENULA POLYMORPHA; INTERLEUKIN-6; KEX2P; SECRETION; SIGNAL SEQUENCE;

AMINO ACIDS; ANTIBIOTICS; GLYCOPROTEINS; MOLECULAR WEIGHT; PEPTIDES; PROCESSING; YEAST;

MOLECULES;

ALPHA2A INTERFERON; AMINO ACID; HYBRID PROTEIN; INTERLEUKIN 6; MATING HORMONE ALPHA FACTOR; SECRETORY PROTEIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; IN VITRO STUDY; MOLECULAR WEIGHT; NONHUMAN; PICHIA ANGUSTA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SECRETION;

ALPHA MATING FACTOR; HANSENULA POLYMORPHA; IFNΑ-2A; IFNΑ-2B; IL-6; INTERFERON-Α 2A; INTERFERON-Α 2B; INTERLEUKIN-6; KEX2P; MATING FACTOR Α; MFΑ; PROCESSING; SECRETION; SIGNAL SEQUENCE;

AMINO ACID SEQUENCE; AMINO ACIDS; BIOTECHNOLOGY; FUNGAL PROTEINS; GENETIC VARIATION; INTERFERON-ALPHA; INTERLEUKIN-6; MOLECULAR SEQUENCE DATA; PEPTIDES; PICHIA; PROPROTEIN CONVERTASES; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

PICHIA ANGUSTA; SACCHAROMYCES CEREVISIAE;

EID: 84881028456     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2012.08.024     Document Type: Article

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