Phospholipase D2 drives mortality in sepsis by inhibiting neutrophil extracellular trap formation and down-regulating CXCR2

Journal of Experimental Medicine

Volumn 212, Issue 9, 2015, Pages 1381-1390

  Lee, Sung Kyun ^a   Kim, Sang Doo ^a   Kook, Minsoo ^a   Lee, Ha Young ^a,b   Ghim, Jaewang ^c   Choi, Youngwoo ^c   Zabel, Brian A ^d   Ryu, Sung Ho ^c   Bae, Yoe Sik ^a,b  

^a Sungkyunkwan University   (South Korea)

^b Dong A University   (South Korea)

^c Pohang University of Science and Technology (POSTECH)   (South Korea)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR2; CITRULLINE; CXCL1 CHEMOKINE; G PROTEIN COUPLED RECEPTOR KINASE 2; HISTONE H3; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 23; PHOSPHOLIPASE D2; PROTEIN ARGININE DEIMINASE; TUMOR NECROSIS FACTOR; ADRBK1 PROTEIN, MOUSE; CYTOKINE; LIPOPOLYSACCHARIDE; PHOSPHOLIPASE D;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; DEATH; DOWN REGULATION; EXPERIMENTAL SEPSIS; EXTRACELLULAR TRAP; LIVER; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; SURVIVAL; SURVIVAL RATE; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED; GENETICS; KNOCKOUT MOUSE; LUNG; METABOLISM; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; PATHOLOGY;

ANIMALS; CYTOKINES; DOWN-REGULATION; EXTRACELLULAR TRAPS; G-PROTEIN-COUPLED RECEPTOR KINASE 2; LIPOPOLYSACCHARIDES; LUNG; MICE; MICE, KNOCKOUT; NEUTROPHIL INFILTRATION; NEUTROPHILS; PHOSPHOLIPASE D; RECEPTORS, INTERLEUKIN-8B; SEPSIS;

EID: 84961131971     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20141813     Document Type: Article

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