Endothelial deletion of phospholipase d2 reduces hypoxic response and pathological angiogenesis

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 34, Issue 8, 2014, Pages 1697-1703

  Ghim, Jaewang ^a   Moon, Jin Sook ^a   Lee, Chang Sup ^a,c   Lee, Junyeop ^b,d   Song, Parkyong ^a,h   Lee, Areum ^a   Jang, Jin Hyeok ^a   Kim, Dayea ^a   Yoon, Jong Hyuk ^a   Koh, Young Jun ^b,e   Chelakkot, Chaithanya ^a   Kang, Byung Jun ^a   Kim, Jung Min ^a,f,h   Kim, Kyung Lock ^a   Yang, Yong Ryoul ^a,h   Kim, Youngmi ^a   Kim, Sun Hee ^a,g   Hwang, Daehee ^a,i   Suh, Pann Ghill ^a   Koh, Gou Young ^b   Kong, Young Yun ^a,j   Ryu, Sung Ho ^a   more..

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^c UNIVERSITY OF VIRGINIA   (United States)

^d University of Ulsan   (South Korea)

^e SAMSUNG Electronics   (South Korea)

^f WEILL CORNELL MEDICAL COLLEGE   (United States)

^g UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^h Ulsan National Institute of Science and Technology   (South Korea)

ⁱ Daegu Gyeongbuk Institute of Science and Technology   (South Korea)

^j Seoul National University   (South Korea)

more..

Author keywords

Angiogenesis; Endothelial cell; Hypoxia inducible factor 1; Phospholipase D2

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CASPASE 3; CELL ADHESION MOLECULE; FRUCTOSE 2,6 BISPHOSPHATASE; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NITRIC OXIDE SYNTHASE; PHOSPHOLIPASE D2; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER TRANSPLANTATION; CARCINOGENESIS; CELL FUNCTION; CELL MIGRATION; CELL SURVIVAL; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION; GENE TARGETING; HUMAN; HYPOXIA; IN VIVO STUDY; KNOCKOUT MOUSE; MOUSE; NERVE SPROUTING; NONHUMAN; OXIDATIVE STRESS; OXYGEN-INDUCED RETINOPATHY; PRIORITY JOURNAL; REGULATORY MECHANISM; TUMOR GROWTH; UPREGULATION; VASCULAR TUMOR;

ANGIOGENESIS; ENDOTHELIAL CELL; HYPOXIA-INDUCIBLE FACTOR-1; PHOSPHOLIPASE D2;

ANIMALS; ANIMALS, NEWBORN; ANOXIA; CARCINOMA, LEWIS LUNG; CELL HYPOXIA; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHOLIPASE D; RETINAL NEOVASCULARIZATION; RETINAL VESSELS; RNA INTERFERENCE; TIME FACTORS; TISSUE CULTURE TECHNIQUES; TRANSFECTION;

EID: 84904573450     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.303416     Document Type: Article

References (43)

1. Pugh CW, Ratcliffe PJ. Regulation of angiogenesis by hypoxia: role of the HIF system. Nat Med. 2003;9:677-684.
2. Chung AS, Ferrara N. Developmental and pathological angiogenesis. Annu Rev Cell Dev Biol. 2011;27:563-584.
3. Chung AS, Lee J, Ferrara N. Targeting the tumour vasculature: insights from physiological angiogenesis. Nat Rev Cancer. 2010;10:505-514.
4. Yee Koh M, Spivak-Kroizman TR, Powis G. HIF-1 regulation: not so easy come, easy go. Trends Biochem Sci. 2008;33:526-534.
5. Oude Weernink PA, López de Jesús M, Schmidt M. Phospholipase D signaling: orchestration by PIP2 and small GTPases. Naunyn Schmiedebergs Arch Pharmacol. 2007;374:399-411.
6. Jenkins GM, Frohman MA. Phospholipase D: a lipid centric review. Cell Mol Life Sci. 2005;62:2305-2316.
7. Peng X, Frohman MA. Mammalian phospholipase D physiological and pathological roles. Acta Physiol (Oxf). 2012;204:219-226.
8. Park JB, Lee CS, Jang JH, Ghim J, Kim YJ, You S, Hwang D, Suh PG, Ryu SH. Phospholipase signalling networks in cancer. Nat Rev Cancer. 2012;12:782-792.
9. Lee CS, Kim KL, Jang JH, Choi YS, Suh PG, Ryu SH. The roles of phospholipase D in EGFR signaling. Biochim Biophys Acta. 2009;1791:862-868.
10. Jang JH, Lee CS, Hwang D, Ryu SH. Understanding of the roles of phospholipase D and phosphatidic acid through their binding partners. Prog Lipid Res. 2012;51:71-81.
11. Zeng XX, Zheng X, Xiang Y, Cho HP, Jessen JR, Zhong TP, Solnica- Krezel L, Brown HA. Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish. Dev Biol. 2009;328:363-376.
12. Elvers M, Stegner D, Hagedorn I, Kleinschnitz C, Braun A, Kuijpers ME, Boesl M, Chen Q, Heemskerk JW, Stoll G, Frohman MA, Nieswandt B. Impaired alpha(IIb)beta(3) integrin activat ion and shear-dependent thrombus formation in mice lacking phospholipase D1. Sci Signal. 2010;3:ra1.
13. Oliveira TG, Chan RB, Tian H, Laredo M, Shui G, Staniszewski A, Zhang H, Wang L, Kim TW, Duff KE, Wenk MR, Arancio O, Di Paolo G. Phospholipase D2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. J Neurosci. 2010;30:16419-16428.
14. Majmundar AJ, Wong WJ, Simon MC. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell. 2010;40:294-309.
15. Greer SN, Metcalf JL, Wang Y, Ohh M. The updated biology of hypoxiainducible factor. EMBO J. 2012;31:2448-2460.
16. Gariano RF, Gardner TW. Retinal angiogenesis in development and disease. Nature. 2005;438:960-966.
17. Weis SM, Cheresh DA. Tumor angiogenesis: molecular pathways and therapeutic targets. Nat Med. 2011;17:1359-1370.
18. Tang N, Wang L, Esko J, Giordano FJ, Huang Y, Gerber HP, Ferrara N, Johnson RS. Loss of HIF-1alpha in endothelial cells disrupts a hypoxiadriven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell. 2004;6:485-495.
19. Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov. 2011;10:417-427.
20. Spriggs KA, Bushell M, Willis AE. Translational regulation of gene expression during conditions of cell stress. Mol Cell. 2010;40:228-237.
21. Lang KJ, Kappel A, Goodall GJ. Hypoxia-inducible factor-1alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol Biol Cell. 2002;13:1792-1801.
22. Galbán S, Kuwano Y, Pullmann R, Jr, Martindale JL, Kim HH, Lal A, Abdelmohsen K, Y ang X, Dang Y, Liu JO, Lewis SM, Holcik M, Gorospe M. RNA-binding proteins HuR and PTB promote the translation of hypoxia-inducible factor 1alpha. Mol Cell Biol. 2008;28:93-107.
23. Schepens B, Tinton SA, Bruynooghe Y, Beyaert R, Cornelis S. The polypyrimidine tract-binding protein stimulates HIF-1alpha IRES-mediated translation during hypoxia. Nucleic Acids Res. 2005;33:6884-6894.
24. Hui AS, Bauer AL, Striet JB, Schnell PO, Czyzyk-Krzeska MF. Calcium signaling stimulates translation of HIF-alpha during hypoxia. FASEB J. 2006;20:466-475.
25. Reiling JH, Sabatini DM. Stress and mTORture signaling. Oncogene. 2006;25:6373-6383.
26. Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronne t S, Kaufman RJ, Weppler SA, Voncken JW, Lambin P, Koumenis C, Sonenberg N, Wouters BG. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. EMBO J. 2006;25:1114-1125.
27. Kaper F, Dornhoefer N, Giaccia AJ. Mutations in the PI3K/PTEN/ TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. Cancer Res. 2006;66:1561-1569.
28. Thomas GV, Tran C, Mellinghoff IK, Welsbie DS, Chan E, Fueger B, Czernin J, Sawyers CL. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med. 2006;12: 122-127.
29. van den Beucken T, Koritzinsky M, Wouters BG. Translational control of gene expression during hypoxia. Cancer Biol Ther. 2006;5:749-755.
30. Foster DA. Regulation of mTOR by phosphatidic acid? Cancer Res. 2007;67:1-4.
31. Ha SH, Kim DH, Kim IS, Kim JH, Lee MN, Lee HJ, Kim JH, Jang SK, Suh PG, Ryu SH. PLD2 forms a functional complex with mTOR/raptor to transduce mitogenic signals. Cell Signal. 2006;18:2283-2291.
32. Semenza GL. Hypoxia-inducible factors in physiology and medicine. Cell. 2012;148:399-408.
33. Lee S, Chen TT, Barber CL, Jordan MC, Murdock J, Desai S, Ferrara N, Nagy A, Roos KP, Iruela-Arispe ML. Autocrine VEGF signaling is required for vascular homeostasis. Cell. 2007;130:691-703.
34. De Bock K, Georgiadou M, Schoors S, et al. Role of PFKFB3-driven glycolysis in vessel sprouting. Cell. 2013;154:651-663.
35. Donovan MJ, Lin MI, Wiegn P, Ringstedt T, Kr aemer R, Hahn R, Wang S, Ibañez CF, Rafii S, Hempstead BL. Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development. 2000;127:4531-4540.
36. Kermani P, Rafii D, Jin DK, Whitlock P, Schaffer W, Chiang A, Vincent L, Friedrich M, Shido K, Hackett NR, Crystal RG, Rafii S, Hempstead BL. Neurotr ophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors. J Clin Invest. 2005;115:653-663.
37. Zhao H, Azuma J, Kalish F, Wong RJ, Stevenson DK. Maternal heme oxygenase 1 regulates placental vasculature development via angiogenic factors in mice. Biol Reprod. 2011;85:1005-1012.
38. Ushio-Fukai M. Redox signaling in angiogenesis: role of NADPH oxidase. Cardiovasc Res. 2006;71:226-235.
39. Wilkinson-Berka JL, Rana I, Armani R, Agrotis A. Reactive oxygen species, Nox and angiotensin II in angiogenesis: implications for retinopathy. Clin Sci (Lond). 2013;124:597-615.
40. Tojo T, Ushio-Fukai M, Yamaoka-Tojo M, Ikeda S, Patrushev N, Alexander RW. Role of gp91phox (Nox2)-containing NAD(P)H oxidase in angiogenesis in response to hindlimb ischemia. Circulation. 2005;111:2347-2355.
41. Diebold I, Petry A, Sabrane K, Djordjevic T, Hess J, Görlach A. The HIF1 target gene NOX2 promotes angiogenesis through urotensin-II. J Cell Sci. 2012;125(Pt 4):956-964.
42. Chen Q, Hongu T, Sato T, Zhang Y, Ali W, Cavallo JA, van der Velden A, Tian H, Di Paolo G, Nieswandt B, Kanaho Y, Frohman MA. Key roles for th e lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis. Sci Signal. 2012;5:ra79.
43. Scott SA, Selvy PE, Buck JR, Cho HP, Criswell TL, Thomas AL, Armstrong MD, Arteaga CL, Lindsley CW, Brown HA. Design of isoform- selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat Chem Biol. 2009;5:108-117.