Inhibition of spleen tyrosine kinase (syk) suppresses renal fibrosis through anti-inflammatory effects and down regulation of the MAPK-p38 pathway

International Journal of Biochemistry and Cell Biology

Volumn 74, Issue , 2016, Pages 135-144

  Chen, Kuan Hsing ^a   Hsu, Hsiang Hao ^a   Yang, Huang Yu ^a   Tian, Ya Chung ^a   Ko, Yi Ching ^a   Yang, Chih Wei ^a   Hung, Cheng Chieh ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

MAPK; Renal fibrosis; Spleen tyrosine kinase (Syk); Transforming growth factor 1; Unilateral ureteral obstruction

Indexed keywords

2 [7 (3,4 DIMETHOXYPHENYL)IMIDAZO[1,2 C]PYRIMIDIN 5 YLAMINO]NICOTINAMIDE DIHYDROCHLORIDE; ALPHA SMOOTH MUSCLE ACTIN; ANTIINFLAMMATORY AGENT; ARGINASE 1; COLLAGEN TYPE 1; COLLAGEN TYPE 4; CONNECTIVE TISSUE GROWTH FACTOR; CRYOPYRIN; FIBRONECTIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 23; MACROPHAGE MANNOSE RECEPTOR; MANNOSE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE SYK; PROTEIN KINASE SYK INHIBITOR; RNA 18S; SODIUM CHLORIDE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; ENZYME INHIBITOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL INFILTRATION; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENZYME INHIBITION; EXTRACELLULAR MATRIX; FIBROGENESIS; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; KIDNEY FIBROSIS; MACROPHAGE; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; TIME-DEPENDENT INHIBITION; URETER OBSTRUCTION; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; FIBROBLAST; FIBROSIS; GENETICS; KIDNEY DISEASES; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME INHIBITORS; FIBROBLASTS; FIBROSIS; KIDNEY DISEASES; MALE; MICE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYK KINASE;

EID: 84960961240     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2016.03.001     Document Type: Article

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