Enhanced anti-tumor activity and reduced toxicity by combination andrographolide and bleomycin in ascitic tumor-bearing mice

European Journal of Pharmacology

Volumn 776, Issue , 2016, Pages 52-63

  Guo, Huizhen ^a,b   Zhang, Zhenbiao ^a   Su, Zuqing ^a,c   Sun, Chaoyue ^a   Zhang, Xie ^a   Zhao, Xiaoning ^a,d   Lai, Xiaoping ^a   Su, Ziren ^a   Li, Yucui ^a   Zhan, Janis Yaxian ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c GUANGDONG PROVINCIAL HOSPITAL OF CHINESE MEDICINE   (China)

^d Guangdong Xinxing Junior College of the Traditional Chinese Medicine   (China)

Author keywords

Andrographolide; Anticancer; Bleomycin; Combination; Pulmonary fibrosis

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANDROGRAPHOLIDE; BLEOMYCIN; CASPASE 3; CASPASE 8; CYCLINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; PROTEIN P21; PROTEIN P53; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; ACTIN; ALPHA-SMOOTH MUSCLE ACTIN, MOUSE; ANTINEOPLASTIC AGENT; CYTOKINE; DITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; ASCITES TUMOR; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CELL CYCLE G0 PHASE; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MEGADOSE; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; G1 PHASE CELL CYCLE CHECKPOINT; LOW DRUG DOSE; LUNG FIBROSIS; MALE; MONOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; ANIMAL; ASCITES FLUID; BIOSYNTHESIS; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CHEMICALLY INDUCED; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; LUNG; METABOLISM; PATHOLOGY; PULMONARY FIBROSIS; TUMOR CELL LINE;

ACTINS; ANIMALS; ANTINEOPLASTIC AGENTS; ASCITIC FLUID; BLEOMYCIN; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CYTOKINES; DITERPENES; DRUG SYNERGISM; GENE EXPRESSION REGULATION, NEOPLASTIC; LUNG; MALE; MICE; PULMONARY FIBROSIS; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84960927929     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2016.02.032     Document Type: Article

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