Xanthohumol induces growth inhibition and apoptosis in Ca Ski human cervical cancer cells

Evidence-based Complementary and Alternative Medicine

Volumn 2015, Issue , 2015, Pages

  Yong, Wai Kuan ^a   Abd Malek, Sri Nurestri ^a  

^a UNIVERSITY OF MALAYA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; DOXORUBICIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLSERINE; PROTEIN BCL 2; PROTEIN P53; SULFORHODAMINE B; X LINKED INHIBITOR OF APOPTOSIS; XANTHOHUMOL;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CA SKI CERVICAL CANCER CELL LINE; CANCER CELL; CANCER INHIBITION; CELL DEATH; CERVICAL CANCER CELL LINE; CONTROLLED STUDY; DNA FRAGMENTATION; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IC50; MITOCHONDRIAL MEMBRANE POTENTIAL; PHASE CONTRAST MICROSCOPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT; UPREGULATION; UTERINE CERVIX CANCER; WESTERN BLOTTING;

EID: 84928473650     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2015/921306     Document Type: Article

References (32)

1. D. T. Gómez and J. L. Santos, "Human papillomavirus infection and cervical cancer: pathogenesis and epidemiology, " in Communicating Current Research and Educational Topics and Trends in Applied Microbiology, A. Méndez-Vilas, Ed., pp. 680-688, Formatex Research Center, Badajoz, Spain, 2007.
2. T. Yugawa and T. Kiyono, "Molecular mechanisms of cervical carcinogenesis by high-risk human papillomaviruses: novel functions of E6 and E7 oncoproteins, " Reviews in Medical Virology, vol. 19, no. 2, pp. 97-113, 2009.
3. International Agency for Research on Cancer, GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012, International Agency for Research on Cancer, 2012, http://globocan.iarc.fr/Default.aspx.
4. F. Zagouri, T. N. Sergentanis, D. Chrysikos, M. Filipits, and R. Bartsch, "Molecularly targeted therapies in cervical cancer. A systematic review, " Gynecologic Oncology, vol. 126, no. 2, pp. 291-303, 2012.
5. J. Strathmann and C. Gerhauser, "Anti-proliferative and apoptosis-inducing properties of xanthohumol, a prenylated chalcone from hops (Humulus lupulus L. ), " in Natural Compounds as Inducers of Cell Death, M. Diederich and K. Noworyta, Eds., pp. 69-93, Springer, Dordrecht, The Netherlands, 2012.
6. R. Monteiro, H. Becker, I. Azevedo, and C. Calhau, "Effect of hop (Humulus lupulus L. ) flavonoids on aromatase (estrogen synthase) activity, " Journal of Agricultural and Food Chemistry, vol. 54, no. 8, pp. 2938-2943, 2006.
7. C. Gerhauser, A. Alt, E. Heiss et al., "Cancer chemopreventive activity of xanthohumol, a natural product derived from hop, " Molecular CancerTherapeutics, vol. 1, no. 11, pp. 959-969, 2002.
8. S. Guerreiro, R. Monteiro, M. J. Martins, C. Calhau, I. Azevedo, and R. Soares, "Distinct modulation of alkaline phosphatase isoenzymes by 17β-estradiol and xanthohumol in breast cancer MCF-7 cells, " Clinical Biochemistry, vol. 40, no. 3-4, pp. 268-273, 2007.
9. R. Monteiro, C. Calhau, A. O. E. Silva et al., "Xanthohumol inhibits inflammatory factor production and angiogenesis in breast cancer xenografts, " Journal of Cellular Biochemistry, vol. 104, no. 5, pp. 1699-1707, 2008.
10. S. Vogel, S. Ohmayer, G. Brunner, and J. Heilmann, "Natural and non-natural prenylated chalcones: synthesis, cytotoxicity and anti-oxidative activity, " Bioorganic and Medicinal Chemistry, vol. 16, no. 8, pp. 4286-4293, 2008.
11. E. Szliszka, D. Jaworska, M. Kłósek, Z. P. Czuba, and W. Król, "Targeting death receptor TRAIL-R2 by chalcones for TRAILinduced apoptosis in cancer cells, " International Journal of Molecular Sciences, vol. 13, no. 11, pp. 15343-15359, 2012.
12. X. Wen, D. Li, Y. Zhang, S. Liu, L. Ghali, and R. K. Iles, "Arsenic trioxide induces cervical cancer apoptosis, but specifically targets human papillomavirus-infected cell populations, " Anti-Cancer Drugs, vol. 23, no. 3, pp. 280-287, 2012.
13. J. D. Meissner, "Nucleotide sequences and further characterization of human papillomavirus DNA present in the CaSki, SiHa andHeLa cervical carcinoma cell lines, " Journal of General Virology, vol. 80, no. 7, pp. 1725-1733, 1999.
14. P. Houghton, R. Fang, I. Techatanawat, G. Steventon, P. J. Hylands, and C. C. Lee, "The sulphorhodamine (SRB) assay and other approaches to testing plant extracts and derived compounds for activities related to reputed anticancer activity, " Methods, vol. 42, no. 4, pp. 377-387, 2007.
15. S. H. Lee, H. J. Kim, J. S. Lee, I.-S. Lee, and B. Y. Kang, "Inhibition of topoisomerase I activity and efflux drug transporters' expression by xanthohumol from hops, " Archives of Pharmacal Research, vol. 30, no. 11, pp. 1435-1439, 2007.
16. W. A. Cliby, K. A. Lewis, K. K. Lilly, and S. H. Kaufmann, "S phase and G2 arrests induced by topoisomerase I poisons are dependent on ATR kinase function, " The Journal of Biological Chemistry, vol. 277, no. 2, pp. 1599-1606, 2002.
17. L. Pan, H. Becker, and C. Gerhäuser, "Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor-and mitochondrial pathway, " Molecular Nutrition and Food Research, vol. 49, no. 9, pp. 837-843, 2005.
18. B. Vanhoecke, L. Derycke, V. Van Marck, H. Depypere, D. De Keukeleire, and M. Bracke, "Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L. ) and beer, " International Journal ofCancer, vol. 117, no. 6, pp. 889-895, 2005.
19. S. Motoyama, C. A. Ladines-Llave, S. L. Villanueva, and T. Maruo, "The role of human papilloma virus in the molecular biology of cervical carcinogenesis, " Kobe Journal of Medical Sciences, vol. 50, no. 1-2, pp. 9-19, 2004.
20. M. C. de Almagro and D. Vucic, "The inhibitor of apoptosis (IAP) proteins are critical regulators of signaling pathways and targets for anti-cancer therapy, " Experimental Oncology, vol. 34, no. 3, pp. 200-211, 2012.
21. K. B. Harikumar, A. B. Kunnumakkara, K. S. Ahn et al., "Modification of the cysteine residues in IκBα kinase and NF-κB (p65) by xanthohumol leads to suppression of NF-κB-regulated gene products and potentiation of apoptosis in leukemia cells, " Blood, vol. 113, no. 9, pp. 2003-2013, 2009.
22. E. Norberg, S. Orrenius, and B. Zhivotovsky, "Mitochondrial regulation of cell death: processing of apoptosis-inducing factor (AIF), " Biochemical and Biophysical Research Communications, vol. 396, no. 1, pp. 95-100, 2010.
23. J. Strathmann, K. Klimo, S. W. Sauer, J. G. Okun, J. H. M. Prehn, and C. Gerhäuser, "Xanthohumol-induced transient superoxide anion radical formation triggers cancer cells into apoptosis via amitochondria-mediated mechanism, " The FASEB Journal, vol. 24, no. 8, pp. 2938-2950, 2010.
24. M. Chen, A. D. Guerrero, L. Huang et al., "Caspase-9-induced mitochondrial disruption through cleavage of anti-apoptotic BCL-2 family members, " The Journal of Biological Chemistry, vol. 282, no. 46, pp. 33888-33895, 2007.
25. M. Mahyar-Roemer, H. Köhler, and K. Roemer, "Role of Bax in resveratrol-induced apoptosis of colorectal carcinoma cells, " BMC Cancer, vol. 2, article 27, 9 pages, 2002.
26. X. Lei, Y. Chen, G. Du et al., "Gossypol induces Bax/Bakindependent activation of apoptosis and cytochrome c release via a conformational change in Bcl-2, " The FASEB Journal, vol. 20, no. 12, pp. 2147-2149, 2006.
27. F. W. Kah, S.-L. Chan, S. K. Sukumaran, M.-C. Lee, and V. C. Yu, "Chelerythrine induces apoptosis through a Bax/Bakindependent mitochondrial mechanism, " The Journal of Biological Chemistry, vol. 283, no. 13, pp. 8423-8433, 2008.
28. K. Gowthamarajan, R. Shanmugam, K. Madhuri, P. Nilani, M. Satish Kumar, and L. Dwarampudi, "The potential therapeutic targets for cervical cancer, " International Journal of Health and Allied Sciences, vol. 2, no. 2, pp. 69-74, 2013.
29. N. Zhang, Z. Liu, Q. Han et al., "Inhibition of bovine viral diarrhea virus in vitro by xanthohumol: comparisons with ribavirin and interferon-α and implications for the development of antihepatitis C virus agents, " European Journal of Pharmaceutical Sciences, vol. 38, no. 4, pp. 332-340, 2009.
30. B. W. Vanhoecke, F. Delporte, E. van Braeckel et al., "A safety study of oral tangeretin and xanthohumol administration to laboratory mice, " In Vivo, vol. 19, no. 1, pp. 103-108, 2005.
31. R. Hussong, N. Frank, J. Knauft et al., "A safety study of oral xanthohumol administration and its influence on fertility in Sprague Dawley rats, " Molecular Nutrition and Food Research, vol. 49, no. 9, pp. 861-867, 2005.
32. R. B. van Breemen, Y. Yuan, S. Banuvar et al., "Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops, " Molecular Nutrition and Food Research, vol. 58, no. 10, pp. 1962-1969, 2014.